UniProtKB - P04053 (TDT_HUMAN)

BLAST

>sp|P04053|TDT_HUMAN DNA nucleotidylexotransferase OS=Homo sapiens OX=9606 GN=DNTT PE=1 SV=3
MDPPRASHLSPRKKRPRQTGALMASSPQDIKFQDLVVFILEKKMGTTRRAFLMELARRKG
FRVENELSDSVTHIVAENNSGSDVLEWLQAQKVQVSSQPELLDVSWLIECIRAGKPVEMT
GKHQLVVRRDYSDSTNPGPPKTPPIAVQKISQYACQRRTTLNNCNQIFTDAFDILAENCE
FRENEDSCVTFMRAASVLKSLPFTIISMKDTEGIPCLGSKVKGIIEEIIEDGESSEVKAV
LNDERYQSFKLFTSVFGVGLKTSEKWFRMGFRTLSKVRSDKSLKFTRMQKAGFLYYEDLV
SCVTRAEAEAVSVLVKEAVWAFLPDAFVTMTGGFRRGKKMGHDVDFLITSPGSTEDEEQL
LQKVMNLWEKKGLLLYYDLVESTFEKLRLPSRKVDALDHFQKCFLIFKLPRQRVDSDQSS
WQEGKTWKAIRVDLVLCPYERRAFALLGWTGSRQFERDLRRYATHERKMILDNHALYDKT
KRIFLKAESEEEIFAHLGLDYIEPWERNA

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History
Entry version 193 (07 Nov 2018)
Sequence version 3 (02 Nov 2010)
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Protein

DNA nucleotidylexotransferase

Gene

DNTT

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.By similarity

Catalytic activityⁱ

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).3 Publications

Cofactorⁱ

Mg²⁺1 PublicationNote: Can also utilize other divalent cations, such as Mn²⁺ and Co²⁺ (in vitro).By similarityCurated

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	343	MagnesiumBy similarity	1
Metal bindingⁱ	345	MagnesiumBy similarity	1
Metal bindingⁱ	433	MagnesiumBy similarity	1

GO - Molecular functionⁱ

DNA binding Source: InterPro
DNA-directed DNA polymerase activity Source: InterPro
DNA nucleotidylexotransferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11473582
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

DNA metabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 11473582
DNA modification Source: UniProtKB-KW
response to ATP Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Nucleotidyltransferase, Transferase
Biological process	Terminal addition
Ligand	Magnesium, Metal-binding

Enzyme and pathway databases

SABIO-RKⁱ	P04053
SignaLinkⁱ	P04053

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DNA nucleotidylexotransferase (EC:2.7.7.313 Publications) Alternative name(s): Terminal addition enzyme Terminal deoxynucleotidyltransferase Short name: Terminal transferase1 Publication
Gene namesⁱ	Name:DNTT Synonyms:TDT1 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000107447.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2983 DNTT
MIMⁱ	187410 gene
neXtProtⁱ	NX_P04053

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	343	D → E: Nearly abolishes enzyme activity. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1791
Open Targets More...OpenTargetsⁱ	ENSG00000107447
PharmGKBⁱ	PA27449

Chemistry databases

ChEMBLⁱ	CHEMBL4810

ChEMBLⁱ

CHEMBL4810

Polymorphism and mutation databases

BioMutaⁱ	DNTT
DMDMⁱ	311033533

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000218791	1 – 509	DNA nucleotidylexotransferaseAdd BLAST		509

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	134	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P04053
PaxDbⁱ	P04053
PeptideAtlas More...PeptideAtlasⁱ	P04053
PRIDEⁱ	P04053
ProteomicsDBⁱ	51639 51640 [P04053-2]

PTM databases

iPTMnetⁱ	P04053
PhosphoSitePlusⁱ	P04053

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000107447 Expressed in 57 organ(s), highest expression level in bone marrow
CleanExⁱ	HS_DNTT
Genevisibleⁱ	P04053 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA044194

HPAⁱ

HPA044194

Interactionⁱ

Subunit structureⁱ

Interacts with PRP19 and DNTTIP1. Forms a ternary complex with DNTTIP2 and core histone. Released from this complex by PCNA. Interacts with TRERF1 (PubMed:16371131).4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
REL	Q04864	3	EBI-1220259,EBI-307352

With

Entry

#Exp.

IntAct

Notes

REL

Q04864

EBI-1220259,EBI-307352

Protein-protein interaction databases

BioGridⁱ	108127, 9 interactors
CORUMⁱ	P04053
IntActⁱ	P04053, 5 interactors
STRINGⁱ	9606.ENSP00000360216

Chemistry databases

BindingDBⁱ

P04053

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	23 – 25	Combined sources	3
Beta strandⁱ	36 – 40	Combined sources	5
Turnⁱ	42 – 44	Combined sources	3
Helixⁱ	46 – 58	Combined sources	13
Beta strandⁱ	73 – 78	Combined sources	6
Helixⁱ	81 – 90	Combined sources	10
Beta strandⁱ	100 – 103	Combined sources	4
Helixⁱ	104 – 112	Combined sources	9
Beta strandⁱ	120 – 124	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	P04053
SMRⁱ	P04053
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P04053

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	27 – 124	BRCTPROSITE-ProRule annotationAdd BLAST		98

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	151 – 509	Mediates interaction with DNTTIP21 PublicationAdd BLAST	359
Regionⁱ	258 – 262	Involved in DNA bindingBy similarity	5
Regionⁱ	333 – 338	Deoxynucleoside triphosphate bindingBy similarity	6
Regionⁱ	342 – 345	Deoxynucleoside triphosphate bindingBy similarity	4
Regionⁱ	448 – 449	Deoxynucleoside triphosphate bindingBy similarity	2

Sequence similaritiesⁱ

Belongs to the DNA polymerase type-X family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2534 Eukaryota COG1796 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063002
HOGENOMⁱ	HOG000263600
HOVERGENⁱ	HBG003670
InParanoidⁱ	P04053
KEGG Orthology (KO) More...KOⁱ	K00977
OMAⁱ	KTWKAIR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G073W
PhylomeDBⁱ	P04053
TreeFamⁱ	TF103012

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00027 BRCT, 1 hit cd00141 NT_POLXc, 1 hit
Gene3Dⁱ	1.10.150.110, 1 hit 3.30.210.10, 1 hit 3.40.50.10190, 1 hit
InterProⁱ	View protein in InterPro IPR001357 BRCT_dom IPR036420 BRCT_dom_sf IPR002054 DNA-dir_DNA_pol_X IPR019843 DNA_pol-X_BS IPR010996 DNA_pol_b-like_N IPR028207 DNA_pol_B_palm_palm IPR018944 DNA_pol_lambd_fingers_domain IPR027421 DNA_pol_lamdba_lyase_dom_sf IPR037160 DNA_Pol_thumb_sf IPR022312 DNA_pol_X IPR029398 PolB_thumb IPR027292 TdT IPR001726 TdT/Mu
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00533 BRCT, 1 hit PF14792 DNA_pol_B_palm, 1 hit PF14791 DNA_pol_B_thumb, 1 hit PF10391 DNA_pol_lambd_f, 1 hit PF14716 HHH_8, 1 hit
PIRSFⁱ	PIRSF000817 DNA_NT, 1 hit PIRSF501175 TDT, 1 hit
PRINTSⁱ	PR00869 DNAPOLX PR00871 DNAPOLXTDT
SMARTⁱ	View protein in SMART SM00292 BRCT, 1 hit SM00483 POLXc, 1 hit
SUPFAMⁱ	SSF47802 SSF47802, 1 hit SSF52113 SSF52113, 1 hit
PROSITEⁱ	View protein in PROSITE PS50172 BRCT, 1 hit PS00522 DNA_POLYMERASE_X, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P04053-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPPRASHLS PRKKRPRQTG ALMASSPQDI KFQDLVVFIL EKKMGTTRRA 
        60         70         80         90        100
FLMELARRKG FRVENELSDS VTHIVAENNS GSDVLEWLQA QKVQVSSQPE 
       110        120        130        140        150
LLDVSWLIEC IRAGKPVEMT GKHQLVVRRD YSDSTNPGPP KTPPIAVQKI 
       160        170        180        190        200
SQYACQRRTT LNNCNQIFTD AFDILAENCE FRENEDSCVT FMRAASVLKS 
       210        220        230        240        250
LPFTIISMKD TEGIPCLGSK VKGIIEEIIE DGESSEVKAV LNDERYQSFK 
       260        270        280        290        300
LFTSVFGVGL KTSEKWFRMG FRTLSKVRSD KSLKFTRMQK AGFLYYEDLV 
       310        320        330        340        350
SCVTRAEAEA VSVLVKEAVW AFLPDAFVTM TGGFRRGKKM GHDVDFLITS 
       360        370        380        390        400
PGSTEDEEQL LQKVMNLWEK KGLLLYYDLV ESTFEKLRLP SRKVDALDHF 
       410        420        430        440        450
QKCFLIFKLP RQRVDSDQSS WQEGKTWKAI RVDLVLCPYE RRAFALLGWT 
       460        470        480        490        500
GSRQFERDLR RYATHERKMI LDNHALYDKT KRIFLKAESE EEIFAHLGLD 

YIEPWERNA

Length:509

Mass (Da):58,536

Last modified:November 2, 2010 - v3

Checksum:ⁱ0EC01E380FA7E5A2

Isoform 2 (identifier: P04053-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
454-454: Missing.

« Hide

        10         20         30         40         50
MDPPRASHLS PRKKRPRQTG ALMASSPQDI KFQDLVVFIL EKKMGTTRRA 
        60         70         80         90        100
FLMELARRKG FRVENELSDS VTHIVAENNS GSDVLEWLQA QKVQVSSQPE 
       110        120        130        140        150
LLDVSWLIEC IRAGKPVEMT GKHQLVVRRD YSDSTNPGPP KTPPIAVQKI 
       160        170        180        190        200
SQYACQRRTT LNNCNQIFTD AFDILAENCE FRENEDSCVT FMRAASVLKS 
       210        220        230        240        250
LPFTIISMKD TEGIPCLGSK VKGIIEEIIE DGESSEVKAV LNDERYQSFK 
       260        270        280        290        300
LFTSVFGVGL KTSEKWFRMG FRTLSKVRSD KSLKFTRMQK AGFLYYEDLV 
       310        320        330        340        350
SCVTRAEAEA VSVLVKEAVW AFLPDAFVTM TGGFRRGKKM GHDVDFLITS 
       360        370        380        390        400
PGSTEDEEQL LQKVMNLWEK KGLLLYYDLV ESTFEKLRLP SRKVDALDHF 
       410        420        430        440        450
QKCFLIFKLP RQRVDSDQSS WQEGKTWKAI RVDLVLCPYE RRAFALLGWT 
       460        470        480        490        500
GSRFERDLRR YATHERKMIL DNHALYDKTK RIFLKAESEE EIFAHLGLDY 

IEPWERNA

Show »

Length:508

Mass (Da):58,408

Checksum:ⁱC72DABE3ACAEADD1

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	51	F → L in BAD97037 (Ref. 4) Curated	1
Sequence conflictⁱ	299	L → P in BAD97037 (Ref. 4) Curated	1
Sequence conflictⁱ	329	T → A in BAD97037 (Ref. 4) Curated	1
Sequence conflictⁱ	383	T → A in BAD97037 (Ref. 4) Curated	1
Sequence conflictⁱ	389	L → M in BAD97037 (Ref. 4) Curated	1
Sequence conflictⁱ	452	S → SP in AAA53100 (PubMed:2833741).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_058200	112	R → G5 PublicationsCorresponds to variant dbSNP:rs6584066Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_038397	454	Missing in isoform 2. 2 Publications		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M11722 mRNA Translation: AAA36726.1 M20703 M20702 mRNA Translation: AAA53100.1 AB046378 mRNA Translation: BAB72001.1 AK223317 mRNA Translation: BAD97037.1 AL136181 Genomic DNA No translation available. BC012920 mRNA Translation: AAH12920.1 M21195 Genomic DNA Translation: AAA61137.1 K01919 mRNA Translation: AAA61136.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44465.1 [P04053-2] CCDS7447.1 [P04053-1]
PIRⁱ	A23924 WXHU
NCBI Reference Sequences More...RefSeqⁱ	NP_001017520.1, NM_001017520.1 [P04053-2] NP_004079.3, NM_004088.3 [P04053-1]
UniGeneⁱ	Hs.534206

Genome annotation databases

Ensemblⁱ	ENST00000371174; ENSP00000360216; ENSG00000107447 [P04053-1] ENST00000630152; ENSP00000486733; ENSG00000107447 [P04053-2]
GeneIDⁱ	1791
KEGGⁱ	hsa:1791
UCSC genome browser More...UCSCⁱ	uc001kmf.4 human [P04053-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
P04053	DNA nucleotidylexotransferase		MACMU		510	UniRef90_P04053
DNA nucleotidylexotransferase		MACFA		510
DNA nucleotidylexotransferase		MACNE		510
DNA nucleotidylexotransferase		CALJA		510
DNA nucleotidylexotransferase		COLAP		510
+42

Protein	Similar proteins		Species	Score	Length	Source
P04053	DNA nucleotidylexotransferase	)	MOUSE		530	UniRef50_P09838
DNA nucleotidylexotransferase		CHICK		506
DNA nucleotidylexotransferase		EULMA		511
DNA nucleotidylexotransferase		AMBME		510
DNA nucleotidylexotransferase		MONDO		518
+303

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M11722 mRNA Translation: AAA36726.1 M20703 M20702 mRNA Translation: AAA53100.1 AB046378 mRNA Translation: BAB72001.1 AK223317 mRNA Translation: BAD97037.1 AL136181 Genomic DNA No translation available. BC012920 mRNA Translation: AAH12920.1 M21195 Genomic DNA Translation: AAA61137.1 K01919 mRNA Translation: AAA61136.1
CCDSⁱ	CCDS44465.1 [P04053-2] CCDS7447.1 [P04053-1]
PIRⁱ	A23924 WXHU
RefSeqⁱ	NP_001017520.1, NM_001017520.1 [P04053-2] NP_004079.3, NM_004088.3 [P04053-1]
UniGeneⁱ	Hs.534206

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2COE	NMR	-	A	19-125	[»]
ProteinModelPortalⁱ	P04053
SMRⁱ	P04053
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108127, 9 interactors
CORUMⁱ	P04053
IntActⁱ	P04053, 5 interactors
STRINGⁱ	9606.ENSP00000360216

Chemistry databases

BindingDBⁱ	P04053
ChEMBLⁱ	CHEMBL4810

PTM databases

iPTMnetⁱ	P04053
PhosphoSitePlusⁱ	P04053

Polymorphism and mutation databases

BioMutaⁱ	DNTT
DMDMⁱ	311033533

Proteomic databases

MaxQBⁱ	P04053
PaxDbⁱ	P04053
PeptideAtlasⁱ	P04053
PRIDEⁱ	P04053
ProteomicsDBⁱ	51639 51640 [P04053-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1791
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000371174; ENSP00000360216; ENSG00000107447 [P04053-1] ENST00000630152; ENSP00000486733; ENSG00000107447 [P04053-2]
GeneIDⁱ	1791
KEGGⁱ	hsa:1791
UCSCⁱ	uc001kmf.4 human [P04053-1]

Organism-specific databases

CTDⁱ	1791
DisGeNETⁱ	1791
EuPathDBⁱ	HostDB:ENSG00000107447.7
GeneCardsⁱ	DNTT
H-InvDBⁱ	HIX0009072
HGNCⁱ	HGNC:2983 DNTT
HPAⁱ	HPA044194
MIMⁱ	187410 gene
neXtProtⁱ	NX_P04053
OpenTargetsⁱ	ENSG00000107447
PharmGKBⁱ	PA27449
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2534 Eukaryota COG1796 LUCA
GeneTreeⁱ	ENSGT00530000063002
HOGENOMⁱ	HOG000263600
HOVERGENⁱ	HBG003670
InParanoidⁱ	P04053
KOⁱ	K00977
OMAⁱ	KTWKAIR
OrthoDBⁱ	EOG091G073W
PhylomeDBⁱ	P04053
TreeFamⁱ	TF103012

Enzyme and pathway databases

SABIO-RKⁱ	P04053
SignaLinkⁱ	P04053

Miscellaneous databases

EvolutionaryTraceⁱ	P04053
GeneWikiⁱ	Terminal_deoxynucleotidyl_transferase
GenomeRNAiⁱ	1791
Protein Ontology More...PROⁱ	PR:P04053
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000107447 Expressed in 57 organ(s), highest expression level in bone marrow
CleanExⁱ	HS_DNTT
Genevisibleⁱ	P04053 HS

Family and domain databases

CDDⁱ	cd00027 BRCT, 1 hit cd00141 NT_POLXc, 1 hit
Gene3Dⁱ	1.10.150.110, 1 hit 3.30.210.10, 1 hit 3.40.50.10190, 1 hit
InterProⁱ	View protein in InterPro IPR001357 BRCT_dom IPR036420 BRCT_dom_sf IPR002054 DNA-dir_DNA_pol_X IPR019843 DNA_pol-X_BS IPR010996 DNA_pol_b-like_N IPR028207 DNA_pol_B_palm_palm IPR018944 DNA_pol_lambd_fingers_domain IPR027421 DNA_pol_lamdba_lyase_dom_sf IPR037160 DNA_Pol_thumb_sf IPR022312 DNA_pol_X IPR029398 PolB_thumb IPR027292 TdT IPR001726 TdT/Mu
Pfamⁱ	View protein in Pfam PF00533 BRCT, 1 hit PF14792 DNA_pol_B_palm, 1 hit PF14791 DNA_pol_B_thumb, 1 hit PF10391 DNA_pol_lambd_f, 1 hit PF14716 HHH_8, 1 hit
PIRSFⁱ	PIRSF000817 DNA_NT, 1 hit PIRSF501175 TDT, 1 hit
PRINTSⁱ	PR00869 DNAPOLX PR00871 DNAPOLXTDT
SMARTⁱ	View protein in SMART SM00292 BRCT, 1 hit SM00483 POLXc, 1 hit
SUPFAMⁱ	SSF47802 SSF47802, 1 hit SSF52113 SSF52113, 1 hit
PROSITEⁱ	View protein in PROSITE PS50172 BRCT, 1 hit PS00522 DNA_POLYMERASE_X, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TDT_HUMAN
Accessionⁱ	P04053Primary (citable) accession number: P04053 Secondary accession number(s): Q53FH1, Q5W103, Q96E50
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1986
	Last sequence update:	November 2, 2010
	Last modified:	November 7, 2018
	This is version 193 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

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UniProtKB - P04053 (TDT_HUMAN)

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DNA nucleotidylexotransferase

DNTT

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ