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UniProtKB - P04181 (OAT_HUMAN)
Protein
Ornithine aminotransferase, mitochondrial
Gene
OAT
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes the reversible interconversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate.
2 PublicationsCatalytic activityi
- EC:2.6.1.132 Publications
Cofactori
pyridoxal 5'-phosphate1 Publication
: L-proline biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine.2 Publications This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.
GO - Molecular functioni
- identical protein binding Source: UniProtKB
- ornithine(lysine) transaminase activity Source: UniProtKB
- ornithine-oxo-acid transaminase activity Source: GO_Central
- pyridoxal phosphate binding Source: GO_Central
GO - Biological processi
- arginine catabolic process to glutamate Source: GO_Central
- arginine catabolic process to proline via ornithine Source: GO_Central
- L-proline biosynthetic process Source: UniProtKB-UniPathway
- visual perception Source: ProtInc
Keywordsi
Molecular function | Aminotransferase, Transferase |
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
BRENDAi | 2.6.1.13, 2681 |
PathwayCommonsi | P04181 |
Reactomei | R-HSA-8964539, Glutamate and glutamine metabolism |
SABIO-RKi | P04181 |
SignaLinki | P04181 |
SIGNORi | P04181 |
UniPathwayi | UPA00098;UER00358 |
Names & Taxonomyi
Protein namesi | Recommended name: Ornithine aminotransferase, mitochondrial (EC:2.6.1.132 Publications)Alternative name(s): Ornithine delta-aminotransferase Ornithine--oxo-acid aminotransferase Cleaved into the following 2 chains: |
Gene namesi | Name:OAT |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8091, OAT |
MIMi | 613349, gene |
neXtProti | NX_P04181 |
VEuPathDBi | HostDB:ENSG00000065154 |
Subcellular locationi
Mitochondrion
- Mitochondrion matrix 1 Publication
Mitochondrion
- mitochondrial matrix Source: UniProtKB
- mitochondrion Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Involvement in diseasei
Hyperornithinemia with gyrate atrophy of choroid and retina (HOGA)7 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder clinically characterized by a triad of progressive chorioretinal degeneration, early cataract formation, and type II muscle fiber atrophy. Characteristic chorioretinal atrophy with progressive constriction of the visual fields leads to blindness at the latest during the sixth decade of life. Patients generally have normal intelligence.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071924 | 51 | G → D in HOGA; loss of protein stability; loss of ornithine aminotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs11553554Ensembl. | 1 | |
Natural variantiVAR_000565 | 54 | N → K in HOGA. 1 PublicationCorresponds to variant dbSNP:rs121965048EnsemblClinVar. | 1 | |
Natural variantiVAR_000566 | 55 | Y → H in HOGA; decreased protein abundance. 1 PublicationCorresponds to variant dbSNP:rs121965037EnsemblClinVar. | 1 | |
Natural variantiVAR_000567 | 89 | N → K in HOGA; no effect on protein abundance. 1 PublicationCorresponds to variant dbSNP:rs386833602EnsemblClinVar. | 1 | |
Natural variantiVAR_015648 | 90 | Q → E in HOGA; mistargeted, accumulates in cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs121965060EnsemblClinVar. | 1 | |
Natural variantiVAR_000568 | 93 | C → F in HOGA; no effect on protein abundance. 1 PublicationCorresponds to variant dbSNP:rs121965038EnsemblClinVar. | 1 | |
Natural variantiVAR_071925 | 104 | Q → R in HOGA; loss of protein stability; loss of ornithine aminotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs386833604EnsemblClinVar. | 1 | |
Natural variantiVAR_000569 | 154 | R → L in HOGA; no effect on protein abundance; loss of ornithine aminotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs121965039EnsemblClinVar. | 1 | |
Natural variantiVAR_000570 | 180 | R → T in HOGA; no effect on protein abundance; loss of ornithine aminotransferase activity. 2 PublicationsCorresponds to variant dbSNP:rs121965040EnsemblClinVar. | 1 | |
Natural variantiVAR_000571 | 184 | Missing in HOGA; no effect on protein abundance; loss of ornithine aminotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs121965035Ensembl. | 1 | |
Natural variantiVAR_071926 | 199 | P → Q in HOGA; loss of protein stability; loss of ornithine aminotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs267606925EnsemblClinVar. | 1 | |
Natural variantiVAR_000572 | 226 | A → V in HOGA; loss of protein stability; loss of ornithine aminotransferase activity. 2 PublicationsCorresponds to variant dbSNP:rs121965059EnsemblClinVar. | 1 | |
Natural variantiVAR_000573 | 241 | P → L in HOGA; no effect on protein abundance. 2 PublicationsCorresponds to variant dbSNP:rs121965051EnsemblClinVar. | 1 | |
Natural variantiVAR_000574 | 245 | Y → C in HOGA; no effect on protein abundance. 1 PublicationCorresponds to variant dbSNP:rs121965046EnsemblClinVar. | 1 | |
Natural variantiVAR_000575 | 250 | R → P in HOGA; no effect on protein abundance. 2 PublicationsCorresponds to variant dbSNP:rs121965052EnsemblClinVar. | 1 | |
Natural variantiVAR_000576 | 267 | T → I in HOGA; decreased protein abundance. 1 PublicationCorresponds to variant dbSNP:rs386833618EnsemblClinVar. | 1 | |
Natural variantiVAR_000578 | 271 | R → K in HOGA; no effect on protein abundance; loss of ornithine aminotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs121965042EnsemblClinVar. | 1 | |
Natural variantiVAR_071927 | 318 | E → K in HOGA; loss of protein stability; loss of ornithine aminotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs386833621EnsemblClinVar. | 1 | |
Natural variantiVAR_000579 | 319 | H → Y in HOGA. 1 PublicationCorresponds to variant dbSNP:rs121965049EnsemblClinVar. | 1 | |
Natural variantiVAR_000580 | 332 | V → M in HOGA; loss of protein stability; loss of ornithine aminotransferase activityx. 2 PublicationsCorresponds to variant dbSNP:rs121965047EnsemblClinVar. | 1 | |
Natural variantiVAR_000581 | 353 | G → D in HOGA; decreased protein abundance. 2 PublicationsCorresponds to variant dbSNP:rs121965053EnsemblClinVar. | 1 | |
Natural variantiVAR_000582 | 375 | G → A in HOGA; decreased protein abundance. 1 PublicationCorresponds to variant dbSNP:rs121965045EnsemblClinVar. | 1 | |
Natural variantiVAR_000583 | 394 | C → R in HOGA; no effect on protein abundance. 2 PublicationsCorresponds to variant dbSNP:rs121965054EnsemblClinVar. | 1 | |
Natural variantiVAR_071928 | 394 | C → Y in HOGA; loss of protein stability; loss of ornithine aminotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs386833597EnsemblClinVar. | 1 | |
Natural variantiVAR_000584 | 402 | L → P in HOGA; may affect protein stability; loss of ornithine aminotransferase activity. 2 PublicationsCorresponds to variant dbSNP:rs121965043EnsemblClinVar. | 1 | |
Natural variantiVAR_000585 | 417 | P → L in HOGA; loss of protein stability; loss of ornithine aminotransferase activity. 2 PublicationsCorresponds to variant dbSNP:rs121965044EnsemblClinVar. | 1 | |
Natural variantiVAR_071929 | 436 | I → N in HOGA; loss of protein stability; loss of ornithine aminotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs386833598EnsemblClinVar. | 1 | |
Natural variantiVAR_000586 | 437 | L → F in HOGA; no effect on protein stability; increased ornithine aminotransferase activity. 2 PublicationsCorresponds to variant dbSNP:rs1800456EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 4942 |
MalaCardsi | OAT |
MIMi | 258870, phenotype |
OpenTargetsi | ENSG00000065154 |
Orphaneti | 414, Gyrate atrophy of choroid and retina |
PharmGKBi | PA31880 |
Miscellaneous databases
Pharosi | P04181, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5954 |
DrugBanki | DB02821, Canaline DB02054, Gabaculine DB00129, Ornithine DB00114, Pyridoxal phosphate |
Genetic variation databases
BioMutai | OAT |
DMDMi | 129018 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 35 | Mitochondrion; in renal form1 PublicationAdd BLAST | 35 | |
Transit peptidei | 1 – 25 | Mitochondrion; in hepatic formAdd BLAST | 25 | |
ChainiPRO_0000001262 | 26 – 439 | Ornithine aminotransferase, hepatic formAdd BLAST | 414 | |
ChainiPRO_0000001263 | 36 – 439 | Ornithine aminotransferase, renal formAdd BLAST | 404 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 49 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 66 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 102 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 107 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 107 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 292 | N6-(pyridoxal phosphate)lysine1 Publication | 1 | |
Modified residuei | 362 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 362 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 386 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 392 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 405 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 405 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 421 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | P04181 |
jPOSTi | P04181 |
MassIVEi | P04181 |
MaxQBi | P04181 |
PaxDbi | P04181 |
PeptideAtlasi | P04181 |
PRIDEi | P04181 |
ProteomicsDBi | 51672 [P04181-1] 51673 [P04181-2] |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00022334 |
PTM databases
CarbonylDBi | P04181 |
GlyGeni | P04181, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P04181 |
MetOSitei | P04181 |
PhosphoSitePlusi | P04181 |
SwissPalmi | P04181 |
Expressioni
Gene expression databases
Bgeei | ENSG00000065154, Expressed in jejunal mucosa and 248 other tissues |
ExpressionAtlasi | P04181, baseline and differential |
Genevisiblei | P04181, HS |
Organism-specific databases
HPAi | ENSG00000065154, Tissue enhanced (intestine) |
Interactioni
Subunit structurei
Homohexamer.
1 PublicationBinary interactionsi
P04181
With | #Exp. | IntAct |
---|---|---|
APP [P05067] | 3 | EBI-721662,EBI-77613 |
GO - Molecular functioni
- identical protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 110996, 147 interactors |
IntActi | P04181, 40 interactors |
MINTi | P04181 |
STRINGi | 9606.ENSP00000357838 |
Chemistry databases
BindingDBi | P04181 |
Miscellaneous databases
RNActi | P04181, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P04181 |
SMRi | P04181 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P04181 |
Family & Domainsi
Sequence similaritiesi
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG1402, Eukaryota |
GeneTreei | ENSGT00630000089895 |
HOGENOMi | CLU_016922_10_3_1 |
InParanoidi | P04181 |
OMAi | DVFPRFA |
PhylomeDBi | P04181 |
TreeFami | TF105720 |
Family and domain databases
CDDi | cd00610, OAT_like, 1 hit |
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR005814, Aminotrans_3 IPR010164, Orn_aminotrans IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major IPR015422, PyrdxlP-dep_Trfase_small |
Pfami | View protein in Pfam PF00202, Aminotran_3, 1 hit |
PIRSFi | PIRSF000521, Transaminase_4ab_Lys_Orn, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
TIGRFAMsi | TIGR01885, Orn_aminotrans, 1 hit |
PROSITEi | View protein in PROSITE PS00600, AA_TRANSFER_CLASS_3, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: P04181-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFSKLAHLQR FAVLSRGVHS SVASATSVAT KKTVQGPPTS DDIFEREYKY
60 70 80 90 100
GAHNYHPLPV ALERGKGIYL WDVEGRKYFD FLSSYSAVNQ GHCHPKIVNA
110 120 130 140 150
LKSQVDKLTL TSRAFYNNVL GEYEEYITKL FNYHKVLPMN TGVEAGETAC
160 170 180 190 200
KLARKWGYTV KGIQKYKAKI VFAAGNFWGR TLSAISSSTD PTSYDGFGPF
210 220 230 240 250
MPGFDIIPYN DLPALERALQ DPNVAAFMVE PIQGEAGVVV PDPGYLMGVR
260 270 280 290 300
ELCTRHQVLF IADEIQTGLA RTGRWLAVDY ENVRPDIVLL GKALSGGLYP
310 320 330 340 350
VSAVLCDDDI MLTIKPGEHG STYGGNPLGC RVAIAALEVL EEENLAENAD
360 370 380 390 400
KLGIILRNEL MKLPSDVVTA VRGKGLLNAI VIKETKDWDA WKVCLRLRDN
410 420 430
GLLAKPTHGD IIRFAPPLVI KEDELRESIE IINKTILSF
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071924 | 51 | G → D in HOGA; loss of protein stability; loss of ornithine aminotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs11553554Ensembl. | 1 | |
Natural variantiVAR_000565 | 54 | N → K in HOGA. 1 PublicationCorresponds to variant dbSNP:rs121965048EnsemblClinVar. | 1 | |
Natural variantiVAR_000566 | 55 | Y → H in HOGA; decreased protein abundance. 1 PublicationCorresponds to variant dbSNP:rs121965037EnsemblClinVar. | 1 | |
Natural variantiVAR_000567 | 89 | N → K in HOGA; no effect on protein abundance. 1 PublicationCorresponds to variant dbSNP:rs386833602EnsemblClinVar. | 1 | |
Natural variantiVAR_015648 | 90 | Q → E in HOGA; mistargeted, accumulates in cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs121965060EnsemblClinVar. | 1 | |
Natural variantiVAR_000568 | 93 | C → F in HOGA; no effect on protein abundance. 1 PublicationCorresponds to variant dbSNP:rs121965038EnsemblClinVar. | 1 | |
Natural variantiVAR_071925 | 104 | Q → R in HOGA; loss of protein stability; loss of ornithine aminotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs386833604EnsemblClinVar. | 1 | |
Natural variantiVAR_000569 | 154 | R → L in HOGA; no effect on protein abundance; loss of ornithine aminotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs121965039EnsemblClinVar. | 1 | |
Natural variantiVAR_000570 | 180 | R → T in HOGA; no effect on protein abundance; loss of ornithine aminotransferase activity. 2 PublicationsCorresponds to variant dbSNP:rs121965040EnsemblClinVar. | 1 | |
Natural variantiVAR_000571 | 184 | Missing in HOGA; no effect on protein abundance; loss of ornithine aminotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs121965035Ensembl. | 1 | |
Natural variantiVAR_071926 | 199 | P → Q in HOGA; loss of protein stability; loss of ornithine aminotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs267606925EnsemblClinVar. | 1 | |
Natural variantiVAR_000572 | 226 | A → V in HOGA; loss of protein stability; loss of ornithine aminotransferase activity. 2 PublicationsCorresponds to variant dbSNP:rs121965059EnsemblClinVar. | 1 | |
Natural variantiVAR_000573 | 241 | P → L in HOGA; no effect on protein abundance. 2 PublicationsCorresponds to variant dbSNP:rs121965051EnsemblClinVar. | 1 | |
Natural variantiVAR_000574 | 245 | Y → C in HOGA; no effect on protein abundance. 1 PublicationCorresponds to variant dbSNP:rs121965046EnsemblClinVar. | 1 | |
Natural variantiVAR_000575 | 250 | R → P in HOGA; no effect on protein abundance. 2 PublicationsCorresponds to variant dbSNP:rs121965052EnsemblClinVar. | 1 | |
Natural variantiVAR_000576 | 267 | T → I in HOGA; decreased protein abundance. 1 PublicationCorresponds to variant dbSNP:rs386833618EnsemblClinVar. | 1 | |
Natural variantiVAR_000577 | 270 | A → P Decreased protein abundance. 1 PublicationCorresponds to variant dbSNP:rs121965041EnsemblClinVar. | 1 | |
Natural variantiVAR_000578 | 271 | R → K in HOGA; no effect on protein abundance; loss of ornithine aminotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs121965042EnsemblClinVar. | 1 | |
Natural variantiVAR_071927 | 318 | E → K in HOGA; loss of protein stability; loss of ornithine aminotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs386833621EnsemblClinVar. | 1 | |
Natural variantiVAR_000579 | 319 | H → Y in HOGA. 1 PublicationCorresponds to variant dbSNP:rs121965049EnsemblClinVar. | 1 | |
Natural variantiVAR_000580 | 332 | V → M in HOGA; loss of protein stability; loss of ornithine aminotransferase activityx. 2 PublicationsCorresponds to variant dbSNP:rs121965047EnsemblClinVar. | 1 | |
Natural variantiVAR_000581 | 353 | G → D in HOGA; decreased protein abundance. 2 PublicationsCorresponds to variant dbSNP:rs121965053EnsemblClinVar. | 1 | |
Natural variantiVAR_000582 | 375 | G → A in HOGA; decreased protein abundance. 1 PublicationCorresponds to variant dbSNP:rs121965045EnsemblClinVar. | 1 | |
Natural variantiVAR_000583 | 394 | C → R in HOGA; no effect on protein abundance. 2 PublicationsCorresponds to variant dbSNP:rs121965054EnsemblClinVar. | 1 | |
Natural variantiVAR_071928 | 394 | C → Y in HOGA; loss of protein stability; loss of ornithine aminotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs386833597EnsemblClinVar. | 1 | |
Natural variantiVAR_000584 | 402 | L → P in HOGA; may affect protein stability; loss of ornithine aminotransferase activity. 2 PublicationsCorresponds to variant dbSNP:rs121965043EnsemblClinVar. | 1 | |
Natural variantiVAR_000585 | 417 | P → L in HOGA; loss of protein stability; loss of ornithine aminotransferase activity. 2 PublicationsCorresponds to variant dbSNP:rs121965044EnsemblClinVar. | 1 | |
Natural variantiVAR_071929 | 436 | I → N in HOGA; loss of protein stability; loss of ornithine aminotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs386833598EnsemblClinVar. | 1 | |
Natural variantiVAR_000586 | 437 | L → F in HOGA; no effect on protein stability; increased ornithine aminotransferase activity. 2 PublicationsCorresponds to variant dbSNP:rs1800456EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043085 | 1 – 138 | Missing in isoform 2. 2 PublicationsAdd BLAST | 138 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000368845.6; ENSP00000357838.5; ENSG00000065154.12 ENST00000539214.5; ENSP00000439042.1; ENSG00000065154.12 [P04181-2] |
GeneIDi | 4942 |
KEGGi | hsa:4942 |
MANE-Selecti | ENST00000368845.6; ENSP00000357838.5; NM_000274.4; NP_000265.1 |
UCSCi | uc001lhp.4, human [P04181-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1GBN | X-ray | 2.30 | A/B/C | 38-439 | [»] | |
1OAT | X-ray | 2.50 | A/B/C | 1-439 | [»] | |
2BYJ | X-ray | 3.02 | A/B/C | 1-439 | [»] | |
2BYL | X-ray | 2.15 | A/B/C | 1-439 | [»] | |
2CAN | X-ray | 2.30 | A/B/C | 38-439 | [»] | |
2OAT | X-ray | 1.95 | A/B/C | 1-439 | [»] | |
5VWO | X-ray | 1.77 | A/B/C | 36-439 | [»] | |
6HX7 | X-ray | 1.80 | A/B/C | 26-439 | [»] | |
6OIA | X-ray | 1.78 | A/B/C | 36-439 | [»] | |
6V8C | X-ray | 1.90 | A/B/C | 36-439 | [»] | |
6V8D | X-ray | 2.25 | A/B/C | 36-439 | [»] | |
7JX9 | X-ray | 1.96 | A/B/C | 36-439 | [»] | |
7LNM | X-ray | 2.00 | B/C/E/F/I/J | 36-439 | [»] | |
7LOM | X-ray | 2.10 | A/B/C | 36-439 | [»] | |
7LON | X-ray | 1.95 | A/B/C | 36-439 | [»] | |
AlphaFoldDBi | P04181 | |||||
SMRi | P04181 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110996, 147 interactors |
IntActi | P04181, 40 interactors |
MINTi | P04181 |
STRINGi | 9606.ENSP00000357838 |
Chemistry databases
BindingDBi | P04181 |
ChEMBLi | CHEMBL5954 |
DrugBanki | DB02821, Canaline DB02054, Gabaculine DB00129, Ornithine DB00114, Pyridoxal phosphate |
PTM databases
CarbonylDBi | P04181 |
GlyGeni | P04181, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P04181 |
MetOSitei | P04181 |
PhosphoSitePlusi | P04181 |
SwissPalmi | P04181 |
Genetic variation databases
BioMutai | OAT |
DMDMi | 129018 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00022334 |
Proteomic databases
EPDi | P04181 |
jPOSTi | P04181 |
MassIVEi | P04181 |
MaxQBi | P04181 |
PaxDbi | P04181 |
PeptideAtlasi | P04181 |
PRIDEi | P04181 |
ProteomicsDBi | 51672 [P04181-1] 51673 [P04181-2] |
Protocols and materials databases
Antibodypediai | 32371, 254 antibodies from 32 providers |
DNASUi | 4942 |
Genome annotation databases
Ensembli | ENST00000368845.6; ENSP00000357838.5; ENSG00000065154.12 ENST00000539214.5; ENSP00000439042.1; ENSG00000065154.12 [P04181-2] |
GeneIDi | 4942 |
KEGGi | hsa:4942 |
MANE-Selecti | ENST00000368845.6; ENSP00000357838.5; NM_000274.4; NP_000265.1 |
UCSCi | uc001lhp.4, human [P04181-1] |
Organism-specific databases
CTDi | 4942 |
DisGeNETi | 4942 |
GeneCardsi | OAT |
HGNCi | HGNC:8091, OAT |
HPAi | ENSG00000065154, Tissue enhanced (intestine) |
MalaCardsi | OAT |
MIMi | 258870, phenotype 613349, gene |
neXtProti | NX_P04181 |
OpenTargetsi | ENSG00000065154 |
Orphaneti | 414, Gyrate atrophy of choroid and retina |
PharmGKBi | PA31880 |
VEuPathDBi | HostDB:ENSG00000065154 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1402, Eukaryota |
GeneTreei | ENSGT00630000089895 |
HOGENOMi | CLU_016922_10_3_1 |
InParanoidi | P04181 |
OMAi | DVFPRFA |
PhylomeDBi | P04181 |
TreeFami | TF105720 |
Enzyme and pathway databases
UniPathwayi | UPA00098;UER00358 |
BRENDAi | 2.6.1.13, 2681 |
PathwayCommonsi | P04181 |
Reactomei | R-HSA-8964539, Glutamate and glutamine metabolism |
SABIO-RKi | P04181 |
SignaLinki | P04181 |
SIGNORi | P04181 |
Miscellaneous databases
BioGRID-ORCSi | 4942, 11 hits in 1084 CRISPR screens |
ChiTaRSi | OAT, human |
EvolutionaryTracei | P04181 |
GenomeRNAii | 4942 |
Pharosi | P04181, Tchem |
PROi | PR:P04181 |
RNActi | P04181, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000065154, Expressed in jejunal mucosa and 248 other tissues |
ExpressionAtlasi | P04181, baseline and differential |
Genevisiblei | P04181, HS |
Family and domain databases
CDDi | cd00610, OAT_like, 1 hit |
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR005814, Aminotrans_3 IPR010164, Orn_aminotrans IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major IPR015422, PyrdxlP-dep_Trfase_small |
Pfami | View protein in Pfam PF00202, Aminotran_3, 1 hit |
PIRSFi | PIRSF000521, Transaminase_4ab_Lys_Orn, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
TIGRFAMsi | TIGR01885, Orn_aminotrans, 1 hit |
PROSITEi | View protein in PROSITE PS00600, AA_TRANSFER_CLASS_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | OAT_HUMAN | |
Accessioni | P04181Primary (citable) accession number: P04181 Secondary accession number(s): D3DRF0 Q9UD03 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 1987 |
Last sequence update: | March 20, 1987 | |
Last modified: | May 25, 2022 | |
This is version 233 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families