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UniProtKB - P04179 (SODM_HUMAN)

Protein

Superoxide dismutase [Mn], mitochondrial

Gene

SOD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+Note: Binds 1 Mn2+ ion per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi50Manganese1
Metal bindingi98Manganese1
Metal bindingi183Manganese1
Metal bindingi187Manganese1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: IntAct
  • manganese ion binding Source: UniProtKB
  • metal ion binding Source: GO_Central
  • superoxide dismutase activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS03515-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.15.1.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

SIGNOR Signaling Network Open Resource

More...SIGNORi		P04179

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Superoxide dismutase [Mn], mitochondrial (EC:1.15.1.1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SOD2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000112096.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:11180 SOD2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		147460 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P04179

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Microvascular complications of diabetes 6 (MVCD6)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionPathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
See also OMIM:612634

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi58Y → A, H, N, V or F: Reduced enzyme activity. 1 Publication1
Mutagenesisi58Y → F: Loss of nitration. Enhanced dityrosine formation on peroxynitrite treatment. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		6648

MalaCards human disease database

More...MalaCardsi		SOD2
MIMi612634 phenotype

Open Targets

More...OpenTargetsi		ENSG00000112096

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36017

Protein family/group databases

Allergome; a platform for allergen knowledge

More...Allergomei		784 Hom s MnSOD

Chemistry databases

Drug and drug target database

More...DrugBanki		DB04436 3-Fluorotyrosine
DB03297 Benzylsulfinic Acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SOD2

Domain mapping of disease mutations (DMDM)

More...DMDMi		134665

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 24Mitochondrion4 PublicationsAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003286925 – 222Superoxide dismutase [Mn], mitochondrialAdd BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei58Nitrated tyrosine2 Publications1
Modified residuei68N6-acetyllysine; alternateCombined sources1
Modified residuei68N6-succinyllysine; alternateBy similarity1
Modified residuei75N6-acetyllysine; alternateBy similarity1
Modified residuei75N6-succinyllysine; alternateBy similarity1
Modified residuei114N6-acetyllysineBy similarity1
Modified residuei122N6-acetyllysine; alternateBy similarity1
Modified residuei122N6-succinyllysine; alternateBy similarity1
Modified residuei130N6-acetyllysine; alternateCombined sources1
Modified residuei130N6-succinyllysine; alternateBy similarity1
Modified residuei202N6-acetyllysineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.2 Publications
Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity).By similarity
Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability.1 Publication

Keywords - PTMi

Acetylation, Nitration, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P04179

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P04179

MaxQB - The MaxQuant DataBase

More...MaxQBi		P04179

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P04179

PeptideAtlas

More...PeptideAtlasi		P04179

PRoteomics IDEntifications database

More...PRIDEi		P04179

ProteomicsDB human proteome resource

More...ProteomicsDBi		51669
51670 [P04179-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P04179-1 [P04179-1]
P04179-2 [P04179-2]

2D gel databases

DOSAC-COBS 2D-PAGE database

More...DOSAC-COBS-2DPAGEi		P04179

USC-OGP 2-DE database

More...OGPi		P04179

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P04179

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P04179

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P04179

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P04179

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P04179

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is regulated by KRIT1.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000112096 Expressed in 229 organ(s), highest expression level in gastrocnemius

CleanEx database of gene expression profiles

More...CleanExi		HS_SOD2

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P04179 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB002013
HPA001814

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-716989,EBI-716989

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		112531, 41 interactors

Protein interaction database and analysis system

More...IntActi		P04179, 21 interactors

Molecular INTeraction database

More...MINTi		P04179

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000356022

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1222
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AP5X-ray2.20A/B25-222[»]
1AP6X-ray1.90A/B25-222[»]
1EM1X-ray2.13A/B25-222[»]
1JA8X-ray2.12A/B25-222[»]
1LUVX-ray1.85A/B25-222[»]
1LUWX-ray2.30A/B25-222[»]
1MSDX-ray3.20A/B25-222[»]
1N0JX-ray2.20A/B25-222[»]
1N0NX-ray1.82A/B25-222[»]
1PL4X-ray1.47A/B/C/D25-222[»]
1PM9X-ray1.70A/B25-222[»]
1QNMX-ray2.30A/B25-222[»]
1SZXX-ray1.95A/B25-222[»]
1VARX-ray2.50A/B25-222[»]
1XDCX-ray1.85A/B25-222[»]
1XILX-ray1.53A/B25-222[»]
1ZSPX-ray1.90A/B25-222[»]
1ZTEX-ray1.85A/B/C/D25-222[»]
1ZUQX-ray2.00A/B25-222[»]
2ADPX-ray2.40A25-222[»]
2ADQX-ray2.40B25-222[»]
2GDSX-ray2.30A/B/C/D25-222[»]
2P4KX-ray1.48A/B/C/D25-222[»]
2QKAX-ray2.20A/C25-220[»]
2QKCX-ray2.30A/C25-220[»]
3C3SX-ray2.50A/B25-222[»]
3C3TX-ray2.20A/B25-222[»]
5GXOX-ray2.30A/B25-222[»]
5T30X-ray1.77A/B24-222[»]
5VF9X-ray1.82A/B24-222[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P04179

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P04179

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P04179

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the iron/manganese superoxide dismutase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0876 Eukaryota
COG0605 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000011877

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000013583

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG004451

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P04179

KEGG Orthology (KO)

More...KOi		K04564

Identification of Orthologs from Complete Genome Data

More...OMAi		KWGSFDK

Database of Orthologous Groups

More...OrthoDBi		926074at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P04179

TreeFam database of animal gene trees

More...TreeFami		TF105132

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.287.990, 1 hit
2.40.500.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000349 SODismutase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01703 MNSODISMTASE

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00088 SOD_MN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P04179-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSRAVCGTS RQLAPVLGYL GSRQKHSLPD LPYDYGALEP HINAQIMQLH 
        60         70         80         90        100
HSKHHAAYVN NLNVTEEKYQ EALAKGDVTA QIALQPALKF NGGGHINHSI 
       110        120        130        140        150
FWTNLSPNGG GEPKGELLEA IKRDFGSFDK FKEKLTAASV GVQGSGWGWL 
       160        170        180        190        200
GFNKERGHLQ IAACPNQDPL QGTTGLIPLL GIDVWEHAYY LQYKNVRPDY 
       210        220 
LKAIWNVINW ENVTERYMAC KK
Length:222
Mass (Da):24,750
Last modified:December 20, 2017 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA047D7900AE5905
GO
Isoform 2 (identifier: P04179-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-113: Missing.

Note: No experimental confirmation available.
Show »
Length:183
Mass (Da):20,724
Checksum:i513D204966621B88
GO
Isoform 3 (identifier: P04179-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     115-174: Missing.

Note: No experimental confirmation available.
Show »
Length:162
Mass (Da):18,262
Checksum:i54271EA009B62959
GO
Isoform 4 (identifier: P04179-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.

Note: No experimental confirmation available.
Show »
Length:176
Mass (Da):19,730
Checksum:i5AB24FB15A80A1AF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H4R2F5H4R2_HUMAN
Superoxide dismutase
SOD2
183Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GYZ5F5GYZ5_HUMAN
Superoxide dismutase
SOD2
190Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H3C5F5H3C5_HUMAN
Superoxide dismutase
SOD2
111Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G8JLJ2G8JLJ2_HUMAN
Superoxide dismutase
SOD2
61Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5E9P6G5E9P6_HUMAN
Superoxide dismutase 2, mitochondri...
SOD2 hCG_34035
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GXZ9F5GXZ9_HUMAN
Superoxide dismutase [Mn], mitochon...
SOD2
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti14A → P (PubMed:3399391).Curated1
Sequence conflicti65T → N in CAA42066 (PubMed:1699607).Curated1
Sequence conflicti65T → N in CAA33228 (PubMed:1699607).Curated1
Sequence conflicti66E → Q (PubMed:1988135).Curated1
Sequence conflicti112E → Q (PubMed:1988135).Curated1
Sequence conflicti123R → L in CAA30687 (PubMed:3399391).Curated1
Sequence conflicti133E → Q (PubMed:1988135).Curated1
Sequence conflicti148 – 149Missing (PubMed:1988135).Curated2
Sequence conflicti155E → Q in CAA68533 (PubMed:3684581).Curated1
Sequence conflicti155E → Q (PubMed:1988135).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01936310S → I1 PublicationCorresponds to variant dbSNP:rs5746096Ensembl.1
Natural variantiVAR_01618316V → A Frequent polymorphism; associated with a decreased susceptibility to diabetic nephropathy in Japanese and Chinese patients with type 2 diabetes. 2 PublicationsCorresponds to variant dbSNP:rs4880EnsemblClinVar.1
Natural variantiVAR_01936466E → V1 PublicationCorresponds to variant dbSNP:rs5746097Ensembl.1
Natural variantiVAR_02589876G → R. Corresponds to variant dbSNP:rs4987023Ensembl.1
Natural variantiVAR_00716582I → T1 PublicationCorresponds to variant dbSNP:rs1141718Ensembl.1
Natural variantiVAR_019365156R → W1 PublicationCorresponds to variant dbSNP:rs5746129Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0537611 – 46Missing in isoform 4. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_04255875 – 113Missing in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_053762115 – 174Missing in isoform 3. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X59445 mRNA Translation: CAA42066.1
Y00472 mRNA Translation: CAA68533.1
Y00985 mRNA Translation: CAA68791.1
X07834 mRNA Translation: CAA30687.1
M36693 mRNA Translation: AAA36622.1
X15132 mRNA Translation: CAA33228.1
X14322 mRNA Translation: CAA32502.1
S77127 Genomic DNA Translation: AAD14248.1 Sequence problems.
BT006967 mRNA Translation: AAP35613.1
AY267901 Genomic DNA Translation: AAP03428.1
AK097395 mRNA Translation: BAG53464.1
AK296809 mRNA Translation: BAG59382.1
AK304766 mRNA Translation: BAG65521.1
AK313082 mRNA Translation: BAG35908.1
AL135914 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47630.1
CH471051 Genomic DNA Translation: EAW47631.1
BC012423 mRNA Translation: AAH12423.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34564.1 [P04179-2]
CCDS5265.1 [P04179-1]
CCDS83141.1 [P04179-4]
CCDS83143.1 [P04179-3]

Protein sequence database of the Protein Information Resource

More...PIRi		S13162 DSHUN

NCBI Reference Sequences

More...RefSeqi		NP_000627.2, NM_000636.3 [P04179-1]
NP_001019636.1, NM_001024465.2 [P04179-1]
NP_001019637.1, NM_001024466.2 [P04179-2]
NP_001309743.1, NM_001322814.1 [P04179-2]
NP_001309744.1, NM_001322815.1 [P04179-3]
NP_001309746.1, NM_001322817.1 [P04179-4]
NP_001309748.1, NM_001322819.1 [P04179-4]
NP_001309749.1, NM_001322820.1 [P04179-4]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.487046

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000337404; ENSP00000337127; ENSG00000112096 [P04179-2]
ENST00000367054; ENSP00000356021; ENSG00000112096 [P04179-2]
ENST00000367055; ENSP00000356022; ENSG00000112096 [P04179-1]
ENST00000444946; ENSP00000404804; ENSG00000112096 [P04179-3]
ENST00000538183; ENSP00000446252; ENSG00000112096 [P04179-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6648

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6648

UCSC genome browser

More...UCSCi		uc003qsf.6 human [P04179-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Superoxide dismutase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59445 mRNA Translation: CAA42066.1
Y00472 mRNA Translation: CAA68533.1
Y00985 mRNA Translation: CAA68791.1
X07834 mRNA Translation: CAA30687.1
M36693 mRNA Translation: AAA36622.1
X15132 mRNA Translation: CAA33228.1
X14322 mRNA Translation: CAA32502.1
S77127 Genomic DNA Translation: AAD14248.1 Sequence problems.
BT006967 mRNA Translation: AAP35613.1
AY267901 Genomic DNA Translation: AAP03428.1
AK097395 mRNA Translation: BAG53464.1
AK296809 mRNA Translation: BAG59382.1
AK304766 mRNA Translation: BAG65521.1
AK313082 mRNA Translation: BAG35908.1
AL135914 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47630.1
CH471051 Genomic DNA Translation: EAW47631.1
BC012423 mRNA Translation: AAH12423.1
CCDSiCCDS34564.1 [P04179-2]
CCDS5265.1 [P04179-1]
CCDS83141.1 [P04179-4]
CCDS83143.1 [P04179-3]
PIRiS13162 DSHUN
RefSeqiNP_000627.2, NM_000636.3 [P04179-1]
NP_001019636.1, NM_001024465.2 [P04179-1]
NP_001019637.1, NM_001024466.2 [P04179-2]
NP_001309743.1, NM_001322814.1 [P04179-2]
NP_001309744.1, NM_001322815.1 [P04179-3]
NP_001309746.1, NM_001322817.1 [P04179-4]
NP_001309748.1, NM_001322819.1 [P04179-4]
NP_001309749.1, NM_001322820.1 [P04179-4]
UniGeneiHs.487046

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AP5X-ray2.20A/B25-222[»]
1AP6X-ray1.90A/B25-222[»]
1EM1X-ray2.13A/B25-222[»]
1JA8X-ray2.12A/B25-222[»]
1LUVX-ray1.85A/B25-222[»]
1LUWX-ray2.30A/B25-222[»]
1MSDX-ray3.20A/B25-222[»]
1N0JX-ray2.20A/B25-222[»]
1N0NX-ray1.82A/B25-222[»]
1PL4X-ray1.47A/B/C/D25-222[»]
1PM9X-ray1.70A/B25-222[»]
1QNMX-ray2.30A/B25-222[»]
1SZXX-ray1.95A/B25-222[»]
1VARX-ray2.50A/B25-222[»]
1XDCX-ray1.85A/B25-222[»]
1XILX-ray1.53A/B25-222[»]
1ZSPX-ray1.90A/B25-222[»]
1ZTEX-ray1.85A/B/C/D25-222[»]
1ZUQX-ray2.00A/B25-222[»]
2ADPX-ray2.40A25-222[»]
2ADQX-ray2.40B25-222[»]
2GDSX-ray2.30A/B/C/D25-222[»]
2P4KX-ray1.48A/B/C/D25-222[»]
2QKAX-ray2.20A/C25-220[»]
2QKCX-ray2.30A/C25-220[»]
3C3SX-ray2.50A/B25-222[»]
3C3TX-ray2.20A/B25-222[»]
5GXOX-ray2.30A/B25-222[»]
5T30X-ray1.77A/B24-222[»]
5VF9X-ray1.82A/B24-222[»]
ProteinModelPortaliP04179
SMRiP04179
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112531, 41 interactors
IntActiP04179, 21 interactors
MINTiP04179
STRINGi9606.ENSP00000356022

Chemistry databases

DrugBankiDB04436 3-Fluorotyrosine
DB03297 Benzylsulfinic Acid

Protein family/group databases

Allergomei784 Hom s MnSOD

PTM databases

iPTMnetiP04179
PhosphoSitePlusiP04179
SwissPalmiP04179

Polymorphism and mutation databases

BioMutaiSOD2
DMDMi134665

2D gel databases

DOSAC-COBS-2DPAGEiP04179
OGPiP04179
SWISS-2DPAGEiP04179
UCD-2DPAGEiP04179

Proteomic databases

EPDiP04179
jPOSTiP04179
MaxQBiP04179
PaxDbiP04179
PeptideAtlasiP04179
PRIDEiP04179
ProteomicsDBi51669
51670 [P04179-2]
TopDownProteomicsiP04179-1 [P04179-1]
P04179-2 [P04179-2]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		6648
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337404; ENSP00000337127; ENSG00000112096 [P04179-2]
ENST00000367054; ENSP00000356021; ENSG00000112096 [P04179-2]
ENST00000367055; ENSP00000356022; ENSG00000112096 [P04179-1]
ENST00000444946; ENSP00000404804; ENSG00000112096 [P04179-3]
ENST00000538183; ENSP00000446252; ENSG00000112096 [P04179-1]
GeneIDi6648
KEGGihsa:6648
UCSCiuc003qsf.6 human [P04179-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6648
DisGeNETi6648
EuPathDBiHostDB:ENSG00000112096.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		ENSG00000285441
SOD2
HGNCiHGNC:11180 SOD2
HPAiCAB002013
HPA001814
MalaCardsiSOD2
MIMi147460 gene
612634 phenotype
neXtProtiNX_P04179
OpenTargetsiENSG00000112096
PharmGKBiPA36017

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0876 Eukaryota
COG0605 LUCA
GeneTreeiENSGT00390000011877
HOGENOMiHOG000013583
HOVERGENiHBG004451
InParanoidiP04179
KOiK04564
OMAiKWGSFDK
OrthoDBi926074at2759
PhylomeDBiP04179
TreeFamiTF105132

Enzyme and pathway databases

BioCyciMetaCyc:HS03515-MONOMER
BRENDAi1.15.1.1 2681
ReactomeiR-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
SIGNORiP04179

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SOD2 human
EvolutionaryTraceiP04179

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SOD2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6648

Protein Ontology

More...PROi		PR:P04179

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000112096 Expressed in 229 organ(s), highest expression level in gastrocnemius
CleanExiHS_SOD2
GenevisibleiP04179 HS

Family and domain databases

Gene3Di1.10.287.990, 1 hit
2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSODM_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P04179
Secondary accession number(s): B2R7R1
, B3KUK2, B4DL20, B4E3K9, E1P5A9, P78434, Q16792, Q5TCM1, Q96EE6, Q9P2Z3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: December 20, 2017
Last modified: January 16, 2019
This is version 228 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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