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Protein

Fructose-bisphosphate aldolase A

Gene

ALDOA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity).By similarity

Miscellaneous

In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Kineticsi

  1. KM=52 µM for fructose 1,6-bisphosphate (at 30 degrees Celsius)1 Publication

    Temperature dependencei

    Thermal denaturation midpoint (Tm) is 54.4 degrees Celsius.1 Publication

    Pathwayi: glycolysis

    This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
    Proteins known to be involved in the 4 steps of the subpathway in this organism are:
    1. no protein annotated in this organism
    2. Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (pgi), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase
    3. ATP-dependent 6-phosphofructokinase, muscle type (PFKM), ATP-dependent 6-phosphofructokinase, liver type (PFKL), ATP-dependent 6-phosphofructokinase, platelet type (PFKP), ATP-dependent 6-phosphofructokinase (PFKM), ATP-dependent 6-phosphofructokinase (PFKM)
    4. Fructose-bisphosphate aldolase B (ALDOB), Fructose-bisphosphate aldolase A (ALDOA), Fructose-bisphosphate aldolase C (ALDOC), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (BQ8482_350140), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (HEL-S-87p), Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOA)
    This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Binding sitei56Substrate1
    Binding sitei147Substrate1
    Active sitei188Proton acceptorBy similarity1
    Active sitei230Schiff-base intermediate with dihydroxyacetone-P1
    Sitei364Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate1

    GO - Molecular functioni

    • actin binding Source: BHF-UCL
    • cadherin binding Source: BHF-UCL
    • cytoskeletal protein binding Source: BHF-UCL
    • fructose binding Source: BHF-UCL
    • fructose-bisphosphate aldolase activity Source: BHF-UCL
    • identical protein binding Source: IntAct
    • RNA binding Source: UniProtKB
    • tubulin binding Source: BHF-UCL

    GO - Biological processi

    Keywordsi

    Molecular functionLyase
    Biological processGlycolysis
    LigandSchiff base

    Enzyme and pathway databases

    BioCyciMetaCyc:HS07647-MONOMER
    BRENDAi4.1.2.13 2681
    ReactomeiR-HSA-114608 Platelet degranulation
    R-HSA-6798695 Neutrophil degranulation
    R-HSA-70171 Glycolysis
    R-HSA-70263 Gluconeogenesis
    SABIO-RKiP04075
    SIGNORiP04075
    UniPathwayi
    UPA00109;UER00183

    Protein family/group databases

    MoonProtiP04075

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase A (EC:4.1.2.13)
    Alternative name(s):
    Lung cancer antigen NY-LU-1
    Muscle-type aldolase
    Gene namesi
    Name:ALDOA
    Synonyms:ALDA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 16

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000149925.16
    HGNCiHGNC:414 ALDOA
    MIMi103850 gene
    neXtProtiNX_P04075

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Involvement in diseasei

    Glycogen storage disease 12 (GSD12)5 Publications
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA metabolic disorder associated with increased hepatic glycogen and hemolytic anemia. It may lead to myopathy with exercise intolerance and rhabdomyolysis.
    See also OMIM:611881
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_000550129D → G in GSD12; thermolabile. 2 PublicationsCorresponds to variant dbSNP:rs121909533Ensembl.1
    Natural variantiVAR_044142207E → K in GSD12; reduces thermal stability; 3-fold decrease in catalytic efficiency mostly due to reduced substrate affinity. 2 PublicationsCorresponds to variant dbSNP:rs121909534Ensembl.1
    Natural variantiVAR_044143339C → Y in GSD12. 1 Publication1
    Natural variantiVAR_044144347G → S in GSD12; does not affect thermal stability; 4-fold decrease in catalytic efficiency due to reduced enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs138824667Ensembl.1

    Keywords - Diseasei

    Disease mutation, Glycogen storage disease, Hereditary hemolytic anemia

    Organism-specific databases

    DisGeNETi226
    MalaCardsiALDOA
    MIMi611881 phenotype
    OpenTargetsiENSG00000149925
    Orphaneti57 Glycogen storage disease due to aldolase A deficiency
    PharmGKBiPA24707

    Chemistry databases

    ChEMBLiCHEMBL2106
    DrugBankiDB08240 N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE

    Polymorphism and mutation databases

    BioMutaiALDOA
    DMDMi113606

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Initiator methionineiRemovedCombined sources5 Publications
    ChainiPRO_00002169362 – 364Fructose-bisphosphate aldolase AAdd BLAST363

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei5PhosphotyrosineBy similarity1
    Modified residuei9PhosphothreonineCombined sources1
    Modified residuei36PhosphoserineCombined sources1
    Modified residuei39PhosphoserineCombined sources1
    Modified residuei42N6-acetyllysine; alternateCombined sources1
    Cross-linki42Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
    Cross-linki42Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
    Modified residuei46PhosphoserineCombined sources1
    Modified residuei108N6-acetyllysineCombined sources1
    Modified residuei111N6-acetyllysine; alternateBy similarity1
    Modified residuei111N6-malonyllysine; alternate1 Publication1
    Modified residuei132PhosphoserineBy similarity1
    Modified residuei272PhosphoserineCombined sources1
    Modified residuei312N6-malonyllysine1 Publication1
    Modified residuei330N6-acetyllysineCombined sources1

    Keywords - PTMi

    Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    EPDiP04075
    PaxDbiP04075
    PeptideAtlasiP04075
    PRIDEiP04075
    ProteomicsDBi51647
    TopDownProteomicsiP04075-1 [P04075-1]

    2D gel databases

    DOSAC-COBS-2DPAGEiP04075
    OGPiP04075
    REPRODUCTION-2DPAGEiIPI00465439
    P04075
    SWISS-2DPAGEiP04075
    UCD-2DPAGEiP04075

    PTM databases

    CarbonylDBiP04075
    iPTMnetiP04075
    PhosphoSitePlusiP04075
    SwissPalmiP04075

    Expressioni

    Gene expression databases

    BgeeiENSG00000149925 Expressed in 238 organ(s), highest expression level in vastus lateralis
    CleanExiHS_ALDOA
    ExpressionAtlasiP04075 baseline and differential
    GenevisibleiP04075 HS

    Organism-specific databases

    HPAiCAB006252
    HPA004177

    Interactioni

    Subunit structurei

    Homotetramer. Interacts with SNX9 and WAS (By similarity). Interacts with FBP2; the interaction blocks FBP2 inhibition by physiological concentrations of AMP and reduces inhibition by Ca2+.By similarity1 Publication

    Binary interactionsi

    GO - Molecular functioni

    Protein-protein interaction databases

    BioGridi106728, 121 interactors
    IntActiP04075, 56 interactors
    MINTiP04075
    STRINGi9606.ENSP00000336927

    Structurei

    Secondary structure

    1364
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    ProteinModelPortaliP04075
    SMRiP04075
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP04075

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiKOG1557 Eukaryota
    COG3588 LUCA
    GeneTreeiENSGT00390000010235
    HOVERGENiHBG002386
    InParanoidiP04075
    KOiK01623
    OMAiDYREMLF
    OrthoDBiEOG091G0A9T
    PhylomeDBiP04075
    TreeFamiTF314203

    Family and domain databases

    Gene3Di3.20.20.70, 1 hit
    InterProiView protein in InterPro
    IPR029768 Aldolase_I_AS
    IPR013785 Aldolase_TIM
    IPR000741 FBA_I
    PfamiView protein in Pfam
    PF00274 Glycolytic, 1 hit
    PROSITEiView protein in PROSITE
    PS00158 ALDOLASE_CLASS_I, 1 hit

    Sequences (2+)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P04075-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MPYQYPALTP EQKKELSDIA HRIVAPGKGI LAADESTGSI AKRLQSIGTE
    60 70 80 90 100
    NTEENRRFYR QLLLTADDRV NPCIGGVILF HETLYQKADD GRPFPQVIKS
    110 120 130 140 150
    KGGVVGIKVD KGVVPLAGTN GETTTQGLDG LSERCAQYKK DGADFAKWRC
    160 170 180 190 200
    VLKIGEHTPS ALAIMENANV LARYASICQQ NGIVPIVEPE ILPDGDHDLK
    210 220 230 240 250
    RCQYVTEKVL AAVYKALSDH HIYLEGTLLK PNMVTPGHAC TQKFSHEEIA
    260 270 280 290 300
    MATVTALRRT VPPAVTGITF LSGGQSEEEA SINLNAINKC PLLKPWALTF
    310 320 330 340 350
    SYGRALQASA LKAWGGKKEN LKAAQEEYVK RALANSLACQ GKYTPSGQAG
    360
    AAASESLFVS NHAY
    Length:364
    Mass (Da):39,420
    Last modified:January 23, 2007 - v2
    Checksum:i0AAED80F755A7BE8
    GO
    Isoform 2 (identifier: P04075-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MARRKPEGSSFNMTHLSMAMAFSFPPVASGQLHPQLGNTQHQTELGKELATTSTM

    Show »
    Length:418
    Mass (Da):45,261
    Checksum:iFAE6E6CA84022A8A
    GO

    Computationally mapped potential isoform sequencesi

    There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    J3KPS3J3KPS3_HUMAN
    Fructose-bisphosphate aldolase
    ALDOA hCG_1811258
    368Annotation score:
    H3BQN4H3BQN4_HUMAN
    Fructose-bisphosphate aldolase
    ALDOA
    361Annotation score:
    H3BU78H3BU78_HUMAN
    Fructose-bisphosphate aldolase
    ALDOA
    204Annotation score:
    H3BPS8H3BPS8_HUMAN
    Fructose-bisphosphate aldolase A
    ALDOA
    278Annotation score:
    H3BUH7H3BUH7_HUMAN
    Fructose-bisphosphate aldolase A
    ALDOA
    155Annotation score:
    H3BMQ8H3BMQ8_HUMAN
    Fructose-bisphosphate aldolase A
    ALDOA
    140Annotation score:
    H3BR04H3BR04_HUMAN
    Fructose-bisphosphate aldolase A
    ALDOA
    162Annotation score:
    H3BR68H3BR68_HUMAN
    Fructose-bisphosphate aldolase A
    ALDOA
    130Annotation score:

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti73C → G in CAA30979 (PubMed:3391172).Curated1
    Sequence conflicti180Q → R in CAG46678 (Ref. 6) Curated1
    Sequence conflicti196D → A in CAA30979 (PubMed:3391172).Curated1
    Sequence conflicti230K → N in CAA30979 (PubMed:3391172).Curated1
    Sequence conflicti280A → S in CAA30979 (PubMed:3391172).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_04821982E → Q. Corresponds to variant dbSNP:rs11553107Ensembl.1
    Natural variantiVAR_000550129D → G in GSD12; thermolabile. 2 PublicationsCorresponds to variant dbSNP:rs121909533Ensembl.1
    Natural variantiVAR_048220142G → V. Corresponds to variant dbSNP:rs11553108Ensembl.1
    Natural variantiVAR_044142207E → K in GSD12; reduces thermal stability; 3-fold decrease in catalytic efficiency mostly due to reduced substrate affinity. 2 PublicationsCorresponds to variant dbSNP:rs121909534Ensembl.1
    Natural variantiVAR_044143339C → Y in GSD12. 1 Publication1
    Natural variantiVAR_044144347G → S in GSD12; does not affect thermal stability; 4-fold decrease in catalytic efficiency due to reduced enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs138824667Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0472611M → MARRKPEGSSFNMTHLSMAM AFSFPPVASGQLHPQLGNTQ HQTELGKELATTSTM in isoform 2. 1 Publication1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    M11560 mRNA Translation: AAA51690.1
    X05236 mRNA Translation: CAA28861.1
    X12447 Genomic DNA Translation: CAA30979.1
    AK301993 mRNA Translation: BAG63399.1
    CR536528 mRNA Translation: CAG38765.1
    CR541880 mRNA Translation: CAG46678.1
    AC093512 Genomic DNA No translation available.
    CH471238 Genomic DNA Translation: EAW79933.1
    BC000367 mRNA Translation: AAH00367.2
    BC004333 mRNA Translation: AAH04333.1
    BC010660 mRNA Translation: AAH10660.1
    BC012880 mRNA Translation: AAH12880.1
    BC013614 mRNA Translation: AAH13614.1
    BC015888 mRNA Translation: AAH15888.1
    BC016170 mRNA Translation: AAH16170.1
    BC016800 mRNA Translation: AAH16800.1
    M21190 mRNA Translation: AAA51697.1
    CCDSiCCDS10668.1 [P04075-1]
    CCDS58450.1 [P04075-2]
    PIRiS14084 ADHUA
    RefSeqiNP_000025.1, NM_000034.3 [P04075-1]
    NP_001121089.1, NM_001127617.2 [P04075-1]
    NP_001230106.1, NM_001243177.1 [P04075-2]
    NP_908930.1, NM_184041.2 [P04075-1]
    NP_908932.1, NM_184043.2 [P04075-1]
    XP_011544070.1, XM_011545768.2
    UniGeneiHs.513490
    Hs.732822

    Genome annotation databases

    EnsembliENST00000412304; ENSP00000400452; ENSG00000149925 [P04075-1]
    ENST00000563060; ENSP00000455800; ENSG00000149925 [P04075-1]
    ENST00000564546; ENSP00000455917; ENSG00000149925 [P04075-1]
    ENST00000564595; ENSP00000457468; ENSG00000149925 [P04075-2]
    ENST00000569545; ENSP00000455700; ENSG00000149925 [P04075-1]
    ENST00000642816; ENSP00000496166; ENSG00000149925 [P04075-2]
    ENST00000643777; ENSP00000494188; ENSG00000149925 [P04075-1]
    GeneIDi226
    KEGGihsa:226
    UCSCiuc010veg.3 human [P04075-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Similar proteinsi

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    M11560 mRNA Translation: AAA51690.1
    X05236 mRNA Translation: CAA28861.1
    X12447 Genomic DNA Translation: CAA30979.1
    AK301993 mRNA Translation: BAG63399.1
    CR536528 mRNA Translation: CAG38765.1
    CR541880 mRNA Translation: CAG46678.1
    AC093512 Genomic DNA No translation available.
    CH471238 Genomic DNA Translation: EAW79933.1
    BC000367 mRNA Translation: AAH00367.2
    BC004333 mRNA Translation: AAH04333.1
    BC010660 mRNA Translation: AAH10660.1
    BC012880 mRNA Translation: AAH12880.1
    BC013614 mRNA Translation: AAH13614.1
    BC015888 mRNA Translation: AAH15888.1
    BC016170 mRNA Translation: AAH16170.1
    BC016800 mRNA Translation: AAH16800.1
    M21190 mRNA Translation: AAA51697.1
    CCDSiCCDS10668.1 [P04075-1]
    CCDS58450.1 [P04075-2]
    PIRiS14084 ADHUA
    RefSeqiNP_000025.1, NM_000034.3 [P04075-1]
    NP_001121089.1, NM_001127617.2 [P04075-1]
    NP_001230106.1, NM_001243177.1 [P04075-2]
    NP_908930.1, NM_184041.2 [P04075-1]
    NP_908932.1, NM_184043.2 [P04075-1]
    XP_011544070.1, XM_011545768.2
    UniGeneiHs.513490
    Hs.732822

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1ALDX-ray2.00A2-364[»]
    2ALDX-ray2.10A2-364[»]
    4ALDX-ray2.80A2-364[»]
    5KY6X-ray1.94A/B/C/D2-364[»]
    ProteinModelPortaliP04075
    SMRiP04075
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi106728, 121 interactors
    IntActiP04075, 56 interactors
    MINTiP04075
    STRINGi9606.ENSP00000336927

    Chemistry databases

    ChEMBLiCHEMBL2106
    DrugBankiDB08240 N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE

    Protein family/group databases

    MoonProtiP04075

    PTM databases

    CarbonylDBiP04075
    iPTMnetiP04075
    PhosphoSitePlusiP04075
    SwissPalmiP04075

    Polymorphism and mutation databases

    BioMutaiALDOA
    DMDMi113606

    2D gel databases

    DOSAC-COBS-2DPAGEiP04075
    OGPiP04075
    REPRODUCTION-2DPAGEiIPI00465439
    P04075
    SWISS-2DPAGEiP04075
    UCD-2DPAGEiP04075

    Proteomic databases

    EPDiP04075
    PaxDbiP04075
    PeptideAtlasiP04075
    PRIDEiP04075
    ProteomicsDBi51647
    TopDownProteomicsiP04075-1 [P04075-1]

    Protocols and materials databases

    DNASUi226
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000412304; ENSP00000400452; ENSG00000149925 [P04075-1]
    ENST00000563060; ENSP00000455800; ENSG00000149925 [P04075-1]
    ENST00000564546; ENSP00000455917; ENSG00000149925 [P04075-1]
    ENST00000564595; ENSP00000457468; ENSG00000149925 [P04075-2]
    ENST00000569545; ENSP00000455700; ENSG00000149925 [P04075-1]
    ENST00000642816; ENSP00000496166; ENSG00000149925 [P04075-2]
    ENST00000643777; ENSP00000494188; ENSG00000149925 [P04075-1]
    GeneIDi226
    KEGGihsa:226
    UCSCiuc010veg.3 human [P04075-1]

    Organism-specific databases

    CTDi226
    DisGeNETi226
    EuPathDBiHostDB:ENSG00000149925.16
    GeneCardsiALDOA
    ENSG00000285043
    HGNCiHGNC:414 ALDOA
    HPAiCAB006252
    HPA004177
    MalaCardsiALDOA
    MIMi103850 gene
    611881 phenotype
    neXtProtiNX_P04075
    OpenTargetsiENSG00000149925
    Orphaneti57 Glycogen storage disease due to aldolase A deficiency
    PharmGKBiPA24707
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG1557 Eukaryota
    COG3588 LUCA
    GeneTreeiENSGT00390000010235
    HOVERGENiHBG002386
    InParanoidiP04075
    KOiK01623
    OMAiDYREMLF
    OrthoDBiEOG091G0A9T
    PhylomeDBiP04075
    TreeFamiTF314203

    Enzyme and pathway databases

    UniPathwayi
    UPA00109;UER00183

    BioCyciMetaCyc:HS07647-MONOMER
    BRENDAi4.1.2.13 2681
    ReactomeiR-HSA-114608 Platelet degranulation
    R-HSA-6798695 Neutrophil degranulation
    R-HSA-70171 Glycolysis
    R-HSA-70263 Gluconeogenesis
    SABIO-RKiP04075
    SIGNORiP04075

    Miscellaneous databases

    ChiTaRSiALDOA human
    EvolutionaryTraceiP04075
    GeneWikiiAldolase_A
    GenomeRNAii226
    PROiPR:P04075
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000149925 Expressed in 238 organ(s), highest expression level in vastus lateralis
    CleanExiHS_ALDOA
    ExpressionAtlasiP04075 baseline and differential
    GenevisibleiP04075 HS

    Family and domain databases

    Gene3Di3.20.20.70, 1 hit
    InterProiView protein in InterPro
    IPR029768 Aldolase_I_AS
    IPR013785 Aldolase_TIM
    IPR000741 FBA_I
    PfamiView protein in Pfam
    PF00274 Glycolytic, 1 hit
    PROSITEiView protein in PROSITE
    PS00158 ALDOLASE_CLASS_I, 1 hit
    ProtoNetiSearch...

    Entry informationi

    Entry nameiALDOA_HUMAN
    AccessioniPrimary (citable) accession number: P04075
    Secondary accession number(s): B4DXI7
    , Q6FH76, Q6FI10, Q96B15, Q9BWD9, Q9UCN2
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1986
    Last sequence update: January 23, 2007
    Last modified: November 7, 2018
    This is version 224 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    7. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    UniProt is an ELIXIR core data resource
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