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Protein

H-2 class II histocompatibility antigen, A-Q alpha chain

Gene

H2-Aa

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • peptide antigen binding Source: MGI
  • protein heterodimerization activity Source: MGI

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen, A-Q alpha chain
Gene namesi
Name:H2-Aa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95895 H2-Aa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini‹1 – 183ExtracellularSequence analysisAdd BLAST›183
Transmembranei184 – 209HelicalSequence analysisAdd BLAST26
Topological domaini210 – 221CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000080746‹1 – 221H-2 class II histocompatibility antigen, A-Q alpha chainAdd BLAST›221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi99 ↔ 155PROSITE-ProRule annotation
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP04227
PRIDEiP04227

Expressioni

Gene expression databases

CleanExiMM_H2-AA

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP04227
SMRiP04227
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 171Ig-like C1-typeAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni‹1 – 76Alpha-1Add BLAST›76
Regioni77 – 170Alpha-2Add BLAST94
Regioni171 – 183Connecting peptideAdd BLAST13

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG006862

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR001003 MHC_II_a_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00993 MHC_II_alpha, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00920 MHC_II_alpha, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

P04227-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GIVVYQSPGD IGQYTHEFDG DEWFYVDLDK KETVWMLPEF GQLTSFDPQG
60 70 80 90 100
GLQNIATGKH NLGGWTKRSN FTPATNEAPQ ATVFPKSPVL LGQPNTLICF
110 120 130 140 150
VDNIFPPVIN ITWLRNSKSV TDGVYETSFL VNRDHSFHKL SYLTFIPSDD
160 170 180 190 200
DIYDCKVEHW GLDEPVLKHW EPEIPAPMSE LTETVVCALG LSVGLVGIVV
210 220
GTIFIIQGLR SGGTSRPPGP L
Length:221
Mass (Da):24,464
Last modified:March 20, 1987 - v1
Checksum:i5C0B16EAC37DB151
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P14434HA2B_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
256Annotation score:
P01910HA2K_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
256Annotation score:
P23150HA2J_MOUSE
H-2 class II histocompatibility ant...
254Annotation score:
P04228HA2D_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
256Annotation score:
P14438HA2U_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
227Annotation score:
P14435HA2F_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
233Annotation score:
P14437HA2S_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
233Annotation score:
P14436HA2R_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
233Annotation score:
G3UWR9G3UWR9_MOUSE
H-2 class II histocompatibility ant...
H2-Aa
173Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01925 mRNA Translation: AAA39620.1
PIRiA02218 HLMSA1
UniGeneiMm.235338

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01925 mRNA Translation: AAA39620.1
PIRiA02218 HLMSA1
UniGeneiMm.235338

3D structure databases

ProteinModelPortaliP04227
SMRiP04227
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiP04227
PRIDEiP04227

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95895 H2-Aa

Phylogenomic databases

HOVERGENiHBG006862

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

CleanExiMM_H2-AA

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR001003 MHC_II_a_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00993 MHC_II_alpha, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00920 MHC_II_alpha, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHA2Q_MOUSE
AccessioniPrimary (citable) accession number: P04227
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: June 20, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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