CD74

Functionⁱ

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.

GO - Molecular functionⁱ

amyloid-beta binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19849849
CD4 receptor binding
Source: CAFA
Inferred from physical interactionⁱ
- 24942581
cytokine binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12782713
cytokine receptor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 17045821
identical protein binding
Source: UniProtKB
Traceable author statementⁱ
- 12782713
macrophage migration inhibitory factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 17045821
MHC class II protein binding Source: BHF-UCL
MHC class II protein binding, via antigen binding groove
Source: UniProtKB
Inferred from direct assayⁱ
- 7477400
MHC class II protein complex binding
Source: UniProtKB
Inferred from direct assayⁱ
- 1448172
nitric-oxide synthase binding Source: Ensembl
protein binding involved in protein folding
Source: UniProtKB
Inferred from direct assayⁱ
- 7477400

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of MAPK activity Source: Ensembl
antigen processing and presentation of endogenous antigen
Source: UniProtKB
Non-traceable author statementⁱ
- 10981873
antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 12782713
chaperone cofactor-dependent protein refolding Source: Ensembl
defense response Source: Ensembl
immunoglobulin mediated immune response Source: UniProtKB
intracellular protein transport Source: UniProtKB
leukocyte migration Source: Reactome
macrophage migration inhibitory factor signaling pathway Source: Ensembl
negative regulation of apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 12782713
negative regulation of DNA damage response, signal transduction by p53 class mediator
Source: BHF-UCL
Inferred from direct assayⁱ
- 17045821
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17045821
negative regulation of mature B cell apoptotic process Source: Ensembl
negative regulation of peptide secretion
Source: BHF-UCL
Inferred from direct assayⁱ
- 19849849
negative regulation of T cell differentiation Source: Ensembl
negative thymic T cell selection Source: Ensembl
positive regulation of B cell proliferation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12782713
positive regulation of chemokine (C-X-C motif) ligand 2 production Source: BHF-UCL
positive regulation of cytokine-mediated signaling pathway
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12782713
positive regulation of dendritic cell antigen processing and presentation Source: Ensembl
positive regulation of ERK1 and ERK2 cascade
Source: BHF-UCL
Inferred from direct assayⁱ
- 17045821
positive regulation of fibroblast proliferation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12782713
positive regulation of I-kappaB kinase/NF-kappaB signaling
Source: CAFA
Inferred from direct assayⁱ
- 24942581
positive regulation of kinase activity
Source: CAFA
Inferred from direct assayⁱ
- 24942581
positive regulation of macrophage cytokine production Source: BHF-UCL
positive regulation of MAPK cascade
Source: CAFA
Inferred from direct assayⁱ
- 24942581
positive regulation of monocyte differentiation
Source: CAFA
Inferred from direct assayⁱ
- 24942581
positive regulation of neutrophil chemotaxis Source: BHF-UCL
positive regulation of peptidyl-tyrosine phosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 17045821
positive regulation of protein phosphorylation
Source: CAFA
Inferred from direct assayⁱ
- 24942581
positive regulation of T cell differentiation Source: Ensembl
positive regulation of transcription, DNA-templated
Source: CAFA
Inferred from direct assayⁱ
- 24942581
positive regulation of type 2 immune response Source: Ensembl
positive regulation of viral entry into host cell
Source: CAFA
Inferred from direct assayⁱ
- 24942581
positive thymic T cell selection Source: Ensembl
prostaglandin biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 12782713
protein-containing complex assembly Source: UniProtKB
protein heterotetramerization
Source: CAFA
Inferred from direct assayⁱ
- 24942581
protein trimerization Source: InterPro
regulation of macrophage activation
Source: UniProtKB
Non-traceable author statementⁱ
- 12782713
signal transduction
Source: UniProtKB
Inferred from direct assayⁱ
- 12782713
T cell selection
Source: UniProtKB
Non-traceable author statementⁱ
- 10981873

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone
Biological process	Adaptive immunity, Immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-2132295 MHC class II antigen presentation
SIGNORⁱ	P04233

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I31.002

MEROPSⁱ

I31.002

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: HLA class II histocompatibility antigen gamma chain Alternative name(s): HLA-DR antigens-associated invariant chain Ia antigen-associated invariant chain Short name: Ii p33 CD_antigen: CD74
Gene namesⁱ	Name:CD74 Synonyms:DHLAG
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000019582.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1697 CD74
MIMⁱ	142790 gene
neXtProtⁱ	NX_P04233

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 46	CytoplasmicSequence analysisAdd BLAST	46
Transmembraneⁱ	47 – 72	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	26
Topological domainⁱ	73 – 296	ExtracellularSequence analysisAdd BLAST	224

Keywords - Cellular componentⁱ

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74-ROS1 chimeric protein.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	208 – 209	Breakpoint for translocation to form a CD74-ROS1 fusion protein		2

Organism-specific databases

DisGeNET More...DisGeNETⁱ	972
Open Targets More...OpenTargetsⁱ	ENSG00000019582
PharmGKBⁱ	PA26236

Chemistry databases

ChEMBLⁱ	CHEMBL4692
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2840

Polymorphism and mutation databases

BioMutaⁱ	CD74
DMDMⁱ	20178292

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000067954	1 – 296	HLA class II histocompatibility antigen gamma chainAdd BLAST		296

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	25	PhosphoserineBy similarity	1
Glycosylationⁱ	130	N-linked (GlcNAc...) asparagine	1
Glycosylationⁱ	136	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	203	O-linked (GalNAc...) threonine2 Publications	1
Disulfide bondⁱ	213 ↔ 232	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	243 ↔ 250	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	252 ↔ 271	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	256	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	281	O-linked (GalNAc...) serine1 Publication	1

Post-translational modificationⁱ

N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.4 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

EPDⁱ	P04233
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P04233
PaxDbⁱ	P04233
PeptideAtlas More...PeptideAtlasⁱ	P04233
PRIDEⁱ	P04233
ProteomicsDBⁱ	51689 51690 [P04233-2] 51691 [P04233-3]

PTM databases

GlyConnectⁱ	659
iPTMnetⁱ	P04233
PhosphoSitePlusⁱ	P04233
SwissPalmⁱ	P04233
UniCarbKBⁱ	P04233

Miscellaneous databases

PMAP-CutDBⁱ	P04233

PMAP-CutDBⁱ

P04233

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000019582 Expressed in 231 organ(s), highest expression level in lung
CleanExⁱ	HS_CD74
ExpressionAtlasⁱ	P04233 baseline and differential
Genevisibleⁱ	P04233 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB002506 HPA010592

HPAⁱ

CAB002506
HPA010592

Interactionⁱ

Subunit structureⁱ

Homotrimer. In the endoplasmic reticulum (ER) it forms a heterononameric MHC II-Ii complex: 3 MHC class II molecules (heterodimers of an alpha and a beta subunit) bind to the CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system, the CD74 component undergoes sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide) attached to the MHC class II molecule (alpha-beta-CLIP complex). This processed complex interacts with HLA_DM and HLA_DO heterodimers in order to release CLIP and facilitate the binding of antigenic peptides to the MHC class II molecules.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CD44	P16070	9	EBI-2622890,EBI-490245
CXCR4	P61073	4	EBI-2622890,EBI-489411
dnaK	P0A6Y8	8	EBI-2622890,EBI-542092	From Escherichia coli (strain K12).
HSPA1A	P0DMV8	4	EBI-2622890,EBI-11052499

GO - Molecular functionⁱ

CD4 receptor binding
Source: CAFA
Inferred from physical interactionⁱ
- 24942581
cytokine binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12782713
identical protein binding
Source: UniProtKB
Traceable author statementⁱ
- 12782713
macrophage migration inhibitory factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 17045821
MHC class II protein binding Source: BHF-UCL
MHC class II protein binding, via antigen binding groove
Source: UniProtKB
Inferred from direct assayⁱ
- 7477400
nitric-oxide synthase binding Source: Ensembl
protein binding involved in protein folding
Source: UniProtKB
Inferred from direct assayⁱ
- 7477400

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107410, 13 interactors
ELMⁱ	P04233
IntActⁱ	P04233, 91 interactors
Molecular INTeraction database More...MINTⁱ	P04233
STRINGⁱ	9606.ENSP00000009530

Chemistry databases

BindingDBⁱ

P04233

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	139 – 149	Combined sources	11
Helixⁱ	162 – 172	Combined sources	11
Helixⁱ	175 – 194	Combined sources	20
Helixⁱ	212 – 217	Combined sources	6
Beta strandⁱ	236 – 238	Combined sources	3
Beta strandⁱ	240 – 244	Combined sources	5
Turnⁱ	245 – 248	Combined sources	4
Beta strandⁱ	249 – 253	Combined sources	5
Beta strandⁱ	265 – 267	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P04233
SMRⁱ	P04233
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P04233

EvolutionaryTraceⁱ

P04233

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	210 – 271	Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST		62

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	103 – 117	CLIPAdd BLAST		15

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IMYW Eukaryota ENOG410Z4PR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008961
HOVERGENⁱ	HBG004444
InParanoidⁱ	P04233
KEGG Orthology (KO) More...KOⁱ	K06505
PhylomeDBⁱ	P04233
TreeFamⁱ	TF317779

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00191 TY, 1 hit
Gene3Dⁱ	1.10.870.10, 1 hit 4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR015386 MHC_II-assoc_invar/CLIP_MHC-bd IPR022339 MHC_II-assoc_invar_chain IPR011988 MHC_II-assoc_invariant_trimer IPR036613 MHCII_invariant_trimer_sf IPR000716 Thyroglobulin_1 IPR036857 Thyroglobulin_1_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09307 MHC2-interact, 1 hit PF08831 MHCassoc_trimer, 1 hit PF00086 Thyroglobulin_1, 1 hit
PRINTSⁱ	PR01990 CD74ANTIGEN
SMARTⁱ	View protein in SMART SM00211 TY, 1 hit
SUPFAMⁱ	SSF48305 SSF48305, 1 hit SSF57610 SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS00484 THYROGLOBULIN_1_1, 1 hit PS51162 THYROGLOBULIN_1_2, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P04233-1) [UniParc]FASTA Add to basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHRRRSRSCR EDQKPVMDDQ RDLISNNEQL PMLGRRPGAP ESKCSRGALY 
        60         70         80         90        100
TGFSILVTLL LAGQATTAYF LYQQQGRLDK LTVTSQNLQL ENLRMKLPKP 
       110        120        130        140        150
PKPVSKMRMA TPLLMQALPM GALPQGPMQN ATKYGNMTED HVMHLLQNAD 
       160        170        180        190        200
PLKVYPPLKG SFPENLRHLK NTMETIDWKV FESWMHHWLL FEMSRHSLEQ 
       210        220        230        240        250
KPTDAPPKVL TKCQEEVSHI PAVHPGSFRP KCDENGNYLP LQCYGSIGYC 
       260        270        280        290 
WCVFPNGTEV PNTRSRGHHN CSESLELEDP SSGLGVTKQD LGPVPM

Length:296

Mass (Da):33,516

Last modified:April 16, 2002 - v3

Checksum:ⁱ27A13F252D5FB91D

GO

Isoform 2 (identifier: P04233-2) [UniParc]FASTA Add to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
209-272: Missing.

« Hide

        10         20         30         40         50
MHRRRSRSCR EDQKPVMDDQ RDLISNNEQL PMLGRRPGAP ESKCSRGALY 
        60         70         80         90        100
TGFSILVTLL LAGQATTAYF LYQQQGRLDK LTVTSQNLQL ENLRMKLPKP 
       110        120        130        140        150
PKPVSKMRMA TPLLMQALPM GALPQGPMQN ATKYGNMTED HVMHLLQNAD 
       160        170        180        190        200
PLKVYPPLKG SFPENLRHLK NTMETIDWKV FESWMHHWLL FEMSRHSLEQ 
       210        220        230 
KPTDAPPKES LELEDPSSGL GVTKQDLGPV PM

Show »

Length:232

Mass (Da):26,399

Checksum:ⁱ5144439D0FD27C99

GO

Isoform 3 (identifier: P04233-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
148-160: NADPLKVYPPLKG → SHWNWRTRLLGWV
161-296: Missing.

« Hide

        10         20         30         40         50
MHRRRSRSCR EDQKPVMDDQ RDLISNNEQL PMLGRRPGAP ESKCSRGALY 
        60         70         80         90        100
TGFSILVTLL LAGQATTAYF LYQQQGRLDK LTVTSQNLQL ENLRMKLPKP 
       110        120        130        140        150
PKPVSKMRMA TPLLMQALPM GALPQGPMQN ATKYGNMTED HVMHLLQSHW 
       160
NWRTRLLGWV

Show »

Length:160

Mass (Da):18,328

Checksum:ⁱ95CB3D7226497DE8

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YBZ2	H0YBZ2_HUMAN	HLA class II histocompatibility ant... HLA class II histocompatibility antigen gamma chain	CD74	316	Annotation score:
E7ESL3	E7ESL3_HUMAN	HLA class II histocompatibility ant... HLA class II histocompatibility antigen gamma chain	CD74	152	Annotation score:
H0YBZ8	H0YBZ8_HUMAN	HLA class II histocompatibility ant... HLA class II histocompatibility antigen gamma chain	CD74	145	Annotation score:
E7EQJ3	E7EQJ3_HUMAN	HLA class II histocompatibility ant... HLA class II histocompatibility antigen gamma chain	CD74	122	Annotation score:
E7ER71	E7ER71_HUMAN	HLA class II histocompatibility ant... HLA class II histocompatibility antigen gamma chain	CD74	52	Annotation score:

Sequence cautionⁱ

The sequence AAA36304 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	167	R → T in CAA27047 (PubMed:3001652).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_037869	148 – 160	NADPL…PPLKG → SHWNWRTRLLGWV in isoform 3. 1 PublicationAdd BLAST	13
Alternative sequenceⁱVSP_037870	161 – 296	Missing in isoform 3. 1 PublicationAdd BLAST	136
Alternative sequenceⁱVSP_005331	209 – 272	Missing in isoform 2. 5 PublicationsAdd BLAST	64

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	K01144 mRNA Translation: AAA36304.1 Different initiation. X00497 mRNA Translation: CAA25192.1 X00497 mRNA Translation: CAA25193.1 X03339 Genomic DNA Translation: CAA27046.1 X03340 Genomic DNA Translation: CAA27047.1 M13560 , M13555, M13556, M13558, M13559 Genomic DNA Translation: AAA36033.1 BT019505 mRNA Translation: AAV38312.1 AK292076 mRNA Translation: BAF84765.1 AK297889 mRNA Translation: BAG60210.1 AC011372 Genomic DNA No translation available. AC011388 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61727.1 CH471062 Genomic DNA Translation: EAW61728.1 CH471062 Genomic DNA Translation: EAW61729.1 CH471062 Genomic DNA Translation: EAW61730.1 CH471062 Genomic DNA Translation: EAW61731.1 BC018726 mRNA Translation: AAH18726.1 BC024272 mRNA Translation: AAH24272.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34276.1 [P04233-3] CCDS47308.1 [P04233-2] CCDS47309.1 [P04233-1]
PIRⁱ	A93981 HLHUG
NCBI Reference Sequences More...RefSeqⁱ	NP_001020329.1, NM_001025158.2 [P04233-3] NP_001020330.1, NM_001025159.2 [P04233-1] NP_004346.1, NM_004355.3 [P04233-2]
UniGeneⁱ	Hs.436568

Genome annotation databases

Ensemblⁱ	ENST00000009530; ENSP00000009530; ENSG00000019582 [P04233-1] ENST00000353334; ENSP00000230685; ENSG00000019582 [P04233-2] ENST00000377795; ENSP00000367026; ENSG00000019582 [P04233-3]
GeneIDⁱ	972
KEGGⁱ	hsa:972
UCSC genome browser More...UCSCⁱ	uc003lsc.4 human [P04233-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P04233	CD74 isoform 5		PANTR		296	UniRef90_P04233
Uncharacterized protein		PANPA		296
CD74 isoform 5		PONAB		296
Uncharacterized protein		NOMLE		296
CD74 molecule		GORGO		296
+4
P04233-2	HLA class II histocompatibility antigen gamma chain isoform b		MACMU		230	UniRef90_P04233-2
Uncharacterized protein		MACFA		230
Uncharacterized protein		MACNE		230
Uncharacterized protein		PAPAN		230
Uncharacterized protein		RHIRO		230
+14
P04233-3	CD74 molecule		GORGO		160	UniRef90_P04233-3
CD74 isoform 1		PONAB		160
Uncharacterized protein		NOMLE		160
CD74 isoform 1		PANTR		160
UPI000D7251BD		HUMAN		192
+1

Protein	Similar proteins		Species	Score	Length	Source
P04233	CD74 isoform 5		PONAB		296	UniRef50_P04233
Uncharacterized protein		NOMLE		296
CD74 isoform 5		PANTR		296
Uncharacterized protein		PANPA		296
CD74 molecule		GORGO		296
+39
P04233-2	Uncharacterized protein		PAPAN		230	UniRef50_P04233-2
Uncharacterized protein		COLAP		230
Uncharacterized protein		CERAT		230
Uncharacterized protein		RHIRO		230
Uncharacterized protein		RHIBE		230
+24
P04233-3	CD74 isoform 1		PONAB		160	UniRef50_P04233-3
CD74 molecule		GORGO		160
CD74 isoform 1		PANTR		160
Uncharacterized protein		NOMLE		160
CD74 molecule, major histocompatibility complex, class II invariant chain		BOVIN		204
+76

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	K01144 mRNA Translation: AAA36304.1 Different initiation. X00497 mRNA Translation: CAA25192.1 X00497 mRNA Translation: CAA25193.1 X03339 Genomic DNA Translation: CAA27046.1 X03340 Genomic DNA Translation: CAA27047.1 M13560 , M13555, M13556, M13558, M13559 Genomic DNA Translation: AAA36033.1 BT019505 mRNA Translation: AAV38312.1 AK292076 mRNA Translation: BAF84765.1 AK297889 mRNA Translation: BAG60210.1 AC011372 Genomic DNA No translation available. AC011388 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61727.1 CH471062 Genomic DNA Translation: EAW61728.1 CH471062 Genomic DNA Translation: EAW61729.1 CH471062 Genomic DNA Translation: EAW61730.1 CH471062 Genomic DNA Translation: EAW61731.1 BC018726 mRNA Translation: AAH18726.1 BC024272 mRNA Translation: AAH24272.1
CCDSⁱ	CCDS34276.1 [P04233-3] CCDS47308.1 [P04233-2] CCDS47309.1 [P04233-1]
PIRⁱ	A93981 HLHUG
RefSeqⁱ	NP_001020329.1, NM_001025158.2 [P04233-3] NP_001020330.1, NM_001025159.2 [P04233-1] NP_004346.1, NM_004355.3 [P04233-2]
UniGeneⁱ	Hs.436568

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1A6A	X-ray	2.75	C	103-117	[»]
	1ICF	X-ray	2.00	I/J	210-274	[»]
	1IIE	NMR	-	A/B/C	134-208	[»]
	1L3H	NMR	-	A	210-274	[»]
	1MUJ	X-ray	2.15	C	97-121	[»]
	3PDO	X-ray	1.95	C	102-120	[»]
	3PGC	X-ray	2.66	C/F	106-120	[»]
	3PGD	X-ray	2.72	C/F	106-120	[»]
	3QXA	X-ray	2.71	C/F	103-117	[»]
	3QXD	X-ray	2.30	C/F	103-117	[»]
	4AEN	X-ray	2.20	C	106-120	[»]
	4AH2	X-ray	2.36	B	106-120	[»]
	4X5W	X-ray	1.34	C	102-120	[»]
	5KSU	X-ray	2.73	C/F	103-117	[»]
	5KSV	X-ray	2.19	C	109-123	[»]
ProteinModelPortalⁱ	P04233
SMRⁱ	P04233
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107410, 13 interactors
ELMⁱ	P04233
IntActⁱ	P04233, 91 interactors
MINTⁱ	P04233
STRINGⁱ	9606.ENSP00000009530

Chemistry databases

BindingDBⁱ	P04233
ChEMBLⁱ	CHEMBL4692
GuidetoPHARMACOLOGYⁱ	2840

Protein family/group databases

MEROPSⁱ	I31.002

MEROPSⁱ

I31.002

PTM databases

GlyConnectⁱ	659
iPTMnetⁱ	P04233
PhosphoSitePlusⁱ	P04233
SwissPalmⁱ	P04233
UniCarbKBⁱ	P04233

Polymorphism and mutation databases

BioMutaⁱ	CD74
DMDMⁱ	20178292

Proteomic databases

EPDⁱ	P04233
MaxQBⁱ	P04233
PaxDbⁱ	P04233
PeptideAtlasⁱ	P04233
PRIDEⁱ	P04233
ProteomicsDBⁱ	51689 51690 [P04233-2] 51691 [P04233-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	972
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000009530; ENSP00000009530; ENSG00000019582 [P04233-1] ENST00000353334; ENSP00000230685; ENSG00000019582 [P04233-2] ENST00000377795; ENSP00000367026; ENSG00000019582 [P04233-3]
GeneIDⁱ	972
KEGGⁱ	hsa:972
UCSCⁱ	uc003lsc.4 human [P04233-1]

Organism-specific databases

CTDⁱ	972
DisGeNETⁱ	972
EuPathDBⁱ	HostDB:ENSG00000019582.14
GeneCardsⁱ	CD74
HGNCⁱ	HGNC:1697 CD74
HPAⁱ	CAB002506 HPA010592
MIMⁱ	142790 gene
neXtProtⁱ	NX_P04233
OpenTargetsⁱ	ENSG00000019582
PharmGKBⁱ	PA26236
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IMYW Eukaryota ENOG410Z4PR LUCA
GeneTreeⁱ	ENSGT00390000008961
HOVERGENⁱ	HBG004444
InParanoidⁱ	P04233
KOⁱ	K06505
PhylomeDBⁱ	P04233
TreeFamⁱ	TF317779

Enzyme and pathway databases

Reactomeⁱ	R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-2132295 MHC class II antigen presentation
SIGNORⁱ	P04233

Miscellaneous databases

ChiTaRSⁱ	CD74 human
EvolutionaryTraceⁱ	P04233
GeneWikiⁱ	CD74
GenomeRNAiⁱ	972
PMAP-CutDBⁱ	P04233
Protein Ontology More...PROⁱ	PR:P04233
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000019582 Expressed in 231 organ(s), highest expression level in lung
CleanExⁱ	HS_CD74
ExpressionAtlasⁱ	P04233 baseline and differential
Genevisibleⁱ	P04233 HS

Family and domain databases

CDDⁱ	cd00191 TY, 1 hit
Gene3Dⁱ	1.10.870.10, 1 hit 4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR015386 MHC_II-assoc_invar/CLIP_MHC-bd IPR022339 MHC_II-assoc_invar_chain IPR011988 MHC_II-assoc_invariant_trimer IPR036613 MHCII_invariant_trimer_sf IPR000716 Thyroglobulin_1 IPR036857 Thyroglobulin_1_sf
Pfamⁱ	View protein in Pfam PF09307 MHC2-interact, 1 hit PF08831 MHCassoc_trimer, 1 hit PF00086 Thyroglobulin_1, 1 hit
PRINTSⁱ	PR01990 CD74ANTIGEN
SMARTⁱ	View protein in SMART SM00211 TY, 1 hit
SUPFAMⁱ	SSF48305 SSF48305, 1 hit SSF57610 SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS00484 THYROGLOBULIN_1_1, 1 hit PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HG2A_HUMAN
Accessionⁱ	P04233Primary (citable) accession number: P04233 Secondary accession number(s): A8K7R1 Q8WLP6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 20, 1987
	Last sequence update:	April 16, 2002
	Last modified:	September 12, 2018
	This is version 209 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P04233 (HG2A_HUMAN)

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HLA class II histocompatibility antigen gamma chain

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Endoplasmic reticulum

Lysosome

Golgi apparatus

Plasma membrane

Endoplasmic reticulum

Endosome

Extracellular region or secreted

Golgi apparatus

Lysosome

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Sites

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ