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Protein

Platelet-derived growth factor subunit A

Gene

PDGFA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Mitogen

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-186763 Downstream signal transduction
R-HSA-186797 Signaling by PDGF
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SignaLinkiP04085
SIGNORiP04085

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-derived growth factor subunit A
Short name:
PDGF subunit A
Alternative name(s):
PDGF-1
Platelet-derived growth factor A chain
Platelet-derived growth factor alpha polypeptide
Gene namesi
Name:PDGFA
Synonyms:PDGF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000197461.13
HGNCiHGNC:8799 PDGFA
MIMi173430 gene
neXtProtiNX_P04085

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5154
OpenTargetsiENSG00000197461
PharmGKBiPA33144

Chemistry databases

ChEMBLiCHEMBL3137294

Polymorphism and mutation databases

BioMutaiPDGFA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
PropeptideiPRO_000002335621 – 86Removed in mature formAdd BLAST66
ChainiPRO_000002335787 – 211Platelet-derived growth factor subunit AAdd BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi96 ↔ 1401 Publication
Disulfide bondi123Interchain1 Publication
Disulfide bondi129 ↔ 1771 Publication
Disulfide bondi132Interchain1 Publication
Disulfide bondi133 ↔ 1791 Publication
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

EPDiP04085
PaxDbiP04085
PeptideAtlasiP04085
PRIDEiP04085
ProteomicsDBi51650
51651 [P04085-2]

PTM databases

iPTMnetiP04085
PhosphoSitePlusiP04085

Expressioni

Gene expression databases

BgeeiENSG00000197461 Expressed in 224 organ(s), highest expression level in left coronary artery
CleanExiHS_PDGFA
ExpressionAtlasiP04085 baseline and differential
GenevisibleiP04085 HS

Organism-specific databases

HPAiCAB005579

Interactioni

Subunit structurei

Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFB; antiparallel disulfide-linked dimer. The PDGFA homodimer interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with CSPG4.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PDGFRAP162346EBI-2881386,EBI-2861522

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111180, 14 interactors
ComplexPortaliCPX-1874 Platelet-derived growth factor AA complex
CPX-1875 Platelet-derived growth factor AB complex
CPX-2881 PDGF receptor alpha - PDGF-AA complex
CPX-2885 PDGF receptor alpha - PDGF-AB complex
CPX-2886 PDGF receptor beta - PDGF-AB complex
CPX-2892 PDGF receptor alpha-beta - PDGF-AB complex
DIPiDIP-5735N
IntActiP04085, 8 interactors
STRINGi9606.ENSP00000346508

Chemistry databases

BindingDBiP04085

Structurei

Secondary structure

1211
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP04085
SMRiP04085
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04085

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni158 – 162Receptor binding siteSequence analysis5

Domaini

The long form contains a basic insert which acts as a cell retention signal.

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEXJ Eukaryota
ENOG4111GMH LUCA
GeneTreeiENSGT00510000046755
HOGENOMiHOG000286027
HOVERGENiHBG053546
InParanoidiP04085
KOiK04359
OMAiMRTWACL
OrthoDBiEOG091G0LNU
PhylomeDBiP04085
TreeFamiTF319554

Family and domain databases

CDDicd00135 PDGF, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR023581 PD_growth_factor_CS
IPR000072 PDGF/VEGF_dom
IPR006782 PDGF_N
PfamiView protein in Pfam
PF00341 PDGF, 1 hit
PF04692 PDGF_N, 1 hit
SMARTiView protein in SMART
SM00141 PDGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00249 PDGF_1, 1 hit
PS50278 PDGF_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: P04085-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRTLACLLLL GCGYLAHVLA EEAEIPREVI ERLARSQIHS IRDLQRLLEI
60 70 80 90 100
DSVGSEDSLD TSLRAHGVHA TKHVPEKRPL PIRRKRSIEE AVPAVCKTRT
110 120 130 140 150
VIYEIPRSQV DPTSANFLIW PPCVEVKRCT GCCNTSSVKC QPSRVHHRSV
160 170 180 190 200
KVAKVEYVRK KPKLKEVQVR LEEHLECACA TTSLNPDYRE EDTGRPRESG
210
KKRKRKRLKP T
Length:211
Mass (Da):24,043
Last modified:November 1, 1986 - v1
Checksum:i48633DDE558EFA43
GO
Isoform Short (identifier: P04085-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     194-196: GRP → DVR
     197-211: Missing.

Show »
Length:196
Mass (Da):22,253
Checksum:i5EDBDB62D565904B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSC4A0A0A0MSC4_HUMAN
Platelet-derived growth factor subu...
PDGFA
86Annotation score:
H7BYW6H7BYW6_HUMAN
Platelet-derived growth factor subu...
PDGFA
205Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64 – 66RAH → TRD in AAA60045 (PubMed:2832727).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004602194 – 196GRP → DVR in isoform Short. 1 Publication3
Alternative sequenceiVSP_004603197 – 211Missing in isoform Short. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03795 mRNA Translation: CAA27421.1
X06374 mRNA Translation: CAA29677.1
M20494
, M20488, M20489, M20490, M20491, M20492, M20493 Genomic DNA Translation: AAA60045.1
M19988
, M21571, M19984, M19985, M19986, M19987 Genomic DNA Translation: AAA60046.1
M19989
, M21571, M19984, M19985, M19986, M19987 Genomic DNA Translation: AAA60047.1
AB451309 mRNA Translation: BAG70123.1
AB451439 mRNA Translation: BAG70253.1
AC147651 Genomic DNA No translation available.
S62078 Genomic DNA Translation: AAB26566.1
CCDSiCCDS34578.1 [P04085-1]
CCDS47524.1 [P04085-2]
PIRiA28964 PFHUG1
B28964
RefSeqiNP_002598.4, NM_002607.5 [P04085-1]
NP_148983.1, NM_033023.4 [P04085-2]
UniGeneiHs.535898

Genome annotation databases

EnsembliENST00000354513; ENSP00000346508; ENSG00000197461 [P04085-1]
ENST00000402802; ENSP00000383889; ENSG00000197461 [P04085-2]
GeneIDi5154
KEGGihsa:5154
UCSCiuc003sir.4 human [P04085-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03795 mRNA Translation: CAA27421.1
X06374 mRNA Translation: CAA29677.1
M20494
, M20488, M20489, M20490, M20491, M20492, M20493 Genomic DNA Translation: AAA60045.1
M19988
, M21571, M19984, M19985, M19986, M19987 Genomic DNA Translation: AAA60046.1
M19989
, M21571, M19984, M19985, M19986, M19987 Genomic DNA Translation: AAA60047.1
AB451309 mRNA Translation: BAG70123.1
AB451439 mRNA Translation: BAG70253.1
AC147651 Genomic DNA No translation available.
S62078 Genomic DNA Translation: AAB26566.1
CCDSiCCDS34578.1 [P04085-1]
CCDS47524.1 [P04085-2]
PIRiA28964 PFHUG1
B28964
RefSeqiNP_002598.4, NM_002607.5 [P04085-1]
NP_148983.1, NM_033023.4 [P04085-2]
UniGeneiHs.535898

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MJKX-ray2.40A/B/E/F/X/Y21-181[»]
ProteinModelPortaliP04085
SMRiP04085
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111180, 14 interactors
ComplexPortaliCPX-1874 Platelet-derived growth factor AA complex
CPX-1875 Platelet-derived growth factor AB complex
CPX-2881 PDGF receptor alpha - PDGF-AA complex
CPX-2885 PDGF receptor alpha - PDGF-AB complex
CPX-2886 PDGF receptor beta - PDGF-AB complex
CPX-2892 PDGF receptor alpha-beta - PDGF-AB complex
DIPiDIP-5735N
IntActiP04085, 8 interactors
STRINGi9606.ENSP00000346508

Chemistry databases

BindingDBiP04085
ChEMBLiCHEMBL3137294

PTM databases

iPTMnetiP04085
PhosphoSitePlusiP04085

Polymorphism and mutation databases

BioMutaiPDGFA

Proteomic databases

EPDiP04085
PaxDbiP04085
PeptideAtlasiP04085
PRIDEiP04085
ProteomicsDBi51650
51651 [P04085-2]

Protocols and materials databases

DNASUi5154
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354513; ENSP00000346508; ENSG00000197461 [P04085-1]
ENST00000402802; ENSP00000383889; ENSG00000197461 [P04085-2]
GeneIDi5154
KEGGihsa:5154
UCSCiuc003sir.4 human [P04085-1]

Organism-specific databases

CTDi5154
DisGeNETi5154
EuPathDBiHostDB:ENSG00000197461.13
GeneCardsiPDGFA
H-InvDBiHIX0167622
HGNCiHGNC:8799 PDGFA
HPAiCAB005579
MIMi173430 gene
neXtProtiNX_P04085
OpenTargetsiENSG00000197461
PharmGKBiPA33144
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEXJ Eukaryota
ENOG4111GMH LUCA
GeneTreeiENSGT00510000046755
HOGENOMiHOG000286027
HOVERGENiHBG053546
InParanoidiP04085
KOiK04359
OMAiMRTWACL
OrthoDBiEOG091G0LNU
PhylomeDBiP04085
TreeFamiTF319554

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-186763 Downstream signal transduction
R-HSA-186797 Signaling by PDGF
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SignaLinkiP04085
SIGNORiP04085

Miscellaneous databases

EvolutionaryTraceiP04085
GeneWikiiPDGFA
GenomeRNAii5154
PROiPR:P04085
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197461 Expressed in 224 organ(s), highest expression level in left coronary artery
CleanExiHS_PDGFA
ExpressionAtlasiP04085 baseline and differential
GenevisibleiP04085 HS

Family and domain databases

CDDicd00135 PDGF, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR023581 PD_growth_factor_CS
IPR000072 PDGF/VEGF_dom
IPR006782 PDGF_N
PfamiView protein in Pfam
PF00341 PDGF, 1 hit
PF04692 PDGF_N, 1 hit
SMARTiView protein in SMART
SM00141 PDGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00249 PDGF_1, 1 hit
PS50278 PDGF_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPDGFA_HUMAN
AccessioniPrimary (citable) accession number: P04085
Secondary accession number(s): B5BU73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: November 1, 1986
Last modified: September 12, 2018
This is version 188 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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