Superoxide dismutase [Mn], mitochondrial

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

• 2 H⁺

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  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  + 2 superoxide

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  • See the description of this molecule in ChEBI.

  = H₂O₂

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  • See the description of this molecule in ChEBI.

  + O₂

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  • See the description of this molecule in ChEBI.
  EC:1.15.1.1
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  • See the description of this EC number in ENZYME.
  Source: Rhea

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  . Show »« Hide
  2

  H⁺

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  +

  2

  superoxide

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  • See the description of this molecule in ChEBI.

  zoom

  =

  H₂O₂

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  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  

  +

  O₂

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  • See the description of this molecule in ChEBI.

  

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: Ensembl
• enzyme binding Source: Ensembl
• identical protein binding Source: IntAct <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Radioprotection by short-term oxidative preconditioning: role of manganese superoxide dismutase."
    Belikova N.A., Glumac A., Rafikov R., Jiang J., Greenberger J.S., Kagan V.E., Bayir H.
    FEBS Lett 583:3437-3442(2009) [PubMed] [Europe PMC] [Abstract]
  • "Toward an understanding of the protein interaction network of the human liver."
    Wang J., Huo K., Ma L., Tang L., Li D., Huang X., Yuan Y., Li C., Wang W., Guan W., Chen H., Jin C., Wei J., Zhang W., Yang Y., Liu Q., Zhou Y., Zhang C.

    , Wu Z., Xu W., Zhang Y., Liu T., Yu D., Zhang Y., Chen L., Zhu D., Zhong X., Kang L., Gan X., Yu X., Ma Q., Yan J., Zhou L., Liu Z., Zhu Y., Zhou T., He F., Yang X.
    Mol Syst Biol 7:536-536(2011) [PubMed] [Europe PMC] [Abstract]
• manganese ion binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.32

    "Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis."
    Perry J.J., Hearn A.S., Cabelli D.E., Nick H.S., Tainer J.A., Silverman D.N.
    Biochemistry 48:3417-3424(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: X-RAY CRYSTALLOGRAPHY (1.48 ANGSTROMS) OF MUTANTS ALA/ASN/HIS/VAL-58 IN COMPLEX WITH MANGANESE IONS, SUBUNIT.
• metal ion binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• oxygen binding Source: Ensembl
• superoxide dismutase activity Source: UniProtKBInferred from direct assayⁱ
  • "Mitochondrial oxidative stress and increased seizure susceptibility in Sod2(-/+) mice."
    Liang L.P., Patel M.
    Free Radic Biol Med 36:542-554(2004) [PubMed] [Europe PMC] [Abstract]
  • Ref.32

    "Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis."
    Perry J.J., Hearn A.S., Cabelli D.E., Nick H.S., Tainer J.A., Silverman D.N.
    Biochemistry 48:3417-3424(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: X-RAY CRYSTALLOGRAPHY (1.48 ANGSTROMS) OF MUTANTS ALA/ASN/HIS/VAL-58 IN COMPLEX WITH MANGANESE IONS, SUBUNIT.

GO - Biological processⁱ

• acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure Source: BHF-UCL
• age-dependent response to reactive oxygen species Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Mitochondrial oxidative stress and increased seizure susceptibility in Sod2(-/+) mice."
    Liang L.P., Patel M.
    Free Radic Biol Med 36:542-554(2004) [PubMed] [Europe PMC] [Abstract]
• cellular response to ethanol Source: Ensembl
• cellular response to oxidative stress Source: Reactome
• detection of oxygen Source: Ensembl
• erythrophore differentiation Source: Ensembl
• glutathione metabolic process Source: Ensembl
• heart development Source: Ensembl
• hemopoiesis Source: Ensembl
• hydrogen peroxide biosynthetic process Source: Ensembl
• interleukin-12-mediated signaling pathway Source: Reactome
• intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
• intrinsic apoptotic signaling pathway in response to oxidative stress Source: Ensembl
• iron ion homeostasis Source: Ensembl
• liver development Source: Ensembl
• locomotory behavior Source: Ensembl
• negative regulation of cell population proliferation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress."
    Hu Y., Rosen D.G., Zhou Y., Feng L., Yang G., Liu J., Huang P.
    J Biol Chem 280:39485-39492(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of fat cell differentiation Source: Ensembl
• negative regulation of fibroblast proliferation Source: Ensembl
• negative regulation of neuron apoptotic process Source: BHF-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Suppression of mitochondrial oxidative stress provides long-term neuroprotection in experimental optic neuritis."
    Qi X., Lewin A.S., Sun L., Hauswirth W.W., Guy J.
    Invest Ophthalmol Vis Sci 48:681-691(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Differential effects of superoxide dismutase isoform expression on hydroperoxide-induced apoptosis in PC-12 cells."
    Pias E.K., Ekshyyan O.Y., Rhoads C.A., Fuseler J., Harrison L., Aw T.Y.
    J Biol Chem 278:13294-13301(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of vascular associated smooth muscle cell proliferation Source: BHF-UCLInferred from direct assayⁱ
  • "MiR-140-5p regulates hypoxia-mediated human pulmonary artery smooth muscle cell proliferation, apoptosis and differentiation by targeting Dnmt1 and promoting SOD2 expression."
    Zhang Y., Xu J.
    Biochem Biophys Res Commun 473:342-348(2016) [PubMed] [Europe PMC] [Abstract]
• neuron development Source: Ensembl
• oxygen homeostasis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress."
    Hu Y., Rosen D.G., Zhou Y., Feng L., Yang G., Liu J., Huang P.
    J Biol Chem 280:39485-39492(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell migration Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Short communication: asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism."
    Fleissner F., Jazbutyte V., Fiedler J., Gupta S.K., Yin X., Xu Q., Galuppo P., Kneitz S., Mayr M., Ertl G., Bauersachs J., Thum T.
    Circ Res 107:138-143(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of nitric oxide biosynthetic process Source: Ensembl
• positive regulation of vascular associated smooth muscle cell apoptotic process Source: BHF-UCLInferred from direct assayⁱ
  • "MiR-140-5p regulates hypoxia-mediated human pulmonary artery smooth muscle cell proliferation, apoptosis and differentiation by targeting Dnmt1 and promoting SOD2 expression."
    Zhang Y., Xu J.
    Biochem Biophys Res Commun 473:342-348(2016) [PubMed] [Europe PMC] [Abstract]
• positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching Source: BHF-UCLInferred from direct assayⁱ
  • "MiR-140-5p regulates hypoxia-mediated human pulmonary artery smooth muscle cell proliferation, apoptosis and differentiation by targeting Dnmt1 and promoting SOD2 expression."
    Zhang Y., Xu J.
    Biochem Biophys Res Commun 473:342-348(2016) [PubMed] [Europe PMC] [Abstract]
• post-embryonic development Source: Ensembl
• protein homotetramerization Source: UniProtKBInferred from physical interactionⁱ
  • Ref.32

    "Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis."
    Perry J.J., Hearn A.S., Cabelli D.E., Nick H.S., Tainer J.A., Silverman D.N.
    Biochemistry 48:3417-3424(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: X-RAY CRYSTALLOGRAPHY (1.48 ANGSTROMS) OF MUTANTS ALA/ASN/HIS/VAL-58 IN COMPLEX WITH MANGANESE IONS, SUBUNIT.
• regulation of blood pressure Source: BHF-UCL
• regulation of catalytic activity Source: Ensembl
• regulation of mitochondrial membrane potential Source: Ensembl
• regulation of transcription by RNA polymerase II Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Overexpression of manganese superoxide dismutase selectively modulates the activity of Jun-associated transcription factors in fibrosarcoma cells."
    Kiningham K.K., St Clair D.K.
    Cancer Res 57:5265-5271(1997) [PubMed] [Europe PMC] [Abstract]
• release of cytochrome c from mitochondria Source: BHF-UCL
• removal of superoxide radicals Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress."
    Hu Y., Rosen D.G., Zhou Y., Feng L., Yang G., Liu J., Huang P.
    J Biol Chem 280:39485-39492(2005) [PubMed] [Europe PMC] [Abstract]
• respiratory electron transport chain Source: Ensembl
• response to activity Source: Ensembl
• response to axon injury Source: Ensembl
• response to cadmium ion Source: Ensembl
• response to cold Source: Ensembl
• response to drug Source: Ensembl
• response to electrical stimulus Source: Ensembl
• response to gamma radiation Source: Ensembl
• response to hydrogen peroxide Source: Ensembl
• response to hyperoxia Source: Ensembl
• response to hypoxia Source: Ensembl
• response to immobilization stress Source: Ensembl
• response to isolation stress Source: Ensembl
• response to L-ascorbic acid Source: Ensembl
• response to lipopolysaccharide Source: Ensembl
• response to magnetism Source: Ensembl
• response to manganese ion Source: Ensembl
• response to selenium ion Source: Ensembl
• response to silicon dioxide Source: Ensembl
• response to superoxide Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress."
    Hu Y., Rosen D.G., Zhou Y., Feng L., Yang G., Liu J., Huang P.
    J Biol Chem 280:39485-39492(2005) [PubMed] [Europe PMC] [Abstract]
• response to zinc ion Source: Ensembl
• superoxide anion generation Source: Ensembl
• superoxide metabolic process Source: UniProtKBInferred from direct assayⁱ
  • "Mitochondrial oxidative stress and increased seizure susceptibility in Sod2(-/+) mice."
    Liang L.P., Patel M.
    Free Radic Biol Med 36:542-554(2004) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Mutagenesis

Organism-specific databases

Miscellaneous databases

Protein family/group databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• enzyme binding Source: Ensembl
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "Radioprotection by short-term oxidative preconditioning: role of manganese superoxide dismutase."
    Belikova N.A., Glumac A., Rafikov R., Jiang J., Greenberger J.S., Kagan V.E., Bayir H.
    FEBS Lett 583:3437-3442(2009) [PubMed] [Europe PMC] [Abstract]
  • "Toward an understanding of the protein interaction network of the human liver."
    Wang J., Huo K., Ma L., Tang L., Li D., Huang X., Yuan Y., Li C., Wang W., Guan W., Chen H., Jin C., Wei J., Zhang W., Yang Y., Liu Q., Zhou Y., Zhang C.

    , Wu Z., Xu W., Zhang Y., Liu T., Yu D., Zhang Y., Chen L., Zhu D., Zhong X., Kang L., Gan X., Yu X., Ma Q., Yan J., Zhou L., Liu Z., Zhu Y., Zhou T., He F., Yang X.
    Mol Syst Biol 7:536-536(2011) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MLSRAVCGTS RQLAPVLGYL GSRQKHSLPD LPYDYGALEP HINAQIMQLH 
        60         70         80         90        100
HSKHHAAYVN NLNVTEEKYQ EALAKGDVTA QIALQPALKF NGGGHINHSI 
       110        120        130        140        150
FWTNLSPNGG GEPKGELLEA IKRDFGSFDK FKEKLTAASV GVQGSGWGWL 
       160        170        180        190        200
GFNKERGHLQ IAACPNQDPL QGTTGLIPLL GIDVWEHAYY LQYKNVRPDY 
       210        220 
LKAIWNVINW ENVTERYMAC KK                               

        10         20         30         40         50
MLSRAVCGTS RQLAPVLGYL GSRQKHSLPD LPYDYGALEP HINAQIMQLH 
        60         70         80         90        100
HSKHHAAYVN NLNVTEEKYQ EALAKGELLE AIKRDFGSFD KFKEKLTAAS 
       110        120        130        140        150
VGVQGSGWGW LGFNKERGHL QIAACPNQDP LQGTTGLIPL LGIDVWEHAY 
       160        170        180 
YLQYKNVRPD YLKAIWNVIN WENVTERYMA CKK                   

        10         20         30         40         50
MLSRAVCGTS RQLAPVLGYL GSRQKHSLPD LPYDYGALEP HINAQIMQLH 
        60         70         80         90        100
HSKHHAAYVN NLNVTEEKYQ EALAKGDVTA QIALQPALKF NGGGHINHSI 
       110        120        130        140        150
FWTNLSPNGG GEPKGLIPLL GIDVWEHAYY LQYKNVRPDY LKAIWNVINW 
       160 
ENVTERYMAC KK                                          

        10         20         30         40         50
MQLHHSKHHA AYVNNLNVTE EKYQEALAKG DVTAQIALQP ALKFNGGGHI 
        60         70         80         90        100
NHSIFWTNLS PNGGGEPKGE LLEAIKRDFG SFDKFKEKLT AASVGVQGSG 
       110        120        130        140        150
WGWLGFNKER GHLQIAACPN QDPLQGTTGL IPLLGIDVWE HAYYLQYKNV 
       160        170 
RPDYLKAIWN VINWENVTER YMACKK                           

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases