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Protein

Fructose-bisphosphate aldolase A

Gene

ALDOA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity).By similarity

Miscellaneous

In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=52 µM for fructose 1,6-bisphosphate (at 30 degrees Celsius)1 Publication

    Temperature dependencei

    Thermal denaturation midpoint (Tm) is 54.4 degrees Celsius.1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

    This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
    Proteins known to be involved in the 4 steps of the subpathway in this organism are:
    1. no protein annotated in this organism
    2. Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase
    3. ATP-dependent 6-phosphofructokinase, muscle type (PFKM), ATP-dependent 6-phosphofructokinase, liver type (PFKL), ATP-dependent 6-phosphofructokinase, platelet type (PFKP), ATP-dependent 6-phosphofructokinase (PFKM), ATP-dependent 6-phosphofructokinase (PFKM)
    4. Fructose-bisphosphate aldolase B (ALDOB), Fructose-bisphosphate aldolase A (ALDOA), Fructose-bisphosphate aldolase C (ALDOC), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (HEL-S-87p), Fructose-bisphosphate aldolase (ALDOC)
    This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei56Substrate1
    Binding sitei147Substrate1
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei188Proton acceptorBy similarity1
    Active sitei230Schiff-base intermediate with dihydroxyacetone-P1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei364Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • actin binding Source: BHF-UCL
    • cadherin binding Source: BHF-UCL
    • cytoskeletal protein binding Source: BHF-UCL
    • fructose binding Source: BHF-UCL
    • fructose-bisphosphate aldolase activity Source: BHF-UCL
    • identical protein binding Source: IntAct
    • RNA binding Source: UniProtKB
    • tubulin binding Source: BHF-UCL

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionLyase
    Biological processGlycolysis
    LigandSchiff base

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS07647-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    4.1.2.13 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-114608 Platelet degranulation
    R-HSA-6798695 Neutrophil degranulation
    R-HSA-70171 Glycolysis
    R-HSA-70263 Gluconeogenesis

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P04075

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    P04075

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00109;UER00183

    Protein family/group databases

    MoonProt database of moonlighting proteins

    More...
    MoonProti
    P04075

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase A (EC:4.1.2.13)
    Alternative name(s):
    Lung cancer antigen NY-LU-1
    Muscle-type aldolase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ALDOA
    Synonyms:ALDA
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000149925.16

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:414 ALDOA

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    103850 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P04075

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Glycogen storage disease 12 (GSD12)5 Publications
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA metabolic disorder associated with increased hepatic glycogen and hemolytic anemia. It may lead to myopathy with exercise intolerance and rhabdomyolysis.
    See also OMIM:611881
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_000550129D → G in GSD12; thermolabile. 2 PublicationsCorresponds to variant dbSNP:rs121909533Ensembl.1
    Natural variantiVAR_044142207E → K in GSD12; reduces thermal stability; 3-fold decrease in catalytic efficiency mostly due to reduced substrate affinity. 2 PublicationsCorresponds to variant dbSNP:rs121909534Ensembl.1
    Natural variantiVAR_044143339C → Y in GSD12. 1 Publication1
    Natural variantiVAR_044144347G → S in GSD12; does not affect thermal stability; 4-fold decrease in catalytic efficiency due to reduced enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs138824667Ensembl.1

    Keywords - Diseasei

    Disease mutation, Glycogen storage disease, Hereditary hemolytic anemia

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    226

    MalaCards human disease database

    More...
    MalaCardsi
    ALDOA
    MIMi611881 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000149925

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    57 Glycogen storage disease due to aldolase A deficiency

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA24707

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL2106

    Drug and drug target database

    More...
    DrugBanki
    DB08240 N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    ALDOA

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    113606

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources5 Publications
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002169362 – 364Fructose-bisphosphate aldolase AAdd BLAST363

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei5PhosphotyrosineBy similarity1
    Modified residuei9PhosphothreonineCombined sources1
    Modified residuei36PhosphoserineCombined sources1
    Modified residuei39PhosphoserineCombined sources1
    Modified residuei42N6-acetyllysine; alternateCombined sources1
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki42Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
    Cross-linki42Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
    Modified residuei46PhosphoserineCombined sources1
    Modified residuei108N6-acetyllysineCombined sources1
    Modified residuei111N6-acetyllysine; alternateBy similarity1
    Modified residuei111N6-malonyllysine; alternate1 Publication1
    Modified residuei132PhosphoserineBy similarity1
    Modified residuei272PhosphoserineCombined sources1
    Modified residuei312N6-malonyllysine1 Publication1
    Modified residuei330N6-acetyllysineCombined sources1

    Keywords - PTMi

    Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P04075

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P04075

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P04075

    PeptideAtlas

    More...
    PeptideAtlasi
    P04075

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P04075

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    51647

    Consortium for Top Down Proteomics

    More...
    TopDownProteomicsi
    P04075-1 [P04075-1]

    2D gel databases

    DOSAC-COBS 2D-PAGE database

    More...
    DOSAC-COBS-2DPAGEi
    P04075

    USC-OGP 2-DE database

    More...
    OGPi
    P04075

    REPRODUCTION-2DPAGE

    More...
    REPRODUCTION-2DPAGEi
    IPI00465439
    P04075

    Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

    More...
    SWISS-2DPAGEi
    P04075

    University College Dublin 2-DE Proteome Database

    More...
    UCD-2DPAGEi
    P04075

    PTM databases

    CarbonylDB database of protein carbonylation sites

    More...
    CarbonylDBi
    P04075

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P04075

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P04075

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    P04075

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000149925 Expressed in 238 organ(s), highest expression level in vastus lateralis

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_ALDOA

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P04075 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P04075 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB006252
    HPA004177

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homotetramer. Interacts with SNX9 and WAS (By similarity). Interacts with FBP2; the interaction blocks FBP2 inhibition by physiological concentrations of AMP and reduces inhibition by Ca2+.By similarity1 Publication

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    106728, 126 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P04075, 58 interactors

    Molecular INTeraction database

    More...
    MINTi
    P04075

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000336927

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1364
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1ALDX-ray2.00A2-364[»]
    2ALDX-ray2.10A2-364[»]
    4ALDX-ray2.80A2-364[»]
    5KY6X-ray1.94A/B/C/D2-364[»]

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    P04075

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P04075

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P04075

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1557 Eukaryota
    COG3588 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000010235

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG002386

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P04075

    KEGG Orthology (KO)

    More...
    KOi
    K01623

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    DYREMLF

    Database of Orthologous Groups

    More...
    OrthoDBi
    799973at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P04075

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314203

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.20.20.70, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR029768 Aldolase_I_AS
    IPR013785 Aldolase_TIM
    IPR000741 FBA_I

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00274 Glycolytic, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00158 ALDOLASE_CLASS_I, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P04075-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MPYQYPALTP EQKKELSDIA HRIVAPGKGI LAADESTGSI AKRLQSIGTE
    60 70 80 90 100
    NTEENRRFYR QLLLTADDRV NPCIGGVILF HETLYQKADD GRPFPQVIKS
    110 120 130 140 150
    KGGVVGIKVD KGVVPLAGTN GETTTQGLDG LSERCAQYKK DGADFAKWRC
    160 170 180 190 200
    VLKIGEHTPS ALAIMENANV LARYASICQQ NGIVPIVEPE ILPDGDHDLK
    210 220 230 240 250
    RCQYVTEKVL AAVYKALSDH HIYLEGTLLK PNMVTPGHAC TQKFSHEEIA
    260 270 280 290 300
    MATVTALRRT VPPAVTGITF LSGGQSEEEA SINLNAINKC PLLKPWALTF
    310 320 330 340 350
    SYGRALQASA LKAWGGKKEN LKAAQEEYVK RALANSLACQ GKYTPSGQAG
    360
    AAASESLFVS NHAY
    Length:364
    Mass (Da):39,420
    Last modified:January 23, 2007 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0AAED80F755A7BE8
    GO
    Isoform 2 (identifier: P04075-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MARRKPEGSSFNMTHLSMAMAFSFPPVASGQLHPQLGNTQHQTELGKELATTSTM

    Show »
    Length:418
    Mass (Da):45,261
    Checksum:iFAE6E6CA84022A8A
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    J3KPS3J3KPS3_HUMAN
    Fructose-bisphosphate aldolase
    ALDOA hCG_1811258
    368Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H3BQN4H3BQN4_HUMAN
    Fructose-bisphosphate aldolase
    ALDOA
    361Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H3BU78H3BU78_HUMAN
    Fructose-bisphosphate aldolase
    ALDOA
    204Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H3BPS8H3BPS8_HUMAN
    Fructose-bisphosphate aldolase A
    ALDOA
    278Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H3BUH7H3BUH7_HUMAN
    Fructose-bisphosphate aldolase A
    ALDOA
    155Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H3BMQ8H3BMQ8_HUMAN
    Fructose-bisphosphate aldolase A
    ALDOA
    140Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H3BR04H3BR04_HUMAN
    Fructose-bisphosphate aldolase A
    ALDOA
    162Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H3BR68H3BR68_HUMAN
    Fructose-bisphosphate aldolase A
    ALDOA
    130Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti73C → G in CAA30979 (PubMed:3391172).Curated1
    Sequence conflicti180Q → R in CAG46678 (Ref. 6) Curated1
    Sequence conflicti196D → A in CAA30979 (PubMed:3391172).Curated1
    Sequence conflicti230K → N in CAA30979 (PubMed:3391172).Curated1
    Sequence conflicti280A → S in CAA30979 (PubMed:3391172).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_04821982E → Q. Corresponds to variant dbSNP:rs11553107Ensembl.1
    Natural variantiVAR_000550129D → G in GSD12; thermolabile. 2 PublicationsCorresponds to variant dbSNP:rs121909533Ensembl.1
    Natural variantiVAR_048220142G → V. Corresponds to variant dbSNP:rs11553108Ensembl.1
    Natural variantiVAR_044142207E → K in GSD12; reduces thermal stability; 3-fold decrease in catalytic efficiency mostly due to reduced substrate affinity. 2 PublicationsCorresponds to variant dbSNP:rs121909534Ensembl.1
    Natural variantiVAR_044143339C → Y in GSD12. 1 Publication1
    Natural variantiVAR_044144347G → S in GSD12; does not affect thermal stability; 4-fold decrease in catalytic efficiency due to reduced enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs138824667Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0472611M → MARRKPEGSSFNMTHLSMAM AFSFPPVASGQLHPQLGNTQ HQTELGKELATTSTM in isoform 2. 1 Publication1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    M11560 mRNA Translation: AAA51690.1
    X05236 mRNA Translation: CAA28861.1
    X12447 Genomic DNA Translation: CAA30979.1
    AK301993 mRNA Translation: BAG63399.1
    CR536528 mRNA Translation: CAG38765.1
    CR541880 mRNA Translation: CAG46678.1
    AC093512 Genomic DNA No translation available.
    CH471238 Genomic DNA Translation: EAW79933.1
    BC000367 mRNA Translation: AAH00367.2
    BC004333 mRNA Translation: AAH04333.1
    BC010660 mRNA Translation: AAH10660.1
    BC012880 mRNA Translation: AAH12880.1
    BC013614 mRNA Translation: AAH13614.1
    BC015888 mRNA Translation: AAH15888.1
    BC016170 mRNA Translation: AAH16170.1
    BC016800 mRNA Translation: AAH16800.1
    M21190 mRNA Translation: AAA51697.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS10668.1 [P04075-1]
    CCDS58450.1 [P04075-2]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    S14084 ADHUA

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_000025.1, NM_000034.3
    NP_001121089.1, NM_001127617.2 [P04075-1]
    NP_001230106.1, NM_001243177.1 [P04075-2]
    NP_908930.1, NM_184041.2 [P04075-1]
    NP_908932.1, NM_184043.2 [P04075-1]
    XP_011544070.1, XM_011545768.2

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.513490
    Hs.732822

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000412304; ENSP00000400452; ENSG00000149925 [P04075-1]
    ENST00000563060; ENSP00000455800; ENSG00000149925 [P04075-1]
    ENST00000564546; ENSP00000455917; ENSG00000149925 [P04075-1]
    ENST00000564595; ENSP00000457468; ENSG00000149925 [P04075-2]
    ENST00000569545; ENSP00000455700; ENSG00000149925 [P04075-1]
    ENST00000642816; ENSP00000496166; ENSG00000149925 [P04075-2]
    ENST00000643777; ENSP00000494188; ENSG00000149925 [P04075-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    226

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:226

    UCSC genome browser

    More...
    UCSCi
    uc010veg.3 human [P04075-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    M11560 mRNA Translation: AAA51690.1
    X05236 mRNA Translation: CAA28861.1
    X12447 Genomic DNA Translation: CAA30979.1
    AK301993 mRNA Translation: BAG63399.1
    CR536528 mRNA Translation: CAG38765.1
    CR541880 mRNA Translation: CAG46678.1
    AC093512 Genomic DNA No translation available.
    CH471238 Genomic DNA Translation: EAW79933.1
    BC000367 mRNA Translation: AAH00367.2
    BC004333 mRNA Translation: AAH04333.1
    BC010660 mRNA Translation: AAH10660.1
    BC012880 mRNA Translation: AAH12880.1
    BC013614 mRNA Translation: AAH13614.1
    BC015888 mRNA Translation: AAH15888.1
    BC016170 mRNA Translation: AAH16170.1
    BC016800 mRNA Translation: AAH16800.1
    M21190 mRNA Translation: AAA51697.1
    CCDSiCCDS10668.1 [P04075-1]
    CCDS58450.1 [P04075-2]
    PIRiS14084 ADHUA
    RefSeqiNP_000025.1, NM_000034.3
    NP_001121089.1, NM_001127617.2 [P04075-1]
    NP_001230106.1, NM_001243177.1 [P04075-2]
    NP_908930.1, NM_184041.2 [P04075-1]
    NP_908932.1, NM_184043.2 [P04075-1]
    XP_011544070.1, XM_011545768.2
    UniGeneiHs.513490
    Hs.732822

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1ALDX-ray2.00A2-364[»]
    2ALDX-ray2.10A2-364[»]
    4ALDX-ray2.80A2-364[»]
    5KY6X-ray1.94A/B/C/D2-364[»]
    ProteinModelPortaliP04075
    SMRiP04075
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi106728, 126 interactors
    IntActiP04075, 58 interactors
    MINTiP04075
    STRINGi9606.ENSP00000336927

    Chemistry databases

    ChEMBLiCHEMBL2106
    DrugBankiDB08240 N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE

    Protein family/group databases

    MoonProtiP04075

    PTM databases

    CarbonylDBiP04075
    iPTMnetiP04075
    PhosphoSitePlusiP04075
    SwissPalmiP04075

    Polymorphism and mutation databases

    BioMutaiALDOA
    DMDMi113606

    2D gel databases

    DOSAC-COBS-2DPAGEiP04075
    OGPiP04075
    REPRODUCTION-2DPAGEiIPI00465439
    P04075
    SWISS-2DPAGEiP04075
    UCD-2DPAGEiP04075

    Proteomic databases

    EPDiP04075
    jPOSTiP04075
    PaxDbiP04075
    PeptideAtlasiP04075
    PRIDEiP04075
    ProteomicsDBi51647
    TopDownProteomicsiP04075-1 [P04075-1]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    226
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000412304; ENSP00000400452; ENSG00000149925 [P04075-1]
    ENST00000563060; ENSP00000455800; ENSG00000149925 [P04075-1]
    ENST00000564546; ENSP00000455917; ENSG00000149925 [P04075-1]
    ENST00000564595; ENSP00000457468; ENSG00000149925 [P04075-2]
    ENST00000569545; ENSP00000455700; ENSG00000149925 [P04075-1]
    ENST00000642816; ENSP00000496166; ENSG00000149925 [P04075-2]
    ENST00000643777; ENSP00000494188; ENSG00000149925 [P04075-1]
    GeneIDi226
    KEGGihsa:226
    UCSCiuc010veg.3 human [P04075-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    226
    DisGeNETi226
    EuPathDBiHostDB:ENSG00000149925.16

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    ALDOA
    ENSG00000285043
    HGNCiHGNC:414 ALDOA
    HPAiCAB006252
    HPA004177
    MalaCardsiALDOA
    MIMi103850 gene
    611881 phenotype
    neXtProtiNX_P04075
    OpenTargetsiENSG00000149925
    Orphaneti57 Glycogen storage disease due to aldolase A deficiency
    PharmGKBiPA24707

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1557 Eukaryota
    COG3588 LUCA
    GeneTreeiENSGT00390000010235
    HOVERGENiHBG002386
    InParanoidiP04075
    KOiK01623
    OMAiDYREMLF
    OrthoDBi799973at2759
    PhylomeDBiP04075
    TreeFamiTF314203

    Enzyme and pathway databases

    UniPathwayi
    UPA00109;UER00183

    BioCyciMetaCyc:HS07647-MONOMER
    BRENDAi4.1.2.13 2681
    ReactomeiR-HSA-114608 Platelet degranulation
    R-HSA-6798695 Neutrophil degranulation
    R-HSA-70171 Glycolysis
    R-HSA-70263 Gluconeogenesis
    SABIO-RKiP04075
    SIGNORiP04075

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    ALDOA human
    EvolutionaryTraceiP04075

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    Aldolase_A

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    226

    Protein Ontology

    More...
    PROi
    PR:P04075

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000149925 Expressed in 238 organ(s), highest expression level in vastus lateralis
    CleanExiHS_ALDOA
    ExpressionAtlasiP04075 baseline and differential
    GenevisibleiP04075 HS

    Family and domain databases

    Gene3Di3.20.20.70, 1 hit
    InterProiView protein in InterPro
    IPR029768 Aldolase_I_AS
    IPR013785 Aldolase_TIM
    IPR000741 FBA_I
    PfamiView protein in Pfam
    PF00274 Glycolytic, 1 hit
    PROSITEiView protein in PROSITE
    PS00158 ALDOLASE_CLASS_I, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiALDOA_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P04075
    Secondary accession number(s): B4DXI7
    , Q6FH76, Q6FI10, Q96B15, Q9BWD9, Q9UCN2
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1986
    Last sequence update: January 23, 2007
    Last modified: January 16, 2019
    This is version 226 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
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