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UniProtKB - P04084 (PA2HA_VIPAE)
Protein
Acidic phospholipase A2 homolog vipoxin A chain
Gene
N/A
Organism
Vipera ammodytes meridionalis (Eastern sand viper)
Status
Functioni
Heterodimer: postsynaptic neurotoxin.
1 PublicationMonomer: Acidic phospholipase A2 homolog that is non-toxic.
1 PublicationCaution
In contrast to other phospholipases, it lacks the typical His active site (His->Gln in position 47).Curated
The acidic chain was originally postulated to act as an inhibitor of the basic chain.1 Publication
GO - Molecular functioni
- calcium ion binding Source: InterPro
- phospholipase A2 activity Source: InterPro
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- arachidonic acid secretion Source: InterPro
- lipid catabolic process Source: InterPro
- phospholipid metabolic process Source: InterPro
Keywordsi
Molecular function | Neurotoxin, Postsynaptic neurotoxin, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Acidic phospholipase A2 homolog vipoxin A chainShort name: svPLA2 homolog Alternative name(s): Acidic phospholipase A2 inhibitor vipoxin A chain Vipoxin acidic component Short name: VAC Vipoxin non-toxic component |
Organismi | Vipera ammodytes meridionalis (Eastern sand viper) |
Taxonomic identifieri | 73841 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Viperidae › Viperinae › Vipera › |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Toxic dosei
Heterodimer: LD50 is 0.7-1.2 mg/kg by intraperitoneal injection into mice and 0.9-1.3 mg/kg by intravenous injection into mice.1 Publication
Heterodimer: LD50 is 0.9-1.3 mg/kg by intravenous injection into mice.1 Publication
Monomer: LD50 is >30 mg/kg by intraperitoneal injection into mice.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000161713 | 1 – 122 | Acidic phospholipase A2 homolog vipoxin A chainAdd BLAST | 122 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 26 ↔ 115 | Combined sources2 Publications | ||
Disulfide bondi | 28 ↔ 44 | Combined sources2 Publications | ||
Disulfide bondi | 43 ↔ 95 | Combined sources2 Publications | ||
Disulfide bondi | 49 ↔ 122 | Combined sources2 Publications | ||
Disulfide bondi | 50 ↔ 88 | Combined sources2 Publications | ||
Disulfide bondi | 57 ↔ 81 | Combined sources2 Publications | ||
Disulfide bondi | 75 ↔ 86 | Combined sources2 Publications |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.
Interactioni
Subunit structurei
Heterodimer of A and B (AC P14420) chains; non-covalently linked. The A chain (acidic) is non-toxic, and increases the toxicity of the B chain (basic). The A chain may act as factor stabilizing the complex structure and hence retaining its toxicity by preventing non-specific binding. Upon binding to the target membranes the A chain may dissociate.
4 PublicationsProtein-protein interaction databases
MINTi | P04084 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P04084 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P04084 |
Family & Domainsi
Sequence similaritiesi
Family and domain databases
CDDi | cd00125, PLA2c, 1 hit |
Gene3Di | 1.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001211, PLipase_A2 IPR033112, PLipase_A2_Asp_AS IPR016090, PLipase_A2_dom IPR036444, PLipase_A2_dom_sf |
PANTHERi | PTHR11716, PTHR11716, 1 hit |
Pfami | View protein in Pfam PF00068, Phospholip_A2_1, 1 hit |
PRINTSi | PR00389, PHPHLIPASEA2 |
SMARTi | View protein in SMART SM00085, PA2c, 1 hit |
SUPFAMi | SSF48619, SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00119, PA2_ASP, 1 hit |
i Sequence
Sequence statusi: Complete.
P04084-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
NLFQFGDMIL QKTGKEAVHS YAIYGCYCGW GGQGRAQDAT DRCCFAQDCC
60 70 80 90 100
YGRVNDCNPK TATYTYSFEN GDIVCGDNDL CLRAVCECDR AAAICLGENV
110 120
NTYDKNYEYY SISHCTEESE QC
Sequence databases
PIRi | B29290, PSVII |
Similar proteinsi
Cross-referencesi
Sequence databases
PIRi | B29290, PSVII |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AOK | X-ray | 2.00 | A | 1-122 | [»] | |
1JLT | X-ray | 1.40 | A | 1-122 | [»] | |
1Q5T | X-ray | 1.90 | A/B | 1-122 | [»] | |
1VPI | X-ray | 1.76 | A | 1-122 | [»] | |
SMRi | P04084 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
MINTi | P04084 |
Miscellaneous databases
EvolutionaryTracei | P04084 |
Family and domain databases
CDDi | cd00125, PLA2c, 1 hit |
Gene3Di | 1.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001211, PLipase_A2 IPR033112, PLipase_A2_Asp_AS IPR016090, PLipase_A2_dom IPR036444, PLipase_A2_dom_sf |
PANTHERi | PTHR11716, PTHR11716, 1 hit |
Pfami | View protein in Pfam PF00068, Phospholip_A2_1, 1 hit |
PRINTSi | PR00389, PHPHLIPASEA2 |
SMARTi | View protein in SMART SM00085, PA2c, 1 hit |
SUPFAMi | SSF48619, SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00119, PA2_ASP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PA2HA_VIPAE | |
Accessioni | P04084Primary (citable) accession number: P04084 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1986 |
Last sequence update: | July 15, 1998 | |
Last modified: | February 23, 2022 | |
This is version 139 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families