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Entry version 216 (18 Sep 2019)
Sequence version 3 (16 Apr 2002)
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Protein

HLA class II histocompatibility antigen gamma chain

Gene

CD74

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-2132295 MHC class II antigen presentation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P04233

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I31.002

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HLA class II histocompatibility antigen gamma chain
Alternative name(s):
HLA-DR antigens-associated invariant chain
Ia antigen-associated invariant chain
Short name:
Ii
p33
CD_antigen: CD74
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD74
Synonyms:DHLAG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1697 CD74

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
142790 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P04233

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 46CytoplasmicSequence analysisAdd BLAST46
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei47 – 72Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST26
Topological domaini73 – 296ExtracellularSequence analysisAdd BLAST224

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74-ROS1 chimeric protein.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei208 – 209Breakpoint for translocation to form a CD74-ROS1 fusion protein2

Organism-specific databases

DisGeNET

More...
DisGeNETi
972

Open Targets

More...
OpenTargetsi
ENSG00000019582

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26236

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4692

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2840

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CD74

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20178292

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000679541 – 296HLA class II histocompatibility antigen gamma chainAdd BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei25PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi130N-linked (GlcNAc...) asparagine1
Glycosylationi136N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi203O-linked (GalNAc...) threonine2 Publications1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi213 ↔ 232PROSITE-ProRule annotation1 Publication
Disulfide bondi243 ↔ 250PROSITE-ProRule annotation1 Publication
Disulfide bondi252 ↔ 271PROSITE-ProRule annotation1 Publication
Glycosylationi256N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi281O-linked (GalNAc...) serine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.4 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P04233

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P04233

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P04233

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P04233

PeptideAtlas

More...
PeptideAtlasi
P04233

PRoteomics IDEntifications database

More...
PRIDEi
P04233

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51689 [P04233-1]
51690 [P04233-2]
51691 [P04233-3]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
659

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P04233

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P04233

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P04233

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P04233

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P04233

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000019582 Expressed in 231 organ(s), highest expression level in lung

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P04233 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P04233 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002506
HPA010592

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer. In the endoplasmic reticulum (ER) it forms a heterononameric MHC II-Ii complex: 3 MHC class II molecules (heterodimers of an alpha and a beta subunit) bind to the CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system, the CD74 component undergoes sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide) attached to the MHC class II molecule (alpha-beta-CLIP complex). This processed complex interacts with HLA_DM and HLA_DO heterodimers in order to release CLIP and facilitate the binding of antigenic peptides to the MHC class II molecules.

Interacts with CD44; this complex is essential for the MIF-induced signaling cascade that results in B cell survival.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107410, 13 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P04233

Protein interaction database and analysis system

More...
IntActi
P04233, 198 interactors

Molecular INTeraction database

More...
MINTi
P04233

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000009530

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P04233

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1296
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P04233

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P04233

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini210 – 271Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni103 – 117CLIPAdd BLAST15

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IMYW Eukaryota
ENOG410Z4PR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008961

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P04233

KEGG Orthology (KO)

More...
KOi
K06505

Database of Orthologous Groups

More...
OrthoDBi
1190626at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P04233

TreeFam database of animal gene trees

More...
TreeFami
TF317779

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00191 TY, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.870.10, 1 hit
4.10.800.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015386 MHC_II-assoc_invar/CLIP_MHC-bd
IPR022339 MHC_II-assoc_invar_chain
IPR011988 MHC_II-assoc_invariant_trimer
IPR036613 MHCII_invariant_trimer_sf
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09307 MHC2-interact, 1 hit
PF08831 MHCassoc_trimer, 1 hit
PF00086 Thyroglobulin_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01990 CD74ANTIGEN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00211 TY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48305 SSF48305, 1 hit
SSF57610 SSF57610, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P04233-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHRRRSRSCR EDQKPVMDDQ RDLISNNEQL PMLGRRPGAP ESKCSRGALY
60 70 80 90 100
TGFSILVTLL LAGQATTAYF LYQQQGRLDK LTVTSQNLQL ENLRMKLPKP
110 120 130 140 150
PKPVSKMRMA TPLLMQALPM GALPQGPMQN ATKYGNMTED HVMHLLQNAD
160 170 180 190 200
PLKVYPPLKG SFPENLRHLK NTMETIDWKV FESWMHHWLL FEMSRHSLEQ
210 220 230 240 250
KPTDAPPKVL TKCQEEVSHI PAVHPGSFRP KCDENGNYLP LQCYGSIGYC
260 270 280 290
WCVFPNGTEV PNTRSRGHHN CSESLELEDP SSGLGVTKQD LGPVPM
Length:296
Mass (Da):33,516
Last modified:April 16, 2002 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i27A13F252D5FB91D
GO
Isoform 2 (identifier: P04233-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     209-272: Missing.

Show »
Length:232
Mass (Da):26,399
Checksum:i5144439D0FD27C99
GO
Isoform 3 (identifier: P04233-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-160: NADPLKVYPPLKG → SHWNWRTRLLGWV
     161-296: Missing.

Show »
Length:160
Mass (Da):18,328
Checksum:i95CB3D7226497DE8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBZ2H0YBZ2_HUMAN
HLA class II histocompatibility ant...
CD74
316Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBZ8H0YBZ8_HUMAN
HLA class II histocompatibility ant...
CD74
145Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ESL3E7ESL3_HUMAN
HLA class II histocompatibility ant...
CD74
152Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EQJ3E7EQJ3_HUMAN
HLA class II histocompatibility ant...
CD74
122Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ER71E7ER71_HUMAN
HLA class II histocompatibility ant...
CD74
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA36304 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti167R → T in CAA27047 (PubMed:3001652).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_037869148 – 160NADPL…PPLKG → SHWNWRTRLLGWV in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_037870161 – 296Missing in isoform 3. 1 PublicationAdd BLAST136
Alternative sequenceiVSP_005331209 – 272Missing in isoform 2. 5 PublicationsAdd BLAST64

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
K01144 mRNA Translation: AAA36304.1 Different initiation.
X00497 mRNA Translation: CAA25192.1
X00497 mRNA Translation: CAA25193.1
X03339 Genomic DNA Translation: CAA27046.1
X03340 Genomic DNA Translation: CAA27047.1
M13560
, M13555, M13556, M13558, M13559 Genomic DNA Translation: AAA36033.1
BT019505 mRNA Translation: AAV38312.1
AK292076 mRNA Translation: BAF84765.1
AK297889 mRNA Translation: BAG60210.1
AC011372 Genomic DNA No translation available.
AC011388 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61727.1
CH471062 Genomic DNA Translation: EAW61728.1
CH471062 Genomic DNA Translation: EAW61729.1
CH471062 Genomic DNA Translation: EAW61730.1
CH471062 Genomic DNA Translation: EAW61731.1
BC018726 mRNA Translation: AAH18726.1
BC024272 mRNA Translation: AAH24272.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34276.1 [P04233-3]
CCDS47308.1 [P04233-2]
CCDS47309.1 [P04233-1]

Protein sequence database of the Protein Information Resource

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PIRi
A93981 HLHUG

NCBI Reference Sequences

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RefSeqi
NP_001020329.1, NM_001025158.2 [P04233-3]
NP_001020330.1, NM_001025159.2 [P04233-1]
NP_004346.1, NM_004355.3 [P04233-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000009530; ENSP00000009530; ENSG00000019582 [P04233-1]
ENST00000353334; ENSP00000230685; ENSG00000019582 [P04233-2]
ENST00000377795; ENSP00000367026; ENSG00000019582 [P04233-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
972

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:972

UCSC genome browser

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UCSCi
uc003lsc.4 human [P04233-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01144 mRNA Translation: AAA36304.1 Different initiation.
X00497 mRNA Translation: CAA25192.1
X00497 mRNA Translation: CAA25193.1
X03339 Genomic DNA Translation: CAA27046.1
X03340 Genomic DNA Translation: CAA27047.1
M13560
, M13555, M13556, M13558, M13559 Genomic DNA Translation: AAA36033.1
BT019505 mRNA Translation: AAV38312.1
AK292076 mRNA Translation: BAF84765.1
AK297889 mRNA Translation: BAG60210.1
AC011372 Genomic DNA No translation available.
AC011388 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61727.1
CH471062 Genomic DNA Translation: EAW61728.1
CH471062 Genomic DNA Translation: EAW61729.1
CH471062 Genomic DNA Translation: EAW61730.1
CH471062 Genomic DNA Translation: EAW61731.1
BC018726 mRNA Translation: AAH18726.1
BC024272 mRNA Translation: AAH24272.1
CCDSiCCDS34276.1 [P04233-3]
CCDS47308.1 [P04233-2]
CCDS47309.1 [P04233-1]
PIRiA93981 HLHUG
RefSeqiNP_001020329.1, NM_001025158.2 [P04233-3]
NP_001020330.1, NM_001025159.2 [P04233-1]
NP_004346.1, NM_004355.3 [P04233-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A6AX-ray2.75C103-117[»]
1ICFX-ray2.00I/J210-274[»]
1IIENMR-A/B/C134-208[»]
1L3HNMR-A210-274[»]
1MUJX-ray2.15C97-121[»]
3PDOX-ray1.95C102-120[»]
3PGCX-ray2.66C/F106-120[»]
3PGDX-ray2.72C/F106-120[»]
3QXAX-ray2.71C/F103-117[»]
3QXDX-ray2.30C/F103-117[»]
4AENX-ray2.20C106-120[»]
4AH2X-ray2.36B106-120[»]
4X5WX-ray1.34C102-120[»]
5KSUX-ray2.73C/F103-117[»]
5KSVX-ray2.19C109-123[»]
SMRiP04233
ModBaseiSearch...

Protein-protein interaction databases

BioGridi107410, 13 interactors
ELMiP04233
IntActiP04233, 198 interactors
MINTiP04233
STRINGi9606.ENSP00000009530

Chemistry databases

BindingDBiP04233
ChEMBLiCHEMBL4692
GuidetoPHARMACOLOGYi2840

Protein family/group databases

MEROPSiI31.002

PTM databases

GlyConnecti659
iPTMnetiP04233
PhosphoSitePlusiP04233
SwissPalmiP04233
UniCarbKBiP04233

Polymorphism and mutation databases

BioMutaiCD74
DMDMi20178292

Proteomic databases

jPOSTiP04233
MassIVEiP04233
MaxQBiP04233
PaxDbiP04233
PeptideAtlasiP04233
PRIDEiP04233
ProteomicsDBi51689 [P04233-1]
51690 [P04233-2]
51691 [P04233-3]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P04233

The DNASU plasmid repository

More...
DNASUi
972
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000009530; ENSP00000009530; ENSG00000019582 [P04233-1]
ENST00000353334; ENSP00000230685; ENSG00000019582 [P04233-2]
ENST00000377795; ENSP00000367026; ENSG00000019582 [P04233-3]
GeneIDi972
KEGGihsa:972
UCSCiuc003lsc.4 human [P04233-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
972
DisGeNETi972

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CD74
HGNCiHGNC:1697 CD74
HPAiCAB002506
HPA010592
MIMi142790 gene
neXtProtiNX_P04233
OpenTargetsiENSG00000019582
PharmGKBiPA26236

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IMYW Eukaryota
ENOG410Z4PR LUCA
GeneTreeiENSGT00390000008961
InParanoidiP04233
KOiK06505
OrthoDBi1190626at2759
PhylomeDBiP04233
TreeFamiTF317779

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-2132295 MHC class II antigen presentation
SIGNORiP04233

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CD74 human
EvolutionaryTraceiP04233

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CD74

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
972

Pharos

More...
Pharosi
P04233
PMAP-CutDBiP04233

Protein Ontology

More...
PROi
PR:P04233

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000019582 Expressed in 231 organ(s), highest expression level in lung
ExpressionAtlasiP04233 baseline and differential
GenevisibleiP04233 HS

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di1.10.870.10, 1 hit
4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR015386 MHC_II-assoc_invar/CLIP_MHC-bd
IPR022339 MHC_II-assoc_invar_chain
IPR011988 MHC_II-assoc_invariant_trimer
IPR036613 MHCII_invariant_trimer_sf
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF09307 MHC2-interact, 1 hit
PF08831 MHCassoc_trimer, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01990 CD74ANTIGEN
SMARTiView protein in SMART
SM00211 TY, 1 hit
SUPFAMiSSF48305 SSF48305, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHG2A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P04233
Secondary accession number(s): A8K7R1
, B4DNE8, D3DQG3, D3DQG4, Q14597, Q29832, Q5U0J8, Q8SNA0, Q8WLP6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: April 16, 2002
Last modified: September 18, 2019
This is version 216 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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