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Entry version 245 (29 Sep 2021)
Sequence version 2 (23 Jan 2007)
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Protein

Fructose-bisphosphate aldolase A

Gene

ALDOA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity).

By similarity

Miscellaneous

In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=52 µM for fructose 1,6-bisphosphate (at 30 degrees Celsius)1 Publication

Temperature dependencei

Thermal denaturation midpoint (Tm) is 54.4 degrees Celsius.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose. This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei56Substrate1
Binding sitei147Substrate1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei188Proton acceptorBy similarity1
Active sitei230Schiff-base intermediate with dihydroxyacetone-P1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei364Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandSchiff base

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS07647-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
4.1.2.13, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P04075

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608, Platelet degranulation
R-HSA-6798695, Neutrophil degranulation
R-HSA-70171, Glycolysis
R-HSA-70263, Gluconeogenesis

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P04075

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P04075

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00109;UER00183

Protein family/group databases

MoonProt database of moonlighting proteins

More...
MoonProti
P04075

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fructose-bisphosphate aldolase A (EC:4.1.2.13)
Alternative name(s):
Lung cancer antigen NY-LU-1
Muscle-type aldolase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ALDOA
Synonyms:ALDA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:414, ALDOA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
103850, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P04075

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000149925

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Glycogen storage disease 12 (GSD12)5 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA metabolic disorder associated with increased hepatic glycogen and hemolytic anemia. It may lead to myopathy with exercise intolerance and rhabdomyolysis.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_000550129D → G in GSD12; thermolabile. 2 PublicationsCorresponds to variant dbSNP:rs121909533Ensembl.1
Natural variantiVAR_044142207E → K in GSD12; reduces thermal stability; 3-fold decrease in catalytic efficiency mostly due to reduced substrate affinity. 2 PublicationsCorresponds to variant dbSNP:rs121909534Ensembl.1
Natural variantiVAR_044143339C → Y in GSD12. 1 Publication1
Natural variantiVAR_044144347G → S in GSD12; likely benign variant; does not affect thermal stability; 4-fold decrease in catalytic efficiency due to reduced enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs138824667Ensembl.1

Keywords - Diseasei

Disease variant, Glycogen storage disease, Hereditary hemolytic anemia

Organism-specific databases

DisGeNET

More...
DisGeNETi
226

MalaCards human disease database

More...
MalaCardsi
ALDOA
MIMi611881, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000149925

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
57, Glycogen storage disease due to aldolase A deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24707

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P04075, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2106

Drug and drug target database

More...
DrugBanki
DB04733, 1,6-DI-O-PHOSPHONO-D-MANNITOL
DB02512, 1,6-Fructose Diphosphate (Linear Form)
DB11638, Artenimol
DB04326, Dihydroxyacetone phosphate
DB08240, N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE
DB01593, Zinc
DB14487, Zinc acetate
DB14533, Zinc chloride
DB14548, Zinc sulfate, unspecified form

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ALDOA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
113606

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources5 Publications
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002169362 – 364Fructose-bisphosphate aldolase AAdd BLAST363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei5PhosphotyrosineBy similarity1
Modified residuei9PhosphothreonineCombined sources1
Modified residuei36PhosphoserineCombined sources1
Modified residuei39PhosphoserineCombined sources1
Modified residuei42N6-acetyllysine; alternateCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki42Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki42Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei46PhosphoserineCombined sources1
Modified residuei99N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei108N6-acetyllysineCombined sources1
Modified residuei111N6-acetyllysine; alternateBy similarity1
Modified residuei111N6-malonyllysine; alternate1 Publication1
Modified residuei132PhosphoserineBy similarity1
Modified residuei272PhosphoserineCombined sources1
Modified residuei312N6-malonyllysine1 Publication1
Modified residuei330N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Hydroxylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-459

Encyclopedia of Proteome Dynamics

More...
EPDi
P04075

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P04075

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P04075

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P04075

PeptideAtlas

More...
PeptideAtlasi
P04075

PRoteomics IDEntifications database

More...
PRIDEi
P04075

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
51647 [P04075-1]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P04075-1 [P04075-1]

2D gel databases

DOSAC-COBS 2D-PAGE database

More...
DOSAC-COBS-2DPAGEi
P04075

USC-OGP 2-DE database

More...
OGPi
P04075

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00465439
P04075

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P04075

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P04075

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P04075

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P04075, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P04075

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
P04075

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P04075

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P04075

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000149925, Expressed in vastus lateralis and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P04075, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P04075, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000149925, Tissue enriched (skeletal)
ENSG00000285043, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

Interacts with SNX9 and WAS (By similarity).

Interacts with FBP2; the interaction blocks FBP2 inhibition by physiological concentrations of AMP and reduces inhibition by Ca2+.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
106728, 201 interactors

Protein interaction database and analysis system

More...
IntActi
P04075, 78 interactors

Molecular INTeraction database

More...
MINTi
P04075

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000378669

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P04075, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1364
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P04075

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P04075

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1557, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182987

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_031243_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P04075

Identification of Orthologs from Complete Genome Data

More...
OMAi
DYREMLF

Database of Orthologous Groups

More...
OrthoDBi
799973at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P04075

TreeFam database of animal gene trees

More...
TreeFami
TF314203

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029768, Aldolase_I_AS
IPR013785, Aldolase_TIM
IPR000741, FBA_I

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00274, Glycolytic, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00158, ALDOLASE_CLASS_I, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P04075-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPYQYPALTP EQKKELSDIA HRIVAPGKGI LAADESTGSI AKRLQSIGTE
60 70 80 90 100
NTEENRRFYR QLLLTADDRV NPCIGGVILF HETLYQKADD GRPFPQVIKS
110 120 130 140 150
KGGVVGIKVD KGVVPLAGTN GETTTQGLDG LSERCAQYKK DGADFAKWRC
160 170 180 190 200
VLKIGEHTPS ALAIMENANV LARYASICQQ NGIVPIVEPE ILPDGDHDLK
210 220 230 240 250
RCQYVTEKVL AAVYKALSDH HIYLEGTLLK PNMVTPGHAC TQKFSHEEIA
260 270 280 290 300
MATVTALRRT VPPAVTGITF LSGGQSEEEA SINLNAINKC PLLKPWALTF
310 320 330 340 350
SYGRALQASA LKAWGGKKEN LKAAQEEYVK RALANSLACQ GKYTPSGQAG
360
AAASESLFVS NHAY
Length:364
Mass (Da):39,420
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0AAED80F755A7BE8
GO
Isoform 2 (identifier: P04075-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MARRKPEGSSFNMTHLSMAMAFSFPPVASGQLHPQLGNTQHQTELGKELATTSTM

Show »
Length:418
Mass (Da):45,261
Checksum:iFAE6E6CA84022A8A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BPS8H3BPS8_HUMAN
Fructose-bisphosphate aldolase
ALDOA
278Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUH7H3BUH7_HUMAN
Fructose-bisphosphate aldolase
ALDOA
155Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KPS3J3KPS3_HUMAN
Fructose-bisphosphate aldolase
ALDOA hCG_1811258
368Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQN4H3BQN4_HUMAN
Fructose-bisphosphate aldolase
ALDOA
361Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMQ8H3BMQ8_HUMAN
Fructose-bisphosphate aldolase
ALDOA
140Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BR04H3BR04_HUMAN
Fructose-bisphosphate aldolase
ALDOA
162Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BU78H3BU78_HUMAN
Fructose-bisphosphate aldolase
ALDOA
204Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BR68H3BR68_HUMAN
Fructose-bisphosphate aldolase
ALDOA
130Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti73C → G in CAA30979 (PubMed:3391172).Curated1
Sequence conflicti180Q → R in CAG46678 (Ref. 6) Curated1
Sequence conflicti196D → A in CAA30979 (PubMed:3391172).Curated1
Sequence conflicti230K → N in CAA30979 (PubMed:3391172).Curated1
Sequence conflicti280A → S in CAA30979 (PubMed:3391172).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04821982E → Q. Corresponds to variant dbSNP:rs11553107Ensembl.1
Natural variantiVAR_000550129D → G in GSD12; thermolabile. 2 PublicationsCorresponds to variant dbSNP:rs121909533Ensembl.1
Natural variantiVAR_048220142G → V. Corresponds to variant dbSNP:rs11553108Ensembl.1
Natural variantiVAR_044142207E → K in GSD12; reduces thermal stability; 3-fold decrease in catalytic efficiency mostly due to reduced substrate affinity. 2 PublicationsCorresponds to variant dbSNP:rs121909534Ensembl.1
Natural variantiVAR_044143339C → Y in GSD12. 1 Publication1
Natural variantiVAR_044144347G → S in GSD12; likely benign variant; does not affect thermal stability; 4-fold decrease in catalytic efficiency due to reduced enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs138824667Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0472611M → MARRKPEGSSFNMTHLSMAM AFSFPPVASGQLHPQLGNTQ HQTELGKELATTSTM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M11560 mRNA Translation: AAA51690.1
X05236 mRNA Translation: CAA28861.1
X12447 Genomic DNA Translation: CAA30979.1
AK301993 mRNA Translation: BAG63399.1
CR536528 mRNA Translation: CAG38765.1
CR541880 mRNA Translation: CAG46678.1
AC093512 Genomic DNA No translation available.
CH471238 Genomic DNA Translation: EAW79933.1
BC000367 mRNA Translation: AAH00367.2
BC004333 mRNA Translation: AAH04333.1
BC010660 mRNA Translation: AAH10660.1
BC012880 mRNA Translation: AAH12880.1
BC013614 mRNA Translation: AAH13614.1
BC015888 mRNA Translation: AAH15888.1
BC016170 mRNA Translation: AAH16170.1
BC016800 mRNA Translation: AAH16800.1
M21190 mRNA Translation: AAA51697.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10668.1 [P04075-1]
CCDS58450.1 [P04075-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
S14084, ADHUA

NCBI Reference Sequences

More...
RefSeqi
NP_000025.1, NM_000034.3
NP_001121089.1, NM_001127617.2 [P04075-1]
NP_001230106.1, NM_001243177.1 [P04075-2]
NP_908930.1, NM_184041.2 [P04075-1]
NP_908932.1, NM_184043.2 [P04075-1]
XP_011544070.1, XM_011545768.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000412304; ENSP00000400452; ENSG00000149925 [P04075-1]
ENST00000563060; ENSP00000455800; ENSG00000149925 [P04075-1]
ENST00000569545; ENSP00000455700; ENSG00000149925 [P04075-1]
ENST00000642816; ENSP00000496166; ENSG00000149925 [P04075-2]
ENST00000643777; ENSP00000494188; ENSG00000149925 [P04075-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
226

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:226

UCSC genome browser

More...
UCSCi
uc010veg.3, human [P04075-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11560 mRNA Translation: AAA51690.1
X05236 mRNA Translation: CAA28861.1
X12447 Genomic DNA Translation: CAA30979.1
AK301993 mRNA Translation: BAG63399.1
CR536528 mRNA Translation: CAG38765.1
CR541880 mRNA Translation: CAG46678.1
AC093512 Genomic DNA No translation available.
CH471238 Genomic DNA Translation: EAW79933.1
BC000367 mRNA Translation: AAH00367.2
BC004333 mRNA Translation: AAH04333.1
BC010660 mRNA Translation: AAH10660.1
BC012880 mRNA Translation: AAH12880.1
BC013614 mRNA Translation: AAH13614.1
BC015888 mRNA Translation: AAH15888.1
BC016170 mRNA Translation: AAH16170.1
BC016800 mRNA Translation: AAH16800.1
M21190 mRNA Translation: AAA51697.1
CCDSiCCDS10668.1 [P04075-1]
CCDS58450.1 [P04075-2]
PIRiS14084, ADHUA
RefSeqiNP_000025.1, NM_000034.3
NP_001121089.1, NM_001127617.2 [P04075-1]
NP_001230106.1, NM_001243177.1 [P04075-2]
NP_908930.1, NM_184041.2 [P04075-1]
NP_908932.1, NM_184043.2 [P04075-1]
XP_011544070.1, XM_011545768.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ALDX-ray2.00A2-364[»]
2ALDX-ray2.10A2-364[»]
4ALDX-ray2.80A2-364[»]
5KY6X-ray1.94A/B/C/D2-364[»]
SMRiP04075
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi106728, 201 interactors
IntActiP04075, 78 interactors
MINTiP04075
STRINGi9606.ENSP00000378669

Chemistry databases

ChEMBLiCHEMBL2106
DrugBankiDB04733, 1,6-DI-O-PHOSPHONO-D-MANNITOL
DB02512, 1,6-Fructose Diphosphate (Linear Form)
DB11638, Artenimol
DB04326, Dihydroxyacetone phosphate
DB08240, N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE
DB01593, Zinc
DB14487, Zinc acetate
DB14533, Zinc chloride
DB14548, Zinc sulfate, unspecified form

Protein family/group databases

MoonProtiP04075

PTM databases

CarbonylDBiP04075
GlyGeniP04075, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP04075
MetOSiteiP04075
PhosphoSitePlusiP04075
SwissPalmiP04075

Genetic variation databases

BioMutaiALDOA
DMDMi113606

2D gel databases

DOSAC-COBS-2DPAGEiP04075
OGPiP04075
REPRODUCTION-2DPAGEiIPI00465439
P04075
SWISS-2DPAGEiP04075
UCD-2DPAGEiP04075

Proteomic databases

CPTACiCPTAC-459
EPDiP04075
jPOSTiP04075
MassIVEiP04075
PaxDbiP04075
PeptideAtlasiP04075
PRIDEiP04075
ProteomicsDBi51647 [P04075-1]
TopDownProteomicsiP04075-1 [P04075-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1031, 689 antibodies

The DNASU plasmid repository

More...
DNASUi
226

Genome annotation databases

EnsembliENST00000412304; ENSP00000400452; ENSG00000149925 [P04075-1]
ENST00000563060; ENSP00000455800; ENSG00000149925 [P04075-1]
ENST00000569545; ENSP00000455700; ENSG00000149925 [P04075-1]
ENST00000642816; ENSP00000496166; ENSG00000149925 [P04075-2]
ENST00000643777; ENSP00000494188; ENSG00000149925 [P04075-1]
GeneIDi226
KEGGihsa:226
UCSCiuc010veg.3, human [P04075-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
226
DisGeNETi226

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ALDOA
HGNCiHGNC:414, ALDOA
HPAiENSG00000149925, Tissue enriched (skeletal)
ENSG00000285043, Low tissue specificity
MalaCardsiALDOA
MIMi103850, gene
611881, phenotype
neXtProtiNX_P04075
OpenTargetsiENSG00000149925
Orphaneti57, Glycogen storage disease due to aldolase A deficiency
PharmGKBiPA24707
VEuPathDBiHostDB:ENSG00000149925

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1557, Eukaryota
GeneTreeiENSGT00950000182987
HOGENOMiCLU_031243_0_0_1
InParanoidiP04075
OMAiDYREMLF
OrthoDBi799973at2759
PhylomeDBiP04075
TreeFamiTF314203

Enzyme and pathway databases

UniPathwayiUPA00109;UER00183
BioCyciMetaCyc:HS07647-MONOMER
BRENDAi4.1.2.13, 2681
PathwayCommonsiP04075
ReactomeiR-HSA-114608, Platelet degranulation
R-HSA-6798695, Neutrophil degranulation
R-HSA-70171, Glycolysis
R-HSA-70263, Gluconeogenesis
SABIO-RKiP04075
SIGNORiP04075

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
226, 744 hits in 1021 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ALDOA, human
EvolutionaryTraceiP04075

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Aldolase_A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
226
PharosiP04075, Tbio

Protein Ontology

More...
PROi
PR:P04075
RNActiP04075, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000149925, Expressed in vastus lateralis and 250 other tissues
ExpressionAtlasiP04075, baseline and differential
GenevisibleiP04075, HS

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR029768, Aldolase_I_AS
IPR013785, Aldolase_TIM
IPR000741, FBA_I
PfamiView protein in Pfam
PF00274, Glycolytic, 1 hit
PROSITEiView protein in PROSITE
PS00158, ALDOLASE_CLASS_I, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiALDOA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P04075
Secondary accession number(s): B4DXI7
, Q6FH76, Q6FI10, Q96B15, Q9BWD9, Q9UCN2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: January 23, 2007
Last modified: September 29, 2021
This is version 245 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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