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Entry version 192 (16 Oct 2019)
Sequence version 1 (01 Nov 1986)
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Protein

Granulocyte-macrophage colony-stimulating factor

Gene

CSF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine, Growth factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6783783 Interleukin-10 signaling
R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
R-HSA-912526 Interleukin receptor SHC signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P04141

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P04141

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Granulocyte-macrophage colony-stimulating factor
Short name:
GM-CSF
Alternative name(s):
Colony-stimulating factor
Short name:
CSF
Molgramostin
Sargramostim
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CSF2
Synonyms:GMCSF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2434 CSF2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
138960 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P04141

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a protein as a pharmaceutical drug. It indicates the name of the drug, the name of the firm that commercializes it and explains in a few words in which context the drug is used. In some cases, drugs that are under development are also described.<p><a href='/help/pharmaceutical_use' target='_top'>More...</a></p>Pharmaceutical usei

Available under the names Leukine (Immunex) and Leucomax (Novartis). Used in myeloid reconstitution following bone marrow transplant, bone marrow transplant engraftment failure or delay, mobilization and following transplantation of autologous peripheral blood progenitor cells, and following induction chemotherapy in older adults with acute myelogenous leukemia.

Organism-specific databases

DisGeNET

More...
DisGeNETi
1437

Open Targets

More...
OpenTargetsi
ENSG00000164400

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26937

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P04141

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3712955

Drug and drug target database

More...
DrugBanki
DB05194 KB002

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CSF2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
117561

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Add BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000586518 – 144Granulocyte-macrophage colony-stimulating factorAdd BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi22O-linked (GalNAc...) serine1 Publication1
Glycosylationi24O-linked (GalNAc...) serine1 Publication1
Glycosylationi26O-linked (GalNAc...) serine1 Publication1
Glycosylationi27O-linked (GalNAc...) threonine; partial1 Publication1
Glycosylationi44N-linked (GlcNAc...) asparagine1
Glycosylationi54N-linked (GlcNAc...) asparagine1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi71 ↔ 113Combined sources2 Publications
Disulfide bondi105 ↔ 138Combined sources2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P04141

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P04141

PeptideAtlas

More...
PeptideAtlasi
P04141

PRoteomics IDEntifications database

More...
PRIDEi
P04141

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
51656

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P04141

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P04141

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P04141

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164400 Expressed in 27 organ(s), highest expression level in upper lobe of left lung

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P04141 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA057404
HPA062006

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107824, 11 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P04141

Database of interacting proteins

More...
DIPi
DIP-386N

Protein interaction database and analysis system

More...
IntActi
P04141, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000296871

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P04141

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1144
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P04141

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P04141

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GM-CSF family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JBQ7 Eukaryota
ENOG411164J LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013425

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000037940

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P04141

KEGG Orthology (KO)

More...
KOi
K05427

Identification of Orthologs from Complete Genome Data

More...
OMAi
VTRPWKH

Database of Orthologous Groups

More...
OrthoDBi
1412355at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P04141

TreeFam database of animal gene trees

More...
TreeFami
TF338611

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00040 CSF2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000773 GM_colony-stim-fac

The PANTHER Classification System

More...
PANTHERi
PTHR10059 PTHR10059, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01109 GM_CSF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00693 GMCSFACTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00040 CSF2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47266 SSF47266, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00702 GM_CSF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P04141-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWLQSLLLLG TVACSISAPA RSPSPSTQPW EHVNAIQEAR RLLNLSRDTA
60 70 80 90 100
AEMNETVEVI SEMFDLQEPT CLQTRLELYK QGLRGSLTKL KGPLTMMASH
110 120 130 140
YKQHCPPTPE TSCATQIITF ESFKENLKDF LLVIPFDCWE PVQE
Length:144
Mass (Da):16,295
Last modified:November 1, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i75D1E50506BCA7A8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti96M → K in AAM44054 (Ref. 9) Curated1
Sequence conflicti123F → L in AAM44054 (Ref. 9) Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Variant Ile-117 may be a risk factor for atopic asthma.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_013089115T → I1 PublicationCorresponds to variant dbSNP:rs2069640Ensembl.1
Natural variantiVAR_001975117I → T3 PublicationsCorresponds to variant dbSNP:rs25882Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M13207 Genomic DNA Translation: AAA98768.1
M11734 mRNA Translation: AAA52122.1
M11220 mRNA Translation: AAA52578.1
X03021 Genomic DNA Translation: CAA26822.1
M10663 mRNA Translation: AAA52121.1
AF373868 Genomic DNA Translation: AAK51563.1
AC004511 Genomic DNA Translation: AAC08707.1
BC108724 mRNA Translation: AAI08725.1
BC113924 mRNA Translation: AAI13925.1
BC113999 mRNA Translation: AAI14000.1
AF510855 mRNA Translation: AAM44054.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4150.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C24636 FQHUGM

NCBI Reference Sequences

More...
RefSeqi
NP_000749.2, NM_000758.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000296871; ENSP00000296871; ENSG00000164400

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1437

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1437

UCSC genome browser

More...
UCSCi
uc003kwf.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Leukine

Clinical information on Leukine

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13207 Genomic DNA Translation: AAA98768.1
M11734 mRNA Translation: AAA52122.1
M11220 mRNA Translation: AAA52578.1
X03021 Genomic DNA Translation: CAA26822.1
M10663 mRNA Translation: AAA52121.1
AF373868 Genomic DNA Translation: AAK51563.1
AC004511 Genomic DNA Translation: AAC08707.1
BC108724 mRNA Translation: AAI08725.1
BC113924 mRNA Translation: AAI13925.1
BC113999 mRNA Translation: AAI14000.1
AF510855 mRNA Translation: AAM44054.1
CCDSiCCDS4150.1
PIRiC24636 FQHUGM
RefSeqiNP_000749.2, NM_000758.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CSGX-ray2.70A/B18-144[»]
2GMFX-ray2.40A/B18-144[»]
4NKQX-ray3.30C18-144[»]
4RS1X-ray2.68A31-142[»]
5C7XX-ray2.95A/B18-144[»]
5D70X-ray2.06A18-144[»]
5D71X-ray2.25A1-127[»]
5D72X-ray2.60A/B1-127[»]
6BFQX-ray2.60G/I/J/K18-144[»]
6BFSX-ray2.00C18-144[»]
SMRiP04141
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi107824, 11 interactors
CORUMiP04141
DIPiDIP-386N
IntActiP04141, 3 interactors
STRINGi9606.ENSP00000296871

Chemistry databases

BindingDBiP04141
ChEMBLiCHEMBL3712955
DrugBankiDB05194 KB002

PTM databases

iPTMnetiP04141
PhosphoSitePlusiP04141

Polymorphism and mutation databases

BioMutaiCSF2
DMDMi117561

Proteomic databases

MassIVEiP04141
PaxDbiP04141
PeptideAtlasiP04141
PRIDEiP04141
ProteomicsDBi51656

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P04141

Genome annotation databases

EnsembliENST00000296871; ENSP00000296871; ENSG00000164400
GeneIDi1437
KEGGihsa:1437
UCSCiuc003kwf.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1437
DisGeNETi1437

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CSF2
HGNCiHGNC:2434 CSF2
HPAiHPA057404
HPA062006
MIMi138960 gene
neXtProtiNX_P04141
OpenTargetsiENSG00000164400
PharmGKBiPA26937

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JBQ7 Eukaryota
ENOG411164J LUCA
GeneTreeiENSGT00390000013425
HOGENOMiHOG000037940
InParanoidiP04141
KOiK05427
OMAiVTRPWKH
OrthoDBi1412355at2759
PhylomeDBiP04141
TreeFamiTF338611

Enzyme and pathway databases

ReactomeiR-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6783783 Interleukin-10 signaling
R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
R-HSA-912526 Interleukin receptor SHC signaling
SignaLinkiP04141
SIGNORiP04141

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CSF2 human
EvolutionaryTraceiP04141

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Granulocyte_macrophage_colony-stimulating_factor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1437
PharosiP04141
PMAP-CutDBiP04141

Protein Ontology

More...
PROi
PR:P04141

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164400 Expressed in 27 organ(s), highest expression level in upper lobe of left lung
GenevisibleiP04141 HS

Family and domain databases

CDDicd00040 CSF2, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000773 GM_colony-stim-fac
PANTHERiPTHR10059 PTHR10059, 1 hit
PfamiView protein in Pfam
PF01109 GM_CSF, 1 hit
PRINTSiPR00693 GMCSFACTOR
SMARTiView protein in SMART
SM00040 CSF2, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00702 GM_CSF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSF2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P04141
Secondary accession number(s): Q14CE8, Q2VPI8, Q8NFI6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: November 1, 1986
Last modified: October 16, 2019
This is version 192 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Pharmaceutical, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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