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Protein

Thy-1 membrane glycoprotein

Gene

THY1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

GO - Molecular functioni

  • GPI anchor binding Source: UniProtKB
  • GTPase activator activity Source: UniProtKB
  • integrin binding Source: UniProtKB
  • protein kinase binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
SIGNORiP04216

Names & Taxonomyi

Protein namesi
Recommended name:
Thy-1 membrane glycoprotein
Alternative name(s):
CDw90
Thy-1 antigen
CD_antigen: CD90
Gene namesi
Name:THY1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000154096.13
HGNCiHGNC:11801 THY1
MIMi188230 gene
neXtProtiNX_P04216

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7070
OpenTargetsiENSG00000154096
PharmGKBiPA36510

Polymorphism and mutation databases

BioMutaiTHY1
DMDMi20455514

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000001497320 – 130Thy-1 membrane glycoproteinAdd BLAST111
PropeptideiPRO_0000014974131 – 161Removed in mature formBy similarityAdd BLAST31

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi28 ↔ 130AlternatePROSITE-ProRule annotation
Disulfide bondi38 ↔ 104PROSITE-ProRule annotation
Glycosylationi42N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei82PhosphoserineBy similarity1
Glycosylationi119N-linked (GlcNAc...) asparagine2 Publications1
Lipidationi130GPI-anchor amidated cysteine; alternateBy similarity1
Glycosylationi139N-linked (GlcNAc...) asparagine1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDiP04216
MaxQBiP04216
PaxDbiP04216
PeptideAtlasiP04216
PRIDEiP04216
ProteomicsDBi51683

PTM databases

GlyConnecti1808
iPTMnetiP04216
PhosphoSitePlusiP04216
SwissPalmiP04216

Expressioni

Gene expression databases

BgeeiENSG00000154096 Expressed in 220 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_THY1
ExpressionAtlasiP04216 baseline and differential
GenevisibleiP04216 HS

Organism-specific databases

HPAiCAB068243
CAB068244
HPA003733

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112926, 37 interactors
IntActiP04216, 2 interactors
STRINGi9606.ENSP00000284240

Structurei

3D structure databases

ProteinModelPortaliP04216
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 126Ig-like V-typeAdd BLAST107

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410IVXA Eukaryota
ENOG410YYC2 LUCA
GeneTreeiENSGT00390000012352
HOGENOMiHOG000048719
HOVERGENiHBG002958
InParanoidiP04216
KOiK06514
OMAiTCELRLS
PhylomeDBiP04216
TreeFamiTF336059

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013106 Ig_V-set
IPR013151 Immunoglobulin
IPR033292 THY1
PANTHERiPTHR19226 PTHR19226, 1 hit
PfamiView protein in Pfam
PF00047 ig, 1 hit
SMARTiView protein in SMART
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P04216-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLAISIALL LTVLQVSRGQ KVTSLTACLV DQSLRLDCRH ENTSSSPIQY
60 70 80 90 100
EFSLTRETKK HVLFGTVGVP EHTYRSRTNF TSKYNMKVLY LSAFTSKDEG
110 120 130 140 150
TYTCALHHSG HSPPISSQNV TVLRDKLVKC EGISLLAQNT SWLLLLLLSL
160
SLLQATDFMS L
Length:161
Mass (Da):17,935
Last modified:May 2, 2002 - v2
Checksum:i2B6796DA8EE7454B
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PNQ8E9PNQ8_HUMAN
Thy-1 membrane glycoprotein
THY1
165Annotation score:
J3QRJ3J3QRJ3_HUMAN
Thy-1 membrane glycoprotein
THY1
144Annotation score:
E9PIM6E9PIM6_HUMAN
Thy-1 membrane glycoprotein
THY1
152Annotation score:
E9PIE1E9PIE1_HUMAN
Thy-1 membrane glycoprotein
THY1
37Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54 – 55LT → AP (PubMed:7683034).Curated2
Sequence conflicti85N → H in AAA61180 (PubMed:2864690).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11749 Genomic DNA Translation: AAA61180.1
AF261093 mRNA Translation: AAG13904.1
AL161958 mRNA Translation: CAB82306.1
BC065559 mRNA Translation: AAH65559.1
S59749 mRNA Translation: AAB26353.2
CCDSiCCDS8424.1
PIRiA02106 TDHU
T47130
RefSeqiNP_001298089.1, NM_001311160.1
NP_001298091.1, NM_001311162.1
NP_006279.2, NM_006288.4
UniGeneiHs.644697

Genome annotation databases

EnsembliENST00000284240; ENSP00000284240; ENSG00000154096
ENST00000528522; ENSP00000431301; ENSG00000154096
GeneIDi7070
KEGGihsa:7070
UCSCiuc001pwr.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11749 Genomic DNA Translation: AAA61180.1
AF261093 mRNA Translation: AAG13904.1
AL161958 mRNA Translation: CAB82306.1
BC065559 mRNA Translation: AAH65559.1
S59749 mRNA Translation: AAB26353.2
CCDSiCCDS8424.1
PIRiA02106 TDHU
T47130
RefSeqiNP_001298089.1, NM_001311160.1
NP_001298091.1, NM_001311162.1
NP_006279.2, NM_006288.4
UniGeneiHs.644697

3D structure databases

ProteinModelPortaliP04216
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112926, 37 interactors
IntActiP04216, 2 interactors
STRINGi9606.ENSP00000284240

PTM databases

GlyConnecti1808
iPTMnetiP04216
PhosphoSitePlusiP04216
SwissPalmiP04216

Polymorphism and mutation databases

BioMutaiTHY1
DMDMi20455514

Proteomic databases

EPDiP04216
MaxQBiP04216
PaxDbiP04216
PeptideAtlasiP04216
PRIDEiP04216
ProteomicsDBi51683

Protocols and materials databases

DNASUi7070
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284240; ENSP00000284240; ENSG00000154096
ENST00000528522; ENSP00000431301; ENSG00000154096
GeneIDi7070
KEGGihsa:7070
UCSCiuc001pwr.4 human

Organism-specific databases

CTDi7070
DisGeNETi7070
EuPathDBiHostDB:ENSG00000154096.13
GeneCardsiTHY1
HGNCiHGNC:11801 THY1
HPAiCAB068243
CAB068244
HPA003733
MIMi188230 gene
neXtProtiNX_P04216
OpenTargetsiENSG00000154096
PharmGKBiPA36510
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVXA Eukaryota
ENOG410YYC2 LUCA
GeneTreeiENSGT00390000012352
HOGENOMiHOG000048719
HOVERGENiHBG002958
InParanoidiP04216
KOiK06514
OMAiTCELRLS
PhylomeDBiP04216
TreeFamiTF336059

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
SIGNORiP04216

Miscellaneous databases

GeneWikiiCD90
GenomeRNAii7070
PROiPR:P04216
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154096 Expressed in 220 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_THY1
ExpressionAtlasiP04216 baseline and differential
GenevisibleiP04216 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013106 Ig_V-set
IPR013151 Immunoglobulin
IPR033292 THY1
PANTHERiPTHR19226 PTHR19226, 1 hit
PfamiView protein in Pfam
PF00047 ig, 1 hit
SMARTiView protein in SMART
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTHY1_HUMAN
AccessioniPrimary (citable) accession number: P04216
Secondary accession number(s): Q16008, Q9NSP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: May 2, 2002
Last modified: October 10, 2018
This is version 188 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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