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Protein

H-2 class II histocompatibility antigen, E-S beta chain

Gene

H2-Eb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen, E-S beta chain
Gene namesi
Name:H2-Eb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95901 H2-Eb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini‹1 – 193ExtracellularSequence analysisAdd BLAST›193
Transmembranei194 – 216HelicalSequence analysisAdd BLAST23
Topological domaini217 – 232CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000080754‹1 – 232H-2 class II histocompatibility antigen, E-S beta chainAdd BLAST›232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi10 ↔ 74PROSITE-ProRule annotation
Glycosylationi14N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi112 ↔ 168PROSITE-ProRule annotation

Post-translational modificationi

Ubiquitinated in immature dendritic cells leading to down-regulation of MHC class II.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiP04231
PRIDEiP04231

Expressioni

Gene expression databases

CleanExiMM_H2-EB1

Structurei

3D structure databases

ProteinModelPortaliP04231
SMRiP04231
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 182Ig-like C1-typeAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni‹1 – 90Beta-1Add BLAST›90
Regioni91 – 193Beta-2Add BLAST103

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWG3 Eukaryota
ENOG410YI0S LUCA
HOVERGENiHBG012730

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR000353 MHC_II_b_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00969 MHC_II_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000328 MHC_II_b_N, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00921 MHC_II_beta, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P04231-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
WFLEYSTSEC HFYNGTQRVR LLERYFYNLE ENLRFDSDVG EFRAVTELGR
60 70 80 90 100
PDAENWNSQP EFLEQRRAAV DTYCRHNYEI LDKFLVPRRV EPTVTVYPTK
110 120 130 140 150
TQPLEHHNLL VCSVSDFYPG NIEVRWFRNG KEEKTGIVST GLVRNGDWTF
160 170 180 190 200
QTLVMLETVP QSGEVYTCQV EHPSLTDPVT VEWKAQSTSA QNKMLSGVGG
210 220 230
FVLGLLFLGA GLFIYFRNQK GQSGLQPTGL LS
Length:232
Mass (Da):26,647
Last modified:March 20, 1987 - v1
Checksum:i8960CFC0BD6A8CB4
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P18468HB2I_MOUSE
H-2 class II histocompatibility ant...
H2-Eb1
264Annotation score:
P18469HB2J_MOUSE
H-2 class II histocompatibility ant...
H2-Eb1
264Annotation score:
P04230HB21_MOUSE
H-2 class II histocompatibility ant...
H2-Eb1
264Annotation score:
O78196O78196_MOUSE
H-2 class II histocompatibility ant...
H2-Eb1 Btnl2, IEbeta
264Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11355 mRNA Translation: AAA39644.1
L38589 Genomic DNA Translation: AAA57293.1
PIRiA02227 HLMSE2
UniGeneiMm.22564

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11355 mRNA Translation: AAA39644.1
L38589 Genomic DNA Translation: AAA57293.1
PIRiA02227 HLMSE2
UniGeneiMm.22564

3D structure databases

ProteinModelPortaliP04231
SMRiP04231
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiP04231
PRIDEiP04231

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95901 H2-Eb1

Phylogenomic databases

eggNOGiENOG410IWG3 Eukaryota
ENOG410YI0S LUCA
HOVERGENiHBG012730

Miscellaneous databases

ChiTaRSiH2-Eb1 mouse
SOURCEiSearch...

Gene expression databases

CleanExiMM_H2-EB1

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR000353 MHC_II_b_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00969 MHC_II_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000328 MHC_II_b_N, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00921 MHC_II_beta, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHB23_MOUSE
AccessioniPrimary (citable) accession number: P04231
Secondary accession number(s): O78225
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: February 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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