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Protein

H-2 class II histocompatibility antigen, A-D alpha chain

Gene

H2-Aa

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • peptide antigen binding Source: MGI
  • protein heterodimerization activity Source: MGI

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen, A-D alpha chain
Gene namesi
Name:H2-Aa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95895 H2-Aa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 218ExtracellularSequence analysisAdd BLAST195
Transmembranei219 – 244HelicalSequence analysisAdd BLAST26
Topological domaini245 – 256CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Add BLAST23
ChainiPRO_000001897624 – 256H-2 class II histocompatibility antigen, A-D alpha chainAdd BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi134 ↔ 190PROSITE-ProRule annotation
Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP04228
PRIDEiP04228

Expressioni

Gene expression databases

CleanExiMM_H2-AA

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP04228, 2 interactors
MINTiP04228

Structurei

Secondary structure

1256
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP04228
SMRiP04228
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04228

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini114 – 206Ig-like C1-typeAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 111Alpha-1Add BLAST88
Regioni112 – 205Alpha-2Add BLAST94
Regioni206 – 218Connecting peptideAdd BLAST13

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG006862

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR001003 MHC_II_a_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00993 MHC_II_alpha, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00920 MHC_II_alpha, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

P04228-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPCSRALILG VLALNTMLSL CGGEDDIEAD HVGFYGTTVY QSPGDIGQYT
60 70 80 90 100
HEFDGDELFY VDLDKKKTVW RLPEFGQLIL FEPQGGLQNI AAEKHNLGIL
110 120 130 140 150
TKRSNFTPAT NEAPQATVFP KSPVLLGQPN TLICFVDNIF PPVINITWLR
160 170 180 190 200
NSKSVTDGVY ETSFLVNRDH SFHKLSYLTF IPSDDDIYDC KVEHWGLEEP
210 220 230 240 250
VLKHWEPEIP APMSELTETV VCALGLSVGL VGIVVGTIFI IQGLRSGGTS

RHPGPL
Length:256
Mass (Da):28,243
Last modified:March 20, 1987 - v1
Checksum:i085B3FE643B58BBB
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P14434HA2B_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
256Annotation score:
P01910HA2K_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
256Annotation score:
P23150HA2J_MOUSE
H-2 class II histocompatibility ant...
254Annotation score:
P14438HA2U_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
227Annotation score:
P14435HA2F_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
233Annotation score:
P04227HA2Q_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
221Annotation score:
P14437HA2S_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
233Annotation score:
P14436HA2R_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
233Annotation score:
G3UWR9G3UWR9_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
173Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01923 mRNA Translation: AAA39615.1
PIRiA02219 HLMSA2
UniGeneiMm.235338

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01923 mRNA Translation: AAA39615.1
PIRiA02219 HLMSA2
UniGeneiMm.235338

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ES0X-ray2.60A24-205[»]
1F3JX-ray3.10A/D27-208[»]
1IAOX-ray2.60A24-209[»]
2IADX-ray2.40A24-209[»]
3CUPX-ray3.09A24-205[»]
3MBEX-ray2.89A/E24-205[»]
5DMKX-ray2.45A/C/E/G26-198[»]
6BLQX-ray1.80A24-208[»]
6BLRX-ray1.96A26-208[»]
6BLXX-ray2.32A26-208[»]
ProteinModelPortaliP04228
SMRiP04228
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP04228, 2 interactors
MINTiP04228

Proteomic databases

MaxQBiP04228
PRIDEiP04228

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95895 H2-Aa

Phylogenomic databases

HOVERGENiHBG006862

Miscellaneous databases

EvolutionaryTraceiP04228
SOURCEiSearch...

Gene expression databases

CleanExiMM_H2-AA

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR001003 MHC_II_a_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00993 MHC_II_alpha, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00920 MHC_II_alpha, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHA2D_MOUSE
AccessioniPrimary (citable) accession number: P04228
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: September 12, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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