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Protein

Catalase

Gene

CAT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.1 Publication

Catalytic activityi

2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation1 Publication

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei751
Active sitei1481
Metal bindingi358Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMitogen, Oxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding, NADP

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER66-341
BRENDAi1.11.1.6 2681
ReactomeiR-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-6798695 Neutrophil degranulation
R-HSA-9033241 Peroxisomal protein import
SABIO-RKiP04040
SIGNORiP04040

Protein family/group databases

PeroxiBasei5282 HsKat01

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase (EC:1.11.1.6)
Gene namesi
Name:CAT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000121691.4
HGNCiHGNC:1516 CAT
MIMi115500 gene
neXtProtiNX_P04040

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Involvement in diseasei

Acatalasemia (ACATLAS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA metabolic disorder characterized by a total or near total loss of catalase activity in red cells. It is often associated with ulcerating oral lesions. Acatalasemia is inherited as an autosomal recessive trait.
See also OMIM:614097

Organism-specific databases

DisGeNETi847
MalaCardsiCAT
MIMi614097 phenotype
OpenTargetsiENSG00000121691
Orphaneti926 Acatalasemia
PharmGKBiPA26099

Chemistry databases

ChEMBLiCHEMBL3627594
DrugBankiDB01213 Fomepizole

Polymorphism and mutation databases

BioMutaiCAT
DMDMi115702

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000849012 – 527CatalaseAdd BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei9PhosphoserineCombined sources1
Modified residuei221N6-succinyllysineBy similarity1
Modified residuei233N6-acetyllysineBy similarity1
Modified residuei306N6-acetyllysine; alternateBy similarity1
Modified residuei306N6-succinyllysine; alternateBy similarity1
Modified residuei417PhosphoserineBy similarity1
Modified residuei422PhosphoserineCombined sources1
Modified residuei480N6-acetyllysine; alternateBy similarity1
Modified residuei480N6-succinyllysine; alternateBy similarity1
Modified residuei499N6-acetyllysineBy similarity1
Modified residuei511PhosphothreonineCombined sources1
Modified residuei515PhosphoserineCombined sources1
Modified residuei517PhosphoserineCombined sources1

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP04040
MaxQBiP04040
PaxDbiP04040
PeptideAtlasiP04040
PRIDEiP04040
ProteomicsDBi12621
51636

2D gel databases

OGPiP04040
REPRODUCTION-2DPAGEiIPI00465436
P04040
SWISS-2DPAGEiP04040

PTM databases

iPTMnetiP04040
PhosphoSitePlusiP04040
SwissPalmiP04040

Expressioni

Gene expression databases

BgeeiENSG00000121691 Expressed in 230 organ(s), highest expression level in bone marrow
CleanExiHS_CAT
GenevisibleiP04040 HS

Organism-specific databases

HPAiCAB001515
HPA051282
HPA055838

Interactioni

Subunit structurei

Homotetramer.

Binary interactionsi

WithEntry#Exp.IntActNotes
itself5EBI-2432181,EBI-2432181

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107297, 50 interactors
ELMiP04040
IntActiP04040, 80 interactors
MINTiP04040
STRINGi9606.ENSP00000241052

Chemistry databases

BindingDBiP04040

Structurei

Secondary structure

1527
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP04040
SMRiP04040
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04040

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.Curated

Phylogenomic databases

eggNOGiKOG0047 Eukaryota
COG0753 LUCA
GeneTreeiENSGT00390000018100
HOVERGENiHBG003986
InParanoidiP04040
KOiK03781
OMAiHADFGRM
OrthoDBiEOG091G04V5
PhylomeDBiP04040
TreeFamiTF300540

Family and domain databases

Gene3Di2.40.180.10, 1 hit
InterProiView protein in InterPro
IPR018028 Catalase
IPR024708 Catalase_AS
IPR024711 Catalase_clade1/3
IPR011614 Catalase_core
IPR037060 Catalase_core_sf
IPR002226 Catalase_haem_BS
IPR010582 Catalase_immune_responsive
IPR020835 Catalase_sf
PANTHERiPTHR11465 PTHR11465, 1 hit
PfamiView protein in Pfam
PF00199 Catalase, 1 hit
PF06628 Catalase-rel, 1 hit
PIRSFiPIRSF038928 Catalase_clade1-3, 1 hit
PRINTSiPR00067 CATALASE
SMARTiView protein in SMART
SM01060 Catalase, 1 hit
SUPFAMiSSF56634 SSF56634, 1 hit
PROSITEiView protein in PROSITE
PS00437 CATALASE_1, 1 hit
PS00438 CATALASE_2, 1 hit
PS51402 CATALASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04040-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADSRDPASD QMQHWKEQRA AQKADVLTTG AGNPVGDKLN VITVGPRGPL
60 70 80 90 100
LVQDVVFTDE MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITKYSKAKVF
110 120 130 140 150
EHIGKKTPIA VRFSTVAGES GSADTVRDPR GFAVKFYTED GNWDLVGNNT
160 170 180 190 200
PIFFIRDPIL FPSFIHSQKR NPQTHLKDPD MVWDFWSLRP ESLHQVSFLF
210 220 230 240 250
SDRGIPDGHR HMNGYGSHTF KLVNANGEAV YCKFHYKTDQ GIKNLSVEDA
260 270 280 290 300
ARLSQEDPDY GIRDLFNAIA TGKYPSWTFY IQVMTFNQAE TFPFNPFDLT
310 320 330 340 350
KVWPHKDYPL IPVGKLVLNR NPVNYFAEVE QIAFDPSNMP PGIEASPDKM
360 370 380 390 400
LQGRLFAYPD THRHRLGPNY LHIPVNCPYR ARVANYQRDG PMCMQDNQGG
410 420 430 440 450
APNYYPNSFG APEQQPSALE HSIQYSGEVR RFNTANDDNV TQVRAFYVNV
460 470 480 490 500
LNEEQRKRLC ENIAGHLKDA QIFIQKKAVK NFTEVHPDYG SHIQALLDKY
510 520
NAEKPKNAIH TFVQSGSHLA AREKANL
Length:527
Mass (Da):59,756
Last modified:January 23, 2007 - v3
Checksum:i7BAA2394D124ED20
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54D → N in AAK29181 (PubMed:11728823).Curated1
Sequence conflicti100F → L in BAG37746 (PubMed:14702039).Curated1
Sequence conflicti239D → G in AAK29181 (PubMed:11728823).Curated1
Sequence conflicti274Y → D in AAK29181 (PubMed:11728823).Curated1
Sequence conflicti301K → R in AAK29181 (PubMed:11728823).Curated1
Sequence conflicti366L → P in BAG37746 (PubMed:14702039).Curated1
Sequence conflicti449N → D in BAG37746 (PubMed:14702039).Curated1
Sequence conflicti514Q → R in AAK29181 (PubMed:11728823).Curated1
Sequence conflicti520A → V in AAK29181 (PubMed:11728823).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04085
, X04086, X04087, X04088, X04089, X04090, X04091, X04092, X04093, X04094, X04095, X04096 Genomic DNA Translation: CAA27721.1
X04076 mRNA Translation: CAA27717.1
AY028632 mRNA Translation: AAK29181.1
AK291585 mRNA Translation: BAF84274.1
AK315350 mRNA Translation: BAG37746.1
AY545477 Genomic DNA Translation: AAS37679.1
AL035079 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68170.1
CH471064 Genomic DNA Translation: EAW68171.1
BC110398 mRNA Translation: AAI10399.1
BC112217 mRNA Translation: AAI12218.1
BC112219 mRNA Translation: AAI12220.1
L13609 Genomic DNA Translation: AAA16651.1
K02400 Genomic DNA Translation: AAB59522.1
CCDSiCCDS7891.1
PIRiA23646 CSHU
RefSeqiNP_001743.1, NM_001752.3
UniGeneiHs.502302

Genome annotation databases

EnsembliENST00000241052; ENSP00000241052; ENSG00000121691
GeneIDi847
KEGGihsa:847
UCSCiuc001mvm.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Catalase entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04085
, X04086, X04087, X04088, X04089, X04090, X04091, X04092, X04093, X04094, X04095, X04096 Genomic DNA Translation: CAA27721.1
X04076 mRNA Translation: CAA27717.1
AY028632 mRNA Translation: AAK29181.1
AK291585 mRNA Translation: BAF84274.1
AK315350 mRNA Translation: BAG37746.1
AY545477 Genomic DNA Translation: AAS37679.1
AL035079 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68170.1
CH471064 Genomic DNA Translation: EAW68171.1
BC110398 mRNA Translation: AAI10399.1
BC112217 mRNA Translation: AAI12218.1
BC112219 mRNA Translation: AAI12220.1
L13609 Genomic DNA Translation: AAA16651.1
K02400 Genomic DNA Translation: AAB59522.1
CCDSiCCDS7891.1
PIRiA23646 CSHU
RefSeqiNP_001743.1, NM_001752.3
UniGeneiHs.502302

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DGBX-ray2.20A/B/C/D4-501[»]
1DGFX-ray1.50A/B/C/D5-501[»]
1DGGX-ray1.80A/B/C/D5-501[»]
1DGHX-ray2.00A/B/C/D4-501[»]
1F4JX-ray2.40A/B/C/D1-527[»]
1QQWX-ray2.75A/B/C/D1-527[»]
ProteinModelPortaliP04040
SMRiP04040
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107297, 50 interactors
ELMiP04040
IntActiP04040, 80 interactors
MINTiP04040
STRINGi9606.ENSP00000241052

Chemistry databases

BindingDBiP04040
ChEMBLiCHEMBL3627594
DrugBankiDB01213 Fomepizole

Protein family/group databases

PeroxiBasei5282 HsKat01

PTM databases

iPTMnetiP04040
PhosphoSitePlusiP04040
SwissPalmiP04040

Polymorphism and mutation databases

BioMutaiCAT
DMDMi115702

2D gel databases

OGPiP04040
REPRODUCTION-2DPAGEiIPI00465436
P04040
SWISS-2DPAGEiP04040

Proteomic databases

EPDiP04040
MaxQBiP04040
PaxDbiP04040
PeptideAtlasiP04040
PRIDEiP04040
ProteomicsDBi12621
51636

Protocols and materials databases

DNASUi847
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000241052; ENSP00000241052; ENSG00000121691
GeneIDi847
KEGGihsa:847
UCSCiuc001mvm.4 human

Organism-specific databases

CTDi847
DisGeNETi847
EuPathDBiHostDB:ENSG00000121691.4
GeneCardsiCAT
H-InvDBiHIX0009550
HGNCiHGNC:1516 CAT
HPAiCAB001515
HPA051282
HPA055838
MalaCardsiCAT
MIMi115500 gene
614097 phenotype
neXtProtiNX_P04040
OpenTargetsiENSG00000121691
Orphaneti926 Acatalasemia
PharmGKBiPA26099
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0047 Eukaryota
COG0753 LUCA
GeneTreeiENSGT00390000018100
HOVERGENiHBG003986
InParanoidiP04040
KOiK03781
OMAiHADFGRM
OrthoDBiEOG091G04V5
PhylomeDBiP04040
TreeFamiTF300540

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER66-341
BRENDAi1.11.1.6 2681
ReactomeiR-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-6798695 Neutrophil degranulation
R-HSA-9033241 Peroxisomal protein import
SABIO-RKiP04040
SIGNORiP04040

Miscellaneous databases

ChiTaRSiCAT human
EvolutionaryTraceiP04040
GeneWikiiCatalase
GenomeRNAii847
PROiPR:P04040
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121691 Expressed in 230 organ(s), highest expression level in bone marrow
CleanExiHS_CAT
GenevisibleiP04040 HS

Family and domain databases

Gene3Di2.40.180.10, 1 hit
InterProiView protein in InterPro
IPR018028 Catalase
IPR024708 Catalase_AS
IPR024711 Catalase_clade1/3
IPR011614 Catalase_core
IPR037060 Catalase_core_sf
IPR002226 Catalase_haem_BS
IPR010582 Catalase_immune_responsive
IPR020835 Catalase_sf
PANTHERiPTHR11465 PTHR11465, 1 hit
PfamiView protein in Pfam
PF00199 Catalase, 1 hit
PF06628 Catalase-rel, 1 hit
PIRSFiPIRSF038928 Catalase_clade1-3, 1 hit
PRINTSiPR00067 CATALASE
SMARTiView protein in SMART
SM01060 Catalase, 1 hit
SUPFAMiSSF56634 SSF56634, 1 hit
PROSITEiView protein in PROSITE
PS00437 CATALASE_1, 1 hit
PS00438 CATALASE_2, 1 hit
PS51402 CATALASE_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCATA_HUMAN
AccessioniPrimary (citable) accession number: P04040
Secondary accession number(s): A8K6C0
, B2RCZ9, D3DR07, Q2M1U4, Q4VXX5, Q9BWT9, Q9UC85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 211 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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