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UniProtKB - P04076 (ARLY_YEAST)
Protein
Argininosuccinate lyase
Gene
ARG4
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Miscellaneous
Present with 10200 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
- EC:4.3.2.1
: L-arginine biosynthesis Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate. This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.
GO - Molecular functioni
- argininosuccinate lyase activity Source: SGD
GO - Biological processi
- arginine biosynthetic process via ornithine Source: SGD
Keywordsi
Molecular function | Lyase |
Biological process | Amino-acid biosynthesis, Arginine biosynthesis |
Enzyme and pathway databases
Reactomei | R-SCE-70635, Urea cycle |
UniPathwayi | UPA00068;UER00114 |
Names & Taxonomyi
Protein namesi | Recommended name: Argininosuccinate lyase (EC:4.3.2.1)Short name: ASAL Alternative name(s): Arginosuccinase |
Gene namesi | Name:ARG4 Ordered Locus Names:YHR018C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001060, ARG4 |
VEuPathDBi | FungiDB:YHR018C |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000137727 | 1 – 463 | Argininosuccinate lyaseAdd BLAST | 463 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 27 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P04076 |
PaxDbi | P04076 |
PRIDEi | P04076 |
TopDownProteomicsi | P04076 |
PTM databases
iPTMneti | P04076 |
Interactioni
Subunit structurei
Homotetramer.
Protein-protein interaction databases
BioGRIDi | 36447, 21 interactors |
DIPi | DIP-4306N |
IntActi | P04076, 3 interactors |
STRINGi | 4932.YHR018C |
Miscellaneous databases
RNActi | P04076, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1316, Eukaryota |
GeneTreei | ENSGT00950000183122 |
HOGENOMi | CLU_027272_2_1_1 |
InParanoidi | P04076 |
OMAi | KKNPDVF |
Family and domain databases
CDDi | cd01359, Argininosuccinate_lyase, 1 hit |
Gene3Di | 1.10.275.10, 1 hit |
HAMAPi | MF_00006, Arg_succ_lyase, 1 hit |
InterProi | View protein in InterPro IPR029419, Arg_succ_lyase_C IPR009049, Argininosuccinate_lyase IPR024083, Fumarase/histidase_N IPR020557, Fumarate_lyase_CS IPR000362, Fumarate_lyase_fam IPR022761, Fumarate_lyase_N IPR008948, L-Aspartase-like |
PANTHERi | PTHR43814, PTHR43814, 1 hit |
Pfami | View protein in Pfam PF14698, ASL_C2, 1 hit PF00206, Lyase_1, 1 hit |
PRINTSi | PR00149, FUMRATELYASE |
SUPFAMi | SSF48557, SSF48557, 1 hit |
TIGRFAMsi | TIGR00838, argH, 1 hit |
PROSITEi | View protein in PROSITE PS00163, FUMARATE_LYASES, 1 hit |
i Sequence
Sequence statusi: Complete.
P04076-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDGTQKLWG GRFTGETDPL MHLYNASLPY DYKMYKADLE GTKVYTAGLQ
60 70 80 90 100
KLGLLTETEL AKIHEGLAEI KKEWDADKFV RHPNDEDIHT ANERRLGELI
110 120 130 140 150
GRDIAGKVHT GRSRNDQVVT DLRIYCRDIV NDTLFPALKG LVEVLIKRAE
160 170 180 190 200
GEIDVLMPGY THLQRAQPIR WSHWLSSYAT YFTEDYKRLG QILHRLNQSP
210 220 230 240 250
LGAGALAGHP YGIDREFLAE GLGFNSVIGN SLVAVSDRDF IVELMFWGTL
260 270 280 290 300
FMNHISRFAE DLIIYCTAEF GFIQLSDAYS TGSSLMPQKK NADSLELLRG
310 320 330 340 350
KSGRVFGDLT GFLMSLKGIP STYDKDMQED KEPLFDCLTT VEHSMLIATG
360 370 380 390 400
VISTLTVNKE KMEAALTMDM LATDLADYLV RKGVPFRETH HISGECVATA
410 420 430 440 450
ERLGLSGIDK LTLEQYQKID SRFGQDLFET FNFEQSVERR DATGGTAKSA
460
VLKQLDNLKS QLN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 103 | D → E in AAA34434 (PubMed:6386606).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M36586 Genomic DNA Translation: AAA34435.1 K01813 Genomic DNA Translation: AAA34434.1 AY693155 Genomic DNA Translation: AAT93174.1 U10400 Genomic DNA Translation: AAB68946.1 BK006934 Genomic DNA Translation: DAA06707.1 |
PIRi | S46792, WZBYRS |
RefSeqi | NP_011882.1, NM_001179148.1 |
Genome annotation databases
EnsemblFungii | YHR018C_mRNA; YHR018C; YHR018C |
GeneIDi | 856411 |
KEGGi | sce:YHR018C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M36586 Genomic DNA Translation: AAA34435.1 K01813 Genomic DNA Translation: AAA34434.1 AY693155 Genomic DNA Translation: AAT93174.1 U10400 Genomic DNA Translation: AAB68946.1 BK006934 Genomic DNA Translation: DAA06707.1 |
PIRi | S46792, WZBYRS |
RefSeqi | NP_011882.1, NM_001179148.1 |
3D structure databases
SMRi | P04076 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 36447, 21 interactors |
DIPi | DIP-4306N |
IntActi | P04076, 3 interactors |
STRINGi | 4932.YHR018C |
PTM databases
iPTMneti | P04076 |
Proteomic databases
MaxQBi | P04076 |
PaxDbi | P04076 |
PRIDEi | P04076 |
TopDownProteomicsi | P04076 |
Genome annotation databases
EnsemblFungii | YHR018C_mRNA; YHR018C; YHR018C |
GeneIDi | 856411 |
KEGGi | sce:YHR018C |
Organism-specific databases
SGDi | S000001060, ARG4 |
VEuPathDBi | FungiDB:YHR018C |
Phylogenomic databases
eggNOGi | KOG1316, Eukaryota |
GeneTreei | ENSGT00950000183122 |
HOGENOMi | CLU_027272_2_1_1 |
InParanoidi | P04076 |
OMAi | KKNPDVF |
Enzyme and pathway databases
UniPathwayi | UPA00068;UER00114 |
Reactomei | R-SCE-70635, Urea cycle |
Miscellaneous databases
PROi | PR:P04076 |
RNActi | P04076, protein |
Family and domain databases
CDDi | cd01359, Argininosuccinate_lyase, 1 hit |
Gene3Di | 1.10.275.10, 1 hit |
HAMAPi | MF_00006, Arg_succ_lyase, 1 hit |
InterProi | View protein in InterPro IPR029419, Arg_succ_lyase_C IPR009049, Argininosuccinate_lyase IPR024083, Fumarase/histidase_N IPR020557, Fumarate_lyase_CS IPR000362, Fumarate_lyase_fam IPR022761, Fumarate_lyase_N IPR008948, L-Aspartase-like |
PANTHERi | PTHR43814, PTHR43814, 1 hit |
Pfami | View protein in Pfam PF14698, ASL_C2, 1 hit PF00206, Lyase_1, 1 hit |
PRINTSi | PR00149, FUMRATELYASE |
SUPFAMi | SSF48557, SSF48557, 1 hit |
TIGRFAMsi | TIGR00838, argH, 1 hit |
PROSITEi | View protein in PROSITE PS00163, FUMARATE_LYASES, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ARLY_YEAST | |
Accessioni | P04076Primary (citable) accession number: P04076 Secondary accession number(s): D3DKW3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1986 |
Last sequence update: | February 1, 1995 | |
Last modified: | September 29, 2021 | |
This is version 194 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VIII
Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families