UniProtKB - P04058 (ACES_TETCF)

BLAST

>sp|P04058|ACES_TETCF Acetylcholinesterase OS=Tetronarce californica OX=7787 GN=ache PE=1 SV=2
MNLLVTSSLGVLLHLVVLCQADDHSELLVNTKSGKVMGTRVPVLSSHISAFLGIPFAEPP
VGNMRFRRPEPKKPWSGVWNASTYPNNCQQYVDEQFPGFSGSEMWNPNREMSEDCLYLNI
WVPSPRPKSTTVMVWIYGGGFYSGSSTLDVYNGKYLAYTEEVVLVSLSYRVGAFGFLALH
GSQEAPGNVGLLDQRMALQWVHDNIQFFGGDPKTVTIFGESAGGASVGMHILSPGSRDLF
RRAILQSGSPNCPWASVSVAEGRRRAVELGRNLNCNLNSDEELIHCLREKKPQELIDVEW
NVLPFDSIFRFSFVPVIDGEFFPTSLESMLNSGNFKKTQILLGVNKDEGSFFLLYGAPGF
SKDSESKISREDFMSGVKLSVPHANDLGLDAVTLQYTDWMDDNNGIKNRDGLDDIVGDHN
VICPLMHFVNKYTKFGNGTYLYFFNHRASNLVWPEWMGVIHGYEIEFVFGLPLVKELNYT
AEEEALSRRIMHYWATFAKTGNPNEPHSQESKWPLFTTKEQKFIDLNTEPMKVHQRLRVQ
MCVFWNQFLPKLLNATACDGELSSSGTSSSKGIIFYVLFSILYLIF

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History
Entry version 163 (07 Nov 2018)
Sequence version 2 (01 Jun 1994)
Previous versions | rss
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Protein

Acetylcholinesterase

Gene

ache

Organism

Tetronarce californica (Pacific electric ray) (Torpedo californica)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.

Catalytic activityⁱ

Acetylcholine + H₂O = choline + acetate.

Activity regulationⁱ

Inhibited by substrate concentrations above 0.5 mM.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	221	Acyl-ester intermediate	1
Active siteⁱ	348	Charge relay system	1
Active siteⁱ	461	Charge relay system	1

GO - Molecular functionⁱ

acetylcholinesterase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

acetylcholine catabolic process in synaptic cleft Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Serine esterase
Biological process	Neurotransmitter degradation

Enzyme and pathway databases

BioCycⁱ	MetaCyc:MONOMER-16823
BRENDAⁱ	3.1.1.7 6395

Protein family/group databases

ESTHERⁱ	torca-ACHE AChE
MEROPS protease database More...MEROPSⁱ	S09.980

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Acetylcholinesterase (EC:3.1.1.7) Short name: AChE
Gene namesⁱ	Name:ache
Organismⁱ	Tetronarce californica (Pacific electric ray) (Torpedo californica)
Taxonomic identifierⁱ	7787 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Chondrichthyes › Elasmobranchii › Batoidea › Torpediniformes › Torpedinidae › Tetronarce

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	220	E → H: Loss of activity. 1 Publication	1
Mutagenesisⁱ	220	E → Q or D: Decrease in activity. 1 Publication	1
Mutagenesisⁱ	221	S → C: Loss of activity. 1 Publication	1
Mutagenesisⁱ	221	S → V: Loss of activity. 1 Publication	1
Mutagenesisⁱ	446	H → Q: Almost no loss of activity. 1 Publication	1
Mutagenesisⁱ	461	H → Q: Loss of activity. 1 Publication	1

Chemistry databases

ChEMBLⁱ	CHEMBL4780

ChEMBLⁱ

CHEMBL4780

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 21	1 PublicationAdd BLAST	21
ChainⁱPRO_0000008595	22 – 564	AcetylcholinesteraseAdd BLAST	543
PropeptideⁱPRO_0000008596	565 – 586	Removed in mature formAdd BLAST	22

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	80	N-linked (GlcNAc...) asparagine2 Publications	1
Disulfide bondⁱ	88 ↔ 115
Disulfide bondⁱ	275 ↔ 286
Disulfide bondⁱ	423 ↔ 542
Glycosylationⁱ	437	N-linked (GlcNAc...) asparagine3 Publications	1
Glycosylationⁱ	478	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	554	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	558	Interchain
Lipidationⁱ	564	GPI-anchor amidated serine1 Publication	1

Post-translational modificationⁱ

An interchain disulfide bond is present in what becomes position 593 of the T isoform.

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

PTM databases

iPTMnetⁱ	P04058

iPTMnetⁱ

P04058

Expressionⁱ

Tissue specificityⁱ

Found in the synapses and to a lower extent in extrajunctional areas of muscle and nerve, and on erythrocyte membranes.

Interactionⁱ

Subunit structureⁱ

Isoform H form is a homodimer; the asymmetric form is a disulfide-bonded oligomer composed of a collagenic subunit (Q) and a variable number of T catalytic subunits.11 Publications

Protein-protein interaction databases

Molecular INTeraction database More...MINTⁱ	P04058

MINTⁱ

P04058

Chemistry databases

BindingDBⁱ

P04058

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	27 – 31	Combined sources	5
Beta strandⁱ	34 – 37	Combined sources	4
Beta strandⁱ	39 – 43	Combined sources	5
Beta strandⁱ	46 – 55	Combined sources	10
Helixⁱ	62 – 64	Combined sources	3
Beta strandⁱ	76 – 80	Combined sources	5
Beta strandⁱ	87 – 89	Combined sources	3
Beta strandⁱ	95 – 98	Combined sources	4
Helixⁱ	100 – 103	Combined sources	4
Beta strandⁱ	111 – 113	Combined sources	3
Beta strandⁱ	117 – 122	Combined sources	6
Beta strandⁱ	128 – 136	Combined sources	9
Turnⁱ	140 – 142	Combined sources	3
Helixⁱ	149 – 151	Combined sources	3
Helixⁱ	154 – 160	Combined sources	7
Beta strandⁱ	163 – 166	Combined sources	4
Helixⁱ	172 – 176	Combined sources	5
Beta strandⁱ	183 – 187	Combined sources	5
Helixⁱ	189 – 204	Combined sources	16
Helixⁱ	205 – 208	Combined sources	4
Beta strandⁱ	210 – 220	Combined sources	11
Helixⁱ	222 – 232	Combined sources	11
Turnⁱ	234 – 236	Combined sources	3
Helixⁱ	237 – 239	Combined sources	3
Beta strandⁱ	241 – 247	Combined sources	7
Turnⁱ	253 – 255	Combined sources	3
Helixⁱ	259 – 272	Combined sources	14
Helixⁱ	280 – 289	Combined sources	10
Helixⁱ	292 – 298	Combined sources	7
Helixⁱ	299 – 302	Combined sources	4
Beta strandⁱ	304 – 306	Combined sources	3
Beta strandⁱ	307 – 309	Combined sources	3
Beta strandⁱ	319 – 324	Combined sources	6
Helixⁱ	326 – 332	Combined sources	7
Beta strandⁱ	340 – 345	Combined sources	6
Beta strandⁱ	347 – 349	Combined sources	3
Helixⁱ	350 – 356	Combined sources	7
Beta strandⁱ	357 – 359	Combined sources	3
Beta strandⁱ	362 – 364	Combined sources	3
Helixⁱ	370 – 380	Combined sources	11
Helixⁱ	386 – 396	Combined sources	11
Beta strandⁱ	401 – 403	Combined sources	3
Helixⁱ	405 – 420	Combined sources	16
Helixⁱ	422 – 435	Combined sources	14
Beta strandⁱ	439 – 444	Combined sources	6
Helixⁱ	455 – 457	Combined sources	3
Turnⁱ	461 – 464	Combined sources	4
Helixⁱ	465 – 468	Combined sources	4
Helixⁱ	471 – 473	Combined sources	3
Helixⁱ	475 – 477	Combined sources	3
Helixⁱ	481 – 500	Combined sources	20
Beta strandⁱ	501 – 504	Combined sources	4
Turnⁱ	518 – 520	Combined sources	3
Beta strandⁱ	522 – 529	Combined sources	8
Beta strandⁱ	533 – 536	Combined sources	4
Helixⁱ	539 – 546	Combined sources	8
Helixⁱ	548 – 555	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	P04058
SMRⁱ	P04058
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P04058

EvolutionaryTraceⁱ

P04058

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the type-B carboxylesterase/lipase family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

HOVERGENⁱ	HBG008839

HOVERGENⁱ

HBG008839

Family and domain databases

Gene3Dⁱ	3.40.50.1820, 1 hit
InterProⁱ	View protein in InterPro IPR029058 AB_hydrolase IPR000908 Acylcholinesterase_fish/snake IPR002018 CarbesteraseB IPR019826 Carboxylesterase_B_AS IPR019819 Carboxylesterase_B_CS IPR000997 Cholinesterase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00135 COesterase, 1 hit
PRINTSⁱ	PR00879 ACHEFISH PR00878 CHOLNESTRASE
SUPFAMⁱ	SSF53474 SSF53474, 1 hit
PROSITEⁱ	View protein in PROSITE PS00122 CARBOXYLESTERASE_B_1, 1 hit PS00941 CARBOXYLESTERASE_B_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

Isoform H (identifier: P04058-1) [UniParc]FASTA Add to basket

Also known as: Globular

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNLLVTSSLG VLLHLVVLCQ ADDHSELLVN TKSGKVMGTR VPVLSSHISA 
        60         70         80         90        100
FLGIPFAEPP VGNMRFRRPE PKKPWSGVWN ASTYPNNCQQ YVDEQFPGFS 
       110        120        130        140        150
GSEMWNPNRE MSEDCLYLNI WVPSPRPKST TVMVWIYGGG FYSGSSTLDV 
       160        170        180        190        200
YNGKYLAYTE EVVLVSLSYR VGAFGFLALH GSQEAPGNVG LLDQRMALQW 
       210        220        230        240        250
VHDNIQFFGG DPKTVTIFGE SAGGASVGMH ILSPGSRDLF RRAILQSGSP 
       260        270        280        290        300
NCPWASVSVA EGRRRAVELG RNLNCNLNSD EELIHCLREK KPQELIDVEW 
       310        320        330        340        350
NVLPFDSIFR FSFVPVIDGE FFPTSLESML NSGNFKKTQI LLGVNKDEGS 
       360        370        380        390        400
FFLLYGAPGF SKDSESKISR EDFMSGVKLS VPHANDLGLD AVTLQYTDWM 
       410        420        430        440        450
DDNNGIKNRD GLDDIVGDHN VICPLMHFVN KYTKFGNGTY LYFFNHRASN 
       460        470        480        490        500
LVWPEWMGVI HGYEIEFVFG LPLVKELNYT AEEEALSRRI MHYWATFAKT 
       510        520        530        540        550
GNPNEPHSQE SKWPLFTTKE QKFIDLNTEP MKVHQRLRVQ MCVFWNQFLP 
       560        570        580 
KLLNATACDG ELSSSGTSSS KGIIFYVLFS ILYLIF

Note: GPI-anchored form.

Length:586

Mass (Da):65,906

Last modified:June 1, 1994 - v2

Checksum:ⁱ731D5F0F3ABA62A8

Isoform T (identifier: P04058-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
557-586: ACDGELSSSGTSSSKGIIFYVLFSILYLIF → ETIDEAERQWKTEFHRWSSYMMHWKNQFDHYSRHESCAEL

« Hide

        10         20         30         40         50
MNLLVTSSLG VLLHLVVLCQ ADDHSELLVN TKSGKVMGTR VPVLSSHISA 
        60         70         80         90        100
FLGIPFAEPP VGNMRFRRPE PKKPWSGVWN ASTYPNNCQQ YVDEQFPGFS 
       110        120        130        140        150
GSEMWNPNRE MSEDCLYLNI WVPSPRPKST TVMVWIYGGG FYSGSSTLDV 
       160        170        180        190        200
YNGKYLAYTE EVVLVSLSYR VGAFGFLALH GSQEAPGNVG LLDQRMALQW 
       210        220        230        240        250
VHDNIQFFGG DPKTVTIFGE SAGGASVGMH ILSPGSRDLF RRAILQSGSP 
       260        270        280        290        300
NCPWASVSVA EGRRRAVELG RNLNCNLNSD EELIHCLREK KPQELIDVEW 
       310        320        330        340        350
NVLPFDSIFR FSFVPVIDGE FFPTSLESML NSGNFKKTQI LLGVNKDEGS 
       360        370        380        390        400
FFLLYGAPGF SKDSESKISR EDFMSGVKLS VPHANDLGLD AVTLQYTDWM 
       410        420        430        440        450
DDNNGIKNRD GLDDIVGDHN VICPLMHFVN KYTKFGNGTY LYFFNHRASN 
       460        470        480        490        500
LVWPEWMGVI HGYEIEFVFG LPLVKELNYT AEEEALSRRI MHYWATFAKT 
       510        520        530        540        550
GNPNEPHSQE SKWPLFTTKE QKFIDLNTEP MKVHQRLRVQ MCVFWNQFLP 
       560        570        580        590 
KLLNATETID EAERQWKTEF HRWSSYMMHW KNQFDHYSRH ESCAEL

Show »

Length:596

Mass (Da):67,818

Checksum:ⁱ36D5E9A30F9E6065

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_001460	557 – 586	ACDGE…LYLIF → ETIDEAERQWKTEFHRWSSY MMHWKNQFDHYSRHESCAEL in isoform T. CuratedAdd BLAST		30

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X03439 mRNA Translation: CAA27169.1 X56516 Genomic DNA No translation available. X56517 Genomic DNA No translation available.
PIRⁱ	A00773 ACRYE

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P04058	Acetylcholinesterase (Fragment)		TETCF		85	UniRef100_P04058
UPI0000111121		TETCF		543
UPI000E32D38A		TETCF		538
UPI000011048C		TETCF		537
P04058-2	Acetylcholinesterase (Fragment)		TETCF		95	UniRef100_P04058-2
UPI000011129F		ELEEL		534
UPI0000110481		TETCF		537
UPI0000D5BE3B		TETCF		535
UPI0000113201		TETCF		532
+1

Protein	Similar proteins		Species	Score	Length	Source
P04058	Acetylcholinesterase		TORMA		590	UniRef90_P04058
Acetylcholinesterase (Fragment)		TETCF		85
UPI000011129F		ELEEL		534
Isoform 3 of Acetylcholinesterase		TORMA		625
Isoform T of Acetylcholinesterase		TORMA		599
+10

Protein	Similar proteins		Species	Score	Length	Source
P04058	Acetylcholinesterase		TORMA		590	UniRef50_P04058
Acetylcholinesterase		DANRE		634
Acetylcholinesterase		ELEEL		633
Acetylcholinesterase (Fragment)		TETCF		85
Carboxylic ester hydrolase		SALSA		630
+89

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X03439 mRNA Translation: CAA27169.1 X56516 Genomic DNA No translation available. X56517 Genomic DNA No translation available.
PIRⁱ	A00773 ACRYE

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1ACJ	X-ray	2.80	A	22-556	[»]
	1ACL	X-ray	2.80	A	22-556	[»]
	1AMN	X-ray	2.80	A	22-558	[»]
	1AX9	X-ray	2.80	A	22-558	[»]
	1CFJ	X-ray	2.60	A	22-558	[»]
	1DX6	X-ray	2.30	A	22-564	[»]
	1E3Q	X-ray	2.85	A	22-564	[»]
	1E66	X-ray	2.10	A	22-564	[»]
	1EA5	X-ray	1.80	A	22-558	[»]
	1EEA	X-ray	4.50	A	22-555	[»]
	1EVE	X-ray	2.50	A	22-564	[»]
	1FSS	X-ray	3.00	A	22-558	[»]
	1GPK	X-ray	2.10	A	22-558	[»]
	1GPN	X-ray	2.35	A	22-558	[»]
	1GQR	X-ray	2.20	A	25-556	[»]
	1GQS	X-ray	3.00	A	25-556	[»]
	1H22	X-ray	2.15	A	22-564	[»]
	1H23	X-ray	2.15	A	22-564	[»]
	1HBJ	X-ray	2.50	A	22-564	[»]
	1JGA	model	-	A	1-586	[»]
	1JGB	model	-	A	1-586	[»]
	1JJB	X-ray	2.30	A	25-556	[»]
	1OCE	X-ray	2.70	A	22-558	[»]
	1ODC	X-ray	2.20	A	22-564	[»]
	1QID	X-ray	2.05	A	22-558	[»]
	1QIE	X-ray	2.10	A	22-558	[»]
	1QIF	X-ray	2.10	A	22-558	[»]
	1QIG	X-ray	2.30	A	22-558	[»]
	1QIH	X-ray	2.50	A	22-558	[»]
	1QII	X-ray	2.65	A	22-558	[»]
	1QIJ	X-ray	2.80	A	22-558	[»]
	1QIK	X-ray	2.90	A	22-558	[»]
	1QIM	X-ray	3.00	A	22-558	[»]
	1QTI	X-ray	2.50	A	22-558	[»]
	1SOM	X-ray	2.20	A	22-564	[»]
	1U65	X-ray	2.61	A	22-564	[»]
	1UT6	X-ray	2.40	A	22-556	[»]
	1VOT	X-ray	2.50	A	22-558	[»]
	1VXO	X-ray	2.40	A	22-558	[»]
	1VXR	X-ray	2.20	A	22-558	[»]
	1W4L	X-ray	2.16	A	22-564	[»]
	1W6R	X-ray	2.05	A	22-564	[»]
	1W75	X-ray	2.40	A/B	22-564	[»]
	1W76	X-ray	2.30	A/B	22-564	[»]
	1ZGB	X-ray	2.30	A	22-564	[»]
	1ZGC	X-ray	2.10	A/B	22-564	[»]
	2ACE	X-ray	2.50	A	22-558	[»]
	2ACK	X-ray	2.40	A	22-558	[»]
	2BAG	X-ray	2.40	A	22-564	[»]
	2C4H	X-ray	2.15	A	22-558	[»]
	2C58	X-ray	2.30	A	22-558	[»]
	2C5F	X-ray	2.60	A	22-558	[»]
	2C5G	X-ray	1.95	A	22-558	[»]
	2CEK	X-ray	2.20	A	22-556	[»]
	2CKM	X-ray	2.15	A	22-564	[»]
	2CMF	X-ray	2.50	A	22-564	[»]
	2DFP	X-ray	2.30	A	23-556	[»]
	2J3D	X-ray	2.60	A	22-564	[»]
	2J3Q	X-ray	2.80	A	22-564	[»]
	2J4F	X-ray	2.80	A	22-564	[»]
	2V96	X-ray	2.40	A/B	22-558	[»]
	2V97	X-ray	2.40	A/B	22-558	[»]
	2V98	X-ray	3.00	A/B	22-558	[»]
2VA9	X-ray	2.40	A/B	22-558	[»]
2VJA	X-ray	2.30	A/B	22-558	[»]
2VJB	X-ray	2.39	A/B	22-558	[»]
2VJC	X-ray	2.20	A/B	22-558	[»]
2VJD	X-ray	2.30	A/B	22-558	[»]
2VQ6	X-ray	2.71	A	22-564	[»]
2VT6	X-ray	2.40	A/B	22-558	[»]
2VT7	X-ray	2.20	A/B	22-558	[»]
2W6C	X-ray	2.69	X	1-586	[»]
2WFZ	X-ray	1.95	A	22-558	[»]
2WG0	X-ray	2.20	A	22-558	[»]
2WG1	X-ray	2.20	A	22-558	[»]
2WG2	X-ray	1.95	A	22-558	[»]
2XI4	X-ray	2.30	A/B	22-558	[»]
3ACE	model	-	A	22-558	[»]
3GEL	X-ray	2.39	A	25-556	[»]
3I6M	X-ray	2.26	A	23-556	[»]
3I6Z	X-ray	2.19	A	23-556	[»]
3M3D	X-ray	2.34	A	22-564	[»]
3ZV7	X-ray	2.26	A	22-564	[»]
4ACE	model	-	A	22-558	[»]
4TVK	X-ray	2.30	A	23-556	[»]
4W63	X-ray	2.80	A	23-556	[»]
4X3C	X-ray	2.60	A	23-556	[»]
5BWB	X-ray	2.57	A	22-558	[»]
5BWC	X-ray	2.45	A	22-558	[»]
5DLP	X-ray	2.70	A	22-564	[»]
5E2I	X-ray	2.65	A	25-556	[»]
5E4J	X-ray	2.54	A	25-556	[»]
5E4T	X-ray	2.43	A	22-564	[»]
5EHX	X-ray	2.10	A	25-556	[»]
5EI5	X-ray	2.10	A	23-556	[»]
5IH7	X-ray	2.40	A	23-556	[»]
5NAP	X-ray	2.17	A	22-564	[»]
5NAU	X-ray	2.25	A	22-564	[»]
5NUU	X-ray	2.50	A	22-564	[»]
6FLD	X-ray	2.40	A	25-556	[»]
6FQN	X-ray	2.30	A	25-556	[»]
6G17	X-ray	2.20	A	22-558	[»]
6G1U	X-ray	1.79	A/B	1-586	[»]
6G1V	X-ray	1.82	A/B	1-586	[»]
6G1W	X-ray	1.90	A/B	1-586	[»]
6G4M	X-ray	2.63	A/B	21-558	[»]
6G4N	X-ray	2.90	A/B	21-558	[»]
6G4O	X-ray	2.78	A/B	21-558	[»]
6G4P	X-ray	2.83	A/B	21-558	[»]
ProteinModelPortalⁱ	P04058
SMRⁱ	P04058
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

MINTⁱ	P04058

MINTⁱ

P04058

Chemistry databases

BindingDBⁱ	P04058
ChEMBLⁱ	CHEMBL4780

Protein family/group databases

ESTHERⁱ	torca-ACHE AChE
MEROPSⁱ	S09.980

PTM databases

iPTMnetⁱ	P04058

iPTMnetⁱ

P04058

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Phylogenomic databases

HOVERGENⁱ	HBG008839

HOVERGENⁱ

HBG008839

Enzyme and pathway databases

BioCycⁱ	MetaCyc:MONOMER-16823
BRENDAⁱ	3.1.1.7 6395

Miscellaneous databases

EvolutionaryTraceⁱ	P04058

EvolutionaryTraceⁱ

P04058

Family and domain databases

Gene3Dⁱ	3.40.50.1820, 1 hit
InterProⁱ	View protein in InterPro IPR029058 AB_hydrolase IPR000908 Acylcholinesterase_fish/snake IPR002018 CarbesteraseB IPR019826 Carboxylesterase_B_AS IPR019819 Carboxylesterase_B_CS IPR000997 Cholinesterase
Pfamⁱ	View protein in Pfam PF00135 COesterase, 1 hit
PRINTSⁱ	PR00879 ACHEFISH PR00878 CHOLNESTRASE
SUPFAMⁱ	SSF53474 SSF53474, 1 hit
PROSITEⁱ	View protein in PROSITE PS00122 CARBOXYLESTERASE_B_1, 1 hit PS00941 CARBOXYLESTERASE_B_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACES_TETCF
Accessionⁱ	P04058Primary (citable) accession number: P04058
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1986
	Last sequence update:	June 1, 1994
	Last modified:	November 7, 2018
	This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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Supporting data

UniProtKB - P04058 (ACES_TETCF)

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Acetylcholinesterase

ache

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma membrane

Other locations

Extracellular region or secreted

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

PTM databases

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<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Protocols and materials databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ