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Protein

Colipase

Gene

CLPS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
Enterostatin has a biological activity as a satiety signal.

GO - Molecular functioni

GO - Biological processi

  • digestion Source: UniProtKB-KW
  • lipid catabolic process Source: UniProtKB-KW
  • lipid metabolic process Source: ProtInc
  • response to bacterium Source: Ensembl
  • response to food Source: GO_Central

Keywordsi

Biological processDigestion, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-HSA-192456 Digestion of dietary lipid
R-HSA-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Colipase
Gene namesi
Name:CLPS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000137392.9
HGNCiHGNC:2085 CLPS
MIMi120105 gene
neXtProtiNX_P04118

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Diabetes mellitus

Organism-specific databases

DisGeNETi1208
OpenTargetsiENSG00000137392
PharmGKBiPA26611

Chemistry databases

DrugBankiDB04233 (Hydroxyethyloxy)Tri(Ethyloxy)Octane
DB08222 METHOXYUNDECYLPHOSPHINIC ACID

Polymorphism and mutation databases

BioMutaiCLPS
DMDMi116900

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Add BLAST17
PropeptideiPRO_000000569618 – 22Enterostatin, activation peptideSequence analysis5
ChainiPRO_000000569723 – 112ColipaseAdd BLAST90

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 45PROSITE-ProRule annotation
Disulfide bondi40 ↔ 56PROSITE-ProRule annotation
Disulfide bondi44 ↔ 78PROSITE-ProRule annotation
Disulfide bondi66 ↔ 86PROSITE-ProRule annotation
Disulfide bondi80 ↔ 104PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP04118
PeptideAtlasiP04118
PRIDEiP04118
ProteomicsDBi51655

PTM databases

iPTMnetiP04118
PhosphoSitePlusiP04118

Miscellaneous databases

PMAP-CutDBiP04118

Expressioni

Tissue specificityi

Expressed by the pancreas.

Gene expression databases

BgeeiENSG00000137392 Expressed in 84 organ(s), highest expression level in body of pancreas
CleanExiHS_CLPS
ExpressionAtlasiP04118 baseline and differential
GenevisibleiP04118 HS

Organism-specific databases

HPAiHPA010512

Interactioni

Subunit structurei

Forms a 1:1 stoichiometric complex with pancreatic lipase.

Protein-protein interaction databases

BioGridi107618, 1 interactor
STRINGi9606.ENSP00000259938

Structurei

3D structure databases

ProteinModelPortaliP04118
SMRiP04118
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the colipase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYZJ Eukaryota
ENOG410YQC6 LUCA
GeneTreeiENSGT00390000012644
HOGENOMiHOG000059253
HOVERGENiHBG005373
InParanoidiP04118
KOiK14460
OMAiCSAKTLY
OrthoDBiEOG091G0Z2E
PhylomeDBiP04118
TreeFamiTF336178

Family and domain databases

CDDicd00039 COLIPASE, 1 hit
InterProiView protein in InterPro
IPR001981 Colipase
IPR017914 Colipase_C
IPR017915 Colipase_CS
IPR017913 Colipase_N
PANTHERiPTHR10041 PTHR10041, 1 hit
PfamiView protein in Pfam
PF01114 Colipase, 1 hit
PF02740 Colipase_C, 1 hit
PRINTSiPR00128 COLIPASE
SMARTiView protein in SMART
SM00023 COLIPASE, 1 hit
PROSITEiView protein in PROSITE
PS00121 COLIPASE_1, 1 hit
PS51342 COLIPASE_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P04118-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKILILLLV ALSVAYAAPG PRGIIINLEN GELCMNSAQC KSNCCQHSSA
60 70 80 90 100
LGLARCTSMA SENSECSVKT LYGIYYKCPC ERGLTCEGDK TIVGSITNTN
110
FGICHDAGRS KQ
Length:112
Mass (Da):11,954
Last modified:April 1, 1990 - v2
Checksum:i772872EBBE7C4DF8
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0Q7A0A087X0Q7_HUMAN
Colipase, pancreatic, isoform CRA_b
CLPS hCG_15776
71Annotation score:
A0A087WZW1A0A087WZW1_HUMAN
Colipase
CLPS
98Annotation score:

Polymorphismi

Variant Cys-109 is statistically significantly associated with an increased risk of type 2 diabetes.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0530408L → P. Corresponds to variant dbSNP:rs2766597Ensembl.1
Natural variantiVAR_047105109R → C1 PublicationCorresponds to variant dbSNP:rs41270082Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02883 mRNA Translation: AAA52054.1
M95529 Genomic DNA Translation: AAB05818.1
BT006812 mRNA Translation: AAP35458.1
AL157823 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03850.1
BC007061 mRNA Translation: AAH07061.1
BC017897 mRNA Translation: AAH17897.1
AY780648 mRNA Translation: AAV35728.1
CCDSiCCDS4811.1
PIRiA42568 XLHU
RefSeqiNP_001823.1, NM_001832.3
UniGeneiHs.1340

Genome annotation databases

EnsembliENST00000259938; ENSP00000259938; ENSG00000137392
GeneIDi1208
KEGGihsa:1208
UCSCiuc003ole.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Colipase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02883 mRNA Translation: AAA52054.1
M95529 Genomic DNA Translation: AAB05818.1
BT006812 mRNA Translation: AAP35458.1
AL157823 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03850.1
BC007061 mRNA Translation: AAH07061.1
BC017897 mRNA Translation: AAH17897.1
AY780648 mRNA Translation: AAV35728.1
CCDSiCCDS4811.1
PIRiA42568 XLHU
RefSeqiNP_001823.1, NM_001832.3
UniGeneiHs.1340

3D structure databases

ProteinModelPortaliP04118
SMRiP04118
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107618, 1 interactor
STRINGi9606.ENSP00000259938

Chemistry databases

DrugBankiDB04233 (Hydroxyethyloxy)Tri(Ethyloxy)Octane
DB08222 METHOXYUNDECYLPHOSPHINIC ACID

PTM databases

iPTMnetiP04118
PhosphoSitePlusiP04118

Polymorphism and mutation databases

BioMutaiCLPS
DMDMi116900

Proteomic databases

PaxDbiP04118
PeptideAtlasiP04118
PRIDEiP04118
ProteomicsDBi51655

Protocols and materials databases

DNASUi1208
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259938; ENSP00000259938; ENSG00000137392
GeneIDi1208
KEGGihsa:1208
UCSCiuc003ole.3 human

Organism-specific databases

CTDi1208
DisGeNETi1208
EuPathDBiHostDB:ENSG00000137392.9
GeneCardsiCLPS
HGNCiHGNC:2085 CLPS
HPAiHPA010512
MIMi120105 gene
neXtProtiNX_P04118
OpenTargetsiENSG00000137392
PharmGKBiPA26611
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYZJ Eukaryota
ENOG410YQC6 LUCA
GeneTreeiENSGT00390000012644
HOGENOMiHOG000059253
HOVERGENiHBG005373
InParanoidiP04118
KOiK14460
OMAiCSAKTLY
OrthoDBiEOG091G0Z2E
PhylomeDBiP04118
TreeFamiTF336178

Enzyme and pathway databases

ReactomeiR-HSA-192456 Digestion of dietary lipid
R-HSA-975634 Retinoid metabolism and transport

Miscellaneous databases

GeneWikiiColipase
GenomeRNAii1208
PMAP-CutDBiP04118
PROiPR:P04118
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137392 Expressed in 84 organ(s), highest expression level in body of pancreas
CleanExiHS_CLPS
ExpressionAtlasiP04118 baseline and differential
GenevisibleiP04118 HS

Family and domain databases

CDDicd00039 COLIPASE, 1 hit
InterProiView protein in InterPro
IPR001981 Colipase
IPR017914 Colipase_C
IPR017915 Colipase_CS
IPR017913 Colipase_N
PANTHERiPTHR10041 PTHR10041, 1 hit
PfamiView protein in Pfam
PF01114 Colipase, 1 hit
PF02740 Colipase_C, 1 hit
PRINTSiPR00128 COLIPASE
SMARTiView protein in SMART
SM00023 COLIPASE, 1 hit
PROSITEiView protein in PROSITE
PS00121 COLIPASE_1, 1 hit
PS51342 COLIPASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOL_HUMAN
AccessioniPrimary (citable) accession number: P04118
Secondary accession number(s): Q5T9G7, Q5U809
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: April 1, 1990
Last modified: November 7, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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