Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
1 to 25 of 109  Show
  1. 1
    "Relaxin gene expression in human ovaries and the predicted structure of a human preprorelaxin by analysis of cDNA clones."
    Hudson P., John M., Crawford R., Haralambidis J., Scanlon D., Gorman J., Tregear G., Shine J., Niall H.
    EMBO J. 3:2333-2339(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Category: Expression, Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 other entry.

  2. 2
    "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 2195 other entries.

  3. 3
    "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Category: Sequences.
    Tissue: Brain.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 50469 other entries.

  4. 4
    "Expression of human relaxin genes: characterization of a novel alternatively-spliced human relaxin mRNA species."
    Gunnersen J.M., Fu P., Roche P.J., Tregear G.W.
    Mol. Cell. Endocrinol. 118:85-94(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-185 (ISOFORM 2), TISSUE SPECIFICITY.
    Category: Expression, Sequences.
    Tissue: Prostate.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 2 other entries.

  5. 5
    "Analysis of the 5'-upstream regions of the human relaxin H1 and H2 genes and their chromosomal localization on chromosome 9p24.1 by radiation hybrid and breakpoint mapping."
    Garibay-Tupas J.L., Csiszar K., Fox M., Povey S., Bryant-Greenwood G.D.
    J. Mol. Endocrinol. 23:355-365(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-15.
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 other entry.

  6. 6
    "Human seminal relaxin is a product of the same gene as human luteal relaxin."
    Winslow J.W., Shih A., Bourell J.H., Weiss G., Reed B., Stults J.T., Goldsmith L.T.
    Endocrinology 130:2660-2668(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-51.
    Category: Sequences.
    Tissue: Semen.
    Source: UniProtKB/Swiss-Prot (reviewed).
  7. 7
    "Structural characterization by mass spectrometry of native and recombinant human relaxin."
    Winslow J.W., Griffin P.R., Rinderknecht E., Vandlen R.L.
    Biomed. Environ. Mass Spectrom. 19:655-664(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-53 AND 162-185 (ISOFORM 1), PYROGLUTAMATE FORMATION AT GLN-162.
    Category: PTM / Processing, Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).
  8. 8
    "Total synthesis of human relaxin and human relaxin derivatives by solid-phase peptide synthesis and site-directed chain combination."
    Buellesbach E.E., Schwabe C.
    J. Biol. Chem. 266:10754-10761(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: SYNTHESIS.
    Source: UniProtKB/Swiss-Prot (reviewed).
  9. 9
    "X-ray structure of human relaxin at 1.5 A. Comparison to insulin and implications for receptor binding determinants."
    Eigenbrot C., Randal M., Quan C., Burnier J., O'Connell L., Rinderknecht E., Kossiakoff A.A.
    J. Mol. Biol. 221:15-21(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS).
    Category: Structure.
    Source: UniProtKB/Swiss-Prot (reviewed).
  10. 10
    "Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus."
    Feldman D.S., Zamah A.M., Pierce K.L., Miller W.E., Kelly F., Rapacciuolo A., Rockman H.A., Koch W.J., Luttrell L.M.
    J. Biol. Chem. 277:28631-28640(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: PathwayImported.
    Source: Reactome:R-HSA-444870, Reactome:R-HSA-444896.

    This publication is mapped to 111 other entries.

  11. 11
    "Similarities and differences in the coupling of human beta1- and beta2-adrenoceptors to Gs(alpha) splice variants."
    Wenzel-Seifert K., Liu H.Y., Seifert R.
    Biochem. Pharmacol. 64:9-20(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: PathwayImported.
    Source: Reactome:R-HSA-444870, Reactome:R-HSA-444896.

    This publication is mapped to 126 other entries.

  12. 12
    "[Expression, purification and characterization of human prorelaxin-like-protein H2 in Escherichia coli]."
    Chen L.M., Yang X.W., Tang J.G.
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34:595-600(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: Expression purification and characterization of human prorelaxin-like-protein H2 in Escherichia coliImported.
    Source: GeneRIF:6019.
  13. 13
    "H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2."
    Sudo S., Kumagai J., Nishi S., Layfield S., Ferraro T., Bathgate R.A.D., Hsueh A.J.W.
    J. Biol. Chem. 278:7855-7862(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: PathwayImported.
    Source: Reactome:R-HSA-444870, Reactome:R-HSA-444896.

    This publication is cited by 2 and mapped to 2 other entries.

  14. 14
    "Relaxin regulates fibrillin 2, but not fibrillin 1, mRNA and protein expression by human dermal fibroblasts and murine fetal skin."
    Samuel C.S., Sakai L.Y., Amento E.P.
    Arch. Biochem. Biophys. 411:47-55(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Expression, Sequences.
    Annotation: regulates fibrillin 2 but not fibrillin 1 mRNA and protein expression by human dermal fibroblasts and murine fetal skinImported.
    Source: GeneRIF:6019.

    This publication is mapped to 23 other entries.

  15. 15
    "Characterization of the 5-HT6 receptor coupled to Ca2+ signaling using an enabling chimeric G-protein."
    Zhang J.Y., Nawoschik S., Kowal D., Smith D., Spangler T., Ochalski R., Schechter L., Dunlop J.
    Eur. J. Pharmacol. 472:33-38(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: PathwayImported.
    Source: Reactome:R-HSA-444870, Reactome:R-HSA-444896.

    This publication is mapped to 111 other entries.

  16. 16
    "Relaxin regulation of endometrial structure and function in the rhesus monkey."
    Goldsmith L.T., Weiss G., Palejwala S., Plant T.M., Wojtczuk A., Lambert W.C., Ammur N., Heller D., Skurnick J.H., Edwards D., Cole D.M.
    Proc. Natl. Acad. Sci. U.S.A. 101:4685-4689(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: Relaxin stimulates new blood vessel formation and increases cytokine-containing lymphocyte number while maintaining endometrial connective tissue integrity.Imported.
    Source: GeneRIF:6019.
  17. 17
    "Porcine and human relaxin bioactivity: bioactivities of porcine relaxin and human relaxin do not differ in mice and rats."
    Zhao S., Lee H.Y., Sherwood O.D.
    Ann. N. Y. Acad. Sci. 1041:126-131(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: No difference in bioactivity was detected between porcine relaxin-1 and recombinant human relaxin-2 in either mice or ratsImported.
    Source: GeneRIF:6019.
  18. 18
    "Central effects of long-term relaxin expression in the rat."
    Silvertown J.D., Fraser R., Poterski R.S., Geddes B., Summerlee A.J.
    Ann. N. Y. Acad. Sci. 1041:216-222(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: Adenovirus-mediated delivery of human H2 preprorelaxin (hH2) to the brain is capable of producing bioactive relaxin that affects cardiovascular parametersImported.
    Source: GeneRIF:6019.
  19. 19
    "Signal switching after stimulation of LGR7 receptors by human relaxin 2."
    Halls M.L., Bathgate R.A., Summers R.J.
    Ann. N. Y. Acad. Sci. 1041:288-291(2005) [PubMed] [Europe PMC] [Abstract]
    Category: PTM / Processing.
    Annotation: relaxin 2 can increase Cyclic AMP via Gs-adenylate cyclase pathwayImported.
    Source: GeneRIF:6019.

    This publication is mapped to 8 other entries.

  20. 20
    "Does human relaxin-2 affect peripheral blood mononuclear cells to increase inflammatory mediators in pathologic bone loss?"
    Kristiansson P., Holding C., Hughes S., Haynes D.
    Ann. N. Y. Acad. Sci. 1041:317-319(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Although all cell types expressed mRNA for the relaxin receptor (LGR7) only peripheral blood mononuclear cells responded to relaxin 2 at physiologic levels by increasing tumor necrosis factor-alpha and interleukin-1beta secretionImported.
    Source: GeneRIF:6019.

    This publication is mapped to 11 other entries.

  21. 21
    "Demonstration of upregulated H2 relaxin mRNA expression during neuroendocrine differentiation of LNCaP prostate cancer cells and production of biologically active mammalian recombinant 6 histidine-tagged H2 relaxin."
    Figueiredo K.A., Palmer J.B., Mui A.L., Nelson C.C., Cox M.E.
    Ann. N. Y. Acad. Sci. 1041:320-327(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Expression, Sequences.
    Annotation: characterization of upregulated H2 relaxin gene expression during neuroendocrine differentiation of the human prostate cancer model LNCaPImported.
    Source: GeneRIF:6019.
  22. 22
    "Human decidual relaxin and preterm birth."
    Bryant-Greenwood G.D., Yamamoto S.Y., Lowndes K.M., Webster L.E., Parg S.S., Amano A., Bullesbach E.E., Schwabe C., Millar L.K.
    Ann. N. Y. Acad. Sci. 1041:338-344(2005) [PubMed] [Europe PMC] [Abstract]
    Annotation: roles of the relaxin system in three potential causes of preterm birth are discussedImported.
    Source: GeneRIF:6013.

    This publication is mapped to 1 other entry.

  23. 23
    "Does human relaxin accelerate orthodontic tooth movement in rats?"
    Liu Z.J., King G.J., Gu G.M., Shin J.Y., Stewart D.R.
    Ann. N. Y. Acad. Sci. 1041:388-394(2005) [PubMed] [Europe PMC] [Abstract]
    Annotation: human relaxin may accelerate the early stages of orthodontic tooth movement in ratsImported.
    Source: GeneRIF:6013.

    This publication is mapped to 1 other entry.

  24. 24
    "Human medullary thyroid carcinoma: a source and potential target for relaxin-like hormones."
    Klonisch T., Mustafa T., Bialek J., Radestock Y., Holzhausen H.J., Dralle H., Hoang-Vu C., Hombach-Klonisch S.
    Ann. N. Y. Acad. Sci. 1041:449-461(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Expression, Sequences.
    Annotation: relaxin-like hormones appear to be present early during C-cell hyperplasia and potentially functional relaxin/INSL3 ligand-receptor systems are present in human medullary thyroid carcinoma tissues and cell linesImported.
    Source: GeneRIF:6019, GeneRIF:6013.

    This publication is mapped to 2 other entries.

  25. 25
    "Relaxin reverses cardiac and renal fibrosis in spontaneously hypertensive rats."
    Lekgabe E.D., Kiriazis H., Zhao C., Xu Q., Moore X.L., Su Y., Bathgate R.A., Du X.J., Samuel C.S.
    Hypertension 46:412-418(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: Relaxin is a potent antifibrotic hormone with a rapid-occurring efficacy that may have therapeutic potential for hypertensive disease.Imported.
    Source: GeneRIF:6019.
1 to 25 of 109  Show
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again