UniProtKB - P04179 (SODM_HUMAN)
Protein
Superoxide dismutase [Mn], mitochondrial
Gene
SOD2
Organism
Homo sapiens (Human)
Status
Functioni
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.1 Publication
Catalytic activityi
- EC:1.15.1.1
Cofactori
Mn2+Note: Binds 1 Mn2+ ion per subunit.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 50 | Manganese | 1 | |
Metal bindingi | 98 | Manganese | 1 | |
Metal bindingi | 183 | Manganese | 1 | |
Metal bindingi | 187 | Manganese | 1 |
GO - Molecular functioni
- DNA binding Source: Ensembl
- enzyme binding Source: Ensembl
- identical protein binding Source: IntAct
- manganese ion binding Source: UniProtKB
- metal ion binding Source: GO_Central
- oxygen binding Source: Ensembl
- superoxide dismutase activity Source: UniProtKB
GO - Biological processi
- acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure Source: BHF-UCL
- age-dependent response to reactive oxygen species Source: UniProtKB
- cellular response to ethanol Source: Ensembl
- cellular response to oxidative stress Source: Reactome
- detection of oxygen Source: Ensembl
- erythrophore differentiation Source: Ensembl
- glutathione metabolic process Source: Ensembl
- heart development Source: Ensembl
- hemopoiesis Source: Ensembl
- hydrogen peroxide biosynthetic process Source: Ensembl
- interleukin-12-mediated signaling pathway Source: Reactome
- intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
- intrinsic apoptotic signaling pathway in response to oxidative stress Source: Ensembl
- iron ion homeostasis Source: Ensembl
- liver development Source: Ensembl
- locomotory behavior Source: Ensembl
- negative regulation of cell population proliferation Source: BHF-UCL
- negative regulation of fat cell differentiation Source: Ensembl
- negative regulation of fibroblast proliferation Source: Ensembl
- negative regulation of neuron apoptotic process Source: BHF-UCL
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: BHF-UCL
- negative regulation of vascular associated smooth muscle cell proliferation Source: BHF-UCL
- neuron development Source: Ensembl
- oxygen homeostasis Source: BHF-UCL
- positive regulation of cell migration Source: BHF-UCL
- positive regulation of nitric oxide biosynthetic process Source: Ensembl
- positive regulation of vascular associated smooth muscle cell apoptotic process Source: BHF-UCL
- positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching Source: BHF-UCL
- post-embryonic development Source: Ensembl
- protein homotetramerization Source: UniProtKB
- regulation of blood pressure Source: BHF-UCL
- regulation of catalytic activity Source: Ensembl
- regulation of mitochondrial membrane potential Source: Ensembl
- regulation of transcription by RNA polymerase II Source: UniProtKB
- release of cytochrome c from mitochondria Source: BHF-UCL
- removal of superoxide radicals Source: BHF-UCL
- respiratory electron transport chain Source: Ensembl
- response to activity Source: Ensembl
- response to axon injury Source: Ensembl
- response to cadmium ion Source: Ensembl
- response to cold Source: Ensembl
- response to drug Source: Ensembl
- response to electrical stimulus Source: Ensembl
- response to gamma radiation Source: Ensembl
- response to hydrogen peroxide Source: Ensembl
- response to hyperoxia Source: Ensembl
- response to hypoxia Source: Ensembl
- response to immobilization stress Source: Ensembl
- response to isolation stress Source: Ensembl
- response to L-ascorbic acid Source: Ensembl
- response to lipopolysaccharide Source: Ensembl
- response to magnetism Source: Ensembl
- response to manganese ion Source: Ensembl
- response to selenium ion Source: Ensembl
- response to silicon dioxide Source: Ensembl
- response to superoxide Source: BHF-UCL
- response to zinc ion Source: Ensembl
- superoxide anion generation Source: Ensembl
- superoxide metabolic process Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Manganese, Metal-binding |
Enzyme and pathway databases
BioCyci | MetaCyc:HS03515-MONOMER |
BRENDAi | 1.15.1.1, 2681 |
PathwayCommonsi | P04179 |
Reactomei | R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis R-HSA-3299685, Detoxification of Reactive Oxygen Species R-HSA-8862803, Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8950505, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-9615017, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes |
SIGNORi | P04179 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:SOD2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000112096.16 |
HGNCi | HGNC:11180, SOD2 |
MIMi | 147460, gene |
neXtProti | NX_P04179 |
Subcellular locationi
Mitochondrion
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Mitochondrion
- mitochondrial matrix Source: UniProtKB
- mitochondrial nucleoid Source: Ensembl
- mitochondrion Source: BHF-UCL
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Involvement in diseasei
Microvascular complications of diabetes 6 (MVCD6)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionPathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
Related information in OMIMMutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 58 | Y → A, H, N, V or F: Reduced enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 58 | Y → F: Loss of nitration. Enhanced dityrosine formation on peroxynitrite treatment. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 6648 |
MalaCardsi | SOD2 |
MIMi | 612634, phenotype |
OpenTargetsi | ENSG00000112096 |
PharmGKBi | PA36017 |
Miscellaneous databases
Pharosi | P04179, Tbio |
Protein family/group databases
Allergomei | 784, Hom s MnSOD |
Chemistry databases
ChEMBLi | CHEMBL4105776 |
DrugBanki | DB04436, 3-Fluoro-L-tyrosine DB03297, Benzylsulfonic acid DB06796, Mangafodipir DB09221, Polaprezinc DB11590, Thimerosal |
DrugCentrali | P04179 |
Polymorphism and mutation databases
BioMutai | SOD2 |
DMDMi | 134665 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 24 | Mitochondrion4 PublicationsAdd BLAST | 24 | |
ChainiPRO_0000032869 | 25 – 222 | Superoxide dismutase [Mn], mitochondrialAdd BLAST | 198 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 58 | 3'-nitrotyrosine2 Publications | 1 | |
Modified residuei | 68 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 68 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 75 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 75 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 114 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 122 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 122 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 130 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 130 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 202 | N6-acetyllysineBy similarity | 1 |
Post-translational modificationi
Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.2 Publications
Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity).By similarity
Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability.1 Publication
Keywords - PTMi
Acetylation, Nitration, Ubl conjugationProteomic databases
EPDi | P04179 |
jPOSTi | P04179 |
MassIVEi | P04179 |
MaxQBi | P04179 |
PaxDbi | P04179 |
PeptideAtlasi | P04179 |
PRIDEi | P04179 |
ProteomicsDBi | 3715 51669 [P04179-1] 51670 [P04179-2] 5907 |
TopDownProteomicsi | P04179-1 [P04179-1] P04179-2 [P04179-2] |
2D gel databases
DOSAC-COBS-2DPAGEi | P04179 |
OGPi | P04179 |
SWISS-2DPAGEi | P04179 |
UCD-2DPAGEi | P04179 |
PTM databases
iPTMneti | P04179 |
PhosphoSitePlusi | P04179 |
SwissPalmi | P04179 |
Expressioni
Inductioni
Expression is regulated by KRIT1.1 Publication
Gene expression databases
Bgeei | ENSG00000112096, Expressed in gastrocnemius and 239 other tissues |
ExpressionAtlasi | P04179, baseline and differential |
Genevisiblei | P04179, HS |
Organism-specific databases
HPAi | ENSG00000285441, Tissue enhanced (blood, bone marrow, seminal vesicle) |
Interactioni
Subunit structurei
Homotetramer.
1 PublicationBinary interactionsi
Hide detailsP04179
With | #Exp. | IntAct |
---|---|---|
CEP70 [Q8NHQ1] | 3 | EBI-716989,EBI-739624 |
itself | 2 | EBI-716989,EBI-716989 |
GO - Molecular functioni
- enzyme binding Source: Ensembl
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 112531, 70 interactors |
IntActi | P04179, 26 interactors |
MINTi | P04179 |
STRINGi | 9606.ENSP00000446252 |
Miscellaneous databases
RNActi | P04179, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P04179 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P04179 |
Family & Domainsi
Sequence similaritiesi
Belongs to the iron/manganese superoxide dismutase family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG0876, Eukaryota |
GeneTreei | ENSGT00390000011877 |
HOGENOMi | CLU_031625_2_0_1 |
InParanoidi | P04179 |
OMAi | KWGSFDK |
OrthoDBi | 1353361at2759 |
PhylomeDBi | P04179 |
TreeFami | TF105132 |
Family and domain databases
Gene3Di | 1.10.287.990, 1 hit 2.40.500.20, 1 hit |
InterProi | View protein in InterPro IPR001189, Mn/Fe_SOD IPR019833, Mn/Fe_SOD_BS IPR019832, Mn/Fe_SOD_C IPR019831, Mn/Fe_SOD_N IPR036324, Mn/Fe_SOD_N_sf IPR036314, SOD_C_sf |
Pfami | View protein in Pfam PF02777, Sod_Fe_C, 1 hit PF00081, Sod_Fe_N, 1 hit |
PIRSFi | PIRSF000349, SODismutase, 1 hit |
PRINTSi | PR01703, MNSODISMTASE |
SUPFAMi | SSF46609, SSF46609, 1 hit SSF54719, SSF54719, 1 hit |
PROSITEi | View protein in PROSITE PS00088, SOD_MN, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P04179-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLSRAVCGTS RQLAPVLGYL GSRQKHSLPD LPYDYGALEP HINAQIMQLH
60 70 80 90 100
HSKHHAAYVN NLNVTEEKYQ EALAKGDVTA QIALQPALKF NGGGHINHSI
110 120 130 140 150
FWTNLSPNGG GEPKGELLEA IKRDFGSFDK FKEKLTAASV GVQGSGWGWL
160 170 180 190 200
GFNKERGHLQ IAACPNQDPL QGTTGLIPLL GIDVWEHAYY LQYKNVRPDY
210 220
LKAIWNVINW ENVTERYMAC KK
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5GYZ5 | F5GYZ5_HUMAN | Superoxide dismutase | SOD2 | 190 | Annotation score: | ||
F5H4R2 | F5H4R2_HUMAN | Superoxide dismutase | SOD2 | 183 | Annotation score: | ||
F5H3C5 | F5H3C5_HUMAN | Superoxide dismutase | SOD2 | 111 | Annotation score: | ||
G8JLJ2 | G8JLJ2_HUMAN | Superoxide dismutase | SOD2 | 61 | Annotation score: | ||
G5E9P6 | G5E9P6_HUMAN | Superoxide dismutase [Mn], mitochon... | SOD2 hCG_34035 | 140 | Annotation score: | ||
F5GXZ9 | F5GXZ9_HUMAN | Superoxide dismutase [Mn], mitochon... | SOD2 | 141 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 14 | A → P (PubMed:3399391).Curated | 1 | |
Sequence conflicti | 65 | T → N in CAA42066 (PubMed:1699607).Curated | 1 | |
Sequence conflicti | 65 | T → N in CAA33228 (PubMed:1699607).Curated | 1 | |
Sequence conflicti | 66 | E → Q (PubMed:1988135).Curated | 1 | |
Sequence conflicti | 112 | E → Q (PubMed:1988135).Curated | 1 | |
Sequence conflicti | 123 | R → L in CAA30687 (PubMed:3399391).Curated | 1 | |
Sequence conflicti | 133 | E → Q (PubMed:1988135).Curated | 1 | |
Sequence conflicti | 148 – 149 | Missing (PubMed:1988135).Curated | 2 | |
Sequence conflicti | 155 | E → Q in CAA68533 (PubMed:3684581).Curated | 1 | |
Sequence conflicti | 155 | E → Q (PubMed:1988135).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019363 | 10 | S → I1 PublicationCorresponds to variant dbSNP:rs5746096Ensembl. | 1 | |
Natural variantiVAR_016183 | 16 | V → A Frequent polymorphism; associated with a decreased susceptibility to diabetic nephropathy in Japanese and Chinese patients with type 2 diabetes. 2 PublicationsCorresponds to variant dbSNP:rs4880EnsemblClinVar. | 1 | |
Natural variantiVAR_019364 | 66 | E → V1 PublicationCorresponds to variant dbSNP:rs5746097Ensembl. | 1 | |
Natural variantiVAR_025898 | 76 | G → R. Corresponds to variant dbSNP:rs4987023Ensembl. | 1 | |
Natural variantiVAR_007165 | 82 | I → T1 PublicationCorresponds to variant dbSNP:rs1141718Ensembl. | 1 | |
Natural variantiVAR_019365 | 156 | R → W1 PublicationCorresponds to variant dbSNP:rs5746129Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053761 | 1 – 46 | Missing in isoform 4. 1 PublicationAdd BLAST | 46 | |
Alternative sequenceiVSP_042558 | 75 – 113 | Missing in isoform 2. 1 PublicationAdd BLAST | 39 | |
Alternative sequenceiVSP_053762 | 115 – 174 | Missing in isoform 3. 1 PublicationAdd BLAST | 60 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000337404; ENSP00000337127; ENSG00000112096 [P04179-2] ENST00000367054; ENSP00000356021; ENSG00000112096 [P04179-2] ENST00000367055; ENSP00000356022; ENSG00000112096 [P04179-1] ENST00000444946; ENSP00000404804; ENSG00000112096 [P04179-3] ENST00000538183; ENSP00000446252; ENSG00000112096 [P04179-1] |
GeneIDi | 6648 |
KEGGi | hsa:6648 |
UCSCi | uc003qsf.6, human [P04179-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
SHMPD The Singapore human mutation and polymorphism database |
Wikipedia Superoxide dismutase entry |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AP5 | X-ray | 2.20 | A/B | 25-222 | [»] | |
1AP6 | X-ray | 1.90 | A/B | 25-222 | [»] | |
1EM1 | X-ray | 2.13 | A/B | 25-222 | [»] | |
1JA8 | X-ray | 2.12 | A/B | 25-222 | [»] | |
1LUV | X-ray | 1.85 | A/B | 25-222 | [»] | |
1LUW | X-ray | 2.30 | A/B | 25-222 | [»] | |
1MSD | X-ray | 3.20 | A/B | 25-222 | [»] | |
1N0J | X-ray | 2.20 | A/B | 25-222 | [»] | |
1N0N | X-ray | 1.82 | A/B | 25-222 | [»] | |
1PL4 | X-ray | 1.47 | A/B/C/D | 25-222 | [»] | |
1PM9 | X-ray | 1.70 | A/B | 25-222 | [»] | |
1QNM | X-ray | 2.30 | A/B | 25-222 | [»] | |
1SZX | X-ray | 1.95 | A/B | 25-222 | [»] | |
1VAR | X-ray | 2.50 | A/B | 25-222 | [»] | |
1XDC | X-ray | 1.85 | A/B | 25-222 | [»] | |
1XIL | X-ray | 1.53 | A/B | 25-222 | [»] | |
1ZSP | X-ray | 1.90 | A/B | 25-222 | [»] | |
1ZTE | X-ray | 1.85 | A/B/C/D | 25-222 | [»] | |
1ZUQ | X-ray | 2.00 | A/B | 25-222 | [»] | |
2ADP | X-ray | 2.40 | A | 25-222 | [»] | |
2ADQ | X-ray | 2.40 | B | 25-222 | [»] | |
2GDS | X-ray | 2.30 | A/B/C/D | 25-222 | [»] | |
2P4K | X-ray | 1.48 | A/B/C/D | 25-222 | [»] | |
2QKA | X-ray | 2.20 | A/C | 25-220 | [»] | |
2QKC | X-ray | 2.30 | A/C | 25-220 | [»] | |
3C3S | X-ray | 2.50 | A/B | 25-222 | [»] | |
3C3T | X-ray | 2.20 | A/B | 25-222 | [»] | |
5GXO | X-ray | 2.30 | A/B | 25-222 | [»] | |
5T30 | X-ray | 1.77 | A/B | 24-222 | [»] | |
5VF9 | X-ray | 1.82 | A/B | 24-222 | [»] | |
SMRi | P04179 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112531, 70 interactors |
IntActi | P04179, 26 interactors |
MINTi | P04179 |
STRINGi | 9606.ENSP00000446252 |
Chemistry databases
ChEMBLi | CHEMBL4105776 |
DrugBanki | DB04436, 3-Fluoro-L-tyrosine DB03297, Benzylsulfonic acid DB06796, Mangafodipir DB09221, Polaprezinc DB11590, Thimerosal |
DrugCentrali | P04179 |
Protein family/group databases
Allergomei | 784, Hom s MnSOD |
PTM databases
iPTMneti | P04179 |
PhosphoSitePlusi | P04179 |
SwissPalmi | P04179 |
Polymorphism and mutation databases
BioMutai | SOD2 |
DMDMi | 134665 |
2D gel databases
DOSAC-COBS-2DPAGEi | P04179 |
OGPi | P04179 |
SWISS-2DPAGEi | P04179 |
UCD-2DPAGEi | P04179 |
Proteomic databases
EPDi | P04179 |
jPOSTi | P04179 |
MassIVEi | P04179 |
MaxQBi | P04179 |
PaxDbi | P04179 |
PeptideAtlasi | P04179 |
PRIDEi | P04179 |
ProteomicsDBi | 3715 51669 [P04179-1] 51670 [P04179-2] 5907 |
TopDownProteomicsi | P04179-1 [P04179-1] P04179-2 [P04179-2] |
Protocols and materials databases
Antibodypediai | 785, 1023 antibodies |
DNASUi | 6648 |
Genome annotation databases
Ensembli | ENST00000337404; ENSP00000337127; ENSG00000112096 [P04179-2] ENST00000367054; ENSP00000356021; ENSG00000112096 [P04179-2] ENST00000367055; ENSP00000356022; ENSG00000112096 [P04179-1] ENST00000444946; ENSP00000404804; ENSG00000112096 [P04179-3] ENST00000538183; ENSP00000446252; ENSG00000112096 [P04179-1] |
GeneIDi | 6648 |
KEGGi | hsa:6648 |
UCSCi | uc003qsf.6, human [P04179-1] |
Organism-specific databases
CTDi | 6648 |
DisGeNETi | 6648 |
EuPathDBi | HostDB:ENSG00000112096.16 |
GeneCardsi | SOD2 |
HGNCi | HGNC:11180, SOD2 |
HPAi | ENSG00000285441, Tissue enhanced (blood, bone marrow, seminal vesicle) |
MalaCardsi | SOD2 |
MIMi | 147460, gene 612634, phenotype |
neXtProti | NX_P04179 |
OpenTargetsi | ENSG00000112096 |
PharmGKBi | PA36017 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0876, Eukaryota |
GeneTreei | ENSGT00390000011877 |
HOGENOMi | CLU_031625_2_0_1 |
InParanoidi | P04179 |
OMAi | KWGSFDK |
OrthoDBi | 1353361at2759 |
PhylomeDBi | P04179 |
TreeFami | TF105132 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS03515-MONOMER |
BRENDAi | 1.15.1.1, 2681 |
PathwayCommonsi | P04179 |
Reactomei | R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis R-HSA-3299685, Detoxification of Reactive Oxygen Species R-HSA-8862803, Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8950505, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-9615017, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes |
SIGNORi | P04179 |
Miscellaneous databases
BioGRID-ORCSi | 6648, 483 hits in 847 CRISPR screens |
ChiTaRSi | SOD2, human |
EvolutionaryTracei | P04179 |
GeneWikii | SOD2 |
GenomeRNAii | 6648 |
Pharosi | P04179, Tbio |
PROi | PR:P04179 |
RNActi | P04179, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000112096, Expressed in gastrocnemius and 239 other tissues |
ExpressionAtlasi | P04179, baseline and differential |
Genevisiblei | P04179, HS |
Family and domain databases
Gene3Di | 1.10.287.990, 1 hit 2.40.500.20, 1 hit |
InterProi | View protein in InterPro IPR001189, Mn/Fe_SOD IPR019833, Mn/Fe_SOD_BS IPR019832, Mn/Fe_SOD_C IPR019831, Mn/Fe_SOD_N IPR036324, Mn/Fe_SOD_N_sf IPR036314, SOD_C_sf |
Pfami | View protein in Pfam PF02777, Sod_Fe_C, 1 hit PF00081, Sod_Fe_N, 1 hit |
PIRSFi | PIRSF000349, SODismutase, 1 hit |
PRINTSi | PR01703, MNSODISMTASE |
SUPFAMi | SSF46609, SSF46609, 1 hit SSF54719, SSF54719, 1 hit |
PROSITEi | View protein in PROSITE PS00088, SOD_MN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SODM_HUMAN | |
Accessioni | P04179Primary (citable) accession number: P04179 Secondary accession number(s): B2R7R1 Q9P2Z3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 1987 |
Last sequence update: | December 20, 2017 | |
Last modified: | December 2, 2020 | |
This is version 242 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations