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UniProtKB - P04114 (APOB_HUMAN)

Protein

Apolipoprotein B-100

Gene

APOB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.

GO - Molecular functioni

  • cholesterol transporter activity Source: BHF-UCL
  • heparin binding Source: BHF-UCL
  • lipase binding Source: BHF-UCL
  • low-density lipoprotein particle receptor binding Source: BHF-UCL
  • phospholipid binding Source: BHF-UCL
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionHeparin-binding
Biological processCholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-3000471 Scavenging by Class B Receptors
R-HSA-3000480 Scavenging by Class A Receptors
R-HSA-3000484 Scavenging by Class F Receptors
R-HSA-3000497 Scavenging by Class H Receptors
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-432142 Platelet sensitization by LDL
R-HSA-5686938 Regulation of TLR by endogenous ligand
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-8866423 VLDL assembly
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-8963888 Chylomicron assembly
R-HSA-8963901 Chylomicron remodeling
R-HSA-8964026 Chylomicron clearance
R-HSA-8964038 LDL clearance
R-HSA-8964041 LDL remodeling
R-HSA-8964046 VLDL clearance
R-HSA-975634 Retinoid metabolism and transport
SIGNORiP04114

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein B-100
Short name:
Apo B-100
Cleaved into the following chain:
Apolipoprotein B-48
Short name:
Apo B-48
Gene namesi
Name:APOB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000084674.13
HGNCiHGNC:603 APOB
MIMi107730 gene+phenotype
neXtProtiNX_P04114

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chylomicron, Cytoplasm, LDL, Secreted, VLDL

Pathology & Biotechi

Involvement in diseasei

Hypobetalipoproteinemia, familial, 1 (FHBL1)3 Publications
The disease is caused by mutations affecting the gene represented in this entry. Most cases of FHBL1 result from nonsense mutations in the APOB gene that lead to a premature stop codon, which generate prematurely truncated apo B protein products (PubMed:21981844).1 Publication
Disease descriptionA disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia.
See also OMIM:615558
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022610490R → W in FHBL1; reduced protein secretion. 1 Publication1
Natural variantiVAR_076539952V → L in FHBL1; unknown pathological significance; does not affect interaction with MTTP. 1 Publication1
Familial ligand-defective apolipoprotein B-100 (FDB)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionDominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia and increased proneness to coronary artery disease (CAD). The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors.
See also OMIM:144010
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0050253527R → Q in FDB. 3 PublicationsCorresponds to variant dbSNP:rs5742904EnsemblClinVar.1
Natural variantiVAR_0050263558R → C in FDB. 2 PublicationsCorresponds to variant dbSNP:rs12713559EnsemblClinVar.1
Defects in APOB associated with defects in other genes (polygenic) can contribute to hypocholesterolemia.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi483D → N: Impairs protein secretion. 1 Publication1
Mutagenesisi483D → Q: Does not affect protein secretion. 1 Publication1
Mutagenesisi490R → A: Impairs protein secretion. 1 Publication1
Mutagenesisi490R → K: Does not affect protein secretion. 1 Publication1

Keywords - Diseasei

Atherosclerosis, Disease mutation

Organism-specific databases

DisGeNETi338
GeneReviewsiAPOB
MalaCardsiAPOB
MIMi107730 gene+phenotype
144010 phenotype
615558 phenotype
Orphaneti391665 Homozygous familial hypercholesterolemia
426 NON RARE IN EUROPE: Familial hypobetalipoproteinemia
406 NON RARE IN EUROPE: Heterozygous familial hypercholesterolemia
PharmGKBiPA50

Chemistry databases

ChEMBLiCHEMBL4549

Polymorphism and mutation databases

BioMutaiAPOB
DMDMi300669605

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Add BLAST27
ChainiPRO_000002075028 – 4563Apolipoprotein B-100Add BLAST4536
ChainiPRO_000002075128 – 2179Apolipoprotein B-48Add BLAST2152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi39 ↔ 88PROSITE-ProRule annotation1 Publication
Disulfide bondi78 ↔ 97PROSITE-ProRule annotation1 Publication
Glycosylationi185N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi186 ↔ 212PROSITE-ProRule annotation1 Publication
Disulfide bondi245 ↔ 261PROSITE-ProRule annotation1 Publication
Disulfide bondi385 ↔ 390PROSITE-ProRule annotation1 Publication
Disulfide bondi478 ↔ 513PROSITE-ProRule annotation1 Publication
Disulfide bondi966 ↔ 976PROSITE-ProRule annotation1 Publication
Glycosylationi983N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi1112S-palmitoyl cysteine1 Publication1
Glycosylationi1368N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1377N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1523N-linked (GlcNAc...) asparagine2 Publications1
Modified residuei2004N6-acetyllysineCombined sources1
Glycosylationi2239N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi2560N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2779N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi2982N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi3101N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi3194 ↔ 3324PROSITE-ProRule annotation1 Publication
Glycosylationi3224N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei3279PhosphoserineCombined sources1
Glycosylationi3336N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3358N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi3411N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi3465N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi3895N-linked (GlcNAc...) asparagine2 Publications1
Modified residuei4048Phosphoserine; by FAM20CCombined sources1 Publication1
Modified residuei4052PhosphothreonineCombined sources1
Glycosylationi4237N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4431N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle.1 Publication

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiP04114
MaxQBiP04114
PaxDbiP04114
PeptideAtlasiP04114
PRIDEiP04114
ProteomicsDBi51654

PTM databases

CarbonylDBiP04114
GlyConnecti57
iPTMnetiP04114
PhosphoSitePlusiP04114
SwissPalmiP04114
UniCarbKBiP04114

Expressioni

Inductioni

Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000084674 Expressed in 86 organ(s), highest expression level in jejunal mucosa
ExpressionAtlasiP04114 baseline and differential
GenevisibleiP04114 HS

Organism-specific databases

HPAiCAB016070
HPA049793

Interactioni

Subunit structurei

Interacts with PCSK9 (PubMed:22580899). Interacts with MTTP (PubMed:26224785, PubMed:27206948).3 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi106835, 71 interactors
DIPiDIP-44767N
IntActiP04114, 31 interactors
MINTiP04114
STRINGi9606.ENSP00000233242

Chemistry databases

BindingDBiP04114

Structurei

3D structure databases

ProteinModelPortaliP04114
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 672VitellogeninPROSITE-ProRule annotationAdd BLAST627

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni32 – 126Heparin-bindingAdd BLAST95
Regioni232 – 306Heparin-bindingAdd BLAST75
Regioni902 – 959Heparin-bindingAdd BLAST58
Regioni2043 – 2178Heparin-bindingAdd BLAST136
Regioni3161 – 3236Heparin-bindingAdd BLAST76
Regioni3174 – 3184Basic (possible receptor binding region)Add BLAST11
Regioni3373 – 3393LDL receptor bindingAdd BLAST21
Regioni3383 – 3516Heparin-bindingAdd BLAST134
Regioni3386 – 3394Basic (possible receptor binding region)9

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4338 Eukaryota
ENOG411104F LUCA
HOVERGENiHBG050546
InParanoidiP04114
KOiK14462
OrthoDBiEOG091G000G
PhylomeDBiP04114
TreeFamiTF331316

Family and domain databases

Gene3Di1.25.10.20, 1 hit
2.30.230.10, 1 hit
InterProiView protein in InterPro
IPR022176 ApoB100_C
IPR016024 ARM-type_fold
IPR015819 Lipid_transp_b-sht_shell
IPR001747 Lipid_transpt_N
IPR009454 Lipid_transpt_open_b-sht
IPR011030 Lipovitellin_superhlx_dom
IPR015816 Vitellinogen_b-sht_N
IPR015255 Vitellinogen_open_b-sht
PfamiView protein in Pfam
PF12491 ApoB100_C, 1 hit
PF06448 DUF1081, 1 hit
PF09172 DUF1943, 1 hit
PF01347 Vitellogenin_N, 1 hit
SMARTiView protein in SMART
SM01169 DUF1943, 1 hit
SM00638 LPD_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF48431 SSF48431, 1 hit
SSF56968 SSF56968, 2 hits
PROSITEiView protein in PROSITE
PS51211 VITELLOGENIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P04114-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPPRPALLA LLALPALLLL LLAGARAEEE MLENVSLVCP KDATRFKHLR 
        60         70         80         90        100
KYTYNYEAES SSGVPGTADS RSATRINCKV ELEVPQLCSF ILKTSQCTLK 
       110        120        130        140        150
EVYGFNPEGK ALLKKTKNSE EFAAAMSRYE LKLAIPEGKQ VFLYPEKDEP 
       160        170        180        190        200
TYILNIKRGI ISALLVPPET EEAKQVLFLD TVYGNCSTHF TVKTRKGNVA 
       210        220        230        240        250
TEISTERDLG QCDRFKPIRT GISPLALIKG MTRPLSTLIS SSQSCQYTLD 
       260        270        280        290        300
AKRKHVAEAI CKEQHLFLPF SYKNKYGMVA QVTQTLKLED TPKINSRFFG 
       310        320        330        340        350
EGTKKMGLAF ESTKSTSPPK QAEAVLKTLQ ELKKLTISEQ NIQRANLFNK 
       360        370        380        390        400
LVTELRGLSD EAVTSLLPQL IEVSSPITLQ ALVQCGQPQC STHILQWLKR 
       410        420        430        440        450
VHANPLLIDV VTYLVALIPE PSAQQLREIF NMARDQRSRA TLYALSHAVN 
       460        470        480        490        500
NYHKTNPTGT QELLDIANYL MEQIQDDCTG DEDYTYLILR VIGNMGQTME 
       510        520        530        540        550
QLTPELKSSI LKCVQSTKPS LMIQKAAIQA LRKMEPKDKD QEVLLQTFLD 
       560        570        580        590        600
DASPGDKRLA AYLMLMRSPS QADINKIVQI LPWEQNEQVK NFVASHIANI 
       610        620        630        640        650
LNSEELDIQD LKKLVKEALK ESQLPTVMDF RKFSRNYQLY KSVSLPSLDP 
       660        670        680        690        700
ASAKIEGNLI FDPNNYLPKE SMLKTTLTAF GFASADLIEI GLEGKGFEPT 
       710        720        730        740        750
LEALFGKQGF FPDSVNKALY WVNGQVPDGV SKVLVDHFGY TKDDKHEQDM 
       760        770        780        790        800
VNGIMLSVEK LIKDLKSKEV PEARAYLRIL GEELGFASLH DLQLLGKLLL 
       810        820        830        840        850
MGARTLQGIP QMIGEVIRKG SKNDFFLHYI FMENAFELPT GAGLQLQISS 
       860        870        880        890        900
SGVIAPGAKA GVKLEVANMQ AELVAKPSVS VEFVTNMGII IPDFARSGVQ 
       910        920        930        940        950
MNTNFFHESG LEAHVALKAG KLKFIIPSPK RPVKLLSGGN TLHLVSTTKT 
       960        970        980        990       1000
EVIPPLIENR QSWSVCKQVF PGLNYCTSGA YSNASSTDSA SYYPLTGDTR 
      1010       1020       1030       1040       1050
LELELRPTGE IEQYSVSATY ELQREDRALV DTLKFVTQAE GAKQTEATMT 
      1060       1070       1080       1090       1100
FKYNRQSMTL SSEVQIPDFD VDLGTILRVN DESTEGKTSY RLTLDIQNKK 
      1110       1120       1130       1140       1150
ITEVALMGHL SCDTKEERKI KGVISIPRLQ AEARSEILAH WSPAKLLLQM 
      1160       1170       1180       1190       1200
DSSATAYGST VSKRVAWHYD EEKIEFEWNT GTNVDTKKMT SNFPVDLSDY 
      1210       1220       1230       1240       1250
PKSLHMYANR LLDHRVPQTD MTFRHVGSKL IVAMSSWLQK ASGSLPYTQT 
      1260       1270       1280       1290       1300
LQDHLNSLKE FNLQNMGLPD FHIPENLFLK SDGRVKYTLN KNSLKIEIPL 
      1310       1320       1330       1340       1350
PFGGKSSRDL KMLETVRTPA LHFKSVGFHL PSREFQVPTF TIPKLYQLQV 
      1360       1370       1380       1390       1400
PLLGVLDLST NVYSNLYNWS ASYSGGNTST DHFSLRARYH MKADSVVDLL 
      1410       1420       1430       1440       1450
SYNVQGSGET TYDHKNTFTL SYDGSLRHKF LDSNIKFSHV EKLGNNPVSK 
      1460       1470       1480       1490       1500
GLLIFDASSS WGPQMSASVH LDSKKKQHLF VKEVKIDGQF RVSSFYAKGT 
      1510       1520       1530       1540       1550
YGLSCQRDPN TGRLNGESNL RFNSSYLQGT NQITGRYEDG TLSLTSTSDL 
      1560       1570       1580       1590       1600
QSGIIKNTAS LKYENYELTL KSDTNGKYKN FATSNKMDMT FSKQNALLRS 
      1610       1620       1630       1640       1650
EYQADYESLR FFSLLSGSLN SHGLELNADI LGTDKINSGA HKATLRIGQD 
      1660       1670       1680       1690       1700
GISTSATTNL KCSLLVLENE LNAELGLSGA SMKLTTNGRF REHNAKFSLD 
      1710       1720       1730       1740       1750
GKAALTELSL GSAYQAMILG VDSKNIFNFK VSQEGLKLSN DMMGSYAEMK 
      1760       1770       1780       1790       1800
FDHTNSLNIA GLSLDFSSKL DNIYSSDKFY KQTVNLQLQP YSLVTTLNSD 
      1810       1820       1830       1840       1850
LKYNALDLTN NGKLRLEPLK LHVAGNLKGA YQNNEIKHIY AISSAALSAS 
      1860       1870       1880       1890       1900
YKADTVAKVQ GVEFSHRLNT DIAGLASAID MSTNYNSDSL HFSNVFRSVM 
      1910       1920       1930       1940       1950
APFTMTIDAH TNGNGKLALW GEHTGQLYSK FLLKAEPLAF TFSHDYKGST 
      1960       1970       1980       1990       2000
SHHLVSRKSI SAALEHKVSA LLTPAEQTGT WKLKTQFNNN EYSQDLDAYN 
      2010       2020       2030       2040       2050
TKDKIGVELT GRTLADLTLL DSPIKVPLLL SEPINIIDAL EMRDAVEKPQ 
      2060       2070       2080       2090       2100
EFTIVAFVKY DKNQDVHSIN LPFFETLQEY FERNRQTIIV VLENVQRNLK 
      2110       2120       2130       2140       2150
HINIDQFVRK YRAALGKLPQ QANDYLNSFN WERQVSHAKE KLTALTKKYR 
      2160       2170       2180       2190       2200
ITENDIQIAL DDAKINFNEK LSQLQTYMIQ FDQYIKDSYD LHDLKIAIAN 
      2210       2220       2230       2240       2250
IIDEIIEKLK SLDEHYHIRV NLVKTIHDLH LFIENIDFNK SGSSTASWIQ 
      2260       2270       2280       2290       2300
NVDTKYQIRI QIQEKLQQLK RHIQNIDIQH LAGKLKQHIE AIDVRVLLDQ 
      2310       2320       2330       2340       2350
LGTTISFERI NDILEHVKHF VINLIGDFEV AEKINAFRAK VHELIERYEV 
      2360       2370       2380       2390       2400
DQQIQVLMDK LVELAHQYKL KETIQKLSNV LQQVKIKDYF EKLVGFIDDA 
      2410       2420       2430       2440       2450
VKKLNELSFK TFIEDVNKFL DMLIKKLKSF DYHQFVDETN DKIREVTQRL 
      2460       2470       2480       2490       2500
NGEIQALELP QKAEALKLFL EETKATVAVY LESLQDTKIT LIINWLQEAL 
      2510       2520       2530       2540       2550
SSASLAHMKA KFRETLEDTR DRMYQMDIQQ ELQRYLSLVG QVYSTLVTYI 
      2560       2570       2580       2590       2600
SDWWTLAAKN LTDFAEQYSI QDWAKRMKAL VEQGFTVPEI KTILGTMPAF 
      2610       2620       2630       2640       2650
EVSLQALQKA TFQTPDFIVP LTDLRIPSVQ INFKDLKNIK IPSRFSTPEF 
      2660       2670       2680       2690       2700
TILNTFHIPS FTIDFVEMKV KIIRTIDQML NSELQWPVPD IYLRDLKVED 
      2710       2720       2730       2740       2750
IPLARITLPD FRLPEIAIPE FIIPTLNLND FQVPDLHIPE FQLPHISHTI 
      2760       2770       2780       2790       2800
EVPTFGKLYS ILKIQSPLFT LDANADIGNG TTSANEAGIA ASITAKGESK 
      2810       2820       2830       2840       2850
LEVLNFDFQA NAQLSNPKIN PLALKESVKF SSKYLRTEHG SEMLFFGNAI 
      2860       2870       2880       2890       2900
EGKSNTVASL HTEKNTLELS NGVIVKINNQ LTLDSNTKYF HKLNIPKLDF 
      2910       2920       2930       2940       2950
SSQADLRNEI KTLLKAGHIA WTSSGKGSWK WACPRFSDEG THESQISFTI 
      2960       2970       2980       2990       3000
EGPLTSFGLS NKINSKHLRV NQNLVYESGS LNFSKLEIQS QVDSQHVGHS 
      3010       3020       3030       3040       3050
VLTAKGMALF GEGKAEFTGR HDAHLNGKVI GTLKNSLFFS AQPFEITAST 
      3060       3070       3080       3090       3100
NNEGNLKVRF PLRLTGKIDF LNNYALFLSP SAQQASWQVS ARFNQYKYNQ 
      3110       3120       3130       3140       3150
NFSAGNNENI MEAHVGINGE ANLDFLNIPL TIPEMRLPYT IITTPPLKDF 
      3160       3170       3180       3190       3200
SLWEKTGLKE FLKTTKQSFD LSVKAQYKKN KHRHSITNPL AVLCEFISQS 
      3210       3220       3230       3240       3250
IKSFDRHFEK NRNNALDFVT KSYNETKIKF DKYKAEKSHD ELPRTFQIPG 
      3260       3270       3280       3290       3300
YTVPVVNVEV SPFTIEMSAF GYVFPKAVSM PSFSILGSDV RVPSYTLILP 
      3310       3320       3330       3340       3350
SLELPVLHVP RNLKLSLPDF KELCTISHIF IPAMGNITYD FSFKSSVITL 
      3360       3370       3380       3390       3400
NTNAELFNQS DIVAHLLSSS SSVIDALQYK LEGTTRLTRK RGLKLATALS 
      3410       3420       3430       3440       3450
LSNKFVEGSH NSTVSLTTKN MEVSVATTTK AQIPILRMNF KQELNGNTKS 
      3460       3470       3480       3490       3500
KPTVSSSMEF KYDFNSSMLY STAKGAVDHK LSLESLTSYF SIESSTKGDV 
      3510       3520       3530       3540       3550
KGSVLSREYS GTIASEANTY LNSKSTRSSV KLQGTSKIDD IWNLEVKENF 
      3560       3570       3580       3590       3600
AGEATLQRIY SLWEHSTKNH LQLEGLFFTN GEHTSKATLE LSPWQMSALV 
      3610       3620       3630       3640       3650
QVHASQPSSF HDFPDLGQEV ALNANTKNQK IRWKNEVRIH SGSFQSQVEL 
      3660       3670       3680       3690       3700
SNDQEKAHLD IAGSLEGHLR FLKNIILPVY DKSLWDFLKL DVTTSIGRRQ 
      3710       3720       3730       3740       3750
HLRVSTAFVY TKNPNGYSFS IPVKVLADKF IIPGLKLNDL NSVLVMPTFH 
      3760       3770       3780       3790       3800
VPFTDLQVPS CKLDFREIQI YKKLRTSSFA LNLPTLPEVK FPEVDVLTKY 
      3810       3820       3830       3840       3850
SQPEDSLIPF FEITVPESQL TVSQFTLPKS VSDGIAALDL NAVANKIADF 
      3860       3870       3880       3890       3900
ELPTIIVPEQ TIEIPSIKFS VPAGIVIPSF QALTARFEVD SPVYNATWSA 
      3910       3920       3930       3940       3950
SLKNKADYVE TVLDSTCSST VQFLEYELNV LGTHKIEDGT LASKTKGTFA 
      3960       3970       3980       3990       4000
HRDFSAEYEE DGKYEGLQEW EGKAHLNIKS PAFTDLHLRY QKDKKGISTS 
      4010       4020       4030       4040       4050
AASPAVGTVG MDMDEDDDFS KWNFYYSPQS SPDKKLTIFK TELRVRESDE 
      4060       4070       4080       4090       4100
ETQIKVNWEE EAASGLLTSL KDNVPKATGV LYDYVNKYHW EHTGLTLREV 
      4110       4120       4130       4140       4150
SSKLRRNLQN NAEWVYQGAI RQIDDIDVRF QKAASGTTGT YQEWKDKAQN 
      4160       4170       4180       4190       4200
LYQELLTQEG QASFQGLKDN VFDGLVRVTQ EFHMKVKHLI DSLIDFLNFP 
      4210       4220       4230       4240       4250
RFQFPGKPGI YTREELCTMF IREVGTVLSQ VYSKVHNGSE ILFSYFQDLV 
      4260       4270       4280       4290       4300
ITLPFELRKH KLIDVISMYR ELLKDLSKEA QEVFKAIQSL KTTEVLRNLQ 
      4310       4320       4330       4340       4350
DLLQFIFQLI EDNIKQLKEM KFTYLINYIQ DEINTIFSDY IPYVFKLLKE 
      4360       4370       4380       4390       4400
NLCLNLHKFN EFIQNELQEA SQELQQIHQY IMALREEYFD PSIVGWTVKY 
      4410       4420       4430       4440       4450
YELEEKIVSL IKNLLVALKD FHSEYIVSAS NFTSQLSSQV EQFLHRNIQE 
      4460       4470       4480       4490       4500
YLSILTDPDG KGKEKIAELS ATAQEIIKSQ AIATKKIISD YHQQFRYKLQ 
      4510       4520       4530       4540       4550
DFSDQLSDYY EKFIAESKRL IDLSIQNYHT FLIYITELLK KLQSTTVMNP 
      4560 
YMKLAPGELT IIL
Length:4,563
Mass (Da):515,605
Last modified:July 13, 2010 - v2
Checksum:i6800F94BF6ADF698
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MUN2A8MUN2_HUMAN
Apolipoprotein B-100
APOB
828Annotation score:

Sequence cautioni

The sequence AAA51752 differs from that shown. Reason: Frameshift at positions 942, 951, 1139, 1165, 1164, 1371 and 1385.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11 – 13Missing in AAB60718 (PubMed:3030729).Curated3
Sequence conflicti11 – 13Missing in CAA28420 (PubMed:3030729).Curated3
Sequence conflicti329L → V in AAA35549 (PubMed:3759943).Curated1
Sequence conflicti645L → I in AAA35549 (PubMed:3759943).Curated1
Sequence conflicti704L → P in AAB04636 (PubMed:3464946).Curated1
Sequence conflicti792 – 809LQLLG…TLQGI → SSSWKAASHGCPHSAGD in AAA51759 (PubMed:3860836).CuratedAdd BLAST18
Sequence conflicti793Q → R in AAB04636 (PubMed:3464946).Curated1
Sequence conflicti893D → K AA sequence (PubMed:6373369).Curated1
Sequence conflicti919A → P in AAA35549 (PubMed:3759943).Curated1
Sequence conflicti1109H → D in CAA28420 (PubMed:3030729).Curated1
Sequence conflicti1180T → R in AAA51752 (PubMed:3461454).Curated1
Sequence conflicti1271F → S in AAB04636 (PubMed:3464946).Curated1
Sequence conflicti1418F → S in CAA28420 (PubMed:3030729).Curated1
Sequence conflicti1445N → I in AAA51752 (PubMed:3461454).Curated1
Sequence conflicti1535G → E in AAA51752 (PubMed:3461454).Curated1
Sequence conflicti1867R → G in AAB04636 (PubMed:3464946).Curated1
Sequence conflicti2098N → K in CAA28420 (PubMed:3030729).Curated1
Sequence conflicti2218I → T in AAB04636 (PubMed:3464946).Curated1
Sequence conflicti2221N → I in CAA28420 (PubMed:3030729).Curated1
Sequence conflicti2324 – 2326LIG → PYW in AAA51741 (PubMed:3676265).Curated3
Sequence conflicti2353Q → H in AAA51741 (PubMed:3676265).Curated1
Sequence conflicti2540G → S in CAA28420 (PubMed:3030729).Curated1
Sequence conflicti2718 – 2737Missing in AAA51758 (PubMed:2883086).CuratedAdd BLAST20
Sequence conflicti2933C → S in AAB04636 (PubMed:3464946).Curated1
Sequence conflicti3114H → L AA sequence (PubMed:6373369).Curated1
Sequence conflicti3131T → R AA sequence (PubMed:6373369).Curated1
Sequence conflicti3134E → P AA sequence (PubMed:6373369).Curated1
Sequence conflicti3137L → R AA sequence (PubMed:6373369).Curated1
Sequence conflicti3239H → Q in CAA28420 (PubMed:3030729).Curated1
Sequence conflicti3286L → I in AAB04636 (PubMed:3464946).Curated1
Sequence conflicti3291R → L in AAA51758 (PubMed:2883086).Curated1
Sequence conflicti3337I → N in AAA51758 (PubMed:2883086).Curated1
Sequence conflicti3431A → P in AAB04636 (PubMed:3464946).Curated1
Sequence conflicti3728D → N in AAA51742 (PubMed:2932736).Curated1
Sequence conflicti3782N → T in AAB04636 (PubMed:3464946).Curated1
Sequence conflicti3824Q → R in CAA28420 (PubMed:3030729).Curated1
Sequence conflicti3824Q → R in AAA51750 (PubMed:2994225).Curated1
Sequence conflicti3876V → A in AAA35549 (PubMed:3759943).Curated1
Sequence conflicti3876V → A in AAA51742 (PubMed:2932736).Curated1
Sequence conflicti3911T → Y AA sequence (PubMed:2115173).Curated1
Sequence conflicti3983F → S in AAA51742 (PubMed:2932736).Curated1
Sequence conflicti4002A → P in AAA51742 (PubMed:2932736).Curated1
Sequence conflicti4110 – 4111NN → DH in AAA35549 (PubMed:3759943).Curated2
Sequence conflicti4110 – 4111NN → DH in AAA51742 (PubMed:2932736).Curated2
Sequence conflicti4122Q → E in AAA35549 (PubMed:3759943).Curated1
Sequence conflicti4122Q → E in AAA51742 (PubMed:2932736).Curated1
Sequence conflicti4128V → E in AAA35549 (PubMed:3759943).Curated1
Sequence conflicti4128V → E in AAA51742 (PubMed:2932736).Curated1
Sequence conflicti4133A → G in AAA35549 (PubMed:3759943).Curated1
Sequence conflicti4133A → G in AAA51742 (PubMed:2932736).Curated1
Sequence conflicti4188H → K in AAB04636 (PubMed:3464946).Curated1
Sequence conflicti4217 – 4218CT → FP in AAA35548 (PubMed:3024665).Curated2
Sequence conflicti4221I → M in AAB04636 (PubMed:3464946).Curated1

RNA editingi

Edited at position 2180.
The stop codon (UAA) at position 2180 is created by RNA editing. Apo B-48, derived from the fully edited RNA, is produced only in the intestine and is found in chylomicrons. Apo B-48 is a shortened form of apo B-100 which lacks the LDL-receptor region. The unedited version (apo B-100) is produced by the liver and is found in the VLDL and LDL.

Polymorphismi

Genetic variations in APOB define the low density lipoprotein cholesterol level quantitative trait locus 4 (LDLCQ4) [MIMi:107730].

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06727712 – 14Missing 1 Publication3
Natural variantiVAR_01618498T → I Polymorphism that influences plasma concentrations of low density lipoprotein cholesterol. 6 PublicationsCorresponds to variant dbSNP:rs1367117EnsemblClinVar.1
Natural variantiVAR_022036103Y → H. Corresponds to variant dbSNP:rs9282603EnsemblClinVar.1
Natural variantiVAR_022037145P → S. Corresponds to variant dbSNP:rs6752026EnsemblClinVar.1
Natural variantiVAR_056737194T → M. Corresponds to variant dbSNP:rs13306198EnsemblClinVar.1
Natural variantiVAR_076538251A → T Polymorphism; does not affect plasma lipid levels. 1 PublicationCorresponds to variant dbSNP:rs61741625EnsemblClinVar.1
Natural variantiVAR_019827273K → N1 Publication1
Natural variantiVAR_029341408I → T. Corresponds to variant dbSNP:rs12714225EnsemblClinVar.1
Natural variantiVAR_022610490R → W in FHBL1; reduced protein secretion. 1 Publication1
Natural variantiVAR_020135554P → L. Corresponds to variant dbSNP:rs12714214EnsemblClinVar.1
Natural variantiVAR_019828618A → V3 PublicationsCorresponds to variant dbSNP:rs679899EnsemblClinVar.1
Natural variantiVAR_020136730V → I1 PublicationCorresponds to variant dbSNP:rs12691202EnsemblClinVar.1
Natural variantiVAR_016185733V → I. Corresponds to variant dbSNP:rs1800476Ensembl.1
Natural variantiVAR_020137741T → N. Corresponds to variant dbSNP:rs12714192EnsemblClinVar.1
Natural variantiVAR_029342877P → L. Corresponds to variant dbSNP:rs12714097EnsemblClinVar.1
Natural variantiVAR_076539952V → L in FHBL1; unknown pathological significance; does not affect interaction with MTTP. 1 Publication1
Natural variantiVAR_056738955P → S. Corresponds to variant dbSNP:rs13306206EnsemblClinVar.1
Natural variantiVAR_0293431086G → S. Corresponds to variant dbSNP:rs12720801EnsemblClinVar.1
Natural variantiVAR_0293441113D → H. Corresponds to variant dbSNP:rs12713844EnsemblClinVar.1
Natural variantiVAR_0226111128R → H1 PublicationCorresponds to variant dbSNP:rs12713843EnsemblClinVar.1
Natural variantiVAR_0198291218Q → E Polymorphism; confirmed at protein level. 2 PublicationsCorresponds to variant dbSNP:rs1041956Ensembl.1
Natural variantiVAR_0293451388R → H. Corresponds to variant dbSNP:rs13306187EnsemblClinVar.1
Natural variantiVAR_0615581422Y → C8 PublicationsCorresponds to variant dbSNP:rs568413Ensembl.1
Natural variantiVAR_0050161437F → L1 PublicationCorresponds to variant dbSNP:rs1801697Ensembl.1
Natural variantiVAR_0672781613S → T1 Publication1
Natural variantiVAR_0689111670E → D Polymorphism; confirmed at protein level. 2 Publications1
Natural variantiVAR_0050171914N → S2 PublicationsCorresponds to variant dbSNP:rs1801699EnsemblClinVar.1
Natural variantiVAR_0050181923H → R2 PublicationsCorresponds to variant dbSNP:rs533617EnsemblClinVar.1
Natural variantiVAR_0689122037I → N Polymorphism; confirmed at protein level. 2 Publications1
Natural variantiVAR_0198302092L → V1 PublicationCorresponds to variant dbSNP:rs1041960Ensembl.1
Natural variantiVAR_0293462299D → H. Corresponds to variant dbSNP:rs12713681EnsemblClinVar.1
Natural variantiVAR_0595822313I → V8 PublicationsCorresponds to variant dbSNP:rs584542Ensembl.1
Natural variantiVAR_0198312365A → T1 PublicationCorresponds to variant dbSNP:rs1041971Ensembl.1
Natural variantiVAR_0201382456A → D. Corresponds to variant dbSNP:rs12713675EnsemblClinVar.1
Natural variantiVAR_0357952564F → C in a colorectal cancer sample; somatic mutation; confirmed at protein level. 2 Publications1
Natural variantiVAR_0050192566E → K Polymorphism; confirmed at protein level. 3 PublicationsCorresponds to variant dbSNP:rs1801696EnsemblClinVar.1
Natural variantiVAR_0198322680L → Q1 PublicationCorresponds to variant dbSNP:rs1042013Ensembl.1
Natural variantiVAR_0050202739P → L3 PublicationsCorresponds to variant dbSNP:rs676210EnsemblClinVar.1
Natural variantiVAR_0220382785N → H. Corresponds to variant dbSNP:rs2163204EnsemblClinVar.1
Natural variantiVAR_0050213121A → T1 PublicationCorresponds to variant dbSNP:rs1801694Ensembl.1
Natural variantiVAR_0293473182H → N. Corresponds to variant dbSNP:rs12720848Ensembl.1
Natural variantiVAR_0293483279S → G. Corresponds to variant dbSNP:rs12720854EnsemblClinVar.1
Natural variantiVAR_0201393294S → P. Corresponds to variant dbSNP:rs12720855EnsemblClinVar.1
Natural variantiVAR_0050223319D → H8 Publications1
Natural variantiVAR_0050233427T → K8 Publications1
Natural variantiVAR_0050243432Q → E8 PublicationsCorresponds to variant dbSNP:rs1042023EnsemblClinVar.1
Natural variantiVAR_0050253527R → Q in FDB. 3 PublicationsCorresponds to variant dbSNP:rs5742904EnsemblClinVar.1
Natural variantiVAR_0050263558R → C in FDB. 2 PublicationsCorresponds to variant dbSNP:rs12713559EnsemblClinVar.1
Natural variantiVAR_0161863638R → Q1 PublicationCorresponds to variant dbSNP:rs1801701EnsemblClinVar.1
Natural variantiVAR_0198333732I → T4 PublicationsCorresponds to variant dbSNP:rs1042025Ensembl.1
Natural variantiVAR_0293493801S → T. Corresponds to variant dbSNP:rs12713540EnsemblClinVar.1
Natural variantiVAR_0672793835I → L1 Publication1
Natural variantiVAR_0050273921V → I1 PublicationCorresponds to variant dbSNP:rs72654409EnsemblClinVar.1
Natural variantiVAR_0050283945T → A1 PublicationCorresponds to variant dbSNP:rs1801698EnsemblClinVar.1
Natural variantiVAR_0198343949F → L5 PublicationsCorresponds to variant dbSNP:rs1042027Ensembl.1
Natural variantiVAR_0198353964Y → F4 PublicationsCorresponds to variant dbSNP:rs1126468Ensembl.1
Natural variantiVAR_0050294128V → M1 PublicationCorresponds to variant dbSNP:rs1801703EnsemblClinVar.1
Natural variantiVAR_0161874181E → K6 PublicationsCorresponds to variant dbSNP:rs1042031EnsemblClinVar.1
Natural variantiVAR_0161884270R → T1 PublicationCorresponds to variant dbSNP:rs1801702EnsemblClinVar.1
Natural variantiVAR_0672804314I → V1 PublicationCorresponds to variant dbSNP:rs72654423EnsemblClinVar.1
Natural variantiVAR_0050304338S → N11 PublicationsCorresponds to variant dbSNP:rs1042034EnsemblClinVar.1
Natural variantiVAR_0293504394V → A. Corresponds to variant dbSNP:rs12720843EnsemblClinVar.1
Natural variantiVAR_0050314481A → T2 PublicationsCorresponds to variant dbSNP:rs1801695EnsemblClinVar.1
Natural variantiVAR_0672814482I → V1 Publication1
Natural variantiVAR_0201404484T → M. Corresponds to variant dbSNP:rs12713450EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04506 mRNA Translation: CAA28191.1
M19828
, M19808, M19809, M19810, M19811, M19812, M19813, M19815, M19816, M19818, M19820, M19821, M19823, M19824, M19825, M19827 Genomic DNA Translation: AAB00481.1
J02610 mRNA Translation: AAA35549.1
M14162 mRNA Translation: AAB04636.1
M15053 Genomic DNA Translation: AAB60718.1
X04714 mRNA Translation: CAA28420.1
AY324608 Genomic DNA Translation: AAP72970.1
AC010872 Genomic DNA Translation: AAX88848.1
AC115619 Genomic DNA Translation: AAX93246.1
M14081 mRNA Translation: AAA51752.1 Frameshift.
M12681 mRNA Translation: AAA51753.1
M12480 mRNA Translation: AAA51751.1
K03175 mRNA Translation: AAA51759.1
M15421 mRNA Translation: AAA51758.1
M17367 mRNA Translation: AAA51741.1
M31030 mRNA Translation: AAA51756.1
X03325 mRNA Translation: CAA27044.1
X03326 mRNA Translation: CAA27045.1
M17779 mRNA Translation: AAA51755.1
M19734 mRNA Translation: AAA35544.1
M18471 mRNA Translation: AAA35541.1
X03045 mRNA Translation: CAA26850.1
M10374 mRNA Translation: AAA51750.1
M12413 mRNA Translation: AAA51742.1
M36676 mRNA Translation: AAA35548.1
CCDSiCCDS1703.1
PIRiA27850 LPHUB
RefSeqiNP_000375.2, NM_000384.2
UniGeneiHs.120759

Genome annotation databases

EnsembliENST00000233242; ENSP00000233242; ENSG00000084674
GeneIDi338
KEGGihsa:338
UCSCiuc002red.3 human

Keywords - Coding sequence diversityi

Polymorphism, RNA editing

Similar proteinsi

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Apolipoprotein B entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04506 mRNA Translation: CAA28191.1
M19828
, M19808, M19809, M19810, M19811, M19812, M19813, M19815, M19816, M19818, M19820, M19821, M19823, M19824, M19825, M19827 Genomic DNA Translation: AAB00481.1
J02610 mRNA Translation: AAA35549.1
M14162 mRNA Translation: AAB04636.1
M15053 Genomic DNA Translation: AAB60718.1
X04714 mRNA Translation: CAA28420.1
AY324608 Genomic DNA Translation: AAP72970.1
AC010872 Genomic DNA Translation: AAX88848.1
AC115619 Genomic DNA Translation: AAX93246.1
M14081 mRNA Translation: AAA51752.1 Frameshift.
M12681 mRNA Translation: AAA51753.1
M12480 mRNA Translation: AAA51751.1
K03175 mRNA Translation: AAA51759.1
M15421 mRNA Translation: AAA51758.1
M17367 mRNA Translation: AAA51741.1
M31030 mRNA Translation: AAA51756.1
X03325 mRNA Translation: CAA27044.1
X03326 mRNA Translation: CAA27045.1
M17779 mRNA Translation: AAA51755.1
M19734 mRNA Translation: AAA35544.1
M18471 mRNA Translation: AAA35541.1
X03045 mRNA Translation: CAA26850.1
M10374 mRNA Translation: AAA51750.1
M12413 mRNA Translation: AAA51742.1
M36676 mRNA Translation: AAA35548.1
CCDSiCCDS1703.1
PIRiA27850 LPHUB
RefSeqiNP_000375.2, NM_000384.2
UniGeneiHs.120759

3D structure databases

ProteinModelPortaliP04114
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106835, 71 interactors
DIPiDIP-44767N
IntActiP04114, 31 interactors
MINTiP04114
STRINGi9606.ENSP00000233242

Chemistry databases

BindingDBiP04114
ChEMBLiCHEMBL4549

PTM databases

CarbonylDBiP04114
GlyConnecti57
iPTMnetiP04114
PhosphoSitePlusiP04114
SwissPalmiP04114
UniCarbKBiP04114

Polymorphism and mutation databases

BioMutaiAPOB
DMDMi300669605

Proteomic databases

EPDiP04114
MaxQBiP04114
PaxDbiP04114
PeptideAtlasiP04114
PRIDEiP04114
ProteomicsDBi51654

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233242; ENSP00000233242; ENSG00000084674
GeneIDi338
KEGGihsa:338
UCSCiuc002red.3 human

Organism-specific databases

CTDi338
DisGeNETi338
EuPathDBiHostDB:ENSG00000084674.13
GeneCardsiAPOB
GeneReviewsiAPOB
H-InvDBiHIX0024005
HGNCiHGNC:603 APOB
HPAiCAB016070
HPA049793
MalaCardsiAPOB
MIMi107730 gene+phenotype
144010 phenotype
615558 phenotype
neXtProtiNX_P04114
Orphaneti391665 Homozygous familial hypercholesterolemia
426 NON RARE IN EUROPE: Familial hypobetalipoproteinemia
406 NON RARE IN EUROPE: Heterozygous familial hypercholesterolemia
PharmGKBiPA50
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4338 Eukaryota
ENOG411104F LUCA
HOVERGENiHBG050546
InParanoidiP04114
KOiK14462
OrthoDBiEOG091G000G
PhylomeDBiP04114
TreeFamiTF331316

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-3000471 Scavenging by Class B Receptors
R-HSA-3000480 Scavenging by Class A Receptors
R-HSA-3000484 Scavenging by Class F Receptors
R-HSA-3000497 Scavenging by Class H Receptors
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-432142 Platelet sensitization by LDL
R-HSA-5686938 Regulation of TLR by endogenous ligand
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-8866423 VLDL assembly
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-8963888 Chylomicron assembly
R-HSA-8963901 Chylomicron remodeling
R-HSA-8964026 Chylomicron clearance
R-HSA-8964038 LDL clearance
R-HSA-8964041 LDL remodeling
R-HSA-8964046 VLDL clearance
R-HSA-975634 Retinoid metabolism and transport
SIGNORiP04114

Miscellaneous databases

ChiTaRSiAPOB human
GeneWikiiApolipoprotein_B
GenomeRNAii338
PROiPR:P04114
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000084674 Expressed in 86 organ(s), highest expression level in jejunal mucosa
ExpressionAtlasiP04114 baseline and differential
GenevisibleiP04114 HS

Family and domain databases

Gene3Di1.25.10.20, 1 hit
2.30.230.10, 1 hit
InterProiView protein in InterPro
IPR022176 ApoB100_C
IPR016024 ARM-type_fold
IPR015819 Lipid_transp_b-sht_shell
IPR001747 Lipid_transpt_N
IPR009454 Lipid_transpt_open_b-sht
IPR011030 Lipovitellin_superhlx_dom
IPR015816 Vitellinogen_b-sht_N
IPR015255 Vitellinogen_open_b-sht
PfamiView protein in Pfam
PF12491 ApoB100_C, 1 hit
PF06448 DUF1081, 1 hit
PF09172 DUF1943, 1 hit
PF01347 Vitellogenin_N, 1 hit
SMARTiView protein in SMART
SM01169 DUF1943, 1 hit
SM00638 LPD_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF48431 SSF48431, 1 hit
SSF56968 SSF56968, 2 hits
PROSITEiView protein in PROSITE
PS51211 VITELLOGENIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAPOB_HUMAN
AccessioniPrimary (citable) accession number: P04114
Secondary accession number(s): O00502
, P78479, P78480, P78481, Q13779, Q13785, Q13786, Q13787, Q13788, Q4ZG63, Q53QC8, Q7Z600, Q9UMN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: July 13, 2010
Last modified: November 7, 2018
This is version 221 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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