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Protein

H-2 class I histocompatibility antigen, K-K alpha chain

Gene

H2-K1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

  • antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent Source: MGI
  • antigen processing and presentation of exogenous peptide antigen via MHC class I Source: MGI
  • defense response to bacterium Source: MGI
  • immune response Source: InterPro
  • inner ear development Source: MGI
  • negative regulation of neuron projection development Source: MGI
  • positive regulation of T cell mediated cytotoxicity Source: MGI

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class I histocompatibility antigen, K-K alpha chain
Short name:
H-2K(K)
Gene namesi
Name:H2-K1
Synonyms:H2-K
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95904 H2-K1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 305ExtracellularSequence analysisAdd BLAST284
Transmembranei306 – 328HelicalSequence analysisAdd BLAST23
Topological domaini329 – 369CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000001893022 – 369H-2 class I histocompatibility antigen, K-K alpha chainAdd BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi107N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi122 ↔ 185PROSITE-ProRule annotation
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi224 ↔ 280PROSITE-ProRule annotation
Modified residuei351PhosphoserineBy similarity1
Modified residuei354PhosphoserineCombined sources1
Isoform 2 (identifier: P04223-2)
Modified residuei351PhosphoserineCombined sources1
Modified residuei354PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP04223
PeptideAtlasiP04223
PRIDEiP04223

PTM databases

iPTMnetiP04223
PhosphoSitePlusiP04223

Expressioni

Gene expression databases

CleanExiMM_H2-K1

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

GO - Molecular functioni

Structurei

Secondary structure

1369
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 33Combined sources11
Turni36 – 38Combined sources3
Beta strandi42 – 49Combined sources8
Beta strandi52 – 59Combined sources8
Beta strandi61 – 63Combined sources3
Beta strandi67 – 70Combined sources4
Helixi71 – 73Combined sources3
Helixi78 – 105Combined sources28
Beta strandi110 – 112Combined sources3
Beta strandi115 – 124Combined sources10
Beta strandi128 – 139Combined sources12
Beta strandi142 – 147Combined sources6
Beta strandi154 – 158Combined sources5
Helixi159 – 170Combined sources12
Helixi173 – 182Combined sources10
Helixi184 – 193Combined sources10
Turni196 – 199Combined sources4
Beta strandi207 – 214Combined sources8
Beta strandi216 – 232Combined sources17
Beta strandi235 – 240Combined sources6
Beta strandi249 – 251Combined sources3
Beta strandi258 – 260Combined sources3
Beta strandi262 – 271Combined sources10
Helixi275 – 277Combined sources3
Beta strandi278 – 283Combined sources6
Beta strandi291 – 293Combined sources3

3D structure databases

ProteinModelPortaliP04223
SMRiP04223
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04223

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini206 – 294Ig-like C1-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 111Alpha-1Add BLAST90
Regioni112 – 203Alpha-2Add BLAST92
Regioni204 – 295Alpha-3Add BLAST92
Regioni296 – 305Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P04223-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPCMLLLLL AAALAPTQTR AGPHSLRYFH TAVSRPGLGK PRFISVGYVD
60 70 80 90 100
DTQFVRFDSD AENPRYEPRV RWMEQVEPEY WERNTQIAKG NEQIFRVNLR
110 120 130 140 150
TALRYYNQSA GGSHTFQRMY GCEVGSDWRL LRGYEQYAYD GCDYIALNED
160 170 180 190 200
LKTWTAADMA ALITKHKWEQ AGDAERDRAY LEGTCVEWLR RYLQLGNATL
210 220 230 240 250
PRTDSPKAHV TRHSRPEDKV TLRCWALGFY PADITLTWQL NGEELTQDME
260 270 280 290 300
LVETRPAGDG TFQKWASVVV PLGKEQYYTC HVYHQGLPEP LTLRWEPPPS
310 320 330 340 350
TVSNTVIIAV LVVLGAAIVT GAVVAFVMKM RRRNTGGKGG DYALAPGSQT
360
SDLSLPDCKV MVHDPHSLA
Length:369
Mass (Da):41,646
Last modified:March 20, 1987 - v1
Checksum:i9533CF96600A595C
GO
Isoform 2 (identifier: P04223-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     360-369: VMVHDPHSLA → A

Note: No experimental confirmation available.Combined sources
Show »
Length:360
Mass (Da):40,630
Checksum:i5193B374DBD584CD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50D → E in AAA39654 (PubMed:3840763).Curated1
Sequence conflicti98N → S in AAA53202 (PubMed:3680952).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti173D → A. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011855360 – 369VMVHDPHSLA → A in isoform 2. 2 Publications10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01652 Genomic DNA Translation: CAA25816.1
M18525 Genomic DNA Translation: AAA53202.1
U47330 mRNA Translation: AAB17608.1
M18964 Genomic DNA Translation: AAA39568.1
M11975 mRNA Translation: AAA39654.1
M34932 mRNA Translation: AAA39596.1
PIRiA02203 HLMSKK
UniGeneiMm.422886
Mm.439675
Mm.440940
Mm.441651
Mm.466882

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHA1K_MOUSE
AccessioniPrimary (citable) accession number: P04223
Secondary accession number(s): O19459
, Q31165, Q31192, Q95458
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: June 20, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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