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Protein

Proto-oncogene Mas

Gene

MAS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.By similarity2 Publications

Caution

Was originally thought to be a receptor for angiotensin II.1 Publication

GO - Molecular functioni

  • angiotensin receptor activity Source: UniProtKB
  • angiotensin type II receptor activity Source: ProtInc
  • G-protein coupled receptor activity Source: UniProtKB
  • peptide binding Source: UniProtKB
  • peptide hormone binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Proto-oncogene Mas
Gene namesi
Name:MAS1
Synonyms:MAS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000130368.5
HGNCiHGNC:6899 MAS1
MIMi165180 gene
neXtProtiNX_P04201

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36ExtracellularSequence analysisAdd BLAST36
Transmembranei37 – 61Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini62 – 65CytoplasmicSequence analysis4
Transmembranei66 – 86Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini87 – 104ExtracellularSequence analysisAdd BLAST18
Transmembranei105 – 128Helical; Name=3Sequence analysisAdd BLAST24
Topological domaini129 – 149CytoplasmicSequence analysisAdd BLAST21
Transmembranei150 – 172Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini173 – 185ExtracellularSequence analysisAdd BLAST13
Transmembranei186 – 206Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini207 – 224CytoplasmicSequence analysisAdd BLAST18
Transmembranei225 – 245Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini246 – 263ExtracellularSequence analysisAdd BLAST18
Transmembranei264 – 284Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini285 – 325CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi138I → D: Fails to activate GNA11. 1 Publication1

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi4142
OpenTargetsiENSG00000130368
PharmGKBiPA30643

Chemistry databases

ChEMBLiCHEMBL3559701
GuidetoPHARMACOLOGYi150

Polymorphism and mutation databases

BioMutaiMAS1
DMDMi135920

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697141 – 325Proto-oncogene MasAdd BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi16N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi22N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP04201
PeptideAtlasiP04201
PRIDEiP04201
ProteomicsDBi51677

PTM databases

iPTMnetiP04201
PhosphoSitePlusiP04201

Expressioni

Gene expression databases

BgeeiENSG00000130368
CleanExiHS_MAS1
ExpressionAtlasiP04201 baseline and differential
GenevisibleiP04201 HS

Interactioni

Subunit structurei

Interacts with AGTR1. Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (PubMed:26460884).1 Publication1 Publication

Protein-protein interaction databases

BioGridi110312, 80 interactors
STRINGi9606.ENSP00000252660

Structurei

3D structure databases

ProteinModelPortaliP04201
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFZP Eukaryota
ENOG410YK5N LUCA
GeneTreeiENSGT00550000074531
HOGENOMiHOG000015412
HOVERGENiHBG098384
InParanoidiP04201
KOiK04303
OMAiPLGFVEN
OrthoDBiEOG091G0BGC
PhylomeDBiP04201
TreeFamiTF336336

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR026234 MRGPCRFAMILY
IPR000820 Proto-oncogene_Mas
PANTHERiPTHR11334 PTHR11334, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00533 MASONCOGENE
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P04201-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGSNVTSFV VEEPTNISTG RNASVGNAHR QIPIVHWVIM SISPVGFVEN
60 70 80 90 100
GILLWFLCFR MRRNPFTVYI THLSIADISL LFCIFILSID YALDYELSSG
110 120 130 140 150
HYYTIVTLSV TFLFGYNTGL YLLTAISVER CLSVLYPIWY RCHRPKYQSA
160 170 180 190 200
LVCALLWALS CLVTTMEYVM CIDREEESHS RNDCRAVIIF IAILSFLVFT
210 220 230 240 250
PLMLVSSTIL VVKIRKNTWA SHSSKLYIVI MVTIIIFLIF AMPMRLLYLL
260 270 280 290 300
YYEYWSTFGN LHHISLLFST INSSANPFIY FFVGSSKKKR FKESLKVVLT
310 320
RAFKDEMQPR RQKDNCNTVT VETVV
Length:325
Mass (Da):37,465
Last modified:March 20, 1987 - v1
Checksum:i3368E7B174744B83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13150 mRNA Translation: AAA36199.1
CR542261 mRNA Translation: CAG47057.1
AL035691 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47610.1
CH471051 Genomic DNA Translation: EAW47611.1
BC069142 mRNA Translation: AAH69142.1
BC069581 mRNA Translation: AAH69581.1
BC110454 mRNA Translation: AAI10455.1
CCDSiCCDS5272.1
PIRiA01375 TVHUAS
RefSeqiNP_002368.1, NM_002377.2
UniGeneiHs.99900

Genome annotation databases

EnsembliENST00000252660; ENSP00000252660; ENSG00000130368
GeneIDi4142
KEGGihsa:4142

Similar proteinsi

Entry informationi

Entry nameiMAS_HUMAN
AccessioniPrimary (citable) accession number: P04201
Secondary accession number(s): E1P5B3, Q2TBC9, Q6FG47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: June 20, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

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