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Protein

Alpha-1B-glycoprotein

Gene

A1BG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-6798695 Neutrophil degranulation

Protein family/group databases

MEROPSiI43.950

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1B-glycoprotein
Alternative name(s):
Alpha-1-B glycoprotein
Gene namesi
Name:A1BG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000121410.11
HGNCiHGNC:5 A1BG
MIMi138670 gene
neXtProtiNX_P04217

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1
OpenTargetsiENSG00000121410
PharmGKBiPA24356

Polymorphism and mutation databases

BioMutaiA1BG
DMDMi317373553

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000001450222 – 495Alpha-1B-glycoproteinAdd BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...) (complex) asparagine4 Publications1
Disulfide bondi49 ↔ 931 Publication
Disulfide bondi139 ↔ 182PROSITE-ProRule annotation1 Publication
Glycosylationi179N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi232 ↔ 279PROSITE-ProRule annotation1 Publication
Disulfide bondi325 ↔ 374PROSITE-ProRule annotation1 Publication
Glycosylationi363N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi371N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi423 ↔ 4701 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP04217
PeptideAtlasiP04217
PRIDEiP04217
ProteomicsDBi51684
51685 [P04217-2]

2D gel databases

DOSAC-COBS-2DPAGEiP04217
REPRODUCTION-2DPAGEiIPI00022895
SWISS-2DPAGEiP04217

PTM databases

GlyConnecti780
iPTMnetiP04217
PhosphoSitePlusiP04217

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

BgeeiENSG00000121410
CleanExiHS_A1BG
ExpressionAtlasiP04217 baseline and differential
GenevisibleiP04217 HS

Organism-specific databases

HPAiCAB016673
HPA044252

Interactioni

Subunit structurei

Interacts with CRISP3.1 Publication

Protein-protein interaction databases

BioGridi106523, 24 interactors
IntActiP04217, 9 interactors
MINTiP04217
STRINGi9606.ENSP00000263100

Structurei

3D structure databases

ProteinModelPortaliP04217
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 113Ig-like V-type 1Add BLAST92
Domaini114 – 206Ig-like V-type 2Add BLAST93
Domaini207 – 299Ig-like V-type 3Add BLAST93
Domaini300 – 397Ig-like V-type 4Add BLAST98
Domaini398 – 495Ig-like V-type 5Add BLAST98

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IY79 Eukaryota
ENOG4111984 LUCA
GeneTreeiENSGT00910000144122
HOGENOMiHOG000152502
HOVERGENiHBG000037
InParanoidiP04217
OMAiCSYRTHA
OrthoDBiEOG091G020P
PhylomeDBiP04217
TreeFamiTF336644

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR016332 A1B_glyco/leuk_Ig-like_rcpt
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PIRSFiPIRSF001979 Alpha_1B_glycoprot_prd, 1 hit
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 5 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P04217-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSMLVVFLLL WGVTWGPVTE AAIFYETQPS LWAESESLLK PLANVTLTCQ
60 70 80 90 100
AHLETPDFQL FKNGVAQEPV HLDSPAIKHQ FLLTGDTQGR YRCRSGLSTG
110 120 130 140 150
WTQLSKLLEL TGPKSLPAPW LSMAPVSWIT PGLKTTAVCR GVLRGVTFLL
160 170 180 190 200
RREGDHEFLE VPEAQEDVEA TFPVHQPGNY SCSYRTDGEG ALSEPSATVT
210 220 230 240 250
IEELAAPPPP VLMHHGESSQ VLHPGNKVTL TCVAPLSGVD FQLRRGEKEL
260 270 280 290 300
LVPRSSTSPD RIFFHLNAVA LGDGGHYTCR YRLHDNQNGW SGDSAPVELI
310 320 330 340 350
LSDETLPAPE FSPEPESGRA LRLRCLAPLE GARFALVRED RGGRRVHRFQ
360 370 380 390 400
SPAGTEALFE LHNISVADSA NYSCVYVDLK PPFGGSAPSE RLELHVDGPP
410 420 430 440 450
PRPQLRATWS GAVLAGRDAV LRCEGPIPDV TFELLREGET KAVKTVRTPG
460 470 480 490
AAANLELIFV GPQHAGNYRC RYRSWVPHTF ESELSDPVEL LVAES
Length:495
Mass (Da):54,254
Last modified:January 11, 2011 - v4
Checksum:i8E611BDC3BC824C8
GO
Isoform 2 (identifier: P04217-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.

Note: No experimental confirmation available.
Show »
Length:373
Mass (Da):40,718
Checksum:i13B698EF0DEEE203
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105S → G in AAL07469 (Ref. 2) Curated1
Sequence conflicti127S → P in AAL07469 (Ref. 2) Curated1
Sequence conflicti146V → E in AAL07469 (Ref. 2) Curated1
Sequence conflicti304E → G in BAF82106 (PubMed:14702039).Curated1
Sequence conflicti413V → A in AAL07469 (Ref. 2) Curated1
Sequence conflicti446 – 447VR → IP in AAL07469 (Ref. 2) Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01836952H → R3 PublicationsCorresponds to variant dbSNP:rs893184Ensembl.1
Natural variantiVAR_018370395H → R. Corresponds to variant dbSNP:rs2241788Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0403231 – 122Missing in isoform 2. 1 PublicationAdd BLAST122

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073611 mRNA Translation: BAD38648.1
AF414429 mRNA Translation: AAL07469.1
AK289417 mRNA Translation: BAF82106.1
AC010642 Genomic DNA No translation available.
AC012313 Genomic DNA No translation available.
BC035719 mRNA Translation: AAH35719.1
CCDSiCCDS12976.1 [P04217-1]
RefSeqiNP_570602.2, NM_130786.3 [P04217-1]
UniGeneiHs.529161
Hs.709582

Genome annotation databases

EnsembliENST00000263100; ENSP00000263100; ENSG00000121410 [P04217-1]
GeneIDi1
KEGGihsa:1

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiA1BG_HUMAN
AccessioniPrimary (citable) accession number: P04217
Secondary accession number(s): A8K052
, Q68CK0, Q8IYJ6, Q96P39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: January 11, 2011
Last modified: June 20, 2018
This is version 173 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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