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Protein

Ornithine aminotransferase, mitochondrial

Gene

OAT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.

Cofactori

pyridoxal 5'-phosphate1 Publication

Pathwayi: L-proline biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:
  1. Ornithine aminotransferase, mitochondrial (OAT), Ornithine aminotransferase, Ornithine aminotransferase
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

  • ornithine-oxo-acid transaminase activity Source: Reactome
  • pyridoxal phosphate binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:HS00832-MONOMER
BRENDAi2.6.1.13 2681
ReactomeiR-HSA-70614 Amino acid synthesis and interconversion (transamination)
SABIO-RKiP04181
SIGNORiP04181
UniPathwayi
UPA00098;UER00358

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine aminotransferase, mitochondrial (EC:2.6.1.13)
Alternative name(s):
Ornithine delta-aminotransferase
Ornithine--oxo-acid aminotransferase
Cleaved into the following 2 chains:
Gene namesi
Name:OAT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000065154.11
HGNCiHGNC:8091 OAT
MIMi613349 gene
neXtProtiNX_P04181

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Involvement in diseasei

Hyperornithinemia with gyrate atrophy of choroid and retina (HOGA)7 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder clinically characterized by a triad of progressive chorioretinal degeneration, early cataract formation, and type II muscle fiber atrophy. Characteristic chorioretinal atrophy with progressive constriction of the visual fields leads to blindness at the latest during the sixth decade of life. Patients generally have normal intelligence.
See also OMIM:258870
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07192451G → D in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant dbSNP:rs11553554Ensembl.1
Natural variantiVAR_00056554N → K in HOGA. 1 PublicationCorresponds to variant dbSNP:rs121965048EnsemblClinVar.1
Natural variantiVAR_00056655Y → H in HOGA. 1 PublicationCorresponds to variant dbSNP:rs121965037EnsemblClinVar.1
Natural variantiVAR_00056789N → K in HOGA. 1 PublicationCorresponds to variant dbSNP:rs386833602EnsemblClinVar.1
Natural variantiVAR_01564890Q → E in HOGA; mistargeted, accumulates in cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs121965060EnsemblClinVar.1
Natural variantiVAR_00056893C → F in HOGA. 1 PublicationCorresponds to variant dbSNP:rs121965038EnsemblClinVar.1
Natural variantiVAR_071925104Q → R in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant dbSNP:rs386833604EnsemblClinVar.1
Natural variantiVAR_000569154R → L in HOGA; complete loss of activity. 1 PublicationCorresponds to variant dbSNP:rs121965039EnsemblClinVar.1
Natural variantiVAR_000570180R → T in HOGA; complete loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs121965040EnsemblClinVar.1
Natural variantiVAR_000571184Missing in HOGA. 1 Publication1
Natural variantiVAR_071926199P → Q in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant dbSNP:rs267606925EnsemblClinVar.1
Natural variantiVAR_000572226A → V in HOGA; loss of activity and protein stability. 2 PublicationsCorresponds to variant dbSNP:rs121965059EnsemblClinVar.1
Natural variantiVAR_000573241P → L in HOGA. 2 PublicationsCorresponds to variant dbSNP:rs121965051EnsemblClinVar.1
Natural variantiVAR_000574245Y → C in HOGA. 1 PublicationCorresponds to variant dbSNP:rs121965046EnsemblClinVar.1
Natural variantiVAR_000575250R → P in HOGA. 2 PublicationsCorresponds to variant dbSNP:rs121965052EnsemblClinVar.1
Natural variantiVAR_000576267T → I in HOGA. 1 PublicationCorresponds to variant dbSNP:rs386833618EnsemblClinVar.1
Natural variantiVAR_000577270A → P in HOGA. Corresponds to variant dbSNP:rs121965041EnsemblClinVar.1
Natural variantiVAR_000578271R → K in HOGA. 1 PublicationCorresponds to variant dbSNP:rs121965042EnsemblClinVar.1
Natural variantiVAR_071927318E → K in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant dbSNP:rs386833621EnsemblClinVar.1
Natural variantiVAR_000579319H → Y in HOGA. 1 PublicationCorresponds to variant dbSNP:rs121965049EnsemblClinVar.1
Natural variantiVAR_000580332V → M in HOGA; loss of activity and protein stability. 2 PublicationsCorresponds to variant dbSNP:rs121965047EnsemblClinVar.1
Natural variantiVAR_000581353G → D in HOGA. 2 PublicationsCorresponds to variant dbSNP:rs121965053EnsemblClinVar.1
Natural variantiVAR_000582375G → A in HOGA. 1 PublicationCorresponds to variant dbSNP:rs121965045EnsemblClinVar.1
Natural variantiVAR_000583394C → R in HOGA. 2 PublicationsCorresponds to variant dbSNP:rs121965054EnsemblClinVar.1
Natural variantiVAR_071928394C → Y in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant dbSNP:rs386833597EnsemblClinVar.1
Natural variantiVAR_000584402L → P in HOGA; loss of activity and protein stability. 2 PublicationsCorresponds to variant dbSNP:rs121965043EnsemblClinVar.1
Natural variantiVAR_000585417P → L in HOGA; loss of activity and protein stability. 2 PublicationsCorresponds to variant dbSNP:rs121965044EnsemblClinVar.1
Natural variantiVAR_071929436I → N in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant dbSNP:rs386833598EnsemblClinVar.1
Natural variantiVAR_000586437L → F in HOGA; no effect on activity and protein stability. 2 PublicationsCorresponds to variant dbSNP:rs1800456EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi4942
MalaCardsiOAT
MIMi258870 phenotype
OpenTargetsiENSG00000065154
Orphaneti414 Gyrate atrophy of choroid and retina
PharmGKBiPA31880

Chemistry databases

ChEMBLiCHEMBL5954
DrugBankiDB02821 Canaline
DB02054 Gabaculine
DB00129 L-Ornithine
DB00114 Pyridoxal Phosphate

Polymorphism and mutation databases

BioMutaiOAT
DMDMi129018

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 35Mitochondrion; in renal form1 PublicationAdd BLAST35
Transit peptidei1 – 25Mitochondrion; in hepatic formAdd BLAST25
ChainiPRO_000000126226 – 439Ornithine aminotransferase, hepatic formAdd BLAST414
ChainiPRO_000000126336 – 439Ornithine aminotransferase, renal formAdd BLAST404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49N6-acetyllysineBy similarity1
Modified residuei66N6-acetyllysineBy similarity1
Modified residuei102N6-succinyllysineBy similarity1
Modified residuei107N6-acetyllysine; alternateBy similarity1
Modified residuei107N6-succinyllysine; alternateBy similarity1
Modified residuei292N6-(pyridoxal phosphate)lysine1 Publication1
Modified residuei362N6-acetyllysine; alternateBy similarity1
Modified residuei362N6-succinyllysine; alternateBy similarity1
Modified residuei386N6-acetyllysineBy similarity1
Modified residuei392N6-acetyllysineBy similarity1
Modified residuei405N6-acetyllysine; alternateBy similarity1
Modified residuei405N6-succinyllysine; alternateBy similarity1
Modified residuei421N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP04181
MaxQBiP04181
PaxDbiP04181
PeptideAtlasiP04181
PRIDEiP04181
ProteomicsDBi51672
51673 [P04181-2]

2D gel databases

REPRODUCTION-2DPAGEiIPI00022334

PTM databases

CarbonylDBiP04181
iPTMnetiP04181
PhosphoSitePlusiP04181
SwissPalmiP04181

Expressioni

Gene expression databases

BgeeiENSG00000065154 Expressed in 239 organ(s), highest expression level in jejunal mucosa
CleanExiHS_OAT
ExpressionAtlasiP04181 baseline and differential
GenevisibleiP04181 HS

Organism-specific databases

HPAiCAB033576
HPA040098
HPA064742

Interactioni

Subunit structurei

Homohexamer.1 Publication

Protein-protein interaction databases

BioGridi110996, 44 interactors
IntActiP04181, 22 interactors
MINTiP04181
STRINGi9606.ENSP00000357838

Chemistry databases

BindingDBiP04181

Structurei

Secondary structure

1439
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP04181
SMRiP04181
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04181

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1402 Eukaryota
COG4992 LUCA
GeneTreeiENSGT00630000089895
HOGENOMiHOG000020206
HOVERGENiHBG000434
InParanoidiP04181
KOiK00819
OMAiHSAWDLC
OrthoDBiEOG091G06WM
PhylomeDBiP04181
TreeFamiTF105720

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR005814 Aminotrans_3
IPR010164 Orn_aminotrans
IPR034758 Orn_aminotrans_mito
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11986:SF18 PTHR11986:SF18, 1 hit
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
PIRSFiPIRSF000521 Transaminase_4ab_Lys_Orn, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01885 Orn_aminotrans, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P04181-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFSKLAHLQR FAVLSRGVHS SVASATSVAT KKTVQGPPTS DDIFEREYKY
60 70 80 90 100
GAHNYHPLPV ALERGKGIYL WDVEGRKYFD FLSSYSAVNQ GHCHPKIVNA
110 120 130 140 150
LKSQVDKLTL TSRAFYNNVL GEYEEYITKL FNYHKVLPMN TGVEAGETAC
160 170 180 190 200
KLARKWGYTV KGIQKYKAKI VFAAGNFWGR TLSAISSSTD PTSYDGFGPF
210 220 230 240 250
MPGFDIIPYN DLPALERALQ DPNVAAFMVE PIQGEAGVVV PDPGYLMGVR
260 270 280 290 300
ELCTRHQVLF IADEIQTGLA RTGRWLAVDY ENVRPDIVLL GKALSGGLYP
310 320 330 340 350
VSAVLCDDDI MLTIKPGEHG STYGGNPLGC RVAIAALEVL EEENLAENAD
360 370 380 390 400
KLGIILRNEL MKLPSDVVTA VRGKGLLNAI VIKETKDWDA WKVCLRLRDN
410 420 430
GLLAKPTHGD IIRFAPPLVI KEDELRESIE IINKTILSF
Length:439
Mass (Da):48,535
Last modified:March 20, 1987 - v1
Checksum:iE9D0636824A83220
GO
Isoform 2 (identifier: P04181-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.

Show »
Length:301
Mass (Da):32,853
Checksum:i9CFA7F66DDB264F0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07192451G → D in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant dbSNP:rs11553554Ensembl.1
Natural variantiVAR_00056554N → K in HOGA. 1 PublicationCorresponds to variant dbSNP:rs121965048EnsemblClinVar.1
Natural variantiVAR_00056655Y → H in HOGA. 1 PublicationCorresponds to variant dbSNP:rs121965037EnsemblClinVar.1
Natural variantiVAR_00056789N → K in HOGA. 1 PublicationCorresponds to variant dbSNP:rs386833602EnsemblClinVar.1
Natural variantiVAR_01564890Q → E in HOGA; mistargeted, accumulates in cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs121965060EnsemblClinVar.1
Natural variantiVAR_00056893C → F in HOGA. 1 PublicationCorresponds to variant dbSNP:rs121965038EnsemblClinVar.1
Natural variantiVAR_071925104Q → R in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant dbSNP:rs386833604EnsemblClinVar.1
Natural variantiVAR_000569154R → L in HOGA; complete loss of activity. 1 PublicationCorresponds to variant dbSNP:rs121965039EnsemblClinVar.1
Natural variantiVAR_000570180R → T in HOGA; complete loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs121965040EnsemblClinVar.1
Natural variantiVAR_000571184Missing in HOGA. 1 Publication1
Natural variantiVAR_071926199P → Q in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant dbSNP:rs267606925EnsemblClinVar.1
Natural variantiVAR_000572226A → V in HOGA; loss of activity and protein stability. 2 PublicationsCorresponds to variant dbSNP:rs121965059EnsemblClinVar.1
Natural variantiVAR_000573241P → L in HOGA. 2 PublicationsCorresponds to variant dbSNP:rs121965051EnsemblClinVar.1
Natural variantiVAR_000574245Y → C in HOGA. 1 PublicationCorresponds to variant dbSNP:rs121965046EnsemblClinVar.1
Natural variantiVAR_000575250R → P in HOGA. 2 PublicationsCorresponds to variant dbSNP:rs121965052EnsemblClinVar.1
Natural variantiVAR_000576267T → I in HOGA. 1 PublicationCorresponds to variant dbSNP:rs386833618EnsemblClinVar.1
Natural variantiVAR_000577270A → P in HOGA. Corresponds to variant dbSNP:rs121965041EnsemblClinVar.1
Natural variantiVAR_000578271R → K in HOGA. 1 PublicationCorresponds to variant dbSNP:rs121965042EnsemblClinVar.1
Natural variantiVAR_071927318E → K in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant dbSNP:rs386833621EnsemblClinVar.1
Natural variantiVAR_000579319H → Y in HOGA. 1 PublicationCorresponds to variant dbSNP:rs121965049EnsemblClinVar.1
Natural variantiVAR_000580332V → M in HOGA; loss of activity and protein stability. 2 PublicationsCorresponds to variant dbSNP:rs121965047EnsemblClinVar.1
Natural variantiVAR_000581353G → D in HOGA. 2 PublicationsCorresponds to variant dbSNP:rs121965053EnsemblClinVar.1
Natural variantiVAR_000582375G → A in HOGA. 1 PublicationCorresponds to variant dbSNP:rs121965045EnsemblClinVar.1
Natural variantiVAR_000583394C → R in HOGA. 2 PublicationsCorresponds to variant dbSNP:rs121965054EnsemblClinVar.1
Natural variantiVAR_071928394C → Y in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant dbSNP:rs386833597EnsemblClinVar.1
Natural variantiVAR_000584402L → P in HOGA; loss of activity and protein stability. 2 PublicationsCorresponds to variant dbSNP:rs121965043EnsemblClinVar.1
Natural variantiVAR_000585417P → L in HOGA; loss of activity and protein stability. 2 PublicationsCorresponds to variant dbSNP:rs121965044EnsemblClinVar.1
Natural variantiVAR_071929436I → N in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant dbSNP:rs386833598EnsemblClinVar.1
Natural variantiVAR_000586437L → F in HOGA; no effect on activity and protein stability. 2 PublicationsCorresponds to variant dbSNP:rs1800456EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0430851 – 138Missing in isoform 2. 2 PublicationsAdd BLAST138

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12267 mRNA Translation: AAA59956.1
M14963 mRNA Translation: AAA59959.1
Y07511 mRNA Translation: CAA68809.1
M23204 mRNA Translation: AAA36386.1
M23205 Genomic DNA No translation available.
M88760 Genomic DNA Translation: AAA59958.1 Sequence problems.
M29927
, M29919, M29920, M29921, M29922, M29923, M29924, M29925, M29926 Genomic DNA Translation: AAA59957.1
AK296032 mRNA Translation: BAH12241.1
AK312561 mRNA Translation: BAG35458.1
AK315947 mRNA Translation: BAH14318.1
CR457045 mRNA Translation: CAG33326.1
CR749808 mRNA Translation: CAH18668.1
AL445237 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49271.1
CH471066 Genomic DNA Translation: EAW49272.1
BC000964 mRNA Translation: AAH00964.1
BC016928 mRNA Translation: AAH16928.1
S66418 mRNA Translation: AAB20298.1
S66421 mRNA Translation: AAB20297.1
CCDSiCCDS53586.1 [P04181-2]
CCDS7639.1 [P04181-1]
PIRiA30806 XNHUO
I55360
RefSeqiNP_000265.1, NM_000274.3 [P04181-1]
NP_001165285.1, NM_001171814.1 [P04181-2]
NP_001309894.1, NM_001322965.1 [P04181-1]
NP_001309895.1, NM_001322966.1 [P04181-1]
NP_001309896.1, NM_001322967.1 [P04181-1]
NP_001309897.1, NM_001322968.1 [P04181-1]
NP_001309898.1, NM_001322969.1 [P04181-1]
NP_001309899.1, NM_001322970.1 [P04181-1]
NP_001309900.1, NM_001322971.1
UniGeneiHs.523332

Genome annotation databases

EnsembliENST00000368845; ENSP00000357838; ENSG00000065154 [P04181-1]
ENST00000539214; ENSP00000439042; ENSG00000065154 [P04181-2]
GeneIDi4942
KEGGihsa:4942
UCSCiuc001lhp.4 human [P04181-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12267 mRNA Translation: AAA59956.1
M14963 mRNA Translation: AAA59959.1
Y07511 mRNA Translation: CAA68809.1
M23204 mRNA Translation: AAA36386.1
M23205 Genomic DNA No translation available.
M88760 Genomic DNA Translation: AAA59958.1 Sequence problems.
M29927
, M29919, M29920, M29921, M29922, M29923, M29924, M29925, M29926 Genomic DNA Translation: AAA59957.1
AK296032 mRNA Translation: BAH12241.1
AK312561 mRNA Translation: BAG35458.1
AK315947 mRNA Translation: BAH14318.1
CR457045 mRNA Translation: CAG33326.1
CR749808 mRNA Translation: CAH18668.1
AL445237 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49271.1
CH471066 Genomic DNA Translation: EAW49272.1
BC000964 mRNA Translation: AAH00964.1
BC016928 mRNA Translation: AAH16928.1
S66418 mRNA Translation: AAB20298.1
S66421 mRNA Translation: AAB20297.1
CCDSiCCDS53586.1 [P04181-2]
CCDS7639.1 [P04181-1]
PIRiA30806 XNHUO
I55360
RefSeqiNP_000265.1, NM_000274.3 [P04181-1]
NP_001165285.1, NM_001171814.1 [P04181-2]
NP_001309894.1, NM_001322965.1 [P04181-1]
NP_001309895.1, NM_001322966.1 [P04181-1]
NP_001309896.1, NM_001322967.1 [P04181-1]
NP_001309897.1, NM_001322968.1 [P04181-1]
NP_001309898.1, NM_001322969.1 [P04181-1]
NP_001309899.1, NM_001322970.1 [P04181-1]
NP_001309900.1, NM_001322971.1
UniGeneiHs.523332

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GBNX-ray2.30A/B/C38-439[»]
1OATX-ray2.50A/B/C1-439[»]
2BYJX-ray3.02A/B/C1-439[»]
2BYLX-ray2.15A/B/C1-439[»]
2CANX-ray2.30A/B/C38-439[»]
2OATX-ray1.95A/B/C1-439[»]
5VWOX-ray1.77A/B/C36-439[»]
ProteinModelPortaliP04181
SMRiP04181
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110996, 44 interactors
IntActiP04181, 22 interactors
MINTiP04181
STRINGi9606.ENSP00000357838

Chemistry databases

BindingDBiP04181
ChEMBLiCHEMBL5954
DrugBankiDB02821 Canaline
DB02054 Gabaculine
DB00129 L-Ornithine
DB00114 Pyridoxal Phosphate

PTM databases

CarbonylDBiP04181
iPTMnetiP04181
PhosphoSitePlusiP04181
SwissPalmiP04181

Polymorphism and mutation databases

BioMutaiOAT
DMDMi129018

2D gel databases

REPRODUCTION-2DPAGEiIPI00022334

Proteomic databases

EPDiP04181
MaxQBiP04181
PaxDbiP04181
PeptideAtlasiP04181
PRIDEiP04181
ProteomicsDBi51672
51673 [P04181-2]

Protocols and materials databases

DNASUi4942
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368845; ENSP00000357838; ENSG00000065154 [P04181-1]
ENST00000539214; ENSP00000439042; ENSG00000065154 [P04181-2]
GeneIDi4942
KEGGihsa:4942
UCSCiuc001lhp.4 human [P04181-1]

Organism-specific databases

CTDi4942
DisGeNETi4942
EuPathDBiHostDB:ENSG00000065154.11
GeneCardsiOAT
HGNCiHGNC:8091 OAT
HPAiCAB033576
HPA040098
HPA064742
MalaCardsiOAT
MIMi258870 phenotype
613349 gene
neXtProtiNX_P04181
OpenTargetsiENSG00000065154
Orphaneti414 Gyrate atrophy of choroid and retina
PharmGKBiPA31880
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1402 Eukaryota
COG4992 LUCA
GeneTreeiENSGT00630000089895
HOGENOMiHOG000020206
HOVERGENiHBG000434
InParanoidiP04181
KOiK00819
OMAiHSAWDLC
OrthoDBiEOG091G06WM
PhylomeDBiP04181
TreeFamiTF105720

Enzyme and pathway databases

UniPathwayi
UPA00098;UER00358

BioCyciMetaCyc:HS00832-MONOMER
BRENDAi2.6.1.13 2681
ReactomeiR-HSA-70614 Amino acid synthesis and interconversion (transamination)
SABIO-RKiP04181
SIGNORiP04181

Miscellaneous databases

ChiTaRSiOAT human
EvolutionaryTraceiP04181
GenomeRNAii4942
PROiPR:P04181
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000065154 Expressed in 239 organ(s), highest expression level in jejunal mucosa
CleanExiHS_OAT
ExpressionAtlasiP04181 baseline and differential
GenevisibleiP04181 HS

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR005814 Aminotrans_3
IPR010164 Orn_aminotrans
IPR034758 Orn_aminotrans_mito
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11986:SF18 PTHR11986:SF18, 1 hit
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
PIRSFiPIRSF000521 Transaminase_4ab_Lys_Orn, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01885 Orn_aminotrans, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOAT_HUMAN
AccessioniPrimary (citable) accession number: P04181
Secondary accession number(s): D3DRF0
, Q16068, Q16069, Q68CS0, Q6IAV9, Q9UD03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: November 7, 2018
This is version 211 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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