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UniProtKB - P04150 (GCR_HUMAN)

Entry version 272 (02 Jun 2021)
Sequence version 1 (01 Nov 1986)
Previous versions | rss
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Protein

Glucocorticoid receptor

Gene

NR3C1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for glucocorticoids (GC) (PubMed:27120390).

Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696).

Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514).

Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity).

By similarity3 Publications

Has transcriptional activation and repression activity (PubMed:15866175, PubMed:19248771, PubMed:20484466, PubMed:23820903, PubMed:11435610, PubMed:15769988, PubMed:17635946, PubMed:19141540, PubMed:21664385).

Mediates glucocorticoid-induced apoptosis (PubMed:23303127).

Promotes accurate chromosome segregation during mitosis (PubMed:25847991).

May act as a tumor suppressor (PubMed:25847991).

May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity).

By similarity11 Publications

Acts as a dominant negative inhibitor of isoform Alpha (PubMed:7769088, PubMed:8621628, PubMed:20484466).

Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253).

Loses this transcription modulator function on its own (PubMed:20484466).

Has no hormone-binding activity (PubMed:8621628).

May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity).

Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253).

Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253).

By similarity5 Publications

Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).

Increases activity of isoform Alpha.

1 Publication

More effective than isoform Alpha in transcriptional activation, but not repression activity.

2 Publications

Has transcriptional activation activity.

1 Publication

Has transcriptional activation activity.

1 Publication

Has transcriptional activation activity.

1 Publication

Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903).

Has transcriptional repression activity (PubMed:23303127).

Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903).

3 Publications

Has transcriptional activation activity.

1 Publication

Has transcriptional activation activity.

1 Publication

Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903).

Has transcriptional repression activity (PubMed:23303127).

3 Publications

Miscellaneous

Can up- or down-modulate aggregation and nuclear localization of expanded polyglutamine polypeptides derived from AR and HD through specific regulation of gene expression. Aggregation and nuclear localization of expanded polyglutamine proteins are regulated cellular processes that can be modulated by this receptor, a well-characterized transcriptional regulator.1 Publication

Caution

Had previously been shown to interact with PELP1. However this paper was retracted as cell-based data was viewed as unreliable.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi418 – 493Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri421 – 441NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri457 – 476NR C4-typePROSITE-ProRule annotationAdd BLAST20

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding, Receptor, RNA-binding
Biological processApoptosis, Cell cycle, Cell division, Chromosome partition, Mitosis, Transcription, Transcription regulation
LigandLipid-binding, Metal-binding, Steroid-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P04150

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-383280, Nuclear Receptor transcription pathway
R-HSA-400253, Circadian Clock
R-HSA-4090294, SUMOylation of intracellular receptors
R-HSA-8849473, PTK6 Expression
R-HSA-8939902, Regulation of RUNX2 expression and activity
R-HSA-9615017, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
R-HSA-9679191, Potential therapeutics for SARS

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P04150

SIGNOR Signaling Network Open Resource

More...SIGNORi		P04150

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glucocorticoid receptor
Short name:
GR
Alternative name(s):
Nuclear receptor subfamily 3 group C member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NR3C1
Synonyms:GRL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7978, NR3C1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		138040, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P04150

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000113580.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Glucocorticoid resistance, generalized (GCCR)14 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disease characterized by increased plasma cortisol concentration and high urinary free cortisol, resistance to adrenal suppression by dexamethasone, and the absence of Cushing syndrome typical signs. Clinical features include hypoglycemia, hypertension, metabolic alkalosis, chronic fatigue and profound anxiety.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075799423V → A in GCCR; unknown pathological significance; reduces transactivation activity; delays nuclear translocation; does not exert a dominant negative effect; impairs DNA binding. 1 Publication1
Natural variantiVAR_013472477R → H in GCCR. 1 PublicationCorresponds to variant dbSNP:rs104893913EnsemblClinVar.1
Natural variantiVAR_077143477R → S in GCCR; loss of DNA-binding and of transactivation activity; incomplete dexamethasone-induced translocation to the nucleus; no effect on dexamethasone-binding affinity compared with wild-type. 1 Publication1
Natural variantiVAR_077144478Y → C in GCCR; decreased DNA-binding and transactivation activity; incomplete dexamethasone-induced translocation to the nucleus; no effect on dexamethasone-binding affinity compared with wild-type. 1 Publication1
Natural variantiVAR_075800556T → I in GCCR; reduces transactivation activity; enhances transrepression activity; reduces affinity for ligand; delays nuclear translocation; does not exert a dominant negative effect; does not impair DNA binding. 2 Publications1
Natural variantiVAR_015632559I → N in GCCR; interferes with translocation to the nucleus and thereby strongly reduces transcription activation; is equally impaired in nuclear export; acts as dominant negative mutant. 1 PublicationCorresponds to variant dbSNP:rs104893909EnsemblClinVar.1
Natural variantiVAR_075801575V → G in GCCR; unknown pathological significance; reduces transactivation activity; enhances transrepression activity; reduces affinity for ligand; delays nuclear translocation; does not exert a dominant negative effect; does not impair DNA binding. 1 Publication1
Natural variantiVAR_004676641D → V in GCCR. 1 PublicationCorresponds to variant dbSNP:rs104893908EnsemblClinVar.1
Natural variantiVAR_077145672L → P in GCCR; loss of dexamethasone-binding, dexamethasone-induced translocation to the nucleus and of transactivation activity. 1 Publication1
Natural variantiVAR_013473679G → S in GCCR; has 50% binding affinity. 1 PublicationCorresponds to variant dbSNP:rs104893914EnsemblClinVar.1
Natural variantiVAR_075802714R → Q in GCCR; unknown pathological significance; reduces transactivation; reduces affinity for ligand; exerts a dominant negative effect; does not impair DNA binding. 1 Publication1
Natural variantiVAR_075803726H → R in GCCR; unknown pathological significance; reduces transactivation and transrepression activity; reduces affinity for ligand; delays nuclear translocation; does not impair DNA binding. 1 Publication1
Natural variantiVAR_004677729V → I in GCCR. 1 PublicationCorresponds to variant dbSNP:rs1027058734Ensembl.1
Natural variantiVAR_071935737F → L in GCCR; reduces transactivation of the glucocorticoid-inducible tumor virus promoter; reduces affinity for ligand; delays its nuclear translocation; acts as dominant negative mutant. 1 PublicationCorresponds to variant dbSNP:rs121909727EnsemblClinVar.1
Natural variantiVAR_015633747I → M in GCCR; alters interaction with NCOA2 and strongly reduces transcription activation; acts as dominant negative mutant. 1 PublicationCorresponds to variant dbSNP:rs104893910EnsemblClinVar.1
Natural variantiVAR_071936773L → P in GCCR; reduces transactivation of the glucocorticoid-inducible tumor virus promoter; reduces affinity for ligand; delays its nuclear translocation; acts as dominant negative mutant. 1 PublicationCorresponds to variant dbSNP:rs104893912EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1M → T: Abolishes expression of A-type isoforms. 2 Publications1
Mutagenesisi27M → T: Abolishes expression of B-type isoforms. 2 Publications1
Mutagenesisi86M → I: Abolishes expression of C-type isoforms; when associated with I-90 and I-98. 1 Publication1
Mutagenesisi90M → I: Abolishes expression of C-type isoforms; when associated with I-86 and I-98. 1 Publication1
Mutagenesisi98M → I: Abolishes expression of C-type isoforms; when associated with I-86 and I-90. 1 Publication1
Mutagenesisi101D → A: Reduces transcription activation activity of isoform Alpha-C3 by half. 1 Publication1
Mutagenesisi101D → K: Reduces transcription activation activity of isoform Alpha-C3 by half. Suppresses apoptosis-inducing activity of isoform Alpha-C3. Impairs recruitment of selected coregulators onto DNA binding sites. 1 Publication1
Mutagenesisi106 – 107QQ → LL: Reduces activity of isoform Alpha-C3 by half. 1 Publication2
Mutagenesisi113 – 114SS → AA: Does not affect the activity of isoform Alpha-C3. 1 Publication2
Mutagenesisi191F → D: Reduces transactivation by the ADA complex. 1 Publication1
Mutagenesisi193I → D: Reduces transactivation by the ADA complex. 1 Publication1
Mutagenesisi194L → A: Strongly reduces transactivation by the ADA complex; when associated with V-224 and F-225. 1 Publication1
Mutagenesisi197L → E: Reduces transactivation by the ADA complex. 1 Publication1
Mutagenesisi211S → A: Reduces expression of target genes IGFBP1 and IRF8. 1 Publication1
Mutagenesisi213W → A: Strongly reduces transactivation by the ADA complex. 1 Publication1
Mutagenesisi224L → V: Strongly reduces transactivation by the ADA complex; when associated with A-194 and F-225. 1 Publication1
Mutagenesisi225L → F: Strongly reduces transactivation by the ADA complex; when associated with A-194 and V-224. 1 Publication1
Mutagenesisi226S → A: Abolishes phosphorylation and enhances transcriptional activation. 1 Publication1
Mutagenesisi235F → L: Strongly reduces transactivation by the ADA complex; when associated with V-236. 1 Publication1
Mutagenesisi236L → V: Strongly reduces transactivation by the ADA complex; when associated with L-235. 1 Publication1
Mutagenesisi277K → R: Strongly reduces sumoylation. Almost complete loss of sumoylation; when associated with R-293. 1 Publication1
Mutagenesisi293K → R: Strongly reduces sumoylation. Almost complete loss of sumoylation; when associated with R-277. 1 Publication1
Mutagenesisi316M → I: Abolishes expression of D-type isoforms; when associated with I-331 and I-336. 1 Publication1
Mutagenesisi331M → I: Abolishes expression of D-type isoforms; when associated with I-316 and I-336. 1 Publication1
Mutagenesisi336M → I: Abolishes expression of D-type isoforms; when associated with I-316 and I-331. 1 Publication1
Mutagenesisi404S → A: Abolishes phosphorylation. Does not affect translocation to the nucleus following ligand stimulation. Increases protein half-life and transcriptional repressor activity. Alters repertoire of regulated genes. Increases cell death. 1 Publication1
Mutagenesisi404S → D: Does not affect translocation to the nucleus following ligand stimulation. 1 Publication1
Mutagenesisi480K → A: Decrease in acetylation and in repression of its transcriptional activity by CLOCK-ARNTL/BMAL1 heterodimer. Complete loss in acetylation and in repression of its transcriptional activity by CLOCK-ARNTL/BMAL1 heterodimer; when associated with A-492; A-494 and A-495. 1 Publication1
Mutagenesisi492K → A: Decrease in acetylation and in repression of its transcriptional activity by CLOCK-ARNTL/BMAL1 heterodimer. Complete loss in acetylation and in repression of its transcriptional activity by CLOCK-ARNTL/BMAL1 heterodimer; when associated with A-480; A-494 and A-495. 1 Publication1
Mutagenesisi494K → A: Decrease in acetylation and in repression of its transcriptional activity by CLOCK-ARNTL/BMAL1 heterodimer; when associated with A-495. Complete loss in acetylation and in repression of its transcriptional activity by CLOCK-ARNTL/BMAL1 heterodimer; when associated with A-480; A-492 and A-495. 1 Publication1
Mutagenesisi495K → A: Decrease in acetylation and in repression of its transcriptional activity by CLOCK-ARNTL/BMAL1 heterodimer; when associated with A-494. Complete loss in acetylation and in repression of its transcriptional activity by CLOCK-ARNTL/BMAL1 heterodimer; when associated with A-480; A-492 and A-494. 1 Publication1
Mutagenesisi585R → A: Reduces activation mediated by ligand binding domain; when associated with A-590. 1 Publication1
Mutagenesisi590D → A: Reduces activation mediated by ligand binding domain; when associated with A-585. 1 Publication1
Mutagenesisi602F → S: Increases solubility. No effect on transactivation by dexamethasone. 1 Publication1
Mutagenesisi625P → A: Decreases transactivation by dexamethasone by 95%. 1 Publication1
Mutagenesisi628I → A: Decreases dimerization and transactivation by dexamethasone; when associated with S-602. 1 Publication1
Mutagenesisi703K → R: Slightly reduces sumoylation. Inhibits the stimulatory effect of RWDD3 on its transcriptional activity. 2 Publications1

Keywords - Diseasei

Disease variant, Pseudohermaphroditism

Organism-specific databases

DisGeNET

More...DisGeNETi		2908

MalaCards human disease database

More...MalaCardsi		NR3C1
MIMi615962, phenotype

Open Targets

More...OpenTargetsi		ENSG00000113580

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		786, Generalized glucocorticoid resistance syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA181

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P04150, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2034

Drug and drug target database

More...DrugBanki		DB00240, Alclometasone
DB04630, Aldosterone
DB00288, Amcinonide
DB00394, Beclomethasone dipropionate
DB00443, Betamethasone
DB14669, Betamethasone phosphate
DB01222, Budesonide
DB01410, Ciclesonide
DB01013, Clobetasol propionate
DB13158, Clobetasone
DB00838, Clocortolone
DB01380, Cortisone acetate
DB13003, Cortivazol
DB11921, Deflazacort
DB01260, Desonide
DB00547, Desoximetasone
DB01234, Dexamethasone
DB14649, Dexamethasone acetate
DB00223, Diflorasone
DB09095, Difluocortolone
DB06781, Difluprednate
DB01395, Drospirenone
DB00687, Fludrocortisone
DB00663, Flumethasone
DB00180, Flunisolide
DB00591, Fluocinolone acetonide
DB01047, Fluocinonide
DB00324, Fluorometholone
DB01185, Fluoxymesterone
DB00846, Flurandrenolide
DB13867, Fluticasone
DB08906, Fluticasone furoate
DB00588, Fluticasone propionate
DB11619, Gestrinone
DB02210, Hexane-1,6-Diol
DB00769, Hydrocortamate
DB00741, Hydrocortisone
DB14538, Hydrocortisone aceponate
DB14539, Hydrocortisone acetate
DB14540, Hydrocortisone butyrate
DB14541, Hydrocortisone cypionate
DB14542, Hydrocortisone phosphate
DB14543, Hydrocortisone probutate
DB14544, Hydrocortisone valerate
DB00367, Levonorgestrel
DB14596, Loteprednol etabonate
DB00253, Medrysone
DB00351, Megestrol acetate
DB00959, Methylprednisolone
DB00834, Mifepristone
DB00764, Mometasone
DB14512, Mometasone furoate
DB00717, Norethisterone
DB12637, Onapristone
DB05423, ORG-34517
DB01384, Paramethasone
DB01130, Prednicarbate
DB00860, Prednisolone
DB15566, Prednisolone acetate
DB14631, Prednisolone phosphate
DB00635, Prednisone
DB00396, Progesterone
DB00896, Rimexolone
DB14583, Segesterone acetate
DB00421, Spironolactone
DB09091, Tixocortol
DB00620, Triamcinolone
DB08867, Ulipristal
DB00596, Ulobetasol

DrugCentral

More...DrugCentrali		P04150

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		625

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NR3C1

Domain mapping of disease mutations (DMDM)

More...DMDMi		121069

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000199371 – 777Glucocorticoid receptorAdd BLAST777

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei8PhosphothreonineCombined sources1
Modified residuei23Omega-N-methylarginineBy similarity1
Modified residuei45PhosphoserineCombined sources1
Modified residuei113PhosphoserineBy similarity1
Modified residuei134PhosphoserineCombined sources1
Modified residuei141PhosphoserineBy similarity1
Modified residuei203PhosphoserineCombined sources3 Publications1
Modified residuei211Phosphoserine3 Publications1
Modified residuei226PhosphoserineCombined sources1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki258Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei267PhosphoserineCombined sources1
Cross-linki277Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate1 Publication
Cross-linki277Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki293Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate1 Publication
Cross-linki293Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei404Phosphoserine; by GSK3-beta1 Publication1
Cross-linki419Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei480N6-acetyllysine1 Publication1
Modified residuei492N6-acetyllysine1 Publication1
Modified residuei494N6-acetyllysine1 Publication1
Modified residuei495N6-acetyllysine1 Publication1
Cross-linki703Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Isoform Alpha-B (identifier: P04150-8)
Modified residuei1N-acetylmethionineCombined sources1
Isoform Beta-B (identifier: P04150-9)
Modified residuei1N-acetylmethionineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylation by CLOCK reduces its binding to glucocorticoid response elements and its transcriptional activity.2 Publications
Increased proteasome-mediated degradation in response to glucocorticoids (PubMed:11555652). Isoform Alpha-B appears to be more susceptible to proteolytic degradation than isoform Alpha (PubMed:11435610).2 Publications
Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoid. The Ser-203, Ser-226 and Ser-404-phosphorylated forms are mainly cytoplasmic, and the Ser-211-phosphorylated form is nuclear (PubMed:12000743, PubMed:18838540). Phosphorylation at Ser-211 increases transcriptional activity (PubMed:12000743, PubMed:18483179). Phosphorylation at Ser-203, Ser-226 and Ser-404 decreases signaling capacity (PubMed:12000743, PubMed:18483179, PubMed:18838540). Phosphorylation at Ser-404 may protect from glucocorticoid-induced apoptosis (PubMed:18838540). Phosphorylation at Ser-203 and Ser-211 is not required in regulation of chromosome segregation (PubMed:25847991). May be dephosphorylated by PPP5C, attenuates NR3C1 action (By similarity).By similarity4 Publications
Sumoylation at Lys-277 and Lys-293 negatively regulates its transcriptional activity (PubMed:12144530). Sumoylation at Lys-703 positively regulates its transcriptional activity in the presence of RWDD3 (By similarity). Sumoylation at Lys-277 and Lys-293 is dispensable whereas sumoylation at Lys-703 is critical for the stimulatory effect of RWDD3 on its transcriptional activity (By similarity). Heat shock increases sumoylation in a RWDD3-dependent manner (By similarity).By similarity1 Publication
Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P04150

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P04150

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P04150

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P04150

PeptideAtlas

More...PeptideAtlasi		P04150

PRoteomics IDEntifications database

More...PRIDEi		P04150

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51657 [P04150-1]
51658 [P04150-10]
51659 [P04150-2]
51660 [P04150-3]
51661 [P04150-5]
51662 [P04150-6]
51663 [P04150-7]
51664 [P04150-8]
51665 [P04150-9]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P04150, 3 sites, 1 O-linked glycan (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P04150

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P04150

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed including bone, stomach, lung, liver, colon, breast, ovary, pancreas and kidney (PubMed:25847991). In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart (PubMed:10902803).2 Publications
Widely expressed including brain, bone marrow, thymus, spleen, liver, kidney, pancreas, lung, fat, skeletal muscle, heart, placenta and blood leukocytes.2 Publications
Widely expressed.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by TNF (at protein level).1 Publication
Induced by TNF and becomes the predominant isoform which may lead to glucocorticoid resistance (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000113580, Expressed in endothelial cell and 261 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P04150, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P04150, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000113580, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B, and FKBP5 or another immunophilin such as PPID, STIP1, or the immunophilin homolog PPP5C (PubMed:21730050). Upon ligand binding FKBP5 dissociates from the complex and FKBP4 takes its place, thereby linking the complex to dynein and mediating transport to the nucleus, where the complex dissociates (By similarity). Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23 (PubMed:29127155). Directly interacts with UNC45A (PubMed:16478993). Binds to DNA as a homodimer, and as heterodimer with NR3C2 or the retinoid X receptor. Binds STAT5A and STAT5B homodimers and heterodimers (By similarity).

Interacts with NRIP1, POU2F1, POU2F2 and TRIM28 (By similarity).

Interacts with several coactivator complexes, including the SMARCA4 complex, CREBBP/EP300, TADA2L (Ada complex) and p160 coactivators such as NCOA2 and NCOA6 (PubMed:10866662, PubMed:12151000, PubMed:12686538, PubMed:9154805, PubMed:9590696). Interaction with BAG1 inhibits transactivation (PubMed:10477749).

Interacts with HEXIM1 and TGFB1I1 (PubMed:12415108, PubMed:15211577, PubMed:15941832).

Interacts with NCOA1 (PubMed:9590696).

Interacts with NCOA3, SMARCA4, SMARCC1, SMARCD1, and SMARCE1 (By similarity).

Interacts with CLOCK, CRY1 and CRY2 in a ligand-dependent fashion (PubMed:19141540, PubMed:21980503, PubMed:22170608).

Interacts with CIART (By similarity).

Interacts with RWDD3 (By similarity).

Interacts with UBE2I/UBC9 and this interaction is enhanced in the presence of RWDD3 (By similarity).

Interacts with GRIP1 (PubMed:15769988, PubMed:17635946).

Interacts with NR4A3 (via nuclear receptor DNA-binding domain), represses transcription activity of NR4A3 on the POMC promoter Nur response element (NurRE) (PubMed:15591535). Directly interacts with PNRC2 to attract and form a complex with UPF1 and DCP1A; the interaction leads to rapid mRNA degradation (PubMed:25775514).

Interacts with GSK3B (PubMed:18838540).

Interacts with FNIP1 and FNIP2 (PubMed:27353360).

Interacts (via C-terminus) with HNRNPU (via C-terminus) (PubMed:9353307).

Interacts with MCM3AP (PubMed:16914116).

Interacts (via domain NR LBD) with HSP90AA1 and HSP90AB1 (By similarity). In the absence of hormonal ligand, interacts with TACC1 (PubMed:20078863).

By similarity23 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109165, 814 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P04150

Database of interacting proteins

More...DIPi		DIP-576N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P04150

Protein interaction database and analysis system

More...IntActi		P04150, 92 interactors

Molecular INTeraction database

More...MINTi		P04150

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000231509

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P04150

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P04150, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1777
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P04150

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P04150

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini524 – 758NR LBDPROSITE-ProRule annotationAdd BLAST235

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 420ModulatingAdd BLAST420
Regioni1 – 23DisorderedSequence analysisAdd BLAST23
Regioni98 – 115Required for high transcriptional activity of isoform Alpha-C31 PublicationAdd BLAST18
Regioni130 – 183DisorderedSequence analysisAdd BLAST54
Regioni394 – 415DisorderedSequence analysisAdd BLAST22
Regioni485 – 777Interaction with CLOCKAdd BLAST293
Regioni487 – 523HingeAdd BLAST37
Regioni532 – 697Interaction with CRY11 PublicationAdd BLAST166

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi130 – 149Polar residuesSequence analysisAdd BLAST20
Compositional biasi166 – 183Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain (PubMed:3841189). The ligand-binding domain is required for correct chromosome segregation during mitosis although ligand binding is not required (PubMed:25847991).2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nuclear hormone receptor family. NR3 subfamily.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri421 – 441NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri457 – 476NR C4-typePROSITE-ProRule annotationAdd BLAST20

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3575, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156385

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_020317_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P04150

Identification of Orthologs from Complete Genome Data

More...OMAi		LSFCFQT

Database for complete collections of gene phylogenies

More...PhylomeDBi		P04150

TreeFam database of animal gene trees

More...TreeFami		TF106510

Family and domain databases

Database of protein disorder

More...DisProti		DP00030

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.565.10, 1 hit
3.30.50.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00014

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001409, Glcrtcd_rcpt
IPR035500, NHR-like_dom_sf
IPR000536, Nucl_hrmn_rcpt_lig-bd
IPR001723, Nuclear_hrmn_rcpt
IPR001628, Znf_hrmn_rcpt
IPR013088, Znf_NHR/GATA

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02155, GCR, 1 hit
PF00104, Hormone_recep, 1 hit
PF00105, zf-C4, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00528, GLCORTICOIDR
PR00398, STRDHORMONER
PR00047, STROIDFINGER

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00430, HOLI, 1 hit
SM00399, ZnF_C4, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48508, SSF48508, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51843, NR_LBD, 1 hit
PS00031, NUCLEAR_REC_DBD_1, 1 hit
PS51030, NUCLEAR_REC_DBD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (16+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 16 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 16 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform Alpha (identifier: P04150-1) [UniParc]FASTAAdd to basket
Also known as: Alpha-A, GR-alphaA

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSKESLTPG REENPSSVLA QERGDVMDFY KTLRGGATVK VSASSPSLAV 
        60         70         80         90        100
ASQSDSKQRR LLVDFPKGSV SNAQQPDLSK AVSLSMGLYM GETETKVMGN 
       110        120        130        140        150
DLGFPQQGQI SLSSGETDLK LLEESIANLN RSTSVPENPK SSASTAVSAA 
       160        170        180        190        200
PTEKEFPKTH SDVSSEQQHL KGQTGTNGGN VKLYTTDQST FDILQDLEFS 
       210        220        230        240        250
SGSPGKETNE SPWRSDLLID ENCLLSPLAG EDDSFLLEGN SNEDCKPLIL 
       260        270        280        290        300
PDTKPKIKDN GDLVLSSPSN VTLPQVKTEK EDFIELCTPG VIKQEKLGTV 
       310        320        330        340        350
YCQASFPGAN IIGNKMSAIS VHGVSTSGGQ MYHYDMNTAS LSQQQDQKPI 
       360        370        380        390        400
FNVIPPIPVG SENWNRCQGS GDDNLTSLGT LNFPGRTVFS NGYSSPSMRP 
       410        420        430        440        450
DVSSPPSSSS TATTGPPPKL CLVCSDEASG CHYGVLTCGS CKVFFKRAVE 
       460        470        480        490        500
GQHNYLCAGR NDCIIDKIRR KNCPACRYRK CLQAGMNLEA RKTKKKIKGI 
       510        520        530        540        550
QQATTGVSQE TSENPGNKTI VPATLPQLTP TLVSLLEVIE PEVLYAGYDS 
       560        570        580        590        600
SVPDSTWRIM TTLNMLGGRQ VIAAVKWAKA IPGFRNLHLD DQMTLLQYSW 
       610        620        630        640        650
MFLMAFALGW RSYRQSSANL LCFAPDLIIN EQRMTLPCMY DQCKHMLYVS 
       660        670        680        690        700
SELHRLQVSY EEYLCMKTLL LLSSVPKDGL KSQELFDEIR MTYIKELGKA 
       710        720        730        740        750
IVKREGNSSQ NWQRFYQLTK LLDSMHEVVE NLLNYCFQTF LDKTMSIEFP 
       760        770 
EMLAEIITNQ IPKYSNGNIK KLLFHQK
Note: Predominant physiological form.1 Publication
Length:777
Mass (Da):85,659
Last modified:November 1, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC5C90C9A5DD16AAB
GO
Isoform Beta (identifier: P04150-2) [UniParc]FASTAAdd to basket
Also known as: Beta-A

The sequence of this isoform differs from the canonical sequence as follows:
     728-777: VVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK → NVMWLKPESTSHTLI

Note: High constitutive expression by neutrophils may provide a mechanism by which these cells escape glucocorticoid-induced cell death and up-regulation by proinflammatory cytokines such as IL8 further enhances their survival in the presence of glucocorticoids during inflammation.1 Publication
Show »
Length:742
Mass (Da):81,509
Checksum:iE2D1F6EA0EE14704
GO
Isoform Alpha-2 (identifier: P04150-3) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     451-451: G → GR

Note: Due to a partial intron retention.Curated
Show »
Length:778
Mass (Da):85,815
Checksum:i23048D99B60B169C
GO
Isoform Beta-2 (identifier: P04150-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     451-451: G → GR
     728-777: VVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK → NVMWLKPESTSHTLI

Note: Due to a partial intron retention.Curated
Show »
Length:743
Mass (Da):81,666
Checksum:i329BE98BCC1DC0E5
GO
Isoform GR-A alpha (identifier: P04150-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     491-674: Missing.

Note: Lacks exons 5, 6 and 7. Found in glucocorticoid-resistant myeloma patients.1 Publication
Show »
Length:593
Mass (Da):64,752
Checksum:i8CB72DE6B0593EFD
GO
Isoform GR-A beta (identifier: P04150-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     491-674: Missing.
     728-777: VVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK → NVMWLKPESTSHTLI

Note: Lacks exons 5, 6 and 7.1 Publication
Show »
Length:558
Mass (Da):60,602
Checksum:i7C1C30CD84689FBE
GO
Isoform GR-P (identifier: P04150-4)
Sequence is not available
Note: Encoded by exons 2-7 plus several basepairs from the subsequent intron region. Lacks the ligand binding domain. Accounts for up to 10-20% of mRNAs.1 Publication
Length:–
Mass (Da):–
Isoform Alpha-B (identifier: P04150-8) [UniParc]FASTAAdd to basket
Also known as: GR-alphaB

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: Missing.

Note: Produced by alternative initiation at Met-27 of isoform Alpha.Curated
Show »
Length:751
Mass (Da):82,845
Checksum:iC6D7A2D88B4025C1
GO
Isoform Beta-B (identifier: P04150-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: Missing.
     728-777: VVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK → NVMWLKPESTSHTLI

Note: Produced by alternative initiation at Met-27 of isoform Beta.Curated1 Publication
Show »
Length:716
Mass (Da):78,695
Checksum:iBCF1D97EFD06AB74
GO
Isoform 10 (identifier: P04150-10) [UniParc]FASTAAdd to basket
Also known as: hGRDelta313-338

The sequence of this isoform differs from the canonical sequence as follows:
     313-338: Missing.

Show »
Length:751
Mass (Da):82,904
Checksum:i39C4B6A962632545
GO
Isoform Alpha-C1 (identifier: P04150-11) [UniParc]FASTAAdd to basket
Also known as: GR-alphaC1

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Note: Produced by alternative initiation at Met-86 of isoform Alpha.1 Publication
Show »
Length:692
Mass (Da):76,650
Checksum:iF73B43BE6F312683
GO
Isoform Alpha-C2 (identifier: P04150-12) [UniParc]FASTAAdd to basket
Also known as: GR-alphaC2

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.

Note: Produced by alternative initiation at Met-90 of isoform Alpha.1 Publication
Show »
Length:688
Mass (Da):76,186
Checksum:i7A51C90C4FAC4A95
GO
Isoform Alpha-C3 (identifier: P04150-13) [UniParc]FASTAAdd to basket
Also known as: GR-alphaC3

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.

Note: Produced by alternative initiation at Met-98 of isoform Alpha.1 Publication
Show »
Length:680
Mass (Da):75,310
Checksum:iF56474496CCAB832
GO
Isoform Alpha-D1 (identifier: P04150-14) [UniParc]FASTAAdd to basket
Also known as: GR-alphaD1

The sequence of this isoform differs from the canonical sequence as follows:
     1-315: Missing.

Note: Produced by alternative initiation at Met-316 of isoform Alpha.1 Publication
Show »
Length:462
Mass (Da):51,912
Checksum:i25B86AA2128DA764
GO
Isoform Alpha-D2 (identifier: P04150-15) [UniParc]FASTAAdd to basket
Also known as: GR-alphaD2

The sequence of this isoform differs from the canonical sequence as follows:
     1-330: Missing.

Note: Produced by alternative initiation at Met-331 of isoform Alpha.1 Publication
Show »
Length:447
Mass (Da):50,512
Checksum:i5FD4D80AFE4572D1
GO
Isoform Alpha-D3 (identifier: P04150-16) [UniParc]FASTAAdd to basket
Also known as: GR-alphaD3

The sequence of this isoform differs from the canonical sequence as follows:
     1-335: Missing.

Note: Produced by alternative initiation at Met-336 of isoform Alpha.1 Publication
Show »
Length:442
Mass (Da):49,802
Checksum:iFE52994682DE7E41
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A494C0P1A0A494C0P1_HUMAN
Glucocorticoid receptor
NR3C1
746Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3MSN4Q3MSN4_HUMAN
Glucocorticoid receptor
NR3C1
145Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDA9D6RDA9_HUMAN
Glucocorticoid receptor
NR3C1
144Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti399R → G in BAD97314 (Ref. 7) Curated1
Sequence conflicti754A → T in BAD97314 (Ref. 7) Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Carriers of the 22-Glu-Lys-23 allele are relatively more resistant to the effects of GCs with respect to the sensitivity of the adrenal feedback mechanism than non-carriers, resulting in a better metabolic health profile. Carriers have a better survival than non-carriers, as well as lower serum CRP levels. The 22-Glu-Lys-23 polymorphism is associated with a sex-specific, beneficial body composition at young-adult age, as well as greater muscle strength in males.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01414023R → K Reduces transactivation activity; does not affect transrepression activity. 8 PublicationsCorresponds to variant dbSNP:rs6190EnsemblClinVar.1
Natural variantiVAR_01562829F → L1 PublicationCorresponds to variant dbSNP:rs148102613Ensembl.1
Natural variantiVAR_01462265F → V2 PublicationsCorresponds to variant dbSNP:rs6192EnsemblClinVar.1
Natural variantiVAR_07579772N → D Variant of uncertain significance; associated in cis with A-321 and S-766 in one individual; doubles transactivation potential. 1 Publication1
Natural variantiVAR_015629112L → F1 PublicationCorresponds to variant dbSNP:rs542110718Ensembl.1
Natural variantiVAR_015630233D → N1 PublicationCorresponds to variant dbSNP:rs1241576112Ensembl.1
Natural variantiVAR_075798321V → A Variant of uncertain significance; associated in cis with D-72 and S-766 in one individual; doubles transactivation potential. 1 Publication1
Natural variantiVAR_004675363N → S Enhances transactivation activity; does not affect transrepression activity; may increase sensitivity to exogenously administered glucocorticoids; may contribute to central obesity in men and show lack of association with other risk factors for coronary heart disease and diabetes mellitus. 6 PublicationsCorresponds to variant dbSNP:rs56149945EnsemblClinVar.1
Natural variantiVAR_015631421C → Y1 Publication1
Natural variantiVAR_075799423V → A in GCCR; unknown pathological significance; reduces transactivation activity; delays nuclear translocation; does not exert a dominant negative effect; impairs DNA binding. 1 Publication1
Natural variantiVAR_013472477R → H in GCCR. 1 PublicationCorresponds to variant dbSNP:rs104893913EnsemblClinVar.1
Natural variantiVAR_077143477R → S in GCCR; loss of DNA-binding and of transactivation activity; incomplete dexamethasone-induced translocation to the nucleus; no effect on dexamethasone-binding affinity compared with wild-type. 1 Publication1
Natural variantiVAR_077144478Y → C in GCCR; decreased DNA-binding and transactivation activity; incomplete dexamethasone-induced translocation to the nucleus; no effect on dexamethasone-binding affinity compared with wild-type. 1 Publication1
Natural variantiVAR_075800556T → I in GCCR; reduces transactivation activity; enhances transrepression activity; reduces affinity for ligand; delays nuclear translocation; does not exert a dominant negative effect; does not impair DNA binding. 2 Publications1
Natural variantiVAR_015632559I → N in GCCR; interferes with translocation to the nucleus and thereby strongly reduces transcription activation; is equally impaired in nuclear export; acts as dominant negative mutant. 1 PublicationCorresponds to variant dbSNP:rs104893909EnsemblClinVar.1
Natural variantiVAR_025014571V → A in pseudohermaphroditism; female with hypokalemia due to glucocorticoid resistance; 6-fold reduction in binding affinity compared with the wild-type receptor. 1 PublicationCorresponds to variant dbSNP:rs104893911EnsemblClinVar.1
Natural variantiVAR_075801575V → G in GCCR; unknown pathological significance; reduces transactivation activity; enhances transrepression activity; reduces affinity for ligand; delays nuclear translocation; does not exert a dominant negative effect; does not impair DNA binding. 1 Publication1
Natural variantiVAR_004676641D → V in GCCR. 1 PublicationCorresponds to variant dbSNP:rs104893908EnsemblClinVar.1
Natural variantiVAR_077145672L → P in GCCR; loss of dexamethasone-binding, dexamethasone-induced translocation to the nucleus and of transactivation activity. 1 Publication1
Natural variantiVAR_013473679G → S in GCCR; has 50% binding affinity. 1 PublicationCorresponds to variant dbSNP:rs104893914EnsemblClinVar.1
Natural variantiVAR_075802714R → Q in GCCR; unknown pathological significance; reduces transactivation; reduces affinity for ligand; exerts a dominant negative effect; does not impair DNA binding. 1 Publication1
Natural variantiVAR_075803726H → R in GCCR; unknown pathological significance; reduces transactivation and transrepression activity; reduces affinity for ligand; delays nuclear translocation; does not impair DNA binding. 1 Publication1
Natural variantiVAR_004677729V → I in GCCR. 1 PublicationCorresponds to variant dbSNP:rs1027058734Ensembl.1
Natural variantiVAR_071935737F → L in GCCR; reduces transactivation of the glucocorticoid-inducible tumor virus promoter; reduces affinity for ligand; delays its nuclear translocation; acts as dominant negative mutant. 1 PublicationCorresponds to variant dbSNP:rs121909727EnsemblClinVar.1
Natural variantiVAR_015633747I → M in GCCR; alters interaction with NCOA2 and strongly reduces transcription activation; acts as dominant negative mutant. 1 PublicationCorresponds to variant dbSNP:rs104893910EnsemblClinVar.1
Natural variantiVAR_004678753L → F2 PublicationsCorresponds to variant dbSNP:rs121909726EnsemblClinVar.1
Natural variantiVAR_075804766N → S Variant of uncertain significance; associated in cis with D-72 and A-321 in one individual; doubles transactivation potential. 1 Publication1
Natural variantiVAR_071936773L → P in GCCR; reduces transactivation of the glucocorticoid-inducible tumor virus promoter; reduces affinity for ligand; delays its nuclear translocation; acts as dominant negative mutant. 1 PublicationCorresponds to variant dbSNP:rs104893912EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0583121 – 335Missing in isoform Alpha-D3. 1 PublicationAdd BLAST335
Alternative sequenceiVSP_0583131 – 330Missing in isoform Alpha-D2. 1 PublicationAdd BLAST330
Alternative sequenceiVSP_0583141 – 315Missing in isoform Alpha-D1. 1 PublicationAdd BLAST315
Alternative sequenceiVSP_0583151 – 97Missing in isoform Alpha-C3. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_0583161 – 89Missing in isoform Alpha-C2. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_0583171 – 85Missing in isoform Alpha-C1. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_0187731 – 26Missing in isoform Alpha-B and isoform Beta-B. CuratedAdd BLAST26
Alternative sequenceiVSP_043908313 – 338Missing in isoform 10. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_007363451G → GR in isoform Alpha-2 and isoform Beta-2. 1 Publication1
Alternative sequenceiVSP_013340491 – 674Missing in isoform GR-A alpha and isoform GR-A beta. CuratedAdd BLAST184
Alternative sequenceiVSP_003703728 – 777VVENL…LFHQK → NVMWLKPESTSHTLI in isoform Beta, isoform Beta-B, isoform Beta-2 and isoform GR-A beta. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X03225 mRNA Translation: CAA26976.1
X03348 mRNA Translation: CAA27054.1
AH005496 Genomic DNA Translation: AAB64353.1
AH005496 Genomic DNA Translation: AAB64354.1
HQ205546 Genomic DNA Translation: ADP91135.1
HQ205547 Genomic DNA Translation: ADP91138.1
HQ205548 Genomic DNA Translation: ADP91141.1
HQ205549 Genomic DNA Translation: ADP91144.1
HQ205550 Genomic DNA Translation: ADP91147.1
HQ205551 Genomic DNA Translation: ADP91150.1
HQ205552 Genomic DNA Translation: ADP91153.1
HQ205553 Genomic DNA Translation: ADP91156.1
HQ205554 Genomic DNA Translation: ADP91159.1
HQ205555 Genomic DNA Translation: ADP91162.1
HQ205556 Genomic DNA Translation: ADP91165.1
HQ205557 Genomic DNA Translation: ADP91168.1
HQ205558 Genomic DNA Translation: ADP91171.1
HQ205559 Genomic DNA Translation: ADP91174.1
HQ205560 Genomic DNA Translation: ADP91177.1
HQ205561 Genomic DNA Translation: ADP91180.1
HQ205562 Genomic DNA Translation: ADP91183.1
HQ205563 Genomic DNA Translation: ADP91186.1
HQ205564 Genomic DNA Translation: ADP91189.1
HQ205565 Genomic DNA Translation: ADP91192.1
HQ205566 Genomic DNA Translation: ADP91195.1
HQ205567 Genomic DNA Translation: ADP91198.1
HQ205568 Genomic DNA Translation: ADP91201.1
HQ205569 Genomic DNA Translation: ADP91204.1
HQ205570 Genomic DNA Translation: ADP91207.1
HQ205571 Genomic DNA Translation: ADP91210.1
HQ205572 Genomic DNA Translation: ADP91213.1
HQ205573 Genomic DNA Translation: ADP91216.1
HQ205574 Genomic DNA Translation: ADP91219.1
HQ205575 Genomic DNA Translation: ADP91222.1
HQ205576 Genomic DNA Translation: ADP91225.1
HQ205577 Genomic DNA Translation: ADP91228.1
HQ205578 Genomic DNA Translation: ADP91231.1
HQ205579 Genomic DNA Translation: ADP91234.1
HQ205580 Genomic DNA Translation: ADP91237.1
HQ205581 Genomic DNA Translation: ADP91240.1
HQ205582 Genomic DNA Translation: ADP91243.1
HQ205583 Genomic DNA Translation: ADP91246.1
HQ205584 Genomic DNA Translation: ADP91249.1
HQ205585 Genomic DNA Translation: ADP91252.1
AM183262 mRNA Translation: CAJ65924.1
HQ450643 mRNA Translation: AED99114.1
U01351 mRNA Translation: AAA16603.1
AK223594 mRNA Translation: BAD97314.1
BX640610 mRNA Translation: CAE45716.1
AY436590 Genomic DNA Translation: AAQ97180.1
EU332858 Genomic DNA Translation: ABY87547.1
AC005601 Genomic DNA Translation: AAC34207.1
AC004782 Genomic DNA No translation available.
AC091925 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61872.1
CH471062 Genomic DNA Translation: EAW61873.1
BC015610 mRNA Translation: AAH15610.1
M69104 Genomic DNA Translation: AAA88049.1
AH002750 Genomic DNA Translation: AAA53151.1
S68378 Genomic DNA Translation: AAB20466.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34258.1 [P04150-3]
CCDS4278.1 [P04150-1]
CCDS47298.1 [P04150-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A93370, QRHUGA
B93370, QRHUGB

NCBI Reference Sequences

More...RefSeqi		NP_000167.1, NM_000176.2 [P04150-1]
NP_001018084.1, NM_001018074.1 [P04150-1]
NP_001018085.1, NM_001018075.1 [P04150-1]
NP_001018086.1, NM_001018076.1 [P04150-1]
NP_001018087.1, NM_001018077.1 [P04150-1]
NP_001018661.1, NM_001020825.1 [P04150-2]
NP_001019265.1, NM_001024094.1 [P04150-3]
NP_001191187.1, NM_001204258.1 [P04150-8]
NP_001191188.1, NM_001204259.1 [P04150-11]
NP_001191189.1, NM_001204260.1 [P04150-12]
NP_001191190.1, NM_001204261.1 [P04150-13]
NP_001191191.1, NM_001204262.1 [P04150-14]
NP_001191192.1, NM_001204263.1 [P04150-15]
NP_001191193.1, NM_001204264.1 [P04150-16]
XP_005268476.1, XM_005268419.3
XP_005268477.1, XM_005268420.4
XP_005268479.1, XM_005268422.3 [P04150-3]
XP_005268480.1, XM_005268423.3 [P04150-3]
XP_016864886.1, XM_017009397.1
XP_016864887.1, XM_017009398.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000231509; ENSP00000231509; ENSG00000113580 [P04150-3]
ENST00000343796; ENSP00000343205; ENSG00000113580 [P04150-1]
ENST00000394464; ENSP00000377977; ENSG00000113580 [P04150-1]
ENST00000394466; ENSP00000377979; ENSG00000113580 [P04150-3]
ENST00000415690; ENSP00000387672; ENSG00000113580 [P04150-2]
ENST00000424646; ENSP00000405282; ENSG00000113580 [P04150-10]
ENST00000503201; ENSP00000427672; ENSG00000113580 [P04150-1]
ENST00000504572; ENSP00000422518; ENSG00000113580 [P04150-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2908

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2908

UCSC genome browser

More...UCSCi		uc003lmy.4, human [P04150-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
Wikipedia

Glucocorticoid receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03225 mRNA Translation: CAA26976.1
X03348 mRNA Translation: CAA27054.1
AH005496 Genomic DNA Translation: AAB64353.1
AH005496 Genomic DNA Translation: AAB64354.1
HQ205546 Genomic DNA Translation: ADP91135.1
HQ205547 Genomic DNA Translation: ADP91138.1
HQ205548 Genomic DNA Translation: ADP91141.1
HQ205549 Genomic DNA Translation: ADP91144.1
HQ205550 Genomic DNA Translation: ADP91147.1
HQ205551 Genomic DNA Translation: ADP91150.1
HQ205552 Genomic DNA Translation: ADP91153.1
HQ205553 Genomic DNA Translation: ADP91156.1
HQ205554 Genomic DNA Translation: ADP91159.1
HQ205555 Genomic DNA Translation: ADP91162.1
HQ205556 Genomic DNA Translation: ADP91165.1
HQ205557 Genomic DNA Translation: ADP91168.1
HQ205558 Genomic DNA Translation: ADP91171.1
HQ205559 Genomic DNA Translation: ADP91174.1
HQ205560 Genomic DNA Translation: ADP91177.1
HQ205561 Genomic DNA Translation: ADP91180.1
HQ205562 Genomic DNA Translation: ADP91183.1
HQ205563 Genomic DNA Translation: ADP91186.1
HQ205564 Genomic DNA Translation: ADP91189.1
HQ205565 Genomic DNA Translation: ADP91192.1
HQ205566 Genomic DNA Translation: ADP91195.1
HQ205567 Genomic DNA Translation: ADP91198.1
HQ205568 Genomic DNA Translation: ADP91201.1
HQ205569 Genomic DNA Translation: ADP91204.1
HQ205570 Genomic DNA Translation: ADP91207.1
HQ205571 Genomic DNA Translation: ADP91210.1
HQ205572 Genomic DNA Translation: ADP91213.1
HQ205573 Genomic DNA Translation: ADP91216.1
HQ205574 Genomic DNA Translation: ADP91219.1
HQ205575 Genomic DNA Translation: ADP91222.1
HQ205576 Genomic DNA Translation: ADP91225.1
HQ205577 Genomic DNA Translation: ADP91228.1
HQ205578 Genomic DNA Translation: ADP91231.1
HQ205579 Genomic DNA Translation: ADP91234.1
HQ205580 Genomic DNA Translation: ADP91237.1
HQ205581 Genomic DNA Translation: ADP91240.1
HQ205582 Genomic DNA Translation: ADP91243.1
HQ205583 Genomic DNA Translation: ADP91246.1
HQ205584 Genomic DNA Translation: ADP91249.1
HQ205585 Genomic DNA Translation: ADP91252.1
AM183262 mRNA Translation: CAJ65924.1
HQ450643 mRNA Translation: AED99114.1
U01351 mRNA Translation: AAA16603.1
AK223594 mRNA Translation: BAD97314.1
BX640610 mRNA Translation: CAE45716.1
AY436590 Genomic DNA Translation: AAQ97180.1
EU332858 Genomic DNA Translation: ABY87547.1
AC005601 Genomic DNA Translation: AAC34207.1
AC004782 Genomic DNA No translation available.
AC091925 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61872.1
CH471062 Genomic DNA Translation: EAW61873.1
BC015610 mRNA Translation: AAH15610.1
M69104 Genomic DNA Translation: AAA88049.1
AH002750 Genomic DNA Translation: AAA53151.1
S68378 Genomic DNA Translation: AAB20466.1
CCDSiCCDS34258.1 [P04150-3]
CCDS4278.1 [P04150-1]
CCDS47298.1 [P04150-2]
PIRiA93370, QRHUGA
B93370, QRHUGB
RefSeqiNP_000167.1, NM_000176.2 [P04150-1]
NP_001018084.1, NM_001018074.1 [P04150-1]
NP_001018085.1, NM_001018075.1 [P04150-1]
NP_001018086.1, NM_001018076.1 [P04150-1]
NP_001018087.1, NM_001018077.1 [P04150-1]
NP_001018661.1, NM_001020825.1 [P04150-2]
NP_001019265.1, NM_001024094.1 [P04150-3]
NP_001191187.1, NM_001204258.1 [P04150-8]
NP_001191188.1, NM_001204259.1 [P04150-11]
NP_001191189.1, NM_001204260.1 [P04150-12]
NP_001191190.1, NM_001204261.1 [P04150-13]
NP_001191191.1, NM_001204262.1 [P04150-14]
NP_001191192.1, NM_001204263.1 [P04150-15]
NP_001191193.1, NM_001204264.1 [P04150-16]
XP_005268476.1, XM_005268419.3
XP_005268477.1, XM_005268420.4
XP_005268479.1, XM_005268422.3 [P04150-3]
XP_005268480.1, XM_005268423.3 [P04150-3]
XP_016864886.1, XM_017009397.1
XP_016864887.1, XM_017009398.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M2ZX-ray2.50A/D521-777[»]
1NHZX-ray2.30A500-777[»]
1P93X-ray2.70A/B/C/D500-777[»]
3BQDX-ray2.50A525-777[»]
3CLDX-ray2.84A/B521-777[»]
3E7CX-ray2.15A/B521-777[»]
3H52X-ray2.80A/B/C/D528-777[»]
3K22X-ray2.10A/B521-777[»]
3K23X-ray3.00A/B/C521-777[»]
4CSJX-ray2.30A500-777[»]
4HN5X-ray1.90A/B417-506[»]
4HN6X-ray2.55A/B417-506[»]
4LSJX-ray2.35A522-777[»]
4MDDX-ray2.40A/B522-777[»]
4P6WX-ray1.95A526-777[»]
4P6XX-ray2.50A/C/E/G/I/K523-777[»]
4UDCX-ray2.50A500-777[»]
4UDDX-ray1.80A500-777[»]
5CBXX-ray2.00A/B/E/F415-495[»]
5CBYX-ray2.00A/B415-495[»]
5CBZX-ray2.20A/B/E/F419-495[»]
5CC1X-ray2.30A/B/W/X417-506[»]
5E69X-ray1.85A/B417-506[»]
5E6AX-ray2.20A/B417-506[»]
5E6BX-ray2.25A/B417-506[»]
5E6CX-ray2.20A/B417-506[»]
5E6DX-ray2.40A/B417-506[»]
5EMCX-ray2.30A/B411-500[»]
5EMPX-ray2.30A/B411-500[»]
5EMQX-ray2.30A/B411-500[»]
5G3JX-ray2.40A500-777[»]
5G5WX-ray2.20A500-777[»]
5NFPX-ray2.10A500-777[»]
5NFTX-ray2.30A500-777[»]
5UC3X-ray2.01A/B522-777[»]
5VA0X-ray2.29A/B419-490[»]
5VA7X-ray2.15A/B419-488[»]
6BQUX-ray2.50A/B421-490[»]
6CFNX-ray2.50A/B/C/D/E/F/G/H418-506[»]
6DXKX-ray3.05A/B522-777[»]
6EL6X-ray2.40A500-777[»]
6EL7X-ray2.18A500-777[»]
6EL9X-ray2.19A500-777[»]
SMRiP04150
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109165, 814 interactors
CORUMiP04150
DIPiDIP-576N
ELMiP04150
IntActiP04150, 92 interactors
MINTiP04150
STRINGi9606.ENSP00000231509

Chemistry databases

BindingDBiP04150
ChEMBLiCHEMBL2034
DrugBankiDB00240, Alclometasone
DB04630, Aldosterone
DB00288, Amcinonide
DB00394, Beclomethasone dipropionate
DB00443, Betamethasone
DB14669, Betamethasone phosphate
DB01222, Budesonide
DB01410, Ciclesonide
DB01013, Clobetasol propionate
DB13158, Clobetasone
DB00838, Clocortolone
DB01380, Cortisone acetate
DB13003, Cortivazol
DB11921, Deflazacort
DB01260, Desonide
DB00547, Desoximetasone
DB01234, Dexamethasone
DB14649, Dexamethasone acetate
DB00223, Diflorasone
DB09095, Difluocortolone
DB06781, Difluprednate
DB01395, Drospirenone
DB00687, Fludrocortisone
DB00663, Flumethasone
DB00180, Flunisolide
DB00591, Fluocinolone acetonide
DB01047, Fluocinonide
DB00324, Fluorometholone
DB01185, Fluoxymesterone
DB00846, Flurandrenolide
DB13867, Fluticasone
DB08906, Fluticasone furoate
DB00588, Fluticasone propionate
DB11619, Gestrinone
DB02210, Hexane-1,6-Diol
DB00769, Hydrocortamate
DB00741, Hydrocortisone
DB14538, Hydrocortisone aceponate
DB14539, Hydrocortisone acetate
DB14540, Hydrocortisone butyrate
DB14541, Hydrocortisone cypionate
DB14542, Hydrocortisone phosphate
DB14543, Hydrocortisone probutate
DB14544, Hydrocortisone valerate
DB00367, Levonorgestrel
DB14596, Loteprednol etabonate
DB00253, Medrysone
DB00351, Megestrol acetate
DB00959, Methylprednisolone
DB00834, Mifepristone
DB00764, Mometasone
DB14512, Mometasone furoate
DB00717, Norethisterone
DB12637, Onapristone
DB05423, ORG-34517
DB01384, Paramethasone
DB01130, Prednicarbate
DB00860, Prednisolone
DB15566, Prednisolone acetate
DB14631, Prednisolone phosphate
DB00635, Prednisone
DB00396, Progesterone
DB00896, Rimexolone
DB14583, Segesterone acetate
DB00421, Spironolactone
DB09091, Tixocortol
DB00620, Triamcinolone