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Protein

Cytochrome c oxidase subunit 6C

Gene

COX6C

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

Enzyme and pathway databases

BRENDAi1.9.3.1 908

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6C
Alternative name(s):
Cytochrome c oxidase polypeptide VIc
Cytochrome c oxidase subunit STA
Gene namesi
Name:COX6C
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 12Mitochondrial matrixAdd BLAST11
Transmembranei13 – 53HelicalAdd BLAST41
Topological domaini54 – 74Mitochondrial intermembraneAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001913012 – 74Cytochrome c oxidase subunit 6CAdd BLAST73

Proteomic databases

PaxDbiP04038
PRIDEiP04038

Expressioni

Gene expression databases

BgeeiENSBTAG00000014130 Expressed in 10 organ(s), highest expression level in brain

Interactioni

Protein-protein interaction databases

CORUMiP04038
DIPiDIP-38980N
IntActiP04038, 3 interactors
STRINGi9913.ENSBTAP00000018778

Structurei

Secondary structure

174
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP04038
SMRiP04038
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04038

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J83U Eukaryota
ENOG41124VH LUCA
GeneTreeiENSGT00390000004573
HOGENOMiHOG000039249
HOVERGENiHBG051091
InParanoidiP04038
KOiK02268
OMAiARRMKFH
OrthoDBiEOG091G10KX
TreeFamiTF353619

Family and domain databases

CDDicd00927 Cyt_c_Oxidase_VIc, 1 hit
Gene3Di4.10.93.10, 1 hit
InterProiView protein in InterPro
IPR004204 COX6C
IPR034884 Cytochrome_c_oxidase_VIc/VIIs
IPR037169 Cytochrome_c_oxidase_VIc_sf
PANTHERiPTHR12916 PTHR12916, 1 hit
PfamiView protein in Pfam
PF02937 COX6C, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD015032 Cyt_c_oxidase_su6c, 1 hit
SUPFAMiSSF81415 SSF81415, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04038-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTALAKPQM RGLLARRLRF HIVGAFMVSL GFATFYKFAV AEKRKKAYAD
60 70
FYRNYDSMKD FEEMRKAGIF QSAK
Length:74
Mass (Da):8,610
Last modified:April 14, 2009 - v2
Checksum:iE063BDB1B7AE9E4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126788 mRNA Translation: AAI26789.1
PIRiA00496 OGBO6C
RefSeqiNP_001231040.1, NM_001244111.1
UniGeneiBt.28261

Genome annotation databases

EnsembliENSBTAT00000018778; ENSBTAP00000018778; ENSBTAG00000014130
GeneIDi614700
KEGGibta:614700

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126788 mRNA Translation: AAI26789.1
PIRiA00496 OGBO6C
RefSeqiNP_001231040.1, NM_001244111.1
UniGeneiBt.28261

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80I/V2-74[»]
1OCOX-ray2.80I/V2-74[»]
1OCRX-ray2.35I/V2-74[»]
1OCZX-ray2.90I/V2-74[»]
1V54X-ray1.80I/V2-74[»]
1V55X-ray1.90I/V2-74[»]
2DYRX-ray1.80I/V2-74[»]
2DYSX-ray2.20I/V2-74[»]
2EIJX-ray1.90I/V2-74[»]
2EIKX-ray2.10I/V2-74[»]
2EILX-ray2.10I/V2-74[»]
2EIMX-ray2.60I/V2-74[»]
2EINX-ray2.70I/V2-74[»]
2OCCX-ray2.30I/V2-74[»]
2Y69X-ray1.95I/V1-74[»]
2YBBelectron microscopy19.00T2-74[»]
2ZXWX-ray2.50I/V2-74[»]
3ABKX-ray2.00I/V2-74[»]
3ABLX-ray2.10I/V2-74[»]
3ABMX-ray1.95I/V2-74[»]
3AG1X-ray2.20I/V2-74[»]
3AG2X-ray1.80I/V2-74[»]
3AG3X-ray1.80I/V2-74[»]
3AG4X-ray2.05I/V2-74[»]
3ASNX-ray3.00I/V2-74[»]
3ASOX-ray2.30I/V2-74[»]
3WG7X-ray1.90I/V2-74[»]
3X2QX-ray2.00I/V2-74[»]
5B1AX-ray1.50I/V2-74[»]
5B1BX-ray1.60I/V2-74[»]
5B3SX-ray1.68I/V3-74[»]
5GPNelectron microscopy5.4062-74[»]
5IY5X-ray2.00I/V2-74[»]
5LUFelectron microscopy9.1062-74[»]
5W97X-ray2.30I/i2-74[»]
5WAUX-ray1.95I/i2-74[»]
5X19X-ray2.20I/V2-74[»]
5X1BX-ray2.40I/V2-74[»]
5X1FX-ray2.20I/V2-74[»]
5XDQX-ray1.77I/V2-74[»]
5XDXX-ray1.99I/V2-74[»]
5XTHelectron microscopy3.9052-74[»]
5XTIelectron microscopy17.405/B52-74[»]
5Z84X-ray1.85I/V2-74[»]
5Z85X-ray1.85I/V2-74[»]
5Z86X-ray1.85I/V2-74[»]
5ZCOX-ray1.90I/V2-74[»]
5ZCPX-ray1.65I/V2-74[»]
5ZCQX-ray1.65I/V2-74[»]
ProteinModelPortaliP04038
SMRiP04038
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiP04038
DIPiDIP-38980N
IntActiP04038, 3 interactors
STRINGi9913.ENSBTAP00000018778

Proteomic databases

PaxDbiP04038
PRIDEiP04038

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000018778; ENSBTAP00000018778; ENSBTAG00000014130
GeneIDi614700
KEGGibta:614700

Phylogenomic databases

eggNOGiENOG410J83U Eukaryota
ENOG41124VH LUCA
GeneTreeiENSGT00390000004573
HOGENOMiHOG000039249
HOVERGENiHBG051091
InParanoidiP04038
KOiK02268
OMAiARRMKFH
OrthoDBiEOG091G10KX
TreeFamiTF353619

Enzyme and pathway databases

BRENDAi1.9.3.1 908

Miscellaneous databases

EvolutionaryTraceiP04038

Gene expression databases

BgeeiENSBTAG00000014130 Expressed in 10 organ(s), highest expression level in brain

Family and domain databases

CDDicd00927 Cyt_c_Oxidase_VIc, 1 hit
Gene3Di4.10.93.10, 1 hit
InterProiView protein in InterPro
IPR004204 COX6C
IPR034884 Cytochrome_c_oxidase_VIc/VIIs
IPR037169 Cytochrome_c_oxidase_VIc_sf
PANTHERiPTHR12916 PTHR12916, 1 hit
PfamiView protein in Pfam
PF02937 COX6C, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD015032 Cyt_c_oxidase_su6c, 1 hit
SUPFAMiSSF81415 SSF81415, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOX6C_BOVIN
AccessioniPrimary (citable) accession number: P04038
Secondary accession number(s): A0JNM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: April 14, 2009
Last modified: October 10, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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