UniProtKB - P04070 (PROC_HUMAN)
Vitamin K-dependent protein C
PROC
Functioni
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265).
Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845).
2 PublicationsMiscellaneous
Catalytic activityi
- Degradation of blood coagulation factors Va and VIIIa. EC:3.4.21.69
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 253 | Charge relay system | 1 | |
Active sitei | 299 | Charge relay system | 1 | |
Active sitei | 402 | Charge relay system | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- serine-type endopeptidase activity Source: UniProtKB
GO - Biological processi
- blood coagulation Source: UniProtKB-KW
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of blood coagulation Source: ComplexPortal
- negative regulation of coagulation Source: UniProtKB
- negative regulation of inflammatory response Source: UniProtKB
- positive regulation of establishment of endothelial barrier Source: UniProtKB
- proteolysis Source: ComplexPortal
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Biological process | Blood coagulation, Hemostasis |
Ligand | Calcium |
Enzyme and pathway databases
BRENDAi | 3.4.21.69, 2681 |
PathwayCommonsi | P04070 |
Reactomei | R-HSA-140837, Intrinsic Pathway of Fibrin Clot Formation R-HSA-140875, Common Pathway of Fibrin Clot Formation R-HSA-159740, Gamma-carboxylation of protein precursors R-HSA-159763, Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-HSA-159782, Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
SABIO-RKi | P04070 |
SignaLinki | P04070 |
SIGNORi | P04070 |
Protein family/group databases
MEROPSi | S01.218 |
Names & Taxonomyi
Protein namesi | Recommended name: Vitamin K-dependent protein C (EC:3.4.21.69)Alternative name(s): Anticoagulant protein C Autoprothrombin IIA Blood coagulation factor XIV Cleaved into the following 3 chains: |
Gene namesi | Name:PROC |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9451, PROC |
MIMi | 612283, gene |
neXtProti | NX_P04070 |
VEuPathDBi | HostDB:ENSG00000115718 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus 2 Publications
Endoplasmic reticulum
- Endoplasmic reticulum 2 Publications
Extracellular region or secreted
- Secreted 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: ComplexPortal
Golgi apparatus
- Golgi apparatus Source: UniProtKB
- Golgi lumen Source: Reactome
Other locations
- serine-type endopeptidase complex Source: ComplexPortal
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatus, SecretedPathology & Biotechi
Involvement in diseasei
Thrombophilia due to protein C deficiency, autosomal dominant (THPH3)16 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_006635 | 32 | R → C in THPH3. 1 Publication | 1 | |
Natural variantiVAR_055074 | 42 | R → S in THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein. 1 PublicationCorresponds to variant dbSNP:rs774572099EnsemblClinVar. | 1 | |
Natural variantiVAR_006642 | 57 | R → W in THPH3. 2 PublicationsCorresponds to variant dbSNP:rs757583846EnsemblClinVar. | 1 | |
Natural variantiVAR_006645 | 62 | E → A in THPH3; Vermont-1. 1 PublicationCorresponds to variant dbSNP:rs121918148EnsemblClinVar. | 1 | |
Natural variantiVAR_006646 | 76 | V → M in THPH3; Vermont-1. 1 PublicationCorresponds to variant dbSNP:rs121918149EnsemblClinVar. | 1 | |
Natural variantiVAR_006651 | 114 | G → R in THPH3. 1 PublicationCorresponds to variant dbSNP:rs374476971EnsemblClinVar. | 1 | |
Natural variantiVAR_006656 | 145 | G → R in THPH3. 1 PublicationCorresponds to variant dbSNP:rs370813536Ensembl. | 1 | |
Natural variantiVAR_073147 | 163 | A → V in THPH3; drastically reduced secretion; colocalizes with 26S proteasome. 1 Publication | 1 | |
Natural variantiVAR_006664 | 210 | P → L in THPH3. 1 PublicationCorresponds to variant dbSNP:rs121918145EnsemblClinVar. | 1 | |
Natural variantiVAR_006665 | 211 | R → W in THPH3; London-1/Tochigi. 2 PublicationsCorresponds to variant dbSNP:rs121918143EnsemblClinVar. | 1 | |
Natural variantiVAR_006669 | 220 | R → Q in THPH3; Vermont-3. 3 PublicationsCorresponds to variant dbSNP:rs121918153EnsemblClinVar. | 1 | |
Natural variantiVAR_006668 | 220 | R → W in THPH3. 2 PublicationsCorresponds to variant dbSNP:rs121918152EnsemblClinVar. | 1 | |
Natural variantiVAR_006671 | 243 | I → T in THPH3. 1 PublicationCorresponds to variant dbSNP:rs774584131Ensembl. | 1 | |
Natural variantiVAR_006677 | 272 | R → C in THPH3. 1 PublicationCorresponds to variant dbSNP:rs121918154EnsemblClinVar. | 1 | |
Natural variantiVAR_074303 | 297 | D → H in THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization. 2 PublicationsCorresponds to variant dbSNP:rs199469471EnsemblClinVar. | 1 | |
Natural variantiVAR_006687 | 321 | P → L in THPH3. 2 PublicationsCorresponds to variant dbSNP:rs1321566264EnsemblClinVar. | 1 | |
Natural variantiVAR_006688 | 324 | G → R in THPH3. 1 Publication | 1 | |
Natural variantiVAR_006689 | 328 | R → C in THPH3. 2 PublicationsCorresponds to variant dbSNP:rs201907715EnsemblClinVar. | 1 | |
Natural variantiVAR_006692 | 340 | T → M in THPH3; Vermont-2. 2 PublicationsCorresponds to variant dbSNP:rs766261022EnsemblClinVar. | 1 | |
Natural variantiVAR_006696 | 369 | P → L in THPH3; Osaka-6. 2 PublicationsCorresponds to variant dbSNP:rs1211098698Ensembl. | 1 | |
Natural variantiVAR_006700 | 392 | G → R in THPH3; Osaka-9. 1 PublicationCorresponds to variant dbSNP:rs756467027EnsemblClinVar. | 1 | |
Natural variantiVAR_006702 | 401 | D → N in THPH3; La Jolla-2/Osaka-7 and -8. 1 PublicationCorresponds to variant dbSNP:rs142742242EnsemblClinVar. | 1 | |
Natural variantiVAR_074307 | 420 | V → L in THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity. 2 PublicationsCorresponds to variant dbSNP:rs199469472Ensembl. | 1 | |
Natural variantiVAR_006704 | 423 | G → S in THPH3. 1 Publication | 1 | |
Natural variantiVAR_006705 | 426 | C → Y in THPH3. 1 Publication | 1 | |
Natural variantiVAR_006707 | 436 | T → N in THPH3. 1 Publication | 1 | |
Natural variantiVAR_006708 | 441 | Y → H in THPH3; Osaka-4. 1 PublicationCorresponds to variant dbSNP:rs753436021Ensembl. | 1 | |
Natural variantiVAR_006709 | 444 | W → C in THPH3. 1 PublicationCorresponds to variant dbSNP:rs121918142EnsemblClinVar. | 1 |
Thrombophilia due to protein C deficiency, autosomal recessive (THPH4)7 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_073145 | 77 | D → G in THPH4; no effect on secretion; no effect on catalytic activity in vitro. 1 Publication | 1 | |
Natural variantiVAR_006655 | 144 – 145 | NG → K in THPH4; neonatal purpura fulminans. 1 Publication | 2 | |
Natural variantiVAR_073146 | 163 | A → E in THPH4; drastically reduced secretion; colocalizes with 26S proteasome. 1 Publication | 1 | |
Natural variantiVAR_006660 | 178 | A → P in THPH4; Clamart. 1 PublicationCorresponds to variant dbSNP:rs1254257945EnsemblClinVar. | 1 | |
Natural variantiVAR_006679 | 289 | P → L in THPH4. 1 PublicationCorresponds to variant dbSNP:rs121918151EnsemblClinVar. | 1 | |
Natural variantiVAR_006690 | 328 | R → H in THPH4; Muenchen. 1 Publication | 1 | |
Natural variantiVAR_006691 | 334 | G → S in THPH4. 1 PublicationCorresponds to variant dbSNP:rs121918150EnsemblClinVar. | 1 | |
Natural variantiVAR_006695 | 367 | V → A in THPH4; neonatal purpura fulminans. 1 PublicationCorresponds to variant dbSNP:rs767730328Ensembl. | 1 | |
Natural variantiVAR_006703 | 418 | G → D in THPH4; Hong Kong-2. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, ThrombophiliaOrganism-specific databases
DisGeNETi | 5624 |
MalaCardsi | PROC |
MIMi | 176860, phenotype 612304, phenotype |
OpenTargetsi | ENSG00000115718 |
Orphaneti | 64738, NON RARE IN EUROPE: Non rare thrombophilia 745, Severe hereditary thrombophilia due to congenital protein C deficiency |
PharmGKBi | PA33799 |
Miscellaneous databases
Pharosi | P04070, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4444 |
DrugBanki | DB13192, Antihemophilic factor human DB00025, Antihemophilic factor, human recombinant DB09131, Cupric Chloride DB09332, Kappadione DB13998, Lonoctocog alfa DB00170, Menadione DB13999, Moroctocog alfa DB13149, Protein S human DB00464, Sodium tetradecyl sulfate DB14738, Turoctocog alfa pegol |
DrugCentrali | P04070 |
GuidetoPHARMACOLOGYi | 2396 |
Genetic variation databases
BioMutai | PROC |
DMDMi | 131067 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
PropeptideiPRO_0000028107 | 19 – 42 | Add BLAST | 24 | |
ChainiPRO_0000028108 | 43 – 461 | Vitamin K-dependent protein CAdd BLAST | 419 | |
ChainiPRO_0000028109 | 43 – 197 | Vitamin K-dependent protein C light chainAdd BLAST | 155 | |
ChainiPRO_0000028110 | 200 – 461 | Vitamin K-dependent protein C heavy chainAdd BLAST | 262 | |
PeptideiPRO_0000028111 | 200 – 211 | Activation peptideAdd BLAST | 12 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 19 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Modified residuei | 48 | 4-carboxyglutamatePROSITE-ProRule annotation1 Publication | 1 | |
Modified residuei | 49 | 4-carboxyglutamatePROSITE-ProRule annotation1 Publication | 1 | |
Modified residuei | 56 | 4-carboxyglutamatePROSITE-ProRule annotation1 Publication | 1 | |
Modified residuei | 58 | 4-carboxyglutamatePROSITE-ProRule annotation1 Publication | 1 | |
Disulfide bondi | 59 ↔ 64 | |||
Modified residuei | 61 | 4-carboxyglutamatePROSITE-ProRule annotation1 Publication | 1 | |
Modified residuei | 62 | 4-carboxyglutamatePROSITE-ProRule annotation1 Publication | 1 | |
Modified residuei | 67 | 4-carboxyglutamatePROSITE-ProRule annotation1 Publication | 1 | |
Modified residuei | 68 | 4-carboxyglutamatePROSITE-ProRule annotation1 Publication | 1 | |
Modified residuei | 71 | 4-carboxyglutamatePROSITE-ProRule annotation1 Publication | 1 | |
Disulfide bondi | 92 ↔ 111 | |||
Disulfide bondi | 101 ↔ 106 | |||
Disulfide bondi | 105 ↔ 120 | |||
Modified residuei | 113 | (3R)-3-hydroxyaspartate1 Publication | 1 | |
Disulfide bondi | 122 ↔ 131 | |||
Glycosylationi | 139 | N-linked (GlcNAc...) asparagine | 1 | |
Disulfide bondi | 140 ↔ 151 | |||
Disulfide bondi | 147 ↔ 160 | |||
Disulfide bondi | 162 ↔ 175 | |||
Disulfide bondi | 183 ↔ 319 | Interchain (between light and heavy chains) | ||
Disulfide bondi | 238 ↔ 254 | |||
Glycosylationi | 290 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Modified residuei | 347 | Phosphoserine; by FAM20C1 Publication | 1 | |
Glycosylationi | 355 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 371 | N-linked (GlcNAc...) asparagine; atypical; partial2 Publications | 1 | |
Disulfide bondi | 373 ↔ 387 | |||
Disulfide bondi | 398 ↔ 426 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 211 – 212 | Cleavage; by thrombin | 2 |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid, Glycoprotein, Hydroxylation, Phosphoprotein, ZymogenProteomic databases
jPOSTi | P04070 |
MassIVEi | P04070 |
MaxQBi | P04070 |
PaxDbi | P04070 |
PeptideAtlasi | P04070 |
PRIDEi | P04070 |
ProteomicsDBi | 4804 51646 [P04070-1] |
PTM databases
GlyConnecti | 620, 17 N-Linked glycans (2 sites), 1 O-Linked glycan (1 site) |
GlyGeni | P04070, 7 sites, 43 N-linked glycans (5 sites), 2 O-linked glycans (2 sites) |
iPTMneti | P04070 |
PhosphoSitePlusi | P04070 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000115718, Expressed in right lobe of liver and 118 other tissues |
ExpressionAtlasi | P04070, baseline and differential |
Genevisiblei | P04070, HS |
Organism-specific databases
HPAi | ENSG00000115718, Tissue enriched (liver) |
Interactioni
Subunit structurei
Synthesized as a single chain precursor, which is cleaved into a light chain and a heavy chain held together by a disulfide bond. The enzyme is then activated by thrombin, which cleaves a tetradecapeptide from the amino end of the heavy chain; this reaction, which occurs at the surface of endothelial cells, is strongly promoted by thrombomodulin.
Binary interactionsi
Protein-protein interaction databases
BioGRIDi | 111608, 18 interactors |
ComplexPortali | CPX-6224, Active Protein C complex |
ELMi | P04070 |
IntActi | P04070, 11 interactors |
MINTi | P04070 |
STRINGi | 9606.ENSP00000234071 |
Chemistry databases
BindingDBi | P04070 |
Miscellaneous databases
RNActi | P04070, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P04070 |
SASBDBi | P04070 |
SMRi | P04070 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P04070 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 43 – 88 | GlaPROSITE-ProRule annotationAdd BLAST | 46 | |
Domaini | 97 – 132 | EGF-like 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 136 – 176 | EGF-like 2PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 212 – 450 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 239 |
Sequence similaritiesi
Keywords - Domaini
EGF-like domain, Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502QQ3W, Eukaryota |
GeneTreei | ENSGT00940000154505 |
HOGENOMi | CLU_006842_19_5_1 |
InParanoidi | P04070 |
OrthoDBi | 1314811at2759 |
PhylomeDBi | P04070 |
TreeFami | TF327329 |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits 4.10.740.10, 1 hit |
InterProi | View protein in InterPro IPR017857, Coagulation_fac-like_Gla_dom IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR035972, GLA-like_dom_SF IPR000294, GLA_domain IPR012224, Pept_S1A_FX IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00008, EGF, 1 hit PF00594, Gla, 1 hit PF00089, Trypsin, 1 hit |
PIRSFi | PIRSF001143, Factor_X, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN PR00001, GLABLOOD |
SMARTi | View protein in SMART SM00181, EGF, 2 hits SM00179, EGF_CA, 1 hit SM00069, GLA, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF57630, SSF57630, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS00022, EGF_1, 1 hit PS01186, EGF_2, 2 hits PS50026, EGF_3, 1 hit PS01187, EGF_CA, 1 hit PS00011, GLA_1, 1 hit PS50998, GLA_2, 1 hit PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MWQLTSLLLF VATWGISGTP APLDSVFSSS ERAHQVLRIR KRANSFLEEL
60 70 80 90 100
RHSSLERECI EEICDFEEAK EIFQNVDDTL AFWSKHVDGD QCLVLPLEHP
110 120 130 140 150
CASLCCGHGT CIDGIGSFSC DCRSGWEGRF CQREVSFLNC SLDNGGCTHY
160 170 180 190 200
CLEEVGWRRC SCAPGYKLGD DLLQCHPAVK FPCGRPWKRM EKKRSHLKRD
210 220 230 240 250
TEDQEDQVDP RLIDGKMTRR GDSPWQVVLL DSKKKLACGA VLIHPSWVLT
260 270 280 290 300
AAHCMDESKK LLVRLGEYDL RRWEKWELDL DIKEVFVHPN YSKSTTDNDI
310 320 330 340 350
ALLHLAQPAT LSQTIVPICL PDSGLAEREL NQAGQETLVT GWGYHSSREK
360 370 380 390 400
EAKRNRTFVL NFIKIPVVPH NECSEVMSNM VSENMLCAGI LGDRQDACEG
410 420 430 440 450
DSGGPMVASF HGTWFLVGLV SWGEGCGLLH NYGVYTKVSR YLDWIHGHIR
460
DKEAPQKSWA P
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7END6 | E7END6_HUMAN | Vitamin K-dependent protein C | PROC | 495 | Annotation score: | ||
E7ENR9 | E7ENR9_HUMAN | Vitamin K-dependent protein C | PROC | 175 | Annotation score: | ||
E7EVH6 | E7EVH6_HUMAN | Vitamin K-dependent protein C | PROC | 126 | Annotation score: | ||
E7EU72 | E7EU72_HUMAN | Vitamin K-dependent protein C | PROC | 116 | Annotation score: | ||
F2Z2A0 | F2Z2A0_HUMAN | Vitamin K-dependent protein C | PROC | 52 | Annotation score: | ||
H7BYX9 | H7BYX9_HUMAN | Vitamin K-dependent protein C | PROC | 236 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 106 | C → Q in AAA60164 (PubMed:6589623).Curated | 1 | |
Sequence conflicti | 445 | I → IL in AAA60165 (PubMed:3511471).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_006634 | 14 | W → G in patients with PROC deficiency. 1 Publication | 1 | |
Natural variantiVAR_006635 | 32 | R → C in THPH3. 1 Publication | 1 | |
Natural variantiVAR_006636 | 38 | R → W in patients with PROC deficiency. 1 PublicationCorresponds to variant dbSNP:rs769900251Ensembl. | 1 | |
Natural variantiVAR_006638 | 42 | R → C in patients with PROC deficiency. 1 PublicationCorresponds to variant dbSNP:rs774572099EnsemblClinVar. | 1 | |
Natural variantiVAR_006637 | 42 | R → H in Malakoff; low anticoagulant activity. 1 PublicationCorresponds to variant dbSNP:rs369504169EnsemblClinVar. | 1 | |
Natural variantiVAR_055074 | 42 | R → S in THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein. 1 PublicationCorresponds to variant dbSNP:rs774572099EnsemblClinVar. | 1 | |
Natural variantiVAR_006639 | 43 | A → T1 PublicationCorresponds to variant dbSNP:rs767626189Ensembl. | 1 | |
Natural variantiVAR_006640 | 49 | E → D in patients with PROC deficiency. 1 Publication | 1 | |
Natural variantiVAR_006641 | 51 | R → C in patients with PROC deficiency. Corresponds to variant dbSNP:rs764546127Ensembl. | 1 | |
Natural variantiVAR_006643 | 57 | R → G in Yonago; defective anticoagulant activity. 1 Publication | 1 | |
Natural variantiVAR_006644 | 57 | R → Q in patients with PROC deficiency. Corresponds to variant dbSNP:rs574949343Ensembl. | 1 | |
Natural variantiVAR_006642 | 57 | R → W in THPH3. 2 PublicationsCorresponds to variant dbSNP:rs757583846EnsemblClinVar. | 1 | |
Natural variantiVAR_006645 | 62 | E → A in THPH3; Vermont-1. 1 PublicationCorresponds to variant dbSNP:rs121918148EnsemblClinVar. | 1 | |
Natural variantiVAR_074296 | 70 | K → E in patients with PROC deficiency. 1 PublicationCorresponds to variant dbSNP:rs199469481Ensembl. | 1 | |
Natural variantiVAR_006646 | 76 | V → M in THPH3; Vermont-1. 1 PublicationCorresponds to variant dbSNP:rs121918149EnsemblClinVar. | 1 | |
Natural variantiVAR_073145 | 77 | D → G in THPH4; no effect on secretion; no effect on catalytic activity in vitro. 1 Publication | 1 | |
Natural variantiVAR_006647 | 89 | G → C in patients with PROC deficiency. 1 Publication | 1 | |
Natural variantiVAR_074297 | 106 | C → G in patients with PROC deficiency. 1 PublicationCorresponds to variant dbSNP:rs199469479Ensembl. | 1 | |
Natural variantiVAR_006648 | 108 | H → N in patients with PROC deficiency; La Jolla-1. Corresponds to variant dbSNP:rs200234655EnsemblClinVar. | 1 | |
Natural variantiVAR_006649 | 109 | G → R in patients with PROC deficiency. | 1 | |
Natural variantiVAR_006650 | 114 – 118 | Missing in patients with PROC deficiency. | 5 | |
Natural variantiVAR_006651 | 114 | G → R in THPH3. 1 PublicationCorresponds to variant dbSNP:rs374476971EnsemblClinVar. | 1 | |
Natural variantiVAR_074298 | 118 | F → A in patients with PROC deficiency; requires 2 nucleotide substitutions. 1 Publication | 1 | |
Natural variantiVAR_006652 | 118 | F → L in patients with PROC deficiency. Corresponds to variant dbSNP:rs1553424043EnsemblClinVar. | 1 | |
Natural variantiVAR_006653 | 119 – 124 | Missing in patients with PROC deficiency; St Louis-2. | 6 | |
Natural variantiVAR_006654 | 120 – 125 | Missing in patients with PROC deficiency; St Louis-3. | 6 | |
Natural variantiVAR_006655 | 144 – 145 | NG → K in THPH4; neonatal purpura fulminans. 1 Publication | 2 | |
Natural variantiVAR_006656 | 145 | G → R in THPH3. 1 PublicationCorresponds to variant dbSNP:rs370813536Ensembl. | 1 | |
Natural variantiVAR_006657 | 147 | C → Y in patients with PROC deficiency. Corresponds to variant dbSNP:rs1247269491EnsemblClinVar. | 1 | |
Natural variantiVAR_006658 | 149 | H → P in patients with PROC deficiency. Corresponds to variant dbSNP:rs121918159EnsemblClinVar. | 1 | |
Natural variantiVAR_006659 | 161 | S → R in patients with PROC deficiency. Corresponds to variant dbSNP:rs1433503391Ensembl. | 1 | |
Natural variantiVAR_073146 | 163 | A → E in THPH4; drastically reduced secretion; colocalizes with 26S proteasome. 1 Publication | 1 | |
Natural variantiVAR_073147 | 163 | A → V in THPH3; drastically reduced secretion; colocalizes with 26S proteasome. 1 Publication | 1 | |
Natural variantiVAR_074299 | 175 | C → Y in patients with PROC deficiency. 1 PublicationCorresponds to variant dbSNP:rs199469474EnsemblClinVar. | 1 | |
Natural variantiVAR_006660 | 178 | A → P in THPH4; Clamart. 1 PublicationCorresponds to variant dbSNP:rs1254257945EnsemblClinVar. | 1 | |
Natural variantiVAR_074300 | 181 | F → V in patients with PROC deficiency. 1 PublicationCorresponds to variant dbSNP:rs199469470Ensembl. | 1 | |
Natural variantiVAR_006661 | 183 | C → R in patients with PROC deficiency. Corresponds to variant dbSNP:rs748920874Ensembl. | 1 | |
Natural variantiVAR_006662 | 189 | R → W in patients with PROC deficiency; La Jolla-3. 1 PublicationCorresponds to variant dbSNP:rs146922325EnsemblClinVar. | 1 | |
Natural variantiVAR_006663 | 194 | R → C in patients with PROC deficiency. Corresponds to variant dbSNP:rs371071104EnsemblClinVar. | 1 | |
Natural variantiVAR_006664 | 210 | P → L in THPH3. 1 PublicationCorresponds to variant dbSNP:rs121918145EnsemblClinVar. | 1 | |
Natural variantiVAR_006666 | 211 | R → Q in patients with PROC deficiency. 2 PublicationsCorresponds to variant dbSNP:rs199469476Ensembl. | 1 | |
Natural variantiVAR_006665 | 211 | R → W in THPH3; London-1/Tochigi. 2 PublicationsCorresponds to variant dbSNP:rs121918143EnsemblClinVar. | 1 | |
Natural variantiVAR_006667 | 220 | R → P in patients with PROC deficiency. 1 Publication | 1 | |
Natural variantiVAR_006669 | 220 | R → Q in THPH3; Vermont-3. 3 PublicationsCorresponds to variant dbSNP:rs121918153EnsemblClinVar. | 1 | |
Natural variantiVAR_006668 | 220 | R → W in THPH3. 2 PublicationsCorresponds to variant dbSNP:rs121918152EnsemblClinVar. | 1 | |
Natural variantiVAR_074301 | 223 | S → R in patients with PROC deficiency. 1 PublicationCorresponds to variant dbSNP:rs199469483Ensembl. | 1 | |
Natural variantiVAR_006670 | 226 | Q → H in patients with PROC deficiency. Corresponds to variant dbSNP:rs121918155EnsemblClinVar. | 1 | |
Natural variantiVAR_074302 | 240 | A → G in patients with PROC deficiency. 1 Publication | 1 | |
Natural variantiVAR_006671 | 243 | I → T in THPH3. 1 PublicationCorresponds to variant dbSNP:rs774584131Ensembl. | 1 | |
Natural variantiVAR_006672 | 244 | H → Y in patients with PROC deficiency. 1 PublicationCorresponds to variant dbSNP:rs759557871EnsemblClinVar. | 1 | |
Natural variantiVAR_006673 | 253 | H → Q in patients with PROC deficiency. 1 PublicationCorresponds to variant dbSNP:rs1458669732Ensembl. | 1 | |
Natural variantiVAR_006674 | 265 | L → F in patients with PROC deficiency. Corresponds to variant dbSNP:rs121918156EnsemblClinVar. | 1 | |
Natural variantiVAR_006675 | 271 | R → Q in Marseille; low anticoagulant activity. 1 PublicationCorresponds to variant dbSNP:rs752290840Ensembl. | 1 | |
Natural variantiVAR_006676 | 271 | R → W in patients with PROC deficiency. Corresponds to variant dbSNP:rs767112991EnsemblClinVar. | 1 | |
Natural variantiVAR_006677 | 272 | R → C in THPH3. 1 PublicationCorresponds to variant dbSNP:rs121918154EnsemblClinVar. | 1 | |
Natural variantiVAR_006678 | 281 | D → DLD in patients with PROC deficiency. | 1 | |
Natural variantiVAR_006679 | 289 | P → L in THPH4. 1 PublicationCorresponds to variant dbSNP:rs121918151EnsemblClinVar. | 1 | |
Natural variantiVAR_006680 | 294 | S → N in Paris; low anticoagulant activity. 1 PublicationCorresponds to variant dbSNP:rs200721675Ensembl. | 1 | |
Natural variantiVAR_074303 | 297 | D → H in THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization. 2 PublicationsCorresponds to variant dbSNP:rs199469471EnsemblClinVar. | 1 | |
Natural variantiVAR_006681 | 298 | N → D in patients with PROC deficiency. | 1 | |
Natural variantiVAR_006682 | 301 | A → T in patients with PROC deficiency. 1 PublicationCorresponds to variant dbSNP:rs1343264503Ensembl. | 1 | |
Natural variantiVAR_006683 | 301 | A → V in patients with PROC deficiency. Corresponds to variant dbSNP:rs121918144EnsemblClinVar. | 1 | |
Natural variantiVAR_006684 | 309 | A → T in patients with PROC deficiency. Corresponds to variant dbSNP:rs121918146EnsemblClinVar. | 1 | |
Natural variantiVAR_006685 | 312 | S → L in patients with PROC deficiency. 1 PublicationCorresponds to variant dbSNP:rs121918160EnsemblClinVar. | 1 | |
Natural variantiVAR_006686 | 312 | S → P in a patient with PROC deficiency; sporadic case. 1 Publication | 1 | |
Natural variantiVAR_074304 | 317 | P → S in patients with PROC deficiency; abolishes Golgi localization. 1 Publication | 1 | |
Natural variantiVAR_006687 | 321 | P → L in THPH3. 2 PublicationsCorresponds to variant dbSNP:rs1321566264EnsemblClinVar. | 1 | |
Natural variantiVAR_006688 | 324 | G → R in THPH3. 1 Publication | 1 | |
Natural variantiVAR_074305 | 327 | E → V in patients with PROC deficiency. 1 PublicationCorresponds to variant dbSNP:rs199469480Ensembl. | 1 | |
Natural variantiVAR_006689 | 328 | R → C in THPH3. 2 PublicationsCorresponds to variant dbSNP:rs201907715EnsemblClinVar. | 1 | |
Natural variantiVAR_006690 | 328 | R → H in THPH4; Muenchen. 1 Publication | 1 | |
Natural variantiVAR_006691 | 334 | G → S in THPH4. 1 PublicationCorresponds to variant dbSNP:rs121918150EnsemblClinVar. | 1 | |
Natural variantiVAR_006692 | 340 | T → M in THPH3; Vermont-2. 2 PublicationsCorresponds to variant dbSNP:rs766261022EnsemblClinVar. | 1 | |
Natural variantiVAR_006693 | 343 | G → D in patients with PROC deficiency. | 1 | |
Natural variantiVAR_074306 | 357 | T → A Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin. 1 Publication | 1 | |
Natural variantiVAR_006694 | 363 | Missing in patients with PROC deficiency. | 1 | |
Natural variantiVAR_006695 | 367 | V → A in THPH4; neonatal purpura fulminans. 1 PublicationCorresponds to variant dbSNP:rs767730328Ensembl. | 1 | |
Natural variantiVAR_006696 | 369 | P → L in THPH3; Osaka-6. 2 PublicationsCorresponds to variant dbSNP:rs1211098698Ensembl. | 1 | |
Natural variantiVAR_006697 | 385 | M → I in patients with PROC deficiency. 1 Publication | 1 | |
Natural variantiVAR_006698 | 388 | A → T in patients with PROC deficiency. 1 Publication | 1 | |
Natural variantiVAR_006699 | 388 | A → V in patients with PROC deficiency. 1 PublicationCorresponds to variant dbSNP:rs769277939EnsemblClinVar. | 1 | |
Natural variantiVAR_006700 | 392 | G → R in THPH3; Osaka-9. 1 PublicationCorresponds to variant dbSNP:rs756467027EnsemblClinVar. | 1 | |
Natural variantiVAR_006701 | 394 | R → W in patients with PROC deficiency. Corresponds to variant dbSNP:rs759316085Ensembl. | 1 | |
Natural variantiVAR_006702 | 401 | D → N in THPH3; La Jolla-2/Osaka-7 and -8. 1 PublicationCorresponds to variant dbSNP:rs142742242EnsemblClinVar. | 1 | |
Natural variantiVAR_006703 | 418 | G → D in THPH4; Hong Kong-2. 1 Publication | 1 | |
Natural variantiVAR_074307 | 420 | V → L in THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity. 2 PublicationsCorresponds to variant dbSNP:rs199469472Ensembl. | 1 | |
Natural variantiVAR_006704 | 423 | G → S in THPH3. 1 Publication | 1 | |
Natural variantiVAR_006705 | 426 | C → Y in THPH3. 1 Publication | 1 | |
Natural variantiVAR_006706 | 433 | G → S in patients with PROC deficiency; Purmerend. Corresponds to variant dbSNP:rs1266965698Ensembl. | 1 | |
Natural variantiVAR_006707 | 436 | T → N in THPH3. 1 Publication | 1 | |
Natural variantiVAR_006708 | 441 | Y → H in THPH3; Osaka-4. 1 PublicationCorresponds to variant dbSNP:rs753436021Ensembl. | 1 | |
Natural variantiVAR_006709 | 444 | W → C in THPH3. 1 PublicationCorresponds to variant dbSNP:rs121918142EnsemblClinVar. | 1 | |
Natural variantiVAR_006710 | 445 | I → M in patients with PROC deficiency. Corresponds to variant dbSNP:rs121918157EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054393 | 1 | M → MAAGRRTCSISTTRPCASAS RM in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_054394 | 133 | R → RGEGERWMLAGGGAGLGPGW GRGTSTSCPRPPLPA in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X02750 mRNA Translation: CAA26528.1 M11228 Genomic DNA Translation: AAA60166.1 M12712 , M12683, M12684, M12685, M12686, M12687 Genomic DNA Translation: AAA60165.1 AF378903 Genomic DNA Translation: AAK56377.1 AK298454 mRNA Translation: BAG60669.1 AC068282 Genomic DNA Translation: AAY15044.1 CH471103 Genomic DNA Translation: EAW95320.1 BC034377 mRNA Translation: AAH34377.1 S58668 Genomic DNA Translation: AAB26335.1 K02059 mRNA Translation: AAA60164.1 S76088 Genomic DNA No translation available. S76090 Genomic DNA No translation available. |
CCDSi | CCDS2145.1 [P04070-1] |
PIRi | A22331, KXHU |
RefSeqi | NP_000303.1, NM_000312.3 [P04070-1] |
Genome annotation databases
Ensembli | ENST00000234071.8; ENSP00000234071.4; ENSG00000115718.18 |
GeneIDi | 5624 |
KEGGi | hsa:5624 |
MANE-Selecti | ENST00000234071.8; ENSP00000234071.4; NM_000312.4; NP_000303.1 |
UCSCi | uc002tok.4, human [P04070-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Protein C entry |
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X02750 mRNA Translation: CAA26528.1 M11228 Genomic DNA Translation: AAA60166.1 M12712 , M12683, M12684, M12685, M12686, M12687 Genomic DNA Translation: AAA60165.1 AF378903 Genomic DNA Translation: AAK56377.1 AK298454 mRNA Translation: BAG60669.1 AC068282 Genomic DNA Translation: AAY15044.1 CH471103 Genomic DNA Translation: EAW95320.1 BC034377 mRNA Translation: AAH34377.1 S58668 Genomic DNA Translation: AAB26335.1 K02059 mRNA Translation: AAA60164.1 S76088 Genomic DNA No translation available. S76090 Genomic DNA No translation available. |
CCDSi | CCDS2145.1 [P04070-1] |
PIRi | A22331, KXHU |
RefSeqi | NP_000303.1, NM_000312.3 [P04070-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AUT | X-ray | 2.80 | C | 212-461 | [»] | |
L | 84-197 | [»] | ||||
1LQV | X-ray | 1.60 | C/D | 43-75 | [»] | |
3F6U | X-ray | 2.80 | H | 212-451 | [»] | |
L | 91-188 | [»] | ||||
3JTC | X-ray | 1.60 | C/D | 43-75 | [»] | |
4DT7 | X-ray | 1.90 | E/F | 204-223 | [»] | |
6M3B | X-ray | 2.20 | A | 212-461 | [»] | |
D | 43-197 | [»] | ||||
6M3C | X-ray | 3.70 | A/C/G | 212-461 | [»] | |
B/D/I | 43-197 | [»] | ||||
AlphaFoldDBi | P04070 | |||||
SASBDBi | P04070 | |||||
SMRi | P04070 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111608, 18 interactors |
ComplexPortali | CPX-6224, Active Protein C complex |
ELMi | P04070 |
IntActi | P04070, 11 interactors |
MINTi | P04070 |
STRINGi | 9606.ENSP00000234071 |
Chemistry databases
BindingDBi | P04070 |
ChEMBLi | CHEMBL4444 |
DrugBanki | DB13192, Antihemophilic factor human DB00025, Antihemophilic factor, human recombinant DB09131, Cupric Chloride DB09332, Kappadione DB13998, Lonoctocog alfa DB00170, Menadione DB13999, Moroctocog alfa DB13149, Protein S human DB00464, Sodium tetradecyl sulfate DB14738, Turoctocog alfa pegol |
DrugCentrali | P04070 |
GuidetoPHARMACOLOGYi | 2396 |
Protein family/group databases
MEROPSi | S01.218 |
PTM databases
GlyConnecti | 620, 17 N-Linked glycans (2 sites), 1 O-Linked glycan (1 site) |
GlyGeni | P04070, 7 sites, 43 N-linked glycans (5 sites), 2 O-linked glycans (2 sites) |
iPTMneti | P04070 |
PhosphoSitePlusi | P04070 |
Genetic variation databases
BioMutai | PROC |
DMDMi | 131067 |
Proteomic databases
jPOSTi | P04070 |
MassIVEi | P04070 |
MaxQBi | P04070 |
PaxDbi | P04070 |
PeptideAtlasi | P04070 |
PRIDEi | P04070 |
ProteomicsDBi | 4804 51646 [P04070-1] |
Protocols and materials databases
ABCDi | P04070, 2 sequenced antibodies |
Antibodypediai | 791, 725 antibodies from 41 providers |
DNASUi | 5624 |
Genome annotation databases
Ensembli | ENST00000234071.8; ENSP00000234071.4; ENSG00000115718.18 |
GeneIDi | 5624 |
KEGGi | hsa:5624 |
MANE-Selecti | ENST00000234071.8; ENSP00000234071.4; NM_000312.4; NP_000303.1 |
UCSCi | uc002tok.4, human [P04070-1] |
Organism-specific databases
CTDi | 5624 |
DisGeNETi | 5624 |
GeneCardsi | PROC |
HGNCi | HGNC:9451, PROC |
HPAi | ENSG00000115718, Tissue enriched (liver) |
MalaCardsi | PROC |
MIMi | 176860, phenotype 612283, gene 612304, phenotype |
neXtProti | NX_P04070 |
OpenTargetsi | ENSG00000115718 |
Orphaneti | 64738, NON RARE IN EUROPE: Non rare thrombophilia 745, Severe hereditary thrombophilia due to congenital protein C deficiency |
PharmGKBi | PA33799 |
VEuPathDBi | HostDB:ENSG00000115718 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQ3W, Eukaryota |
GeneTreei | ENSGT00940000154505 |
HOGENOMi | CLU_006842_19_5_1 |
InParanoidi | P04070 |
OrthoDBi | 1314811at2759 |
PhylomeDBi | P04070 |
TreeFami | TF327329 |
Enzyme and pathway databases
BRENDAi | 3.4.21.69, 2681 |
PathwayCommonsi | P04070 |
Reactomei | R-HSA-140837, Intrinsic Pathway of Fibrin Clot Formation R-HSA-140875, Common Pathway of Fibrin Clot Formation R-HSA-159740, Gamma-carboxylation of protein precursors R-HSA-159763, Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-HSA-159782, Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
SABIO-RKi | P04070 |
SignaLinki | P04070 |
SIGNORi | P04070 |
Miscellaneous databases
BioGRID-ORCSi | 5624, 6 hits in 1068 CRISPR screens |
ChiTaRSi | PROC, human |
EvolutionaryTracei | P04070 |
GeneWikii | Protein_C |
GenomeRNAii | 5624 |
Pharosi | P04070, Tchem |
PROi | PR:P04070 |
RNActi | P04070, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000115718, Expressed in right lobe of liver and 118 other tissues |
ExpressionAtlasi | P04070, baseline and differential |
Genevisiblei | P04070, HS |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits 4.10.740.10, 1 hit |
InterProi | View protein in InterPro IPR017857, Coagulation_fac-like_Gla_dom IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR035972, GLA-like_dom_SF IPR000294, GLA_domain IPR012224, Pept_S1A_FX IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00008, EGF, 1 hit PF00594, Gla, 1 hit PF00089, Trypsin, 1 hit |
PIRSFi | PIRSF001143, Factor_X, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN PR00001, GLABLOOD |
SMARTi | View protein in SMART SM00181, EGF, 2 hits SM00179, EGF_CA, 1 hit SM00069, GLA, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF57630, SSF57630, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS00022, EGF_1, 1 hit PS01186, EGF_2, 2 hits PS50026, EGF_3, 1 hit PS01187, EGF_CA, 1 hit PS00011, GLA_1, 1 hit PS50998, GLA_2, 1 hit PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PROC_HUMAN | |
Accessioni | P04070Primary (citable) accession number: P04070 Secondary accession number(s): B4DPQ7 Q9UC55 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1986 |
Last sequence update: | November 1, 1986 | |
Last modified: | May 25, 2022 | |
This is version 259 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families