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Entry version 202 (16 Oct 2019)
Sequence version 4 (24 Jul 2007)
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Protein

Tissue alpha-L-fucosidase

Gene

FUCA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei296May be important for catalysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.2.1.51 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695 Neutrophil degranulation
R-HSA-975578 Reactions specific to the complex N-glycan synthesis pathway

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P04066

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH29 Glycoside Hydrolase Family 29

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001407

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tissue alpha-L-fucosidase (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucosidase I
Alpha-L-fucoside fucohydrolase 1
Short name:
Alpha-L-fucosidase 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FUCA1
ORF Names:Nbla10230
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:4006 FUCA1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612280 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P04066

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Fucosidosis (FUCA1D)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive lysosomal storage disease characterized by accumulation of fucose-containing glycolipids and glycoproteins in various tissues. Clinical signs include facial dysmorphism, dysostosis multiplex, moderate hepatomegaly, severe intellectual deficit, deafness, and according to age, angiokeratomas.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00244265G → D in FUCA1D; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs1353778985Ensembl.1
Natural variantiVAR_00244368S → L in FUCA1D. 1 Publication1
Natural variantiVAR_016235410L → R in FUCA1D; less than 1% of residual activity. 1 PublicationCorresponds to variant dbSNP:rs80358199EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
2517

MalaCards human disease database

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MalaCardsi
FUCA1
MIMi230000 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000179163

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
349 Fucosidosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28422

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P04066

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4176

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FUCA1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
156631012

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001030832 – 466Tissue alpha-L-fucosidaseAdd BLAST435

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei170PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi241N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi268N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi382N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

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CPTACi
CPTAC-2215

Encyclopedia of Proteome Dynamics

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EPDi
P04066

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P04066

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P04066

MaxQB - The MaxQuant DataBase

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MaxQBi
P04066

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P04066

PeptideAtlas

More...
PeptideAtlasi
P04066

PRoteomics IDEntifications database

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PRIDEi
P04066

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
51645

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1810

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P04066

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P04066

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000179163 Expressed in 235 organ(s), highest expression level in colon

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P04066 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA046542
HPA056371

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108793, 15 interactors

Protein interaction database and analysis system

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IntActi
P04066, 14 interactors

Molecular INTeraction database

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MINTi
P04066

STRING: functional protein association networks

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STRINGi
9606.ENSP00000363603

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P04066

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P04066

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 29 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3340 Eukaryota
COG3669 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00440000035378

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000029598

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P04066

KEGG Orthology (KO)

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KOi
K01206

Identification of Orthologs from Complete Genome Data

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OMAi
CLIGNNH

Database of Orthologous Groups

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OrthoDBi
929780at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P04066

TreeFam database of animal gene trees

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TreeFami
TF313034

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.1180, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016286 FUC_metazoa-typ
IPR028755 FUCA1
IPR031919 Fucosidase_C
IPR000933 Glyco_hydro_29
IPR018526 Glyco_hydro_29_CS
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF

The PANTHER Classification System

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PANTHERi
PTHR10030 PTHR10030, 1 hit
PTHR10030:SF2 PTHR10030:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01120 Alpha_L_fucos, 1 hit
PF16757 Fucosidase_C, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF001092 Alpha-L-fucosidase, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00741 GLHYDRLASE29

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00812 Alpha_L_fucos, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF51445 SSF51445, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00385 ALPHA_L_FUCOSIDASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P04066-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRAPGMRSRP AGPALLLLLL FLGAAESVRR AQPPRRYTPD WPSLDSRPLP
60 70 80 90 100
AWFDEAKFGV FIHWGVFSVP AWGSEWFWWH WQGEGRPQYQ RFMRDNYPPG
110 120 130 140 150
FSYADFGPQF TARFFHPEEW ADLFQAAGAK YVVLTTKHHE GFTNWPSPVS
160 170 180 190 200
WNWNSKDVGP HRDLVGELGT ALRKRNIRYG LYHSLLEWFH PLYLLDKKNG
210 220 230 240 250
FKTQHFVSAK TMPELYDLVN SYKPDLIWSD GEWECPDTYW NSTNFLSWLY
260 270 280 290 300
NDSPVKDEVV VNDRWGQNCS CHHGGYYNCE DKFKPQSLPD HKWEMCTSID
310 320 330 340 350
KFSWGYRRDM ALSDVTEESE IISELVQTVS LGGNYLLNIG PTKDGLIVPI
360 370 380 390 400
FQERLLAVGK WLSINGEAIY ASKPWRVQWE KNTTSVWYTS KGSAVYAIFL
410 420 430 440 450
HWPENGVLNL ESPITTSTTK ITMLGIQGDL KWSTDPDKGL FISLPQLPPS
460
AVPAEFAWTI KLTGVK
Length:466
Mass (Da):53,689
Last modified:July 24, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD9A38ECC7BADCBBB
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA35519 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAA52481 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH17338 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG37210 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAA25646 differs from that shown. Translation of X01390 sequence produces a larger peptide than that shown in CAA25646.1.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti54 – 56DEA → NEV in BAC04002 (PubMed:14702039).Curated3
Sequence conflicti74S → T no nucleotide entry (PubMed:2174090).Curated1
Sequence conflicti76 – 77WF → FL in AAA52482 (PubMed:2983333).Curated2
Sequence conflicti76 – 77WF → FL in CAA25646 (PubMed:6096099).Curated2
Sequence conflicti93 – 114Missing in BAC04002 (PubMed:14702039).CuratedAdd BLAST22
Sequence conflicti127A → T in BAC04002 (PubMed:14702039).Curated1
Sequence conflicti171A → G in BAC04002 (PubMed:14702039).Curated1
Sequence conflicti244N → D in BAC04002 (PubMed:14702039).Curated1
Sequence conflicti427Q → P in AAA52482 (PubMed:2983333).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

There are two common alleles of FUCA1; FUCA1*1; also known as Fu1; has Arg-281 and FUCA1*2; also known as Fu2; has Gln-281.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0491062R → W. Corresponds to variant dbSNP:rs2070955EnsemblClinVar.1
Natural variantiVAR_01623310P → R. Corresponds to variant dbSNP:rs2070956EnsemblClinVar.1
Natural variantiVAR_00244265G → D in FUCA1D; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs1353778985Ensembl.1
Natural variantiVAR_00244368S → L in FUCA1D. 1 Publication1
Natural variantiVAR_049107146P → L. Corresponds to variant dbSNP:rs2228424EnsemblClinVar.1
Natural variantiVAR_049108260V → I. Corresponds to variant dbSNP:rs665EnsemblClinVar.1
Natural variantiVAR_016234269C → S3 PublicationsCorresponds to variant dbSNP:rs1126512Ensembl.1
Natural variantiVAR_002444286Q → R in allele FUCA1*2. 5 PublicationsCorresponds to variant dbSNP:rs13551EnsemblClinVar.1
Natural variantiVAR_016235410L → R in FUCA1D; less than 1% of residual activity. 1 PublicationCorresponds to variant dbSNP:rs80358199EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M80815
, M80809, M80810, M80811, M80812, M80813, M80814 Genomic DNA Translation: AAA52481.1 Different initiation.
AB074175 mRNA Translation: BAE45738.1
AK092914 mRNA Translation: BAC04002.1
AK314649 mRNA Translation: BAG37210.1 Different initiation.
AL590728 Genomic DNA No translation available.
BC017338 mRNA Translation: AAH17338.1 Different initiation.
M29877 mRNA Translation: AAA35519.1 Different initiation.
M10355 mRNA Translation: AAA52482.1
X01390 mRNA Translation: CAA25646.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS244.2

Protein sequence database of the Protein Information Resource

More...
PIRi
A33427 HWHUFA

NCBI Reference Sequences

More...
RefSeqi
NP_000138.2, NM_000147.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000374479; ENSP00000363603; ENSG00000179163

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2517

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2517

UCSC genome browser

More...
UCSCi
uc001bie.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80815
, M80809, M80810, M80811, M80812, M80813, M80814 Genomic DNA Translation: AAA52481.1 Different initiation.
AB074175 mRNA Translation: BAE45738.1
AK092914 mRNA Translation: BAC04002.1
AK314649 mRNA Translation: BAG37210.1 Different initiation.
AL590728 Genomic DNA No translation available.
BC017338 mRNA Translation: AAH17338.1 Different initiation.
M29877 mRNA Translation: AAA35519.1 Different initiation.
M10355 mRNA Translation: AAA52482.1
X01390 mRNA Translation: CAA25646.1 Sequence problems.
CCDSiCCDS244.2
PIRiA33427 HWHUFA
RefSeqiNP_000138.2, NM_000147.4

3D structure databases

SMRiP04066
ModBaseiSearch...

Protein-protein interaction databases

BioGridi108793, 15 interactors
IntActiP04066, 14 interactors
MINTiP04066
STRINGi9606.ENSP00000363603

Chemistry databases

BindingDBiP04066
ChEMBLiCHEMBL4176
SwissLipidsiSLP:000001407

Protein family/group databases

CAZyiGH29 Glycoside Hydrolase Family 29

PTM databases

GlyConnecti1810
iPTMnetiP04066
PhosphoSitePlusiP04066

Polymorphism and mutation databases

BioMutaiFUCA1
DMDMi156631012

Proteomic databases

CPTACiCPTAC-2215
EPDiP04066
jPOSTiP04066
MassIVEiP04066
MaxQBiP04066
PaxDbiP04066
PeptideAtlasiP04066
PRIDEiP04066
ProteomicsDBi51645

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
2517

Genome annotation databases

EnsembliENST00000374479; ENSP00000363603; ENSG00000179163
GeneIDi2517
KEGGihsa:2517
UCSCiuc001bie.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2517
DisGeNETi2517

GeneCards: human genes, protein and diseases

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GeneCardsi
FUCA1
HGNCiHGNC:4006 FUCA1
HPAiHPA046542
HPA056371
MalaCardsiFUCA1
MIMi230000 phenotype
612280 gene
neXtProtiNX_P04066
OpenTargetsiENSG00000179163
Orphaneti349 Fucosidosis
PharmGKBiPA28422

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3340 Eukaryota
COG3669 LUCA
GeneTreeiENSGT00440000035378
HOGENOMiHOG000029598
InParanoidiP04066
KOiK01206
OMAiCLIGNNH
OrthoDBi929780at2759
PhylomeDBiP04066
TreeFamiTF313034

Enzyme and pathway databases

BRENDAi3.2.1.51 2681
ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-975578 Reactions specific to the complex N-glycan synthesis pathway
SABIO-RKiP04066

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FUCA1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Fucosidase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2517
PharosiP04066

Protein Ontology

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PROi
PR:P04066

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000179163 Expressed in 235 organ(s), highest expression level in colon
GenevisibleiP04066 HS

Family and domain databases

Gene3Di2.60.40.1180, 1 hit
InterProiView protein in InterPro
IPR016286 FUC_metazoa-typ
IPR028755 FUCA1
IPR031919 Fucosidase_C
IPR000933 Glyco_hydro_29
IPR018526 Glyco_hydro_29_CS
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR10030 PTHR10030, 1 hit
PTHR10030:SF2 PTHR10030:SF2, 1 hit
PfamiView protein in Pfam
PF01120 Alpha_L_fucos, 1 hit
PF16757 Fucosidase_C, 1 hit
PIRSFiPIRSF001092 Alpha-L-fucosidase, 1 hit
PRINTSiPR00741 GLHYDRLASE29
SMARTiView protein in SMART
SM00812 Alpha_L_fucos, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00385 ALPHA_L_FUCOSIDASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFUCO_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P04066
Secondary accession number(s): B2RBG3
, Q14334, Q14335, Q3LID0, Q8NAC2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: July 24, 2007
Last modified: October 16, 2019
This is version 202 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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