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Protein

H-2 class II histocompatibility antigen, E-B beta chain

Gene

H2-Eb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen, E-B beta chain
Gene namesi
Name:H2-Eb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95901 H2-Eb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 225ExtracellularSequence analysisAdd BLAST199
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Topological domaini247 – 264CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Add BLAST26
ChainiPRO_000001900027 – 264H-2 class II histocompatibility antigen, E-B beta chainAdd BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 106PROSITE-ProRule annotation
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi144 ↔ 200PROSITE-ProRule annotation

Post-translational modificationi

Ubiquitinated in immature dendritic cells leading to down-regulation of MHC class II.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiP04230
PaxDbiP04230
PRIDEiP04230

Expressioni

Gene expression databases

CleanExiMM_H2-EB1

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074143

Structurei

Secondary structure

1264
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP04230
SMRiP04230
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04230

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 214Ig-like C1-typeAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni27 – 121Beta-1Add BLAST95
Regioni122 – 225Beta-2Add BLAST104

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWG3 Eukaryota
ENOG410YI0S LUCA
HOGENOMiHOG000100909
HOVERGENiHBG012730
InParanoidiP04230
PhylomeDBiP04230

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR000353 MHC_II_b_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00969 MHC_II_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000328 MHC_II_b_N, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00921 MHC_II_beta, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P04230-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVWLPRVPCV AAVILLLTVL SPPMALVRDS RPWFLEYCKS ECHFYNGTQR
60 70 80 90 100
VRLLERYFYN LEENLRFDSD VGEFHAVTEL GRPDAENWNS QPEFLEQKRA
110 120 130 140 150
EVDTVCRHNY EISDKFLVRR RVEPTVTVYP TKTQPLEHHN LLVCSVSDFY
160 170 180 190 200
PGNIEVRWFR NGKEEKTGIV STGLVRNGDW TFQTLVMLET VPQSGEVYTC
210 220 230 240 250
QVEHPSLTDP VTVEWKAQST SAQNKMLSGV GGFVLGLLFL GAGLFIYFRN
260
QKGQSGLQPT GLLS
Length:264
Mass (Da):30,166
Last modified:March 20, 1987 - v1
Checksum:iBF1264C41AF8D1C0
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P18468HB2I_MOUSE
H-2 class II histocompatibility ant...
H2-Eb1
264Annotation score:
P18469HB2J_MOUSE
H-2 class II histocompatibility ant...
H2-Eb1
264Annotation score:
P04231HB23_MOUSE
H-2 class II histocompatibility ant...
H2-Eb1
232Annotation score:
O78196O78196_MOUSE
H-2 class II histocompatibility ant...
H2-Eb1 Btnl2, IEbeta
264Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00623 Genomic DNA Translation: CAA25257.1
X00701, X00702 Genomic DNA Translation: CAB51615.2 Sequence problems.
M36940 mRNA Translation: AAA39590.1
L38590 Genomic DNA Translation: AAA57294.1
CCDSiCCDS37584.1
PIRiA02226 HLMSE1
UniGeneiMm.22564

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00623 Genomic DNA Translation: CAA25257.1
X00701, X00702 Genomic DNA Translation: CAB51615.2 Sequence problems.
M36940 mRNA Translation: AAA39590.1
L38590 Genomic DNA Translation: AAA57294.1
CCDSiCCDS37584.1
PIRiA02226 HLMSE1
UniGeneiMm.22564

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I3RX-ray2.40B/D/F/H30-225[»]
1KT2X-ray2.80B/D30-215[»]
1KTDX-ray2.40B/D30-215[»]
3QIBX-ray2.70B30-225[»]
3QIUX-ray2.70B30-225[»]
3QIWX-ray3.30B30-225[»]
ProteinModelPortaliP04230
SMRiP04230
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074143

Proteomic databases

MaxQBiP04230
PaxDbiP04230
PRIDEiP04230

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95901 H2-Eb1

Phylogenomic databases

eggNOGiENOG410IWG3 Eukaryota
ENOG410YI0S LUCA
HOGENOMiHOG000100909
HOVERGENiHBG012730
InParanoidiP04230
PhylomeDBiP04230

Miscellaneous databases

ChiTaRSiH2-Eb1 mouse
EvolutionaryTraceiP04230
SOURCEiSearch...

Gene expression databases

CleanExiMM_H2-EB1

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR000353 MHC_II_b_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00969 MHC_II_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000328 MHC_II_b_N, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00921 MHC_II_beta, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHB21_MOUSE
AccessioniPrimary (citable) accession number: P04230
Secondary accession number(s): O78226
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: April 25, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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