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Protein

Type-1 fimbrial protein, A chain

Gene

fimA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, enable bacteria to colonize the epithelium of specific host organs.

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

  • cell adhesion Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:EG10308-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1 fimbrial protein, A chain
Alternative name(s):
Type-1A pilin
Gene namesi
Name:fimA
Synonyms:pilA
Ordered Locus Names:b4314, JW4277
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10308 fimA

Subcellular locationi

GO - Cellular componenti

  • pilus Source: UniProtKB-SubCell

Keywords - Cellular componenti

Fimbrium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Add BLAST23
ChainiPRO_000000917024 – 182Type-1 fimbrial protein, A chainAdd BLAST159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 84Curated

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP04128
PRIDEiP04128

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-15697528,EBI-15697528

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi4262746, 9 interactors
DIPiDIP-9609N
IntActiP04128, 2 interactors
STRINGi316407.85677057

Structurei

Secondary structure

1182
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 32Combined sources4
Beta strandi45 – 51Combined sources7
Beta strandi54 – 56Combined sources3
Turni62 – 64Combined sources3
Beta strandi67 – 71Combined sources5
Beta strandi75 – 84Combined sources10
Helixi86 – 90Combined sources5
Beta strandi93 – 97Combined sources5
Beta strandi100 – 102Combined sources3
Helixi103 – 105Combined sources3
Turni115 – 117Combined sources3
Beta strandi120 – 127Combined sources8
Beta strandi131 – 134Combined sources4
Beta strandi136 – 138Combined sources3
Helixi148 – 150Combined sources3
Beta strandi152 – 167Combined sources16
Beta strandi173 – 180Combined sources8

3D structure databases

ProteinModelPortaliP04128
SMRiP04128
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04128

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108RQP Bacteria
ENOG4111KX6 LUCA
HOGENOMiHOG000260127
InParanoidiP04128
KOiK07345
OMAiQLNDCDS
PhylomeDBiP04128

Family and domain databases

Gene3Di2.60.40.1090, 1 hit
InterProiView protein in InterPro
IPR000259 Adhesion_dom_fimbrial
IPR036937 Adhesion_dom_fimbrial_sf
IPR008966 Adhesion_dom_sf
PfamiView protein in Pfam
PF00419 Fimbrial, 1 hit
SUPFAMiSSF49401 SSF49401, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04128-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIKTLAIVV LSALSLSSTA ALAAATTVNG GTVHFKGEVV NAACAVDAGS
60 70 80 90 100
VDQTVQLGQV RTASLAQEGA TSSAVGFNIQ LNDCDTNVAS KAAVAFLGTA
110 120 130 140 150
IDAGHTNVLA LQSSAAGSAT NVGVQILDRT GAALTLDGAT FSSETTLNNG
160 170 180
TNTIPFQARY FATGAATPGA ANADATFKVQ YQ
Length:182
Mass (Da):18,111
Last modified:February 1, 1995 - v2
Checksum:i35B2016BDD21A2C1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20A → T in AAA24389 (PubMed:2858471).Curated1
Sequence conflicti163Missing in CAA25489 (PubMed:6147250).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00981 Genomic DNA Translation: CAA25489.1
M27603 Genomic DNA Translation: AAA24389.1
U14003 Genomic DNA Translation: AAA97210.1
U00096 Genomic DNA Translation: AAC77270.1
AP009048 Genomic DNA Translation: BAE78307.1
PIRiS56539 YQECT1
RefSeqiNP_418734.1, NC_000913.3
WP_000695564.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77270; AAC77270; b4314
BAE78307; BAE78307; BAE78307
GeneIDi948838
KEGGiecj:JW4277
eco:b4314
PATRICifig|1411691.4.peg.2378

Similar proteinsi

Entry informationi

Entry nameiFIMA1_ECOLI
AccessioniPrimary (citable) accession number: P04128
Secondary accession number(s): Q2M5Z9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: February 1, 1995
Last modified: July 18, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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