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UniProtKB - P04117 (FABP4_MOUSE)
Protein
Fatty acid-binding protein, adipocyte
Gene
Fabp4
Organism
Mus musculus (Mouse)
Status
Functioni
Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.
3 PublicationsGO - Molecular functioni
- fatty acid binding Source: GO_Central
- hormone receptor binding Source: UniProtKB
- long-chain fatty acid binding Source: UniProtKB
- long-chain fatty acid transporter activity Source: UniProtKB
GO - Biological processi
- brown fat cell differentiation Source: MGI
- cellular response to lithium ion Source: MGI
- cellular response to tumor necrosis factor Source: MGI
- cholesterol homeostasis Source: MGI
- fatty acid metabolic process Source: MGI
- fatty acid transport Source: GO_Central
- long-chain fatty acid transport Source: UniProtKB
- negative regulation of protein kinase activity Source: MGI
- negative regulation of transcription, DNA-templated Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of inflammatory response Source: MGI
- response to bacterium Source: MGI
- white fat cell differentiation Source: MGI
Keywordsi
Biological process | Transport |
Ligand | Lipid-binding |
Enzyme and pathway databases
Reactomei | R-MMU-163560, Triglyceride catabolism |
Names & Taxonomyi
Protein namesi | Recommended name: Fatty acid-binding protein, adipocyteAlternative name(s): 3T3-L1 lipid-binding protein Adipocyte lipid-binding protein Short name: ALBP Adipocyte-type fatty acid-binding protein Short name: A-FABP Short name: AFABP Fatty acid-binding protein 4 Myelin P2 protein homolog P15 P2 adipocyte protein Protein 422 |
Gene namesi | Name:Fabp4 Synonyms:Ap2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88038, Fabp4 |
VEuPathDBi | HostDB:ENSMUSG00000062515 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 2 Publications
Nucleus
- Nucleus 2 Publications
Note: Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus (PubMed:17516629). Subject to constitutive nuclear export (PubMed:17516629, PubMed:17761196).2 Publications
Cytosol
- cytosol Source: MGI
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 22 | K → A: Abolishes ligand-induced translocation to the nucleus; when associated with A-31 and A-32. 1 Publication | 1 | |
Mutagenesisi | 31 | R → A: Abolishes ligand-induced translocation to the nucleus; when associated with A-22 and A-32. 1 Publication | 1 | |
Mutagenesisi | 32 | K → A: Abolishes ligand-induced translocation to the nucleus; when associated with A-22 and A-31. 1 Publication | 1 | |
Mutagenesisi | 58 | F → A: Abolishes ligand-induced translocation to the nucleus. 1 Publication | 1 | |
Mutagenesisi | 67 | L → A: Abolishes export from nucleus; when associated with A-87 and A-92. 2 Publications | 1 | |
Mutagenesisi | 87 | L → A: Abolishes export from nucleus; when associated with A-67 and A-92. 2 Publications | 1 | |
Mutagenesisi | 92 | L → A: Abolishes export from nucleus; when associated with A-67 and A-87. 2 Publications | 1 |
Chemistry databases
ChEMBLi | CHEMBL1075118 |
GuidetoPHARMACOLOGYi | 2534 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000067367 | 2 – 132 | Fatty acid-binding protein, adipocyte1 PublicationAdd BLAST | 131 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylcysteineBy similarity | 1 | |
Modified residuei | 13 | PhosphoserineCombined sources | 1 | |
Modified residuei | 20 | Phosphotyrosine; by Tyr-kinasesBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | P04117 |
PaxDbi | P04117 |
PeptideAtlasi | P04117 |
PRIDEi | P04117 |
ProteomicsDBi | 271547 |
2D gel databases
SWISS-2DPAGEi | P04117 |
PTM databases
CarbonylDBi | P04117 |
iPTMneti | P04117 |
MetOSitei | P04117 |
PhosphoSitePlusi | P04117 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000062515, Expressed in lymph node and 244 other tissues |
Genevisiblei | P04117, MM |
Interactioni
Subunit structurei
Monomer (By similarity). Homodimer.
Interacts with PPARG.
By similarity6 PublicationsGO - Molecular functioni
- hormone receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 198128, 2 interactors |
STRINGi | 10090.ENSMUSP00000029041 |
Miscellaneous databases
RNActi | P04117, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P04117 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P04117 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 127 – 129 | Fatty acid binding | 3 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 22 – 32 | Nuclear localization signal1 PublicationAdd BLAST | 11 |
Domaini
Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4015, Eukaryota |
GeneTreei | ENSGT00940000160340 |
HOGENOMi | CLU_113772_0_0_1 |
InParanoidi | P04117 |
OMAi | YMKAVGM |
OrthoDBi | 1417203at2759 |
PhylomeDBi | P04117 |
TreeFami | TF316894 |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR012674, Calycin IPR033073, FABP4 IPR000463, Fatty_acid-bd IPR031259, ILBP IPR000566, Lipocln_cytosolic_FA-bd_dom |
PANTHERi | PTHR11955, PTHR11955, 1 hit PTHR11955:SF83, PTHR11955:SF83, 1 hit |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PRINTSi | PR00178, FATTYACIDBP |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00214, FABP, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P04117-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCDAFVGTWK LVSSENFDDY MKEVGVGFAT RKVAGMAKPN MIISVNGDLV
60 70 80 90 100
TIRSESTFKN TEISFKLGVE FDEITADDRK VKSIITLDGG ALVQVQKWDG
110 120 130
KSTTIKRKRD GDKLVVECVM KGVTSTRVYE RA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 40 | N → T in AAA39870 (PubMed:6206497).Curated | 1 | |
Sequence conflicti | 111 | G → V in AAA39417 (PubMed:3520554).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K02109 mRNA Translation: AAA39416.1 M13264 , M13261, M13262, M13263 Genomic DNA Translation: AAA39870.1 M13385 Genomic DNA Translation: AAA39417.1 AK003143 mRNA Translation: BAB22601.1 BC054426 mRNA Translation: AAH54426.1 M20497 Genomic DNA Translation: AAA37188.1 M28726 mRNA Translation: AAA37112.1 |
CCDSi | CCDS17238.1 |
PIRi | B25952 |
RefSeqi | NP_077717.1, NM_024406.2 |
Genome annotation databases
Ensembli | ENSMUST00000029041; ENSMUSP00000029041; ENSMUSG00000062515 |
GeneIDi | 11770 |
KEGGi | mmu:11770 |
UCSCi | uc008opl.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K02109 mRNA Translation: AAA39416.1 M13264 , M13261, M13262, M13263 Genomic DNA Translation: AAA39870.1 M13385 Genomic DNA Translation: AAA39417.1 AK003143 mRNA Translation: BAB22601.1 BC054426 mRNA Translation: AAH54426.1 M20497 Genomic DNA Translation: AAA37188.1 M28726 mRNA Translation: AAA37112.1 |
CCDSi | CCDS17238.1 |
PIRi | B25952 |
RefSeqi | NP_077717.1, NM_024406.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1A18 | X-ray | 2.40 | A | 2-132 | [»] | |
1A2D | X-ray | 2.40 | A/B | 2-132 | [»] | |
1AB0 | X-ray | 1.90 | A | 3-132 | [»] | |
1ACD | X-ray | 2.70 | A | 3-132 | [»] | |
1ADL | X-ray | 1.60 | A | 2-132 | [»] | |
1ALB | X-ray | 2.50 | A | 2-132 | [»] | |
1G74 | X-ray | 1.70 | A | 2-132 | [»] | |
1G7N | X-ray | 1.50 | A | 2-132 | [»] | |
1LIB | X-ray | 1.70 | A | 2-132 | [»] | |
1LIC | X-ray | 1.60 | A | 2-132 | [»] | |
1LID | X-ray | 1.60 | A | 2-132 | [»] | |
1LIE | X-ray | 1.60 | A | 2-132 | [»] | |
1LIF | X-ray | 1.60 | A | 2-132 | [»] | |
2ANS | X-ray | 2.50 | A/B | 2-132 | [»] | |
2Q9S | X-ray | 2.30 | A | 1-132 | [»] | |
2QM9 | X-ray | 2.31 | A/B | 1-132 | [»] | |
3HK1 | X-ray | 1.70 | A | 2-132 | [»] | |
3JS1 | X-ray | 1.81 | A/B | 2-132 | [»] | |
3JSQ | X-ray | 2.30 | A | 2-132 | [»] | |
5C0N | X-ray | 3.00 | A/B | 1-132 | [»] | |
5D8J | X-ray | 3.00 | A | 1-132 | [»] | |
SMRi | P04117 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 198128, 2 interactors |
STRINGi | 10090.ENSMUSP00000029041 |
Chemistry databases
ChEMBLi | CHEMBL1075118 |
GuidetoPHARMACOLOGYi | 2534 |
PTM databases
CarbonylDBi | P04117 |
iPTMneti | P04117 |
MetOSitei | P04117 |
PhosphoSitePlusi | P04117 |
2D gel databases
SWISS-2DPAGEi | P04117 |
Proteomic databases
jPOSTi | P04117 |
PaxDbi | P04117 |
PeptideAtlasi | P04117 |
PRIDEi | P04117 |
ProteomicsDBi | 271547 |
Protocols and materials databases
ABCDi | P04117, 2 sequenced antibodies |
Antibodypediai | 994, 831 antibodies from 46 providers |
DNASUi | 11770 |
Genome annotation databases
Ensembli | ENSMUST00000029041; ENSMUSP00000029041; ENSMUSG00000062515 |
GeneIDi | 11770 |
KEGGi | mmu:11770 |
UCSCi | uc008opl.2, mouse |
Organism-specific databases
CTDi | 2167 |
MGIi | MGI:88038, Fabp4 |
VEuPathDBi | HostDB:ENSMUSG00000062515 |
Phylogenomic databases
eggNOGi | KOG4015, Eukaryota |
GeneTreei | ENSGT00940000160340 |
HOGENOMi | CLU_113772_0_0_1 |
InParanoidi | P04117 |
OMAi | YMKAVGM |
OrthoDBi | 1417203at2759 |
PhylomeDBi | P04117 |
TreeFami | TF316894 |
Enzyme and pathway databases
Reactomei | R-MMU-163560, Triglyceride catabolism |
Miscellaneous databases
BioGRID-ORCSi | 11770, 0 hits in 65 CRISPR screens |
ChiTaRSi | Fabp4, mouse |
EvolutionaryTracei | P04117 |
PROi | PR:P04117 |
RNActi | P04117, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000062515, Expressed in lymph node and 244 other tissues |
Genevisiblei | P04117, MM |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR012674, Calycin IPR033073, FABP4 IPR000463, Fatty_acid-bd IPR031259, ILBP IPR000566, Lipocln_cytosolic_FA-bd_dom |
PANTHERi | PTHR11955, PTHR11955, 1 hit PTHR11955:SF83, PTHR11955:SF83, 1 hit |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PRINTSi | PR00178, FATTYACIDBP |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00214, FABP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FABP4_MOUSE | |
Accessioni | P04117Primary (citable) accession number: P04117 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1986 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 205 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families