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Entry version 220 (18 Sep 2019)
Sequence version 3 (23 Jan 2007)
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Protein

Catalase

Gene

CAT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei751
Active sitei1481
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi358Iron (heme axial ligand)1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMitogen, Oxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding, NADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:MONOMER66-341

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.11.1.6 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-6798695 Neutrophil degranulation
R-HSA-9033241 Peroxisomal protein import
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P04040

SIGNOR Signaling Network Open Resource

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SIGNORi
P04040

Protein family/group databases

PeroxiBase, a peroxidase database

More...
PeroxiBasei
5282 HsKat01

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Catalase (EC:1.11.1.6)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1516 CAT

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
115500 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P04040

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Acatalasemia (ACATLAS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA metabolic disorder characterized by a total or near total loss of catalase activity in red cells. It is often associated with ulcerating oral lesions. Acatalasemia is inherited as an autosomal recessive trait.
Related information in OMIM

Organism-specific databases

DisGeNET

More...
DisGeNETi
847

MalaCards human disease database

More...
MalaCardsi
CAT
MIMi614097 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000121691

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
926 Acatalasemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26099

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3627594

Drug and drug target database

More...
DrugBanki
DB09116 Calcium carbimide
DB09061 Cannabidiol
DB13257 Ferrous sulfate anhydrous
DB01213 Fomepizole
DB11091 Hydrogen peroxide
DB14009 Medical Cannabis
DB14011 Nabiximols

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CAT

Domain mapping of disease mutations (DMDM)

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DMDMi
115702

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000849012 – 527CatalaseAdd BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei9PhosphoserineCombined sources1
Modified residuei221N6-succinyllysineBy similarity1
Modified residuei233N6-acetyllysineBy similarity1
Modified residuei306N6-acetyllysine; alternateBy similarity1
Modified residuei306N6-succinyllysine; alternateBy similarity1
Modified residuei417PhosphoserineBy similarity1
Modified residuei422PhosphoserineCombined sources1
Modified residuei480N6-acetyllysine; alternateBy similarity1
Modified residuei480N6-succinyllysine; alternateBy similarity1
Modified residuei499N6-acetyllysineBy similarity1
Modified residuei511PhosphothreonineCombined sources1
Modified residuei515PhosphoserineCombined sources1
Modified residuei517PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

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CPTACi
CPTAC-472
CPTAC-473

Encyclopedia of Proteome Dynamics

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EPDi
P04040

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P04040

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P04040

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P04040

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P04040

PeptideAtlas

More...
PeptideAtlasi
P04040

PRoteomics IDEntifications database

More...
PRIDEi
P04040

ProteomicsDB human proteome resource

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ProteomicsDBi
12621
51636

2D gel databases

USC-OGP 2-DE database

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OGPi
P04040

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00465436
P04040

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P04040

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1925

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P04040

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P04040

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P04040

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000121691 Expressed in 230 organ(s), highest expression level in bone marrow

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P04040 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P04040 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB001515
HPA051282
HPA055838

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself5EBI-2432181,EBI-2432181

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107297, 113 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P04040

Protein interaction database and analysis system

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IntActi
P04040, 83 interactors

Molecular INTeraction database

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MINTi
P04040

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000241052

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P04040

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1527
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P04040

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P04040

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the catalase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0047 Eukaryota
COG0753 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018100

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P04040

KEGG Orthology (KO)

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KOi
K03781

Identification of Orthologs from Complete Genome Data

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OMAi
HADFGRM

Database of Orthologous Groups

More...
OrthoDBi
1377095at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P04040

TreeFam database of animal gene trees

More...
TreeFami
TF300540

Family and domain databases

Conserved Domains Database

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CDDi
cd08156 catalase_clade_3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.40.180.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR018028 Catalase
IPR040333 Catalase_3
IPR024708 Catalase_AS
IPR024711 Catalase_clade1/3
IPR011614 Catalase_core
IPR037060 Catalase_core_sf
IPR002226 Catalase_haem_BS
IPR010582 Catalase_immune_responsive
IPR020835 Catalase_sf

The PANTHER Classification System

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PANTHERi
PTHR11465 PTHR11465, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00199 Catalase, 1 hit
PF06628 Catalase-rel, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF038928 Catalase_clade1-3, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00067 CATALASE

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01060 Catalase, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56634 SSF56634, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00437 CATALASE_1, 1 hit
PS00438 CATALASE_2, 1 hit
PS51402 CATALASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P04040-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADSRDPASD QMQHWKEQRA AQKADVLTTG AGNPVGDKLN VITVGPRGPL
60 70 80 90 100
LVQDVVFTDE MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITKYSKAKVF
110 120 130 140 150
EHIGKKTPIA VRFSTVAGES GSADTVRDPR GFAVKFYTED GNWDLVGNNT
160 170 180 190 200
PIFFIRDPIL FPSFIHSQKR NPQTHLKDPD MVWDFWSLRP ESLHQVSFLF
210 220 230 240 250
SDRGIPDGHR HMNGYGSHTF KLVNANGEAV YCKFHYKTDQ GIKNLSVEDA
260 270 280 290 300
ARLSQEDPDY GIRDLFNAIA TGKYPSWTFY IQVMTFNQAE TFPFNPFDLT
310 320 330 340 350
KVWPHKDYPL IPVGKLVLNR NPVNYFAEVE QIAFDPSNMP PGIEASPDKM
360 370 380 390 400
LQGRLFAYPD THRHRLGPNY LHIPVNCPYR ARVANYQRDG PMCMQDNQGG
410 420 430 440 450
APNYYPNSFG APEQQPSALE HSIQYSGEVR RFNTANDDNV TQVRAFYVNV
460 470 480 490 500
LNEEQRKRLC ENIAGHLKDA QIFIQKKAVK NFTEVHPDYG SHIQALLDKY
510 520
NAEKPKNAIH TFVQSGSHLA AREKANL
Length:527
Mass (Da):59,756
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7BAA2394D124ED20
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3ITJ0A0A3B3ITJ0_HUMAN
Catalase
CAT
31Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti54D → N in AAK29181 (PubMed:11728823).Curated1
Sequence conflicti100F → L in BAG37746 (PubMed:14702039).Curated1
Sequence conflicti239D → G in AAK29181 (PubMed:11728823).Curated1
Sequence conflicti274Y → D in AAK29181 (PubMed:11728823).Curated1
Sequence conflicti301K → R in AAK29181 (PubMed:11728823).Curated1
Sequence conflicti366L → P in BAG37746 (PubMed:14702039).Curated1
Sequence conflicti449N → D in BAG37746 (PubMed:14702039).Curated1
Sequence conflicti514Q → R in AAK29181 (PubMed:11728823).Curated1
Sequence conflicti520A → V in AAK29181 (PubMed:11728823).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X04085
, X04086, X04087, X04088, X04089, X04090, X04091, X04092, X04093, X04094, X04095, X04096 Genomic DNA Translation: CAA27721.1
X04076 mRNA Translation: CAA27717.1
AY028632 mRNA Translation: AAK29181.1
AK291585 mRNA Translation: BAF84274.1
AK315350 mRNA Translation: BAG37746.1
AY545477 Genomic DNA Translation: AAS37679.1
AL035079 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68170.1
CH471064 Genomic DNA Translation: EAW68171.1
BC110398 mRNA Translation: AAI10399.1
BC112217 mRNA Translation: AAI12218.1
BC112219 mRNA Translation: AAI12220.1
L13609 Genomic DNA Translation: AAA16651.1
K02400 Genomic DNA Translation: AAB59522.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS7891.1

Protein sequence database of the Protein Information Resource

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PIRi
A23646 CSHU

NCBI Reference Sequences

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RefSeqi
NP_001743.1, NM_001752.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000241052; ENSP00000241052; ENSG00000121691

Database of genes from NCBI RefSeq genomes

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GeneIDi
847

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:847

UCSC genome browser

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UCSCi
uc001mvm.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Catalase entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04085
, X04086, X04087, X04088, X04089, X04090, X04091, X04092, X04093, X04094, X04095, X04096 Genomic DNA Translation: CAA27721.1
X04076 mRNA Translation: CAA27717.1
AY028632 mRNA Translation: AAK29181.1
AK291585 mRNA Translation: BAF84274.1
AK315350 mRNA Translation: BAG37746.1
AY545477 Genomic DNA Translation: AAS37679.1
AL035079 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68170.1
CH471064 Genomic DNA Translation: EAW68171.1
BC110398 mRNA Translation: AAI10399.1
BC112217 mRNA Translation: AAI12218.1
BC112219 mRNA Translation: AAI12220.1
L13609 Genomic DNA Translation: AAA16651.1
K02400 Genomic DNA Translation: AAB59522.1
CCDSiCCDS7891.1
PIRiA23646 CSHU
RefSeqiNP_001743.1, NM_001752.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DGBX-ray2.20A/B/C/D4-501[»]
1DGFX-ray1.50A/B/C/D5-501[»]
1DGGX-ray1.80A/B/C/D5-501[»]
1DGHX-ray2.00A/B/C/D4-501[»]
1F4JX-ray2.40A/B/C/D1-527[»]
1QQWX-ray2.75A/B/C/D1-527[»]
SMRiP04040
ModBaseiSearch...

Protein-protein interaction databases

BioGridi107297, 113 interactors
ELMiP04040
IntActiP04040, 83 interactors
MINTiP04040
STRINGi9606.ENSP00000241052

Chemistry databases

BindingDBiP04040
ChEMBLiCHEMBL3627594
DrugBankiDB09116 Calcium carbimide
DB09061 Cannabidiol
DB13257 Ferrous sulfate anhydrous
DB01213 Fomepizole
DB11091 Hydrogen peroxide
DB14009 Medical Cannabis
DB14011 Nabiximols

Protein family/group databases

PeroxiBasei5282 HsKat01

PTM databases

GlyConnecti1925
iPTMnetiP04040
PhosphoSitePlusiP04040
SwissPalmiP04040

Polymorphism and mutation databases

BioMutaiCAT
DMDMi115702

2D gel databases

OGPiP04040
REPRODUCTION-2DPAGEiIPI00465436
P04040
SWISS-2DPAGEiP04040

Proteomic databases

CPTACiCPTAC-472
CPTAC-473
EPDiP04040
jPOSTiP04040
MassIVEiP04040
MaxQBiP04040
PaxDbiP04040
PeptideAtlasiP04040
PRIDEiP04040
ProteomicsDBi12621
51636

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
P04040

The DNASU plasmid repository

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DNASUi
847
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000241052; ENSP00000241052; ENSG00000121691
GeneIDi847
KEGGihsa:847
UCSCiuc001mvm.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
847
DisGeNETi847

GeneCards: human genes, protein and diseases

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GeneCardsi
CAT
HGNCiHGNC:1516 CAT
HPAiCAB001515
HPA051282
HPA055838
MalaCardsiCAT
MIMi115500 gene
614097 phenotype
neXtProtiNX_P04040
OpenTargetsiENSG00000121691
Orphaneti926 Acatalasemia
PharmGKBiPA26099

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0047 Eukaryota
COG0753 LUCA
GeneTreeiENSGT00390000018100
InParanoidiP04040
KOiK03781
OMAiHADFGRM
OrthoDBi1377095at2759
PhylomeDBiP04040
TreeFamiTF300540

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER66-341
BRENDAi1.11.1.6 2681
ReactomeiR-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-6798695 Neutrophil degranulation
R-HSA-9033241 Peroxisomal protein import
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
SABIO-RKiP04040
SIGNORiP04040

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CAT human
EvolutionaryTraceiP04040

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Catalase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
847

Pharos

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Pharosi
P04040

Protein Ontology

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PROi
PR:P04040

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000121691 Expressed in 230 organ(s), highest expression level in bone marrow
ExpressionAtlasiP04040 baseline and differential
GenevisibleiP04040 HS

Family and domain databases

CDDicd08156 catalase_clade_3, 1 hit
Gene3Di2.40.180.10, 1 hit
InterProiView protein in InterPro
IPR018028 Catalase
IPR040333 Catalase_3
IPR024708 Catalase_AS
IPR024711 Catalase_clade1/3
IPR011614 Catalase_core
IPR037060 Catalase_core_sf
IPR002226 Catalase_haem_BS
IPR010582 Catalase_immune_responsive
IPR020835 Catalase_sf
PANTHERiPTHR11465 PTHR11465, 1 hit
PfamiView protein in Pfam
PF00199 Catalase, 1 hit
PF06628 Catalase-rel, 1 hit
PIRSFiPIRSF038928 Catalase_clade1-3, 1 hit
PRINTSiPR00067 CATALASE
SMARTiView protein in SMART
SM01060 Catalase, 1 hit
SUPFAMiSSF56634 SSF56634, 1 hit
PROSITEiView protein in PROSITE
PS00437 CATALASE_1, 1 hit
PS00438 CATALASE_2, 1 hit
PS51402 CATALASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCATA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P04040
Secondary accession number(s): A8K6C0
, B2RCZ9, D3DR07, Q2M1U4, Q4VXX5, Q9BWT9, Q9UC85
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: January 23, 2007
Last modified: September 18, 2019
This is version 220 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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