Fabp4

Functionⁱ

Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.3 Publications

GO - Molecular functionⁱ

hormone receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12077340
long-chain fatty acid binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12077340
long-chain fatty acid transporter activity
Source: UniProtKB
Inferred from direct assayⁱ
- 12077340

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

brown fat cell differentiation
Source: MGI
Inferred from direct assayⁱ
- 18492766
cellular response to lithium ion
Source: MGI
Inferred from direct assayⁱ
- 15673614
cellular response to tumor necrosis factor
Source: MGI
Inferred from direct assayⁱ
- 1618860
cholesterol homeostasis
Source: MGI
Inferred from mutant phenotypeⁱ
- 15684432
cytokine production
Source: MGI
Inferred from mutant phenotypeⁱ
- 15684432
fatty acid metabolic process Source: MGI
long-chain fatty acid transport
Source: UniProtKB
Inferred from direct assayⁱ
- 12077340
negative regulation of protein kinase activity
Source: MGI
Inferred from mutant phenotypeⁱ
- 15684432
negative regulation of transcription, DNA-templated
Source: MGI
Inferred from mutant phenotypeⁱ
- 15684432
positive regulation of cell proliferation Source: MGI
positive regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from genetic interactionⁱ
- 24603714
positive regulation of inflammatory response
Source: MGI
Inferred from mutant phenotypeⁱ
- 15684432
response to bacterium
Source: MGI
Inferred from expression patternⁱ
- 23012479
white fat cell differentiation
Source: MGI
Inferred from direct assayⁱ
- 18492766

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport
Ligand	Lipid-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-163560 Triglyceride catabolism

Reactomeⁱ

R-MMU-163560 Triglyceride catabolism

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Fatty acid-binding protein, adipocyte Alternative name(s): 3T3-L1 lipid-binding protein Adipocyte lipid-binding protein Short name: ALBP Adipocyte-type fatty acid-binding protein Short name: A-FABP Short name: AFABP Fatty acid-binding protein 4 Myelin P2 protein homolog P15 P2 adipocyte protein Protein 422
Gene namesⁱ	Name:Fabp4 Synonyms:Ap2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 3

Organism-specific databases

MGIⁱ	MGI:88038 Fabp4

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	22	K → A: Abolishes ligand-induced translocation to the nucleus; when associated with A-31 and A-32. 1 Publication	1
Mutagenesisⁱ	31	R → A: Abolishes ligand-induced translocation to the nucleus; when associated with A-22 and A-32. 1 Publication	1
Mutagenesisⁱ	32	K → A: Abolishes ligand-induced translocation to the nucleus; when associated with A-22 and A-31. 1 Publication	1
Mutagenesisⁱ	58	F → A: Abolishes ligand-induced translocation to the nucleus. 1 Publication	1
Mutagenesisⁱ	67	L → A: Abolishes export from nucleus; when associated with A-87 and A-92. 2 Publications	1
Mutagenesisⁱ	87	L → A: Abolishes export from nucleus; when associated with A-67 and A-92. 2 Publications	1
Mutagenesisⁱ	92	L → A: Abolishes export from nucleus; when associated with A-67 and A-87. 2 Publications	1

Chemistry databases

ChEMBLⁱ	CHEMBL1075118
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2534

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000067367	2 – 132	Fatty acid-binding protein, adipocyte1 PublicationAdd BLAST		131

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylcysteineBy similarity	1
Modified residueⁱ	13	PhosphoserineCombined sources	1
Modified residueⁱ	20	Phosphotyrosine; by Tyr-kinasesBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

PaxDbⁱ	P04117
PeptideAtlas More...PeptideAtlasⁱ	P04117
PRIDEⁱ	P04117

2D gel databases

SWISS-2DPAGEⁱ	P04117

SWISS-2DPAGEⁱ

P04117

PTM databases

CarbonylDBⁱ	P04117
iPTMnetⁱ	P04117
PhosphoSitePlusⁱ	P04117

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000062515 Expressed in 220 organ(s), highest expression level in lymph node
CleanExⁱ	MM_FABP4
ExpressionAtlasⁱ	P04117 baseline and differential
Genevisibleⁱ	P04117 MM

Interactionⁱ

Subunit structureⁱ

Monomer (By similarity). Homodimer. Interacts with PPARG.By similarity6 Publications

GO - Molecular functionⁱ

hormone receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12077340

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	P04117, 1 interactor
Molecular INTeraction database More...MINTⁱ	P04117
STRINGⁱ	10090.ENSMUSP00000029041

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	3 – 5	Combined sources	3
Beta strandⁱ	7 – 16	Combined sources	10
Helixⁱ	17 – 24	Combined sources	8
Helixⁱ	28 – 37	Combined sources	10
Beta strandⁱ	41 – 46	Combined sources	6
Beta strandⁱ	49 – 54	Combined sources	6
Beta strandⁱ	61 – 65	Combined sources	5
Beta strandⁱ	67 – 69	Combined sources	3
Beta strandⁱ	71 – 74	Combined sources	4
Beta strandⁱ	80 – 88	Combined sources	9
Beta strandⁱ	91 – 98	Combined sources	8
Beta strandⁱ	101 – 110	Combined sources	10
Beta strandⁱ	113 – 120	Combined sources	8
Beta strandⁱ	123 – 131	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	P04117
SMRⁱ	P04117
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P04117

EvolutionaryTraceⁱ

P04117

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	127 – 129	Fatty acid binding		3

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	22 – 32	Nuclear localization signal1 PublicationAdd BLAST		11

Domainⁱ

Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.

Sequence similaritiesⁱ

Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4015 Eukaryota ENOG4111US8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118898
HOGENOMⁱ	HOG000004829
HOVERGENⁱ	HBG005633
InParanoidⁱ	P04117
KEGG Orthology (KO) More...KOⁱ	K08753
OMAⁱ	ATRKMAG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QSV
PhylomeDBⁱ	P04117
TreeFamⁱ	TF316894

Family and domain databases

Gene3Dⁱ	2.40.128.20, 1 hit
InterProⁱ	View protein in InterPro IPR012674 Calycin IPR033073 FABP4 IPR000463 Fatty_acid-bd IPR031259 ILBP IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERⁱ	PTHR11955 PTHR11955, 1 hit PTHR11955:SF83 PTHR11955:SF83, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00061 Lipocalin, 1 hit
PRINTSⁱ	PR00178 FATTYACIDBP
SUPFAMⁱ	SSF50814 SSF50814, 1 hit
PROSITEⁱ	View protein in PROSITE PS00214 FABP, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P04117-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MCDAFVGTWK LVSSENFDDY MKEVGVGFAT RKVAGMAKPN MIISVNGDLV 
        60         70         80         90        100
TIRSESTFKN TEISFKLGVE FDEITADDRK VKSIITLDGG ALVQVQKWDG 
       110        120        130 
KSTTIKRKRD GDKLVVECVM KGVTSTRVYE RA

Length:132

Mass (Da):14,650

Last modified:January 23, 2007 - v3

Checksum:ⁱED08EDDBBE2D7E32

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	40	N → T in AAA39870 (PubMed:6206497).Curated		1
Sequence conflictⁱ	111	G → V in AAA39417 (PubMed:3520554).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	K02109 mRNA Translation: AAA39416.1 M13264 , M13261, M13262, M13263 Genomic DNA Translation: AAA39870.1 M13385 Genomic DNA Translation: AAA39417.1 AK003143 mRNA Translation: BAB22601.1 BC054426 mRNA Translation: AAH54426.1 M20497 Genomic DNA Translation: AAA37188.1 M28726 mRNA Translation: AAA37112.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS17238.1
PIRⁱ	B25952
NCBI Reference Sequences More...RefSeqⁱ	NP_077717.1, NM_024406.2
UniGeneⁱ	Mm.582

Genome annotation databases

Ensemblⁱ	ENSMUST00000029041; ENSMUSP00000029041; ENSMUSG00000062515
GeneIDⁱ	11770
KEGGⁱ	mmu:11770
UCSC genome browser More...UCSCⁱ	uc008opl.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P04117	Fabp4 protein		MOUSE		132	UniRef100_P04117
UPI0001753E68		MOUSE		155
UPI00000278F6		MOUSE		131

Protein	Similar proteins		Species	Score	Length	Source
P04117	Fatty acid-binding protein, adipocyte		ICTTR		132	UniRef90_P04117
Fatty acid-binding protein, adipocyte		RAT		132
Fabp4 protein		MOUSE		132
Adipose-type fatty acid-binding protein (Fragment)		UROPR		47
Adipocyte-type fatty acid-binding protein		MACMU		132
+65

Protein	Similar proteins		Species	Score	Length	Source
P04117	Fatty acid-binding protein, adipocyte		ICTTR		132	UniRef50_P04117
Fatty acid-binding protein, adipocyte		RAT		132
Myelin P2 protein		RABIT		132
Myelin P2 protein	)	HUMAN		132
Myelin P2 protein		PIG		132
+549

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	K02109 mRNA Translation: AAA39416.1 M13264 , M13261, M13262, M13263 Genomic DNA Translation: AAA39870.1 M13385 Genomic DNA Translation: AAA39417.1 AK003143 mRNA Translation: BAB22601.1 BC054426 mRNA Translation: AAH54426.1 M20497 Genomic DNA Translation: AAA37188.1 M28726 mRNA Translation: AAA37112.1
CCDSⁱ	CCDS17238.1
PIRⁱ	B25952
RefSeqⁱ	NP_077717.1, NM_024406.2
UniGeneⁱ	Mm.582

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1A18	X-ray	2.40	A	2-132	[»]
	1A2D	X-ray	2.40	A/B	2-132	[»]
	1AB0	X-ray	1.90	A	3-132	[»]
	1ACD	X-ray	2.70	A	3-132	[»]
	1ADL	X-ray	1.60	A	2-132	[»]
	1ALB	X-ray	2.50	A	2-132	[»]
	1G74	X-ray	1.70	A	2-132	[»]
	1G7N	X-ray	1.50	A	2-132	[»]
	1LIB	X-ray	1.70	A	2-132	[»]
	1LIC	X-ray	1.60	A	2-132	[»]
	1LID	X-ray	1.60	A	2-132	[»]
	1LIE	X-ray	1.60	A	2-132	[»]
	1LIF	X-ray	1.60	A	2-132	[»]
	2ANS	X-ray	2.50	A/B	2-132	[»]
	2Q9S	X-ray	2.30	A	1-132	[»]
	2QM9	X-ray	2.31	A/B	1-132	[»]
	3HK1	X-ray	1.70	A	2-132	[»]
	3JS1	X-ray	1.81	A/B	2-132	[»]
	3JSQ	X-ray	2.30	A	2-132	[»]
	5C0N	X-ray	3.00	A/B	1-132	[»]
	5D8J	X-ray	3.00	A	1-132	[»]
ProteinModelPortalⁱ	P04117
SMRⁱ	P04117
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P04117, 1 interactor
MINTⁱ	P04117
STRINGⁱ	10090.ENSMUSP00000029041

Chemistry databases

ChEMBLⁱ	CHEMBL1075118
GuidetoPHARMACOLOGYⁱ	2534

PTM databases

CarbonylDBⁱ	P04117
iPTMnetⁱ	P04117
PhosphoSitePlusⁱ	P04117

2D gel databases

SWISS-2DPAGEⁱ	P04117

SWISS-2DPAGEⁱ

P04117

Proteomic databases

PaxDbⁱ	P04117
PeptideAtlasⁱ	P04117
PRIDEⁱ	P04117

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000029041; ENSMUSP00000029041; ENSMUSG00000062515
GeneIDⁱ	11770
KEGGⁱ	mmu:11770
UCSCⁱ	uc008opl.2 mouse

Organism-specific databases

CTDⁱ	2167
MGIⁱ	MGI:88038 Fabp4

Phylogenomic databases

eggNOGⁱ	KOG4015 Eukaryota ENOG4111US8 LUCA
GeneTreeⁱ	ENSGT00760000118898
HOGENOMⁱ	HOG000004829
HOVERGENⁱ	HBG005633
InParanoidⁱ	P04117
KOⁱ	K08753
OMAⁱ	ATRKMAG
OrthoDBⁱ	EOG091G0QSV
PhylomeDBⁱ	P04117
TreeFamⁱ	TF316894

Enzyme and pathway databases

Reactomeⁱ	R-MMU-163560 Triglyceride catabolism

Reactomeⁱ

R-MMU-163560 Triglyceride catabolism

Miscellaneous databases

ChiTaRSⁱ	Tfap2a mouse
EvolutionaryTraceⁱ	P04117
Protein Ontology More...PROⁱ	PR:P04117
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000062515 Expressed in 220 organ(s), highest expression level in lymph node
CleanExⁱ	MM_FABP4
ExpressionAtlasⁱ	P04117 baseline and differential
Genevisibleⁱ	P04117 MM

Family and domain databases

Gene3Dⁱ	2.40.128.20, 1 hit
InterProⁱ	View protein in InterPro IPR012674 Calycin IPR033073 FABP4 IPR000463 Fatty_acid-bd IPR031259 ILBP IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERⁱ	PTHR11955 PTHR11955, 1 hit PTHR11955:SF83 PTHR11955:SF83, 1 hit
Pfamⁱ	View protein in Pfam PF00061 Lipocalin, 1 hit
PRINTSⁱ	PR00178 FATTYACIDBP
SUPFAMⁱ	SSF50814 SSF50814, 1 hit
PROSITEⁱ	View protein in PROSITE PS00214 FABP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FABP4_MOUSE
Accessionⁱ	P04117Primary (citable) accession number: P04117
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1986
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 187 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P04117 (FABP4_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Fatty acid-binding protein, adipocyte

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ