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Entry version 206 (08 May 2019)
Sequence version 2 (01 Jul 1989)
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Protein

N-myc proto-oncogene protein

Gene

MYCN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Positively regulates the transcription of MYCNOS in neuroblastoma cells.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P04198

SIGNOR Signaling Network Open Resource

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SIGNORi
P04198

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
N-myc proto-oncogene protein
Alternative name(s):
Class E basic helix-loop-helix protein 37
Short name:
bHLHe37
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYCN
Synonyms:BHLHE37, NMYC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:7559 MYCN

Online Mendelian Inheritance in Man (OMIM)

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MIMi
164840 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P04198

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Amplification of the N-MYC gene is associated with a variety of human tumors, most frequently neuroblastoma, where the level of amplification appears to increase as the tumor progresses.1 Publication
Feingold syndrome 1 (FGLDS1)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by variable combinations of esophageal and duodenal atresias, microcephaly, learning disability, mental retardation, and limb malformations. Hand and foot abnormalities may include hypoplastic thumbs, clinodactyly of second and fifth fingers, syndactyly (characteristically between second and third and fourth and fifth toes), and shortened or absent middle phalanges. Cardiac and renal malformations, vertebral anomalies, and deafness have also been described.
See also OMIM:164280
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031952393R → H in FGLDS1. 1 PublicationCorresponds to variant dbSNP:rs104893646EnsemblClinVar.1
Natural variantiVAR_031953393R → S in FGLDS1. 1 PublicationCorresponds to variant dbSNP:rs104893647EnsemblClinVar.1
Natural variantiVAR_031954394R → H in FGLDS1. 1 PublicationCorresponds to variant dbSNP:rs104893648EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi28F → A: Reduces interaction with AURKA; when associated with A-35. 1 Publication1
Mutagenesisi29Y → A: Reduces interaction with AURKA; when associated with A-36. 1 Publication1
Mutagenesisi35F → A: Reduces interaction with AURKA; when associated with A-28. 1 Publication1
Mutagenesisi36Y → A: Reduces interaction with AURKA; when associated with A-29. 1 Publication1
Mutagenesisi52 – 56KFELL → AAAAA: Does not affect AURKA binding. 1 Publication5
Mutagenesisi73E → K: Reduces binding to AURKA. 1 Publication1
Mutagenesisi77W → A: Reduces binding to AURKA. 1 Publication1
Mutagenesisi88W → A: Abrogates the interaction with AURKA. 1 Publication1

Keywords - Diseasei

Disease mutation, Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
4613

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
MYCN

MalaCards human disease database

More...
MalaCardsi
MYCN
MIMi164280 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000134323

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
391641 Feingold syndrome type 1
357027 Hereditary retinoblastoma
635 Neuroblastoma
357034 Non-hereditary retinoblastoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31359

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MYCN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
127604

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001273231 – 464N-myc proto-oncogene proteinAdd BLAST464

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei261Phosphoserine; by CK21 Publication1
Modified residuei263Phosphoserine; by CK21 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by GSK3-beta which may promote its degradation (PubMed:24391509). Phosphorylated by AURKA (PubMed:27837025).2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P04198

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P04198

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P04198

PeptideAtlas

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PeptideAtlasi
P04198

PRoteomics IDEntifications database

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PRIDEi
P04198

ProteomicsDB human proteome resource

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ProteomicsDBi
51676

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P04198

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P04198

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level).1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during fetal development.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000134323 Expressed in 178 organ(s), highest expression level in neocortex

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P04198 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P04198 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA057420

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with KDM5A, KDM5B and HUWE1. Interacts with MYCNOS. Interacts with AURKA; interaction is phospho-independent and triggers AURKA activation; AURKA competes with FBXW7 for binding to unphosphorylated MYCN but not for binding to unphosphorylated MYCN (PubMed:27837025). Interacts with FBXW7; FBXW7 competes with AURKA for binding to unphosphorylated MYCN but not for binding to phosphorylated MYCN (PubMed:27837025).4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110698, 39 interactors

Database of interacting proteins

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DIPi
DIP-36822N

Protein interaction database and analysis system

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IntActi
P04198, 17 interactors

Molecular INTeraction database

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MINTi
P04198

STRING: functional protein association networks

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STRINGi
9606.ENSP00000281043

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1464
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5G1XX-ray1.72B28-89[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P04198

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini381 – 433bHLHPROSITE-ProRule annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni19 – 47Interaction with AURKA1 PublicationAdd BLAST29
Regioni61 – 89Interaction with AURKA and FBXW71 PublicationAdd BLAST29
Regioni433 – 454Leucine-zipperAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi262 – 278Asp/Glu-rich (acidic)Add BLAST17

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IJ8V Eukaryota
ENOG41105VW LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158432

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000043075

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P04198

KEGG Orthology (KO)

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KOi
K09109

Identification of Orthologs from Complete Genome Data

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OMAi
FAEHSSE

Database of Orthologous Groups

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OrthoDBi
877891at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P04198

TreeFam database of animal gene trees

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TreeFami
TF106001

Family and domain databases

Conserved Domains Database

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CDDi
cd00083 HLH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR002418 Tscrpt_reg_Myc
IPR012682 Tscrpt_reg_Myc_N

Pfam protein domain database

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Pfami
View protein in Pfam
PF00010 HLH, 1 hit
PF01056 Myc_N, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF001705 Myc_protein, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00044 LEUZIPPRMYC

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00353 HLH, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47459 SSF47459, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50888 BHLH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P04198-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSCSTSTMP GMICKNPDLE FDSLQPCFYP DEDDFYFGGP DSTPPGEDIW
60 70 80 90 100
KKFELLPTPP LSPSRGFAEH SSEPPSWVTE MLLENELWGS PAEEDAFGLG
110 120 130 140 150
GLGGLTPNPV ILQDCMWSGF SAREKLERAV SEKLQHGRGP PTAGSTAQSP
160 170 180 190 200
GAGAASPAGR GHGGAAGAGR AGAALPAELA HPAAECVDPA VVFPFPVNKR
210 220 230 240 250
EPAPVPAAPA SAPAAGPAVA SGAGIAAPAG APGVAPPRPG GRQTSGGDHK
260 270 280 290 300
ALSTSGEDTL SDSDDEDDEE EDEEEEIDVV TVEKRRSSSN TKAVTTFTIT
310 320 330 340 350
VRPKNAALGP GRAQSSELIL KRCLPIHQQH NYAAPSPYVE SEDAPPQKKI
360 370 380 390 400
KSEASPRPLK SVIPPKAKSL SPRNSDSEDS ERRRNHNILE RQRRNDLRSS
410 420 430 440 450
FLTLRDHVPE LVKNEKAAKV VILKKATEYV HSLQAEEHQL LLEKEKLQAR
460
QQQLLKKIEH ARTC
Length:464
Mass (Da):49,561
Last modified:July 1, 1989 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i560E885602E30DAD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PPD9A0A1W2PPD9_HUMAN
N-myc proto-oncogene protein
MYCN
253Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA36371 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA68678 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti227A → P in CAA27037 (PubMed:3510398).Curated1
Sequence conflicti363I → V in CAA68678 (PubMed:2834684).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031952393R → H in FGLDS1. 1 PublicationCorresponds to variant dbSNP:rs104893646EnsemblClinVar.1
Natural variantiVAR_031953393R → S in FGLDS1. 1 PublicationCorresponds to variant dbSNP:rs104893647EnsemblClinVar.1
Natural variantiVAR_031954394R → H in FGLDS1. 1 PublicationCorresponds to variant dbSNP:rs104893648EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X03294 Genomic DNA Translation: CAA27037.1
X03295 Genomic DNA Translation: CAA27038.1
M13241 Genomic DNA Translation: AAA36371.1 Different initiation.
M13228 Genomic DNA Translation: AAA36370.1
BT007384 mRNA Translation: AAP36048.1
AC010145 Genomic DNA Translation: AAY14952.1
CH471053 Genomic DNA Translation: EAX00885.1
CH471053 Genomic DNA Translation: EAX00886.1
CH471053 Genomic DNA Translation: EAX00887.1
CH471053 Genomic DNA Translation: EAX00888.1
BC002712 mRNA Translation: AAH02712.1
M18090 Genomic DNA Translation: AAA59885.1
X02363 Genomic DNA No translation available.
Y00664 Genomic DNA Translation: CAA68678.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS1687.1

Protein sequence database of the Protein Information Resource

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PIRi
A01355 TVHUMC
A25744 TVHUM2

NCBI Reference Sequences

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RefSeqi
NP_001280157.1, NM_001293228.1
NP_001280160.1, NM_001293231.1
NP_001280162.1, NM_001293233.1
NP_005369.2, NM_005378.5
XP_016859657.1, XM_017004168.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000281043; ENSP00000281043; ENSG00000134323

Database of genes from NCBI RefSeq genomes

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GeneIDi
4613

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4613

UCSC genome browser

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UCSCi
uc002rci.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03294 Genomic DNA Translation: CAA27037.1
X03295 Genomic DNA Translation: CAA27038.1
M13241 Genomic DNA Translation: AAA36371.1 Different initiation.
M13228 Genomic DNA Translation: AAA36370.1
BT007384 mRNA Translation: AAP36048.1
AC010145 Genomic DNA Translation: AAY14952.1
CH471053 Genomic DNA Translation: EAX00885.1
CH471053 Genomic DNA Translation: EAX00886.1
CH471053 Genomic DNA Translation: EAX00887.1
CH471053 Genomic DNA Translation: EAX00888.1
BC002712 mRNA Translation: AAH02712.1
M18090 Genomic DNA Translation: AAA59885.1
X02363 Genomic DNA No translation available.
Y00664 Genomic DNA Translation: CAA68678.1 Different initiation.
CCDSiCCDS1687.1
PIRiA01355 TVHUMC
A25744 TVHUM2
RefSeqiNP_001280157.1, NM_001293228.1
NP_001280160.1, NM_001293231.1
NP_001280162.1, NM_001293233.1
NP_005369.2, NM_005378.5
XP_016859657.1, XM_017004168.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5G1XX-ray1.72B28-89[»]
SMRiP04198
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110698, 39 interactors
DIPiDIP-36822N
IntActiP04198, 17 interactors
MINTiP04198
STRINGi9606.ENSP00000281043

PTM databases

iPTMnetiP04198
PhosphoSitePlusiP04198

Polymorphism and mutation databases

BioMutaiMYCN
DMDMi127604

Proteomic databases

EPDiP04198
jPOSTiP04198
PaxDbiP04198
PeptideAtlasiP04198
PRIDEiP04198
ProteomicsDBi51676

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
4613
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281043; ENSP00000281043; ENSG00000134323
GeneIDi4613
KEGGihsa:4613
UCSCiuc002rci.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4613
DisGeNETi4613

GeneCards: human genes, protein and diseases

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GeneCardsi
MYCN
GeneReviewsiMYCN

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0117705
HGNCiHGNC:7559 MYCN
HPAiHPA057420
MalaCardsiMYCN
MIMi164280 phenotype
164840 gene
neXtProtiNX_P04198
OpenTargetsiENSG00000134323
Orphaneti391641 Feingold syndrome type 1
357027 Hereditary retinoblastoma
635 Neuroblastoma
357034 Non-hereditary retinoblastoma
PharmGKBiPA31359

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IJ8V Eukaryota
ENOG41105VW LUCA
GeneTreeiENSGT00940000158432
HOGENOMiHOG000043075
InParanoidiP04198
KOiK09109
OMAiFAEHSSE
OrthoDBi877891at2759
PhylomeDBiP04198
TreeFamiTF106001

Enzyme and pathway databases

SignaLinkiP04198
SIGNORiP04198

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MYCN human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
N-Myc

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4613

Protein Ontology

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PROi
PR:P04198

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000134323 Expressed in 178 organ(s), highest expression level in neocortex
ExpressionAtlasiP04198 baseline and differential
GenevisibleiP04198 HS

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR002418 Tscrpt_reg_Myc
IPR012682 Tscrpt_reg_Myc_N
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF01056 Myc_N, 1 hit
PIRSFiPIRSF001705 Myc_protein, 1 hit
PRINTSiPR00044 LEUZIPPRMYC
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYCN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P04198
Secondary accession number(s): Q53XS5, Q6LDT9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: July 1, 1989
Last modified: May 8, 2019
This is version 206 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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