OAT

Functionⁱ

Catalytic activityⁱ

L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.

Cofactorⁱ

Pathwayⁱ: L-proline biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:

Ornithine aminotransferase, mitochondrial (OAT), Ornithine aminotransferase, Ornithine aminotransferase

This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functionⁱ

ornithine-oxo-acid transaminase activity
Source: Reactome
Inferred from experimentⁱ
- 6819292
pyridoxal phosphate binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

arginine catabolic process to glutamate
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
arginine catabolic process to proline via ornithine
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular amino acid biosynthetic process Source: Reactome
L-proline biosynthetic process Source: UniProtKB-UniPathway
protein hexamerization
Source: UniProtKB
Inferred from direct assayⁱ
- 9514741
visual perception
Source: ProtInc
Traceable author statementⁱ
- 2793865

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Aminotransferase, Transferase
Ligand	Pyridoxal phosphate

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS00832-MONOMER
BRENDAⁱ	2.6.1.13 2681
Reactomeⁱ	R-HSA-70614 Amino acid synthesis and interconversion (transamination)
SABIO-RKⁱ	P04181
SIGNORⁱ	P04181
UniPathwayⁱ	UPA00098;UER00358

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ornithine aminotransferase, mitochondrial (EC:2.6.1.13) Alternative name(s): Ornithine delta-aminotransferase Ornithine--oxo-acid aminotransferase Cleaved into the following 2 chains: Ornithine aminotransferase, hepatic form Ornithine aminotransferase, renal form
Gene namesⁱ	Name:OAT
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000065154.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8091 OAT
MIMⁱ	613349 gene
neXtProtⁱ	NX_P04181

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Hyperornithinemia with gyrate atrophy of choroid and retina (HOGA)7 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder clinically characterized by a triad of progressive chorioretinal degeneration, early cataract formation, and type II muscle fiber atrophy. Characteristic chorioretinal atrophy with progressive constriction of the visual fields leads to blindness at the latest during the sixth decade of life. Patients generally have normal intelligence.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4942
MalaCards human disease database More...MalaCardsⁱ	OAT
MIMⁱ	258870 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000065154
Orphanetⁱ	414 Gyrate atrophy of choroid and retina
PharmGKBⁱ	PA31880

Chemistry databases

ChEMBLⁱ	CHEMBL5954
Drug and drug target database More...DrugBankⁱ	DB02821 Canaline DB02054 Gabaculine DB00129 L-Ornithine DB00114 Pyridoxal Phosphate

Polymorphism and mutation databases

BioMutaⁱ	OAT
DMDMⁱ	129018

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Transit peptideⁱ	1 – 35	Mitochondrion; in renal form1 PublicationAdd BLAST	35
Transit peptideⁱ	1 – 25	Mitochondrion; in hepatic formAdd BLAST	25
ChainⁱPRO_0000001262	26 – 439	Ornithine aminotransferase, hepatic formAdd BLAST	414
ChainⁱPRO_0000001263	36 – 439	Ornithine aminotransferase, renal formAdd BLAST	404

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	49	N6-acetyllysineBy similarity	1
Modified residueⁱ	66	N6-acetyllysineBy similarity	1
Modified residueⁱ	102	N6-succinyllysineBy similarity	1
Modified residueⁱ	107	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	107	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	292	N6-(pyridoxal phosphate)lysine1 Publication	1
Modified residueⁱ	362	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	362	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	386	N6-acetyllysineBy similarity	1
Modified residueⁱ	392	N6-acetyllysineBy similarity	1
Modified residueⁱ	405	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	405	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	421	N6-acetyllysineBy similarity	1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	P04181
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P04181
PaxDbⁱ	P04181
PeptideAtlas More...PeptideAtlasⁱ	P04181
PRIDEⁱ	P04181
ProteomicsDBⁱ	51672 51673 [P04181-2]

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00022334

REPRODUCTION-2DPAGEⁱ

IPI00022334

PTM databases

CarbonylDBⁱ	P04181
iPTMnetⁱ	P04181
PhosphoSitePlusⁱ	P04181
SwissPalmⁱ	P04181

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000065154 Expressed in 239 organ(s), highest expression level in jejunal mucosa
CleanExⁱ	HS_OAT
ExpressionAtlasⁱ	P04181 baseline and differential
Genevisibleⁱ	P04181 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB033576 HPA040098 HPA064742

HPAⁱ

CAB033576
HPA040098
HPA064742

Interactionⁱ

Subunit structureⁱ

Homohexamer.1 Publication

Protein-protein interaction databases

BioGridⁱ	110996, 44 interactors
IntActⁱ	P04181, 22 interactors
Molecular INTeraction database More...MINTⁱ	P04181
STRINGⁱ	9606.ENSP00000357838

Chemistry databases

BindingDBⁱ

P04181

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	40 – 50	Combined sources	11
Beta strandⁱ	61 – 67	Combined sources	7
Beta strandⁱ	69 – 72	Combined sources	4
Beta strandⁱ	77 – 82	Combined sources	6
Helixⁱ	83 – 86	Combined sources	4
Turnⁱ	87 – 90	Combined sources	4
Helixⁱ	95 – 104	Combined sources	10
Turnⁱ	105 – 107	Combined sources	3
Beta strandⁱ	115 – 119	Combined sources	5
Helixⁱ	120 – 131	Combined sources	12
Beta strandⁱ	134 – 141	Combined sources	8
Helixⁱ	142 – 159	Combined sources	18
Beta strandⁱ	169 – 173	Combined sources	5
Helixⁱ	182 – 186	Combined sources	5
Helixⁱ	191 – 194	Combined sources	4
Beta strandⁱ	204 – 207	Combined sources	4
Helixⁱ	212 – 218	Combined sources	7
Beta strandⁱ	224 – 229	Combined sources	6
Beta strandⁱ	231 – 233	Combined sources	3
Turnⁱ	234 – 237	Combined sources	4
Helixⁱ	245 – 255	Combined sources	11
Beta strandⁱ	259 – 263	Combined sources	5
Turnⁱ	265 – 272	Combined sources	8
Beta strandⁱ	273 – 276	Combined sources	4
Helixⁱ	277 – 281	Combined sources	5
Beta strandⁱ	286 – 290	Combined sources	5
Helixⁱ	292 – 295	Combined sources	4
Beta strandⁱ	302 – 306	Combined sources	5
Helixⁱ	308 – 311	Combined sources	4
Helixⁱ	327 – 342	Combined sources	16
Helixⁱ	345 – 360	Combined sources	16
Turnⁱ	365 – 367	Combined sources	3
Beta strandⁱ	368 – 374	Combined sources	7
Beta strandⁱ	377 – 382	Combined sources	6
Helixⁱ	390 – 399	Combined sources	10
Turnⁱ	408 – 410	Combined sources	3
Beta strandⁱ	411 – 414	Combined sources	4
Helixⁱ	422 – 437	Combined sources	16

Show more details

3D structure databases

ProteinModelPortalⁱ	P04181
SMRⁱ	P04181
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P04181

EvolutionaryTraceⁱ

P04181

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG1402 Eukaryota COG4992 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00630000089895
HOGENOMⁱ	HOG000020206
HOVERGENⁱ	HBG000434
InParanoidⁱ	P04181
KEGG Orthology (KO) More...KOⁱ	K00819
OMAⁱ	HSAWDLC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06WM
PhylomeDBⁱ	P04181
TreeFamⁱ	TF105720

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00610 OAT_like, 1 hit
Gene3Dⁱ	3.40.640.10, 1 hit 3.90.1150.10, 1 hit
InterProⁱ	View protein in InterPro IPR005814 Aminotrans_3 IPR010164 Orn_aminotrans IPR034758 Orn_aminotrans_mito IPR015424 PyrdxlP-dep_Trfase IPR015422 PyrdxlP-dep_Trfase_dom1 IPR015421 PyrdxlP-dep_Trfase_major
PANTHERⁱ	PTHR11986:SF18 PTHR11986:SF18, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00202 Aminotran_3, 1 hit
PIRSFⁱ	PIRSF000521 Transaminase_4ab_Lys_Orn, 1 hit
SUPFAMⁱ	SSF53383 SSF53383, 1 hit
TIGRFAMsⁱ	TIGR01885 Orn_aminotrans, 1 hit
PROSITEⁱ	View protein in PROSITE PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P04181-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSKLAHLQR FAVLSRGVHS SVASATSVAT KKTVQGPPTS DDIFEREYKY 
        60         70         80         90        100
GAHNYHPLPV ALERGKGIYL WDVEGRKYFD FLSSYSAVNQ GHCHPKIVNA 
       110        120        130        140        150
LKSQVDKLTL TSRAFYNNVL GEYEEYITKL FNYHKVLPMN TGVEAGETAC 
       160        170        180        190        200
KLARKWGYTV KGIQKYKAKI VFAAGNFWGR TLSAISSSTD PTSYDGFGPF 
       210        220        230        240        250
MPGFDIIPYN DLPALERALQ DPNVAAFMVE PIQGEAGVVV PDPGYLMGVR 
       260        270        280        290        300
ELCTRHQVLF IADEIQTGLA RTGRWLAVDY ENVRPDIVLL GKALSGGLYP 
       310        320        330        340        350
VSAVLCDDDI MLTIKPGEHG STYGGNPLGC RVAIAALEVL EEENLAENAD 
       360        370        380        390        400
KLGIILRNEL MKLPSDVVTA VRGKGLLNAI VIKETKDWDA WKVCLRLRDN 
       410        420        430 
GLLAKPTHGD IIRFAPPLVI KEDELRESIE IINKTILSF

Length:439

Mass (Da):48,535

Last modified:March 20, 1987 - v1

Checksum:ⁱE9D0636824A83220

GO

Isoform 2 (identifier: P04181-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-138: Missing.

« Hide

        10         20         30         40         50
MNTGVEAGET ACKLARKWGY TVKGIQKYKA KIVFAAGNFW GRTLSAISSS 
        60         70         80         90        100
TDPTSYDGFG PFMPGFDIIP YNDLPALERA LQDPNVAAFM VEPIQGEAGV 
       110        120        130        140        150
VVPDPGYLMG VRELCTRHQV LFIADEIQTG LARTGRWLAV DYENVRPDIV 
       160        170        180        190        200
LLGKALSGGL YPVSAVLCDD DIMLTIKPGE HGSTYGGNPL GCRVAIAALE 
       210        220        230        240        250
VLEEENLAEN ADKLGIILRN ELMKLPSDVV TAVRGKGLLN AIVIKETKDW 
       260        270        280        290        300
DAWKVCLRLR DNGLLAKPTH GDIIRFAPPL VIKEDELRES IEIINKTILS 

F

Show »

Length:301

Mass (Da):32,853

Checksum:ⁱ9CFA7F66DDB264F0

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_071924	51	G → D in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant dbSNP:rs11553554Ensembl.	1
Natural variantⁱVAR_000565	54	N → K in HOGA. 1 PublicationCorresponds to variant dbSNP:rs121965048EnsemblClinVar.	1
Natural variantⁱVAR_000566	55	Y → H in HOGA. 1 PublicationCorresponds to variant dbSNP:rs121965037EnsemblClinVar.	1
Natural variantⁱVAR_000567	89	N → K in HOGA. 1 PublicationCorresponds to variant dbSNP:rs386833602EnsemblClinVar.	1
Natural variantⁱVAR_015648	90	Q → E in HOGA; mistargeted, accumulates in cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs121965060EnsemblClinVar.	1
Natural variantⁱVAR_000568	93	C → F in HOGA. 1 PublicationCorresponds to variant dbSNP:rs121965038EnsemblClinVar.	1
Natural variantⁱVAR_071925	104	Q → R in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant dbSNP:rs386833604EnsemblClinVar.	1
Natural variantⁱVAR_000569	154	R → L in HOGA; complete loss of activity. 1 PublicationCorresponds to variant dbSNP:rs121965039EnsemblClinVar.	1
Natural variantⁱVAR_000570	180	R → T in HOGA; complete loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs121965040EnsemblClinVar.	1
Natural variantⁱVAR_000571	184	Missing in HOGA. 1 Publication	1
Natural variantⁱVAR_071926	199	P → Q in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant dbSNP:rs267606925EnsemblClinVar.	1
Natural variantⁱVAR_000572	226	A → V in HOGA; loss of activity and protein stability. 2 PublicationsCorresponds to variant dbSNP:rs121965059EnsemblClinVar.	1
Natural variantⁱVAR_000573	241	P → L in HOGA. 2 PublicationsCorresponds to variant dbSNP:rs121965051EnsemblClinVar.	1
Natural variantⁱVAR_000574	245	Y → C in HOGA. 1 PublicationCorresponds to variant dbSNP:rs121965046EnsemblClinVar.	1
Natural variantⁱVAR_000575	250	R → P in HOGA. 2 PublicationsCorresponds to variant dbSNP:rs121965052EnsemblClinVar.	1
Natural variantⁱVAR_000576	267	T → I in HOGA. 1 PublicationCorresponds to variant dbSNP:rs386833618EnsemblClinVar.	1
Natural variantⁱVAR_000577	270	A → P in HOGA. Corresponds to variant dbSNP:rs121965041EnsemblClinVar.	1
Natural variantⁱVAR_000578	271	R → K in HOGA. 1 PublicationCorresponds to variant dbSNP:rs121965042EnsemblClinVar.	1
Natural variantⁱVAR_071927	318	E → K in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant dbSNP:rs386833621EnsemblClinVar.	1
Natural variantⁱVAR_000579	319	H → Y in HOGA. 1 PublicationCorresponds to variant dbSNP:rs121965049EnsemblClinVar.	1
Natural variantⁱVAR_000580	332	V → M in HOGA; loss of activity and protein stability. 2 PublicationsCorresponds to variant dbSNP:rs121965047EnsemblClinVar.	1
Natural variantⁱVAR_000581	353	G → D in HOGA. 2 PublicationsCorresponds to variant dbSNP:rs121965053EnsemblClinVar.	1
Natural variantⁱVAR_000582	375	G → A in HOGA. 1 PublicationCorresponds to variant dbSNP:rs121965045EnsemblClinVar.	1
Natural variantⁱVAR_000583	394	C → R in HOGA. 2 PublicationsCorresponds to variant dbSNP:rs121965054EnsemblClinVar.	1
Natural variantⁱVAR_071928	394	C → Y in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant dbSNP:rs386833597EnsemblClinVar.	1
Natural variantⁱVAR_000584	402	L → P in HOGA; loss of activity and protein stability. 2 PublicationsCorresponds to variant dbSNP:rs121965043EnsemblClinVar.	1
Natural variantⁱVAR_000585	417	P → L in HOGA; loss of activity and protein stability. 2 PublicationsCorresponds to variant dbSNP:rs121965044EnsemblClinVar.	1
Natural variantⁱVAR_071929	436	I → N in HOGA; loss of activity and protein stability. 1 PublicationCorresponds to variant dbSNP:rs386833598EnsemblClinVar.	1
Natural variantⁱVAR_000586	437	L → F in HOGA; no effect on activity and protein stability. 2 PublicationsCorresponds to variant dbSNP:rs1800456EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_043085	1 – 138	Missing in isoform 2. 2 PublicationsAdd BLAST		138

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M12267 mRNA Translation: AAA59956.1 M14963 mRNA Translation: AAA59959.1 Y07511 mRNA Translation: CAA68809.1 M23204 mRNA Translation: AAA36386.1 M23205 Genomic DNA No translation available. M88760 Genomic DNA Translation: AAA59958.1 Sequence problems. M29927 M29926 Genomic DNA Translation: AAA59957.1 AK296032 mRNA Translation: BAH12241.1 AK312561 mRNA Translation: BAG35458.1 AK315947 mRNA Translation: BAH14318.1 CR457045 mRNA Translation: CAG33326.1 CR749808 mRNA Translation: CAH18668.1 AL445237 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49271.1 CH471066 Genomic DNA Translation: EAW49272.1 BC000964 mRNA Translation: AAH00964.1 BC016928 mRNA Translation: AAH16928.1 S66418 mRNA Translation: AAB20298.1 S66421 mRNA Translation: AAB20297.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS53586.1 [P04181-2] CCDS7639.1 [P04181-1]
PIRⁱ	A30806 XNHUO I55360
NCBI Reference Sequences More...RefSeqⁱ	NP_000265.1, NM_000274.3 [P04181-1] NP_001165285.1, NM_001171814.1 [P04181-2] NP_001309894.1, NM_001322965.1 [P04181-1] NP_001309895.1, NM_001322966.1 [P04181-1] NP_001309896.1, NM_001322967.1 [P04181-1] NP_001309897.1, NM_001322968.1 [P04181-1] NP_001309898.1, NM_001322969.1 [P04181-1] NP_001309899.1, NM_001322970.1 [P04181-1] NP_001309900.1, NM_001322971.1
UniGeneⁱ	Hs.523332

Genome annotation databases

Ensemblⁱ	ENST00000368845; ENSP00000357838; ENSG00000065154 [P04181-1] ENST00000539214; ENSP00000439042; ENSG00000065154 [P04181-2]
GeneIDⁱ	4942
KEGGⁱ	hsa:4942
UCSC genome browser More...UCSCⁱ	uc001lhp.4 human [P04181-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P04181	Ornithine aminotransferase		HUMAN		439	UniRef100_P04181
Ornithine aminotransferase		PANTR		439
Ornithine aminotransferase		PANPA		439
Ornithine aminotransferase		PANTR		301
Isoform 2 of Ornithine aminotransferase, mitochondrial		HUMAN		301
+3

Protein	Similar proteins		Species	Score	Length	Source
P04181	Ornithine aminotransferase, mitochondrial		MOUSE		439	UniRef90_P04181
Ornithine aminotransferase, mitochondrial		BOVIN		439
Ornithine aminotransferase		HUMAN		439
Ornithine aminotransferase		PANTR		439
Ornithine aminotransferase		PANPA		439
+83

Protein	Similar proteins		Species	Score	Length	Source
P04181	Ornithine aminotransferase, mitochondrial		MOUSE		439	UniRef50_P04181
Ornithine aminotransferase, mitochondrial		BOVIN		439
Ornithine aminotransferase		HUMAN		439
Ornithine aminotransferase		PANTR		439
Ornithine aminotransferase		PANPA		439
+551

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M12267 mRNA Translation: AAA59956.1 M14963 mRNA Translation: AAA59959.1 Y07511 mRNA Translation: CAA68809.1 M23204 mRNA Translation: AAA36386.1 M23205 Genomic DNA No translation available. M88760 Genomic DNA Translation: AAA59958.1 Sequence problems. M29927 M29926 Genomic DNA Translation: AAA59957.1 AK296032 mRNA Translation: BAH12241.1 AK312561 mRNA Translation: BAG35458.1 AK315947 mRNA Translation: BAH14318.1 CR457045 mRNA Translation: CAG33326.1 CR749808 mRNA Translation: CAH18668.1 AL445237 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49271.1 CH471066 Genomic DNA Translation: EAW49272.1 BC000964 mRNA Translation: AAH00964.1 BC016928 mRNA Translation: AAH16928.1 S66418 mRNA Translation: AAB20298.1 S66421 mRNA Translation: AAB20297.1
CCDSⁱ	CCDS53586.1 [P04181-2] CCDS7639.1 [P04181-1]
PIRⁱ	A30806 XNHUO I55360
RefSeqⁱ	NP_000265.1, NM_000274.3 [P04181-1] NP_001165285.1, NM_001171814.1 [P04181-2] NP_001309894.1, NM_001322965.1 [P04181-1] NP_001309895.1, NM_001322966.1 [P04181-1] NP_001309896.1, NM_001322967.1 [P04181-1] NP_001309897.1, NM_001322968.1 [P04181-1] NP_001309898.1, NM_001322969.1 [P04181-1] NP_001309899.1, NM_001322970.1 [P04181-1] NP_001309900.1, NM_001322971.1
UniGeneⁱ	Hs.523332

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1GBN	X-ray	2.30	A/B/C	38-439	[»]
	1OAT	X-ray	2.50	A/B/C	1-439	[»]
	2BYJ	X-ray	3.02	A/B/C	1-439	[»]
	2BYL	X-ray	2.15	A/B/C	1-439	[»]
	2CAN	X-ray	2.30	A/B/C	38-439	[»]
	2OAT	X-ray	1.95	A/B/C	1-439	[»]
	5VWO	X-ray	1.77	A/B/C	36-439	[»]
ProteinModelPortalⁱ	P04181
SMRⁱ	P04181
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110996, 44 interactors
IntActⁱ	P04181, 22 interactors
MINTⁱ	P04181
STRINGⁱ	9606.ENSP00000357838

Chemistry databases

BindingDBⁱ	P04181
ChEMBLⁱ	CHEMBL5954
DrugBankⁱ	DB02821 Canaline DB02054 Gabaculine DB00129 L-Ornithine DB00114 Pyridoxal Phosphate

PTM databases

CarbonylDBⁱ	P04181
iPTMnetⁱ	P04181
PhosphoSitePlusⁱ	P04181
SwissPalmⁱ	P04181

Polymorphism and mutation databases

BioMutaⁱ	OAT
DMDMⁱ	129018

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00022334

REPRODUCTION-2DPAGEⁱ

IPI00022334

Proteomic databases

EPDⁱ	P04181
MaxQBⁱ	P04181
PaxDbⁱ	P04181
PeptideAtlasⁱ	P04181
PRIDEⁱ	P04181
ProteomicsDBⁱ	51672 51673 [P04181-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4942
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000368845; ENSP00000357838; ENSG00000065154 [P04181-1] ENST00000539214; ENSP00000439042; ENSG00000065154 [P04181-2]
GeneIDⁱ	4942
KEGGⁱ	hsa:4942
UCSCⁱ	uc001lhp.4 human [P04181-1]

Organism-specific databases

CTDⁱ	4942
DisGeNETⁱ	4942
EuPathDBⁱ	HostDB:ENSG00000065154.11
GeneCardsⁱ	OAT
HGNCⁱ	HGNC:8091 OAT
HPAⁱ	CAB033576 HPA040098 HPA064742
MalaCardsⁱ	OAT
MIMⁱ	258870 phenotype 613349 gene
neXtProtⁱ	NX_P04181
OpenTargetsⁱ	ENSG00000065154
Orphanetⁱ	414 Gyrate atrophy of choroid and retina
PharmGKBⁱ	PA31880
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1402 Eukaryota COG4992 LUCA
GeneTreeⁱ	ENSGT00630000089895
HOGENOMⁱ	HOG000020206
HOVERGENⁱ	HBG000434
InParanoidⁱ	P04181
KOⁱ	K00819
OMAⁱ	HSAWDLC
OrthoDBⁱ	EOG091G06WM
PhylomeDBⁱ	P04181
TreeFamⁱ	TF105720

Enzyme and pathway databases

UniPathwayⁱ	UPA00098;UER00358
BioCycⁱ	MetaCyc:HS00832-MONOMER
BRENDAⁱ	2.6.1.13 2681
Reactomeⁱ	R-HSA-70614 Amino acid synthesis and interconversion (transamination)
SABIO-RKⁱ	P04181
SIGNORⁱ	P04181

Miscellaneous databases

ChiTaRSⁱ	OAT human
EvolutionaryTraceⁱ	P04181
GenomeRNAiⁱ	4942
Protein Ontology More...PROⁱ	PR:P04181
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000065154 Expressed in 239 organ(s), highest expression level in jejunal mucosa
CleanExⁱ	HS_OAT
ExpressionAtlasⁱ	P04181 baseline and differential
Genevisibleⁱ	P04181 HS

Family and domain databases

CDDⁱ	cd00610 OAT_like, 1 hit
Gene3Dⁱ	3.40.640.10, 1 hit 3.90.1150.10, 1 hit
InterProⁱ	View protein in InterPro IPR005814 Aminotrans_3 IPR010164 Orn_aminotrans IPR034758 Orn_aminotrans_mito IPR015424 PyrdxlP-dep_Trfase IPR015422 PyrdxlP-dep_Trfase_dom1 IPR015421 PyrdxlP-dep_Trfase_major
PANTHERⁱ	PTHR11986:SF18 PTHR11986:SF18, 1 hit
Pfamⁱ	View protein in Pfam PF00202 Aminotran_3, 1 hit
PIRSFⁱ	PIRSF000521 Transaminase_4ab_Lys_Orn, 1 hit
SUPFAMⁱ	SSF53383 SSF53383, 1 hit
TIGRFAMsⁱ	TIGR01885 Orn_aminotrans, 1 hit
PROSITEⁱ	View protein in PROSITE PS00600 AA_TRANSFER_CLASS_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OAT_HUMAN
Accessionⁱ	P04181Primary (citable) accession number: P04181 Secondary accession number(s): D3DRF0 , Q16068, Q16069, Q68CS0, Q6IAV9, Q9UD03
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 20, 1987
	Last sequence update:	March 20, 1987
	Last modified:	November 7, 2018
	This is version 211 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

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UniProtKB - P04181 (OAT_HUMAN)

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Ornithine aminotransferase, mitochondrial

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-proline biosynthesis

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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Keywords - PTMi

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<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

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<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

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2D gel databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

Pathwayⁱ: L-proline biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ