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UniProtKB - P04053 (TDT_HUMAN)

Entry version 207 (02 Dec 2020)
Sequence version 3 (02 Nov 2010)
Previous versions | rss
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Protein

DNA nucleotidylexotransferase

Gene

DNTT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 PublicationNote: Can also utilize other divalent cations, such as Mn2+ and Co2+ (in vitro).By similarityCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi343MagnesiumBy similarity1
Metal bindingi345MagnesiumBy similarity1
Metal bindingi433MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processTerminal addition
LigandMagnesium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P04053

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P04053

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P04053

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA nucleotidylexotransferase (EC:2.7.7.313 Publications)
Alternative name(s):
Terminal addition enzyme
Terminal deoxynucleotidyltransferase
Short name:
Terminal transferase1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNTT
Synonyms:TDT1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000107447.7

Human Gene Nomenclature Database

More...HGNCi		HGNC:2983, DNTT

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		187410, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P04053

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi343D → E: Nearly abolishes enzyme activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		1791

Open Targets

More...OpenTargetsi		ENSG00000107447

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27449

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P04053, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4810

Drug and drug target database

More...DrugBanki		DB02189, 2',3'-Dideoxyadenosine triphosphate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DNTT

Domain mapping of disease mutations (DMDM)

More...DMDMi		311033533

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002187911 – 509DNA nucleotidylexotransferaseAdd BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei134PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P04053

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P04053

MaxQB - The MaxQuant DataBase

More...MaxQBi		P04053

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P04053

PeptideAtlas

More...PeptideAtlasi		P04053

PRoteomics IDEntifications database

More...PRIDEi		P04053

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51639 [P04053-1]
51640 [P04053-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P04053

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P04053

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000107447, Expressed in bone marrow and 69 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P04053, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000107447, Tissue enriched (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PRP19 and DNTTIP1.

Forms a ternary complex with DNTTIP2 and core histone. Released from this complex by PCNA.

Interacts with TRERF1 (PubMed:16371131).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108127, 11 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P04053

Protein interaction database and analysis system

More...IntActi		P04053, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000360216

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P04053

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P04053, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1509
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P04053

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P04053

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 124BRCTPROSITE-ProRule annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni151 – 509Mediates interaction with DNTTIP21 PublicationAdd BLAST359
Regioni258 – 262Involved in DNA bindingBy similarity5
Regioni333 – 338Deoxynucleoside triphosphate bindingBy similarity6
Regioni342 – 345Deoxynucleoside triphosphate bindingBy similarity4
Regioni448 – 449Deoxynucleoside triphosphate bindingBy similarity2

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi11 – 17Nuclear localization signalBy similarity7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-X family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2534, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158584

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008698_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P04053

Identification of Orthologs from Complete Genome Data

More...OMAi		YCDLVES

Database of Orthologous Groups

More...OrthoDBi		1212057at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P04053

TreeFam database of animal gene trees

More...TreeFami		TF103012

Family and domain databases

Conserved Domains Database

More...CDDi		cd00141, NT_POLXc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.110, 1 hit
3.30.210.10, 1 hit
3.30.460.10, 1 hit
3.40.50.10190, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
IPR002054, DNA-dir_DNA_pol_X
IPR019843, DNA_pol-X_BS
IPR010996, DNA_pol_b-like_N
IPR028207, DNA_pol_B_palm_palm
IPR018944, DNA_pol_lambd_fingers_domain
IPR027421, DNA_pol_lamdba_lyase_dom_sf
IPR037160, DNA_Pol_thumb_sf
IPR022312, DNA_pol_X
IPR043519, NT_sf
IPR029398, PolB_thumb
IPR027292, TdT
IPR001726, TdT/Mu

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00533, BRCT, 1 hit
PF14792, DNA_pol_B_palm, 1 hit
PF14791, DNA_pol_B_thumb, 1 hit
PF10391, DNA_pol_lambd_f, 1 hit
PF14716, HHH_8, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000817, DNA_NT, 1 hit
PIRSF501175, TDT, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00869, DNAPOLX
PR00871, DNAPOLXTDT

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00292, BRCT, 1 hit
SM00483, POLXc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47802, SSF47802, 1 hit
SSF52113, SSF52113, 1 hit
SSF81301, SSF81301, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50172, BRCT, 1 hit
PS00522, DNA_POLYMERASE_X, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P04053-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPPRASHLS PRKKRPRQTG ALMASSPQDI KFQDLVVFIL EKKMGTTRRA 
        60         70         80         90        100
FLMELARRKG FRVENELSDS VTHIVAENNS GSDVLEWLQA QKVQVSSQPE 
       110        120        130        140        150
LLDVSWLIEC IRAGKPVEMT GKHQLVVRRD YSDSTNPGPP KTPPIAVQKI 
       160        170        180        190        200
SQYACQRRTT LNNCNQIFTD AFDILAENCE FRENEDSCVT FMRAASVLKS 
       210        220        230        240        250
LPFTIISMKD TEGIPCLGSK VKGIIEEIIE DGESSEVKAV LNDERYQSFK 
       260        270        280        290        300
LFTSVFGVGL KTSEKWFRMG FRTLSKVRSD KSLKFTRMQK AGFLYYEDLV 
       310        320        330        340        350
SCVTRAEAEA VSVLVKEAVW AFLPDAFVTM TGGFRRGKKM GHDVDFLITS 
       360        370        380        390        400
PGSTEDEEQL LQKVMNLWEK KGLLLYYDLV ESTFEKLRLP SRKVDALDHF 
       410        420        430        440        450
QKCFLIFKLP RQRVDSDQSS WQEGKTWKAI RVDLVLCPYE RRAFALLGWT 
       460        470        480        490        500
GSRQFERDLR RYATHERKMI LDNHALYDKT KRIFLKAESE EEIFAHLGLD 

YIEPWERNA
Length:509
Mass (Da):58,536
Last modified:November 2, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0EC01E380FA7E5A2
GO
Isoform 2 (identifier: P04053-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     454-454: Missing.

Show »
Length:508
Mass (Da):58,408
Checksum:iC72DABE3ACAEADD1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti51F → L in BAD97037 (Ref. 4) Curated1
Sequence conflicti299L → P in BAD97037 (Ref. 4) Curated1
Sequence conflicti329T → A in BAD97037 (Ref. 4) Curated1
Sequence conflicti383T → A in BAD97037 (Ref. 4) Curated1
Sequence conflicti389L → M in BAD97037 (Ref. 4) Curated1
Sequence conflicti452S → SP in AAA53100 (PubMed:2833741).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_058200112R → G5 PublicationsCorresponds to variant dbSNP:rs6584066Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_038397454Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M11722 mRNA Translation: AAA36726.1
M20703 M20702 mRNA Translation: AAA53100.1
AB046378 mRNA Translation: BAB72001.1
AK223317 mRNA Translation: BAD97037.1
AL136181 Genomic DNA No translation available.
BC012920 mRNA Translation: AAH12920.1
M21195 Genomic DNA Translation: AAA61137.1
K01919 mRNA Translation: AAA61136.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44465.1 [P04053-2]
CCDS7447.1 [P04053-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A23924, WXHU

NCBI Reference Sequences

More...RefSeqi		NP_001017520.1, NM_001017520.1 [P04053-2]
NP_004079.3, NM_004088.3 [P04053-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000371174; ENSP00000360216; ENSG00000107447 [P04053-1]
ENST00000630152; ENSP00000486733; ENSG00000107447 [P04053-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1791

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1791

UCSC genome browser

More...UCSCi		uc001kmf.4, human [P04053-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11722 mRNA Translation: AAA36726.1
M20703 M20702 mRNA Translation: AAA53100.1
AB046378 mRNA Translation: BAB72001.1
AK223317 mRNA Translation: BAD97037.1
AL136181 Genomic DNA No translation available.
BC012920 mRNA Translation: AAH12920.1
M21195 Genomic DNA Translation: AAA61137.1
K01919 mRNA Translation: AAA61136.1
CCDSiCCDS44465.1 [P04053-2]
CCDS7447.1 [P04053-1]
PIRiA23924, WXHU
RefSeqiNP_001017520.1, NM_001017520.1 [P04053-2]
NP_004079.3, NM_004088.3 [P04053-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2COENMR-A19-125[»]
5W4EX-ray2.18A/D7-22[»]
SMRiP04053
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108127, 11 interactors
CORUMiP04053
IntActiP04053, 5 interactors
STRINGi9606.ENSP00000360216

Chemistry databases

BindingDBiP04053
ChEMBLiCHEMBL4810
DrugBankiDB02189, 2',3'-Dideoxyadenosine triphosphate

PTM databases

iPTMnetiP04053
PhosphoSitePlusiP04053

Polymorphism and mutation databases

BioMutaiDNTT
DMDMi311033533

Proteomic databases

jPOSTiP04053
MassIVEiP04053
MaxQBiP04053
PaxDbiP04053
PeptideAtlasiP04053
PRIDEiP04053
ProteomicsDBi51639 [P04053-1]
51640 [P04053-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		16924, 563 antibodies

The DNASU plasmid repository

More...DNASUi		1791

Genome annotation databases

EnsembliENST00000371174; ENSP00000360216; ENSG00000107447 [P04053-1]
ENST00000630152; ENSP00000486733; ENSG00000107447 [P04053-2]
GeneIDi1791
KEGGihsa:1791
UCSCiuc001kmf.4, human [P04053-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1791
DisGeNETi1791
EuPathDBiHostDB:ENSG00000107447.7

GeneCards: human genes, protein and diseases

More...GeneCardsi		DNTT
HGNCiHGNC:2983, DNTT
HPAiENSG00000107447, Tissue enriched (lymphoid)
MIMi187410, gene
neXtProtiNX_P04053
OpenTargetsiENSG00000107447
PharmGKBiPA27449

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2534, Eukaryota
GeneTreeiENSGT00940000158584
HOGENOMiCLU_008698_0_0_1
InParanoidiP04053
OMAiYCDLVES
OrthoDBi1212057at2759
PhylomeDBiP04053
TreeFamiTF103012

Enzyme and pathway databases

PathwayCommonsiP04053
SABIO-RKiP04053
SignaLinkiP04053

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1791, 8 hits in 845 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DNTT, human
EvolutionaryTraceiP04053

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Terminal_deoxynucleotidyl_transferase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1791
PharosiP04053, Tchem

Protein Ontology

More...PROi		PR:P04053
RNActiP04053, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000107447, Expressed in bone marrow and 69 other tissues
GenevisibleiP04053, HS

Family and domain databases

CDDicd00141, NT_POLXc, 1 hit
Gene3Di1.10.150.110, 1 hit
3.30.210.10, 1 hit
3.30.460.10, 1 hit
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
IPR002054, DNA-dir_DNA_pol_X
IPR019843, DNA_pol-X_BS
IPR010996, DNA_pol_b-like_N
IPR028207, DNA_pol_B_palm_palm
IPR018944, DNA_pol_lambd_fingers_domain
IPR027421, DNA_pol_lamdba_lyase_dom_sf
IPR037160, DNA_Pol_thumb_sf
IPR022312, DNA_pol_X
IPR043519, NT_sf
IPR029398, PolB_thumb
IPR027292, TdT
IPR001726, TdT/Mu
PfamiView protein in Pfam
PF00533, BRCT, 1 hit
PF14792, DNA_pol_B_palm, 1 hit
PF14791, DNA_pol_B_thumb, 1 hit
PF10391, DNA_pol_lambd_f, 1 hit
PF14716, HHH_8, 1 hit
PIRSFiPIRSF000817, DNA_NT, 1 hit
PIRSF501175, TDT, 1 hit
PRINTSiPR00869, DNAPOLX
PR00871, DNAPOLXTDT
SMARTiView protein in SMART
SM00292, BRCT, 1 hit
SM00483, POLXc, 1 hit
SUPFAMiSSF47802, SSF47802, 1 hit
SSF52113, SSF52113, 1 hit
SSF81301, SSF81301, 1 hit
PROSITEiView protein in PROSITE
PS50172, BRCT, 1 hit
PS00522, DNA_POLYMERASE_X, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTDT_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P04053
Secondary accession number(s): Q53FH1, Q5W103, Q96E50
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: November 2, 2010
Last modified: December 2, 2020
This is version 207 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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