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Protein

Fatty acid-binding protein, adipocyte

Gene

Fabp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.3 Publications

GO - Molecular functioni

  • hormone receptor binding Source: UniProtKB
  • long-chain fatty acid binding Source: UniProtKB
  • long-chain fatty acid transporter activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-163560 Triglyceride catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, adipocyte
Alternative name(s):
3T3-L1 lipid-binding protein
Adipocyte lipid-binding protein
Short name:
ALBP
Adipocyte-type fatty acid-binding protein
Short name:
A-FABP
Short name:
AFABP
Fatty acid-binding protein 4
Myelin P2 protein homolog
P15
P2 adipocyte protein
Protein 422
Gene namesi
Name:Fabp4
Synonyms:Ap2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:88038 Fabp4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi22K → A: Abolishes ligand-induced translocation to the nucleus; when associated with A-31 and A-32. 1 Publication1
Mutagenesisi31R → A: Abolishes ligand-induced translocation to the nucleus; when associated with A-22 and A-32. 1 Publication1
Mutagenesisi32K → A: Abolishes ligand-induced translocation to the nucleus; when associated with A-22 and A-31. 1 Publication1
Mutagenesisi58F → A: Abolishes ligand-induced translocation to the nucleus. 1 Publication1
Mutagenesisi67L → A: Abolishes export from nucleus; when associated with A-87 and A-92. 2 Publications1
Mutagenesisi87L → A: Abolishes export from nucleus; when associated with A-67 and A-92. 2 Publications1
Mutagenesisi92L → A: Abolishes export from nucleus; when associated with A-67 and A-87. 2 Publications1

Chemistry databases

ChEMBLiCHEMBL1075118
GuidetoPHARMACOLOGYi2534

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000673672 – 132Fatty acid-binding protein, adipocyte1 PublicationAdd BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylcysteineBy similarity1
Modified residuei13PhosphoserineCombined sources1
Modified residuei20Phosphotyrosine; by Tyr-kinasesBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP04117
PeptideAtlasiP04117
PRIDEiP04117

2D gel databases

SWISS-2DPAGEiP04117

PTM databases

CarbonylDBiP04117
iPTMnetiP04117
PhosphoSitePlusiP04117

Expressioni

Gene expression databases

BgeeiENSMUSG00000062515 Expressed in 220 organ(s), highest expression level in lymph node
CleanExiMM_FABP4
ExpressionAtlasiP04117 baseline and differential
GenevisibleiP04117 MM

Interactioni

Subunit structurei

Monomer (By similarity). Homodimer. Interacts with PPARG.By similarity6 Publications

GO - Molecular functioni

Protein-protein interaction databases

IntActiP04117, 1 interactor
MINTiP04117
STRINGi10090.ENSMUSP00000029041

Structurei

Secondary structure

1132
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP04117
SMRiP04117
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04117

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni127 – 129Fatty acid binding3

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi22 – 32Nuclear localization signal1 PublicationAdd BLAST11

Domaini

Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004829
HOVERGENiHBG005633
InParanoidiP04117
KOiK08753
OMAiATRKMAG
OrthoDBiEOG091G0QSV
PhylomeDBiP04117
TreeFamiTF316894

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR033073 FABP4
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF83 PTHR11955:SF83, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04117-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCDAFVGTWK LVSSENFDDY MKEVGVGFAT RKVAGMAKPN MIISVNGDLV
60 70 80 90 100
TIRSESTFKN TEISFKLGVE FDEITADDRK VKSIITLDGG ALVQVQKWDG
110 120 130
KSTTIKRKRD GDKLVVECVM KGVTSTRVYE RA
Length:132
Mass (Da):14,650
Last modified:January 23, 2007 - v3
Checksum:iED08EDDBBE2D7E32
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40N → T in AAA39870 (PubMed:6206497).Curated1
Sequence conflicti111G → V in AAA39417 (PubMed:3520554).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02109 mRNA Translation: AAA39416.1
M13264
, M13261, M13262, M13263 Genomic DNA Translation: AAA39870.1
M13385 Genomic DNA Translation: AAA39417.1
AK003143 mRNA Translation: BAB22601.1
BC054426 mRNA Translation: AAH54426.1
M20497 Genomic DNA Translation: AAA37188.1
M28726 mRNA Translation: AAA37112.1
CCDSiCCDS17238.1
PIRiB25952
RefSeqiNP_077717.1, NM_024406.2
UniGeneiMm.582

Genome annotation databases

EnsembliENSMUST00000029041; ENSMUSP00000029041; ENSMUSG00000062515
GeneIDi11770
KEGGimmu:11770
UCSCiuc008opl.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02109 mRNA Translation: AAA39416.1
M13264
, M13261, M13262, M13263 Genomic DNA Translation: AAA39870.1
M13385 Genomic DNA Translation: AAA39417.1
AK003143 mRNA Translation: BAB22601.1
BC054426 mRNA Translation: AAH54426.1
M20497 Genomic DNA Translation: AAA37188.1
M28726 mRNA Translation: AAA37112.1
CCDSiCCDS17238.1
PIRiB25952
RefSeqiNP_077717.1, NM_024406.2
UniGeneiMm.582

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A18X-ray2.40A2-132[»]
1A2DX-ray2.40A/B2-132[»]
1AB0X-ray1.90A3-132[»]
1ACDX-ray2.70A3-132[»]
1ADLX-ray1.60A2-132[»]
1ALBX-ray2.50A2-132[»]
1G74X-ray1.70A2-132[»]
1G7NX-ray1.50A2-132[»]
1LIBX-ray1.70A2-132[»]
1LICX-ray1.60A2-132[»]
1LIDX-ray1.60A2-132[»]
1LIEX-ray1.60A2-132[»]
1LIFX-ray1.60A2-132[»]
2ANSX-ray2.50A/B2-132[»]
2Q9SX-ray2.30A1-132[»]
2QM9X-ray2.31A/B1-132[»]
3HK1X-ray1.70A2-132[»]
3JS1X-ray1.81A/B2-132[»]
3JSQX-ray2.30A2-132[»]
5C0NX-ray3.00A/B1-132[»]
5D8JX-ray3.00A1-132[»]
ProteinModelPortaliP04117
SMRiP04117
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP04117, 1 interactor
MINTiP04117
STRINGi10090.ENSMUSP00000029041

Chemistry databases

ChEMBLiCHEMBL1075118
GuidetoPHARMACOLOGYi2534

PTM databases

CarbonylDBiP04117
iPTMnetiP04117
PhosphoSitePlusiP04117

2D gel databases

SWISS-2DPAGEiP04117

Proteomic databases

PaxDbiP04117
PeptideAtlasiP04117
PRIDEiP04117

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029041; ENSMUSP00000029041; ENSMUSG00000062515
GeneIDi11770
KEGGimmu:11770
UCSCiuc008opl.2 mouse

Organism-specific databases

CTDi2167
MGIiMGI:88038 Fabp4

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004829
HOVERGENiHBG005633
InParanoidiP04117
KOiK08753
OMAiATRKMAG
OrthoDBiEOG091G0QSV
PhylomeDBiP04117
TreeFamiTF316894

Enzyme and pathway databases

ReactomeiR-MMU-163560 Triglyceride catabolism

Miscellaneous databases

ChiTaRSiTfap2a mouse
EvolutionaryTraceiP04117
PROiPR:P04117
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062515 Expressed in 220 organ(s), highest expression level in lymph node
CleanExiMM_FABP4
ExpressionAtlasiP04117 baseline and differential
GenevisibleiP04117 MM

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR033073 FABP4
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF83 PTHR11955:SF83, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFABP4_MOUSE
AccessioniPrimary (citable) accession number: P04117
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 187 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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