UniProtKB - P04233 (HG2A_HUMAN)
HLA class II histocompatibility antigen gamma chain
CD74
Functioni
GO - Molecular functioni
- amyloid-beta binding Source: BHF-UCL
- CD4 receptor binding Source: CAFA
- cytokine binding Source: BHF-UCL
- cytokine receptor activity Source: BHF-UCL
- identical protein binding Source: UniProtKB
- macrophage migration inhibitory factor binding Source: BHF-UCL
- MHC class II protein binding Source: BHF-UCL
- MHC class II protein binding, via antigen binding groove Source: UniProtKB
- MHC class II protein complex binding Source: UniProtKB
- protein folding chaperone Source: UniProtKB
GO - Biological processi
- antigen processing and presentation Source: GO_Central
- antigen processing and presentation of endogenous antigen Source: UniProtKB
- antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
- immunoglobulin mediated immune response Source: UniProtKB
- intracellular protein transport Source: UniProtKB
- leukocyte migration Source: Reactome
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of cell migration Source: ARUK-UCL
- negative regulation of DNA damage response, signal transduction by p53 class mediator Source: BHF-UCL
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: BHF-UCL
- negative regulation of peptide secretion Source: BHF-UCL
- positive regulation of B cell proliferation Source: BHF-UCL
- positive regulation of chemokine (C-X-C motif) ligand 2 production Source: BHF-UCL
- positive regulation of chemokine production Source: ARUK-UCL
- positive regulation of cytokine-mediated signaling pathway Source: BHF-UCL
- positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
- positive regulation of fibroblast proliferation Source: BHF-UCL
- positive regulation of gene expression Source: ARUK-UCL
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: CAFA
- positive regulation of interleukin-6 production Source: ARUK-UCL
- positive regulation of interleukin-8 production Source: ARUK-UCL
- positive regulation of kinase activity Source: CAFA
- positive regulation of macrophage cytokine production Source: BHF-UCL
- positive regulation of macrophage migration inhibitory factor signaling pathway Source: ARUK-UCL
- positive regulation of MAPK cascade Source: CAFA
- positive regulation of monocyte differentiation Source: CAFA
- positive regulation of neutrophil chemotaxis Source: BHF-UCL
- positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
- positive regulation of prostaglandin biosynthetic process Source: ARUK-UCL
- positive regulation of protein phosphorylation Source: CAFA
- positive regulation of transcription, DNA-templated Source: CAFA
- positive regulation of type 2 immune response Source: GO_Central
- positive regulation of viral entry into host cell Source: CAFA
- prostaglandin biosynthetic process Source: UniProtKB
- protein-containing complex assembly Source: UniProtKB
- protein stabilization Source: UniProtKB
- protein trimerization Source: InterPro
- regulation of macrophage activation Source: UniProtKB
- T cell activation involved in immune response Source: GO_Central
- T cell selection Source: UniProtKB
Keywordsi
Molecular function | Chaperone |
Biological process | Adaptive immunity, Immunity |
Enzyme and pathway databases
PathwayCommonsi | P04233 |
Reactomei | R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-2132295, MHC class II antigen presentation |
SIGNORi | P04233 |
Protein family/group databases
MEROPSi | I31.002 |
TCDBi | 9.A.75.1.1, the mhc ii receptor (mhc2r) family |
Names & Taxonomyi
Protein namesi | Recommended name: HLA class II histocompatibility antigen gamma chainCuratedAlternative name(s): HLA-DR antigens-associated invariant chain Ia antigen-associated invariant chain Short name: Ii CD_antigen: CD74 Cleaved into the following chain: |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1697, CD74 |
MIMi | 142790, gene |
neXtProti | NX_P04233 |
VEuPathDBi | HostDB:ENSG00000019582.14 |
Subcellular locationi
Endosome
Lysosome
Plasma membrane
- Cell membrane Curated; Single-pass type II membrane protein Curated
Endoplasmic reticulum
Golgi apparatus
Note: Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.
Endosome
- Late endosome By similarity
Lysosome
- Lysosome By similarity
Endoplasmic reticulum
- integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
Endosome
- late endosome Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi membrane Source: Reactome
- trans-Golgi network membrane Source: Reactome
Lysosome
- lysosomal lumen Source: Reactome
- lysosomal membrane Source: Reactome
- lysosome Source: UniProtKB
Nucleus
- nucleus Source: ARUK-UCL
Plasma Membrane
- plasma membrane Source: ARUK-UCL
Other locations
- cell surface Source: BHF-UCL
- clathrin-coated endocytic vesicle membrane Source: Reactome
- cytoplasm Source: ARUK-UCL
- endocytic vesicle membrane Source: Reactome
- ER to Golgi transport vesicle membrane Source: Reactome
- integral component of membrane Source: BHF-UCL
- macrophage migration inhibitory factor receptor complex Source: BHF-UCL
- membrane Source: UniProtKB
- protein-containing complex Source: ARUK-UCL
- transport vesicle membrane Source: Reactome
- vacuole Source: BHF-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 46 | CytoplasmicSequence analysisAdd BLAST | 46 | |
Transmembranei | 47 – 72 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 26 | |
Topological domaini | 73 – 296 | ExtracellularSequence analysisAdd BLAST | 224 |
Keywords - Cellular componenti
Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, MembranePathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 225 – 226 | PG → RR or DD: Decreases inhibition of Ebola virus infection. 1 Publication | 2 | |
Mutagenesisi | 225 – 226 | PG → TT: No effect on inhibition of Ebola virus infection. 1 Publication | 2 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 208 – 209 | Breakpoint for translocation to form a CD74-ROS1 fusion protein | 2 |
Organism-specific databases
DisGeNETi | 972 |
OpenTargetsi | ENSG00000019582 |
PharmGKBi | PA26236 |
Miscellaneous databases
Pharosi | P04233, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4692 |
GuidetoPHARMACOLOGYi | 2840 |
Genetic variation databases
BioMutai | CD74 |
DMDMi | 20178292 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000067954 | 1 – 296 | HLA class II histocompatibility antigen gamma chainAdd BLAST | 296 | |
PeptideiPRO_0000448886 | 97 – 120 | Class-II-associated invariant chain peptide1 PublicationAdd BLAST | 24 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 25 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 130 | N-linked (GlcNAc...) asparagine | 1 | |
Glycosylationi | 136 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 203 | O-linked (GalNAc...) threonine2 Publications | 1 | |
Disulfide bondi | 213 ↔ 232 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 243 ↔ 250 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 252 ↔ 271 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 256 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 281 | O-linked (GalNAc...) serine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, ProteoglycanProteomic databases
jPOSTi | P04233 |
MassIVEi | P04233 |
MaxQBi | P04233 |
PaxDbi | P04233 |
PeptideAtlasi | P04233 |
PRIDEi | P04233 |
ProteomicsDBi | 51689 [P04233-1] 51690 [P04233-2] 51691 [P04233-3] |
PTM databases
GlyConnecti | 659, 9 N-Linked glycans (2 sites), 1 O-Linked glycan (1 site) |
GlyGeni | P04233, 9 sites, 1 O-linked glycan (4 sites) |
iPTMneti | P04233 |
PhosphoSitePlusi | P04233 |
SwissPalmi | P04233 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000019582, Expressed in spleen and 246 other tissues |
ExpressionAtlasi | P04233, baseline and differential |
Genevisiblei | P04233, HS |
Organism-specific databases
HPAi | ENSG00000019582, Tissue enhanced (blood) |
Interactioni
Subunit structurei
Homotrimer. In the endoplasmic reticulum (ER) it forms a heterononameric MHC II-Ii complex: 3 MHC class II molecules (heterodimers of an alpha and a beta subunit) bind to the CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system, the CD74 component undergoes sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide) attached to the MHC class II molecule (alpha-beta-CLIP complex). This processed complex interacts with HLA_DM and HLA_DO heterodimers in order to release CLIP and facilitate the binding of antigenic peptides to the MHC class II molecules.
Interacts with CD44; this complex is essential for the MIF-induced signaling cascade that results in B cell survival.
By similarity2 PublicationsInteracts with the mature form of CTSL; the complex survive in neutral pH environment.
1 PublicationBinary interactionsi
Hide detailsP04233
Isoform p35 [P04233-2]
GO - Molecular functioni
- CD4 receptor binding Source: CAFA
- cytokine binding Source: BHF-UCL
- identical protein binding Source: UniProtKB
- macrophage migration inhibitory factor binding Source: BHF-UCL
- MHC class II protein binding Source: BHF-UCL
- MHC class II protein binding, via antigen binding groove Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107410, 138 interactors |
ELMi | P04233 |
IntActi | P04233, 200 interactors |
MINTi | P04233 |
STRINGi | 9606.ENSP00000009530 |
Chemistry databases
BindingDBi | P04233 |
Miscellaneous databases
RNActi | P04233, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P04233 |
SMRi | P04233 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P04233 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 210 – 271 | Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST | 62 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 225 – 226 | Required for interaction with CTSL2 Publications | 2 |
Domaini
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1214, Eukaryota |
GeneTreei | ENSGT00390000008961 |
InParanoidi | P04233 |
OrthoDBi | 1190626at2759 |
PhylomeDBi | P04233 |
TreeFami | TF317779 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 1.10.870.10, 1 hit 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR043530, CD74_antigen IPR015386, MHC_II-assoc_invar/CLIP_MHC-bd IPR022339, MHC_II-assoc_invar_chain IPR011988, MHC_II-assoc_invariant_trimer IPR036613, MHCII_invariant_trimer_sf IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
Pfami | View protein in Pfam PF09307, MHC2-interact, 1 hit PF08831, MHCassoc_trimer, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PIRSFi | PIRSF001992, CD74_antigen, 1 hit |
PRINTSi | PR01990, CD74ANTIGEN |
SMARTi | View protein in SMART SM00211, TY, 1 hit |
SUPFAMi | SSF48305, SSF48305, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing and alternative initiation. AlignAdd to basketThis entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MHRRRSRSCR EDQKPVMDDQ RDLISNNEQL PMLGRRPGAP ESKCSRGALY
60 70 80 90 100
TGFSILVTLL LAGQATTAYF LYQQQGRLDK LTVTSQNLQL ENLRMKLPKP
110 120 130 140 150
PKPVSKMRMA TPLLMQALPM GALPQGPMQN ATKYGNMTED HVMHLLQNAD
160 170 180 190 200
PLKVYPPLKG SFPENLRHLK NTMETIDWKV FESWMHHWLL FEMSRHSLEQ
210 220 230 240 250
KPTDAPPKVL TKCQEEVSHI PAVHPGSFRP KCDENGNYLP LQCYGSIGYC
260 270 280 290
WCVFPNGTEV PNTRSRGHHN CSESLELEDP SSGLGVTKQD LGPVPM
The sequence of this isoform differs from the canonical sequence as follows:
209-272: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-16: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-16: Missing.
209-272: Missing.
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YBZ2 | H0YBZ2_HUMAN | HLA class II histocompatibility ant... | CD74 | 316 | Annotation score: | ||
H0YBZ8 | H0YBZ8_HUMAN | HLA class II histocompatibility ant... | CD74 | 145 | Annotation score: | ||
E7ESL3 | E7ESL3_HUMAN | HLA class II histocompatibility ant... | CD74 | 152 | Annotation score: | ||
E7EQJ3 | E7EQJ3_HUMAN | HLA class II histocompatibility ant... | CD74 | 122 | Annotation score: | ||
E7ER71 | E7ER71_HUMAN | HLA class II histocompatibility ant... | CD74 | 52 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 167 | R → T in CAA27047 (PubMed:3001652).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_060904 | 1 – 16 | Missing in isoform p41 and isoform p33. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_037869 | 148 – 160 | NADPL…PPLKG → SHWNWRTRLLGWV in isoform 3. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_037870 | 161 – 296 | Missing in isoform 3. 1 PublicationAdd BLAST | 136 | |
Alternative sequenceiVSP_005331 | 209 – 272 | Missing in isoform p35 and isoform p33. 5 PublicationsAdd BLAST | 64 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K01144 mRNA Translation: AAA36304.1 Different initiation. X00497 mRNA Translation: CAA25192.1 X00497 mRNA Translation: CAA25193.1 X03339 Genomic DNA Translation: CAA27046.1 X03340 Genomic DNA Translation: CAA27047.1 M13560 , M13555, M13556, M13558, M13559 Genomic DNA Translation: AAA36033.1 BT019505 mRNA Translation: AAV38312.1 AK292076 mRNA Translation: BAF84765.1 AK297889 mRNA Translation: BAG60210.1 AC011372 Genomic DNA No translation available. AC011388 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61727.1 CH471062 Genomic DNA Translation: EAW61728.1 CH471062 Genomic DNA Translation: EAW61729.1 CH471062 Genomic DNA Translation: EAW61730.1 CH471062 Genomic DNA Translation: EAW61731.1 BC018726 mRNA Translation: AAH18726.1 BC024272 mRNA Translation: AAH24272.1 |
CCDSi | CCDS34276.1 [P04233-3] CCDS47308.1 [P04233-2] CCDS47309.1 [P04233-1] |
PIRi | A93981, HLHUG |
RefSeqi | NP_001020329.1, NM_001025158.2 [P04233-3] NP_001020330.1, NM_001025159.2 [P04233-1] NP_004346.1, NM_004355.3 [P04233-2] |
Genome annotation databases
Ensembli | ENST00000009530; ENSP00000009530; ENSG00000019582 [P04233-1] ENST00000353334; ENSP00000230685; ENSG00000019582 [P04233-2] ENST00000377795; ENSP00000367026; ENSG00000019582 [P04233-3] |
GeneIDi | 972 |
KEGGi | hsa:972 |
UCSCi | uc003lsc.4, human [P04233-1] |
Keywords - Coding sequence diversityi
Alternative initiation, Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K01144 mRNA Translation: AAA36304.1 Different initiation. X00497 mRNA Translation: CAA25192.1 X00497 mRNA Translation: CAA25193.1 X03339 Genomic DNA Translation: CAA27046.1 X03340 Genomic DNA Translation: CAA27047.1 M13560 , M13555, M13556, M13558, M13559 Genomic DNA Translation: AAA36033.1 BT019505 mRNA Translation: AAV38312.1 AK292076 mRNA Translation: BAF84765.1 AK297889 mRNA Translation: BAG60210.1 AC011372 Genomic DNA No translation available. AC011388 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61727.1 CH471062 Genomic DNA Translation: EAW61728.1 CH471062 Genomic DNA Translation: EAW61729.1 CH471062 Genomic DNA Translation: EAW61730.1 CH471062 Genomic DNA Translation: EAW61731.1 BC018726 mRNA Translation: AAH18726.1 BC024272 mRNA Translation: AAH24272.1 |
CCDSi | CCDS34276.1 [P04233-3] CCDS47308.1 [P04233-2] CCDS47309.1 [P04233-1] |
PIRi | A93981, HLHUG |
RefSeqi | NP_001020329.1, NM_001025158.2 [P04233-3] NP_001020330.1, NM_001025159.2 [P04233-1] NP_004346.1, NM_004355.3 [P04233-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1A6A | X-ray | 2.75 | C | 103-117 | [»] | |
1ICF | X-ray | 2.00 | I/J | 210-274 | [»] | |
1IIE | NMR | - | A/B/C | 134-208 | [»] | |
1L3H | NMR | - | A | 210-274 | [»] | |
1MUJ | X-ray | 2.15 | C | 97-121 | [»] | |
3PDO | X-ray | 1.95 | C | 102-120 | [»] | |
3PGC | X-ray | 2.66 | C/F | 106-120 | [»] | |
3PGD | X-ray | 2.72 | C/F | 106-120 | [»] | |
3QXA | X-ray | 2.71 | C/F | 103-117 | [»] | |
3QXD | X-ray | 2.30 | C/F | 103-117 | [»] | |
4AEN | X-ray | 2.20 | C | 106-120 | [»] | |
4AH2 | X-ray | 2.36 | B | 106-120 | [»] | |
4X5W | X-ray | 1.34 | C | 102-120 | [»] | |
5KSU | X-ray | 2.73 | C/F | 103-117 | [»] | |
5KSV | X-ray | 2.19 | C | 109-123 | [»] | |
BMRBi | P04233 | |||||
SMRi | P04233 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107410, 138 interactors |
ELMi | P04233 |
IntActi | P04233, 200 interactors |
MINTi | P04233 |
STRINGi | 9606.ENSP00000009530 |
Chemistry databases
BindingDBi | P04233 |
ChEMBLi | CHEMBL4692 |
GuidetoPHARMACOLOGYi | 2840 |
Protein family/group databases
MEROPSi | I31.002 |
TCDBi | 9.A.75.1.1, the mhc ii receptor (mhc2r) family |
PTM databases
GlyConnecti | 659, 9 N-Linked glycans (2 sites), 1 O-Linked glycan (1 site) |
GlyGeni | P04233, 9 sites, 1 O-linked glycan (4 sites) |
iPTMneti | P04233 |
PhosphoSitePlusi | P04233 |
SwissPalmi | P04233 |
Genetic variation databases
BioMutai | CD74 |
DMDMi | 20178292 |
Proteomic databases
jPOSTi | P04233 |
MassIVEi | P04233 |
MaxQBi | P04233 |
PaxDbi | P04233 |
PeptideAtlasi | P04233 |
PRIDEi | P04233 |
ProteomicsDBi | 51689 [P04233-1] 51690 [P04233-2] 51691 [P04233-3] |
Protocols and materials databases
ABCDi | P04233, 19 sequenced antibodies |
Antibodypediai | 2245, 2129 antibodies |
CPTCi | P04233, 1 antibody |
DNASUi | 972 |
Genome annotation databases
Ensembli | ENST00000009530; ENSP00000009530; ENSG00000019582 [P04233-1] ENST00000353334; ENSP00000230685; ENSG00000019582 [P04233-2] ENST00000377795; ENSP00000367026; ENSG00000019582 [P04233-3] |
GeneIDi | 972 |
KEGGi | hsa:972 |
UCSCi | uc003lsc.4, human [P04233-1] |
Organism-specific databases
CTDi | 972 |
DisGeNETi | 972 |
GeneCardsi | CD74 |
HGNCi | HGNC:1697, CD74 |
HPAi | ENSG00000019582, Tissue enhanced (blood) |
MIMi | 142790, gene |
neXtProti | NX_P04233 |
OpenTargetsi | ENSG00000019582 |
PharmGKBi | PA26236 |
VEuPathDBi | HostDB:ENSG00000019582.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1214, Eukaryota |
GeneTreei | ENSGT00390000008961 |
InParanoidi | P04233 |
OrthoDBi | 1190626at2759 |
PhylomeDBi | P04233 |
TreeFami | TF317779 |
Enzyme and pathway databases
PathwayCommonsi | P04233 |
Reactomei | R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-2132295, MHC class II antigen presentation |
SIGNORi | P04233 |
Miscellaneous databases
BioGRID-ORCSi | 972, 3 hits in 875 CRISPR screens |
ChiTaRSi | CD74, human |
EvolutionaryTracei | P04233 |
GeneWikii | CD74 |
GenomeRNAii | 972 |
Pharosi | P04233, Tchem |
PROi | PR:P04233 |
RNActi | P04233, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000019582, Expressed in spleen and 246 other tissues |
ExpressionAtlasi | P04233, baseline and differential |
Genevisiblei | P04233, HS |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 1.10.870.10, 1 hit 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR043530, CD74_antigen IPR015386, MHC_II-assoc_invar/CLIP_MHC-bd IPR022339, MHC_II-assoc_invar_chain IPR011988, MHC_II-assoc_invariant_trimer IPR036613, MHCII_invariant_trimer_sf IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
Pfami | View protein in Pfam PF09307, MHC2-interact, 1 hit PF08831, MHCassoc_trimer, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PIRSFi | PIRSF001992, CD74_antigen, 1 hit |
PRINTSi | PR01990, CD74ANTIGEN |
SMARTi | View protein in SMART SM00211, TY, 1 hit |
SUPFAMi | SSF48305, SSF48305, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HG2A_HUMAN | |
Accessioni | P04233Primary (citable) accession number: P04233 Secondary accession number(s): A8K7R1 Q8WLP6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 1987 |
Last sequence update: | April 16, 2002 | |
Last modified: | February 10, 2021 | |
This is version 225 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references