Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 147 (18 Sep 2019)
Sequence version 2 (14 Apr 2009)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Cytochrome c oxidase subunit 6C

Gene

COX6C

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.9.3.1 908

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6C
Alternative name(s):
Cytochrome c oxidase polypeptide VIc
Cytochrome c oxidase subunit STA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COX6C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 12Mitochondrial matrixAdd BLAST11
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei13 – 53HelicalAdd BLAST41
Topological domaini54 – 74Mitochondrial intermembraneAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved2 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001913012 – 74Cytochrome c oxidase subunit 6CAdd BLAST73

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P04038

PRoteomics IDEntifications database

More...
PRIDEi
P04038

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000014130 Expressed in 10 organ(s), highest expression level in brain

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P04038

Database of interacting proteins

More...
DIPi
DIP-38980N

Protein interaction database and analysis system

More...
IntActi
P04038, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000018778

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

174
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P04038

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P04038

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J83U Eukaryota
ENOG41124VH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163089

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000039249

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P04038

KEGG Orthology (KO)

More...
KOi
K02268

Identification of Orthologs from Complete Genome Data

More...
OMAi
LYKFAVA

Database of Orthologous Groups

More...
OrthoDBi
1618740at2759

TreeFam database of animal gene trees

More...
TreeFami
TF353619

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00927 Cyt_c_Oxidase_VIc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.93.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004204 COX6C
IPR034884 Cytochrome_c_oxidase_VIc/VIIs
IPR037169 Cytochrome_c_oxidase_VIc_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02937 COX6C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81415 SSF81415, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P04038-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTALAKPQM RGLLARRLRF HIVGAFMVSL GFATFYKFAV AEKRKKAYAD
60 70
FYRNYDSMKD FEEMRKAGIF QSAK
Length:74
Mass (Da):8,610
Last modified:April 14, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE063BDB1B7AE9E4C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC126788 mRNA Translation: AAI26789.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A00496 OGBO6C

NCBI Reference Sequences

More...
RefSeqi
NP_001231040.1, NM_001244111.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000018778; ENSBTAP00000018778; ENSBTAG00000014130
ENSBTAT00000076438; ENSBTAP00000067188; ENSBTAG00000014130
ENSBTAT00000081914; ENSBTAP00000065630; ENSBTAG00000014130

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
614700

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:614700

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126788 mRNA Translation: AAI26789.1
PIRiA00496 OGBO6C
RefSeqiNP_001231040.1, NM_001244111.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80I/V2-74[»]
1OCOX-ray2.80I/V2-74[»]
1OCRX-ray2.35I/V2-74[»]
1OCZX-ray2.90I/V2-74[»]
1V54X-ray1.80I/V2-74[»]
1V55X-ray1.90I/V2-74[»]
2DYRX-ray1.80I/V2-74[»]
2DYSX-ray2.20I/V2-74[»]
2EIJX-ray1.90I/V2-74[»]
2EIKX-ray2.10I/V2-74[»]
2EILX-ray2.10I/V2-74[»]
2EIMX-ray2.60I/V2-74[»]
2EINX-ray2.70I/V2-74[»]
2OCCX-ray2.30I/V2-74[»]
2Y69X-ray1.95I/V1-74[»]
2YBBelectron microscopy19.00T2-74[»]
2ZXWX-ray2.50I/V2-74[»]
3ABKX-ray2.00I/V2-74[»]
3ABLX-ray2.10I/V2-74[»]
3ABMX-ray1.95I/V2-74[»]
3AG1X-ray2.20I/V2-74[»]
3AG2X-ray1.80I/V2-74[»]
3AG3X-ray1.80I/V2-74[»]
3AG4X-ray2.05I/V2-74[»]
3ASNX-ray3.00I/V2-74[»]
3ASOX-ray2.30I/V2-74[»]
3WG7X-ray1.90I/V2-74[»]
3X2QX-ray2.00I/V2-74[»]
5B1AX-ray1.50I/V2-74[»]
5B1BX-ray1.60I/V2-74[»]
5B3SX-ray1.68I/V3-74[»]
5GPNelectron microscopy5.4062-74[»]
5IY5X-ray2.00I/V2-74[»]
5LUFelectron microscopy9.1062-74[»]
5W97X-ray2.30I/i2-74[»]
5WAUX-ray1.95I/i2-74[»]
5X19X-ray2.20I/V2-74[»]
5X1BX-ray2.40I/V2-74[»]
5X1FX-ray2.20I/V2-74[»]
5XDQX-ray1.77I/V2-74[»]
5XDXX-ray1.99I/V2-74[»]
5XTHelectron microscopy3.9052-74[»]
5XTIelectron microscopy17.405/B52-74[»]
5Z84X-ray1.85I/V2-74[»]
5Z85X-ray1.85I/V2-74[»]
5Z86X-ray1.85I/V2-74[»]
5ZCOX-ray1.90I/V2-74[»]
5ZCPX-ray1.65I/V2-74[»]
5ZCQX-ray1.65I/V2-74[»]
6J8MX-ray1.90I/V2-74[»]
6NKNX-ray2.50I/V2-74[»]
6NMFX-ray2.80I/V2-74[»]
6NMPX-ray2.90I/V2-74[»]
SMRiP04038
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

CORUMiP04038
DIPiDIP-38980N
IntActiP04038, 3 interactors
STRINGi9913.ENSBTAP00000018778

Proteomic databases

PaxDbiP04038
PRIDEiP04038

Genome annotation databases

EnsembliENSBTAT00000018778; ENSBTAP00000018778; ENSBTAG00000014130
ENSBTAT00000076438; ENSBTAP00000067188; ENSBTAG00000014130
ENSBTAT00000081914; ENSBTAP00000065630; ENSBTAG00000014130
GeneIDi614700
KEGGibta:614700

Phylogenomic databases

eggNOGiENOG410J83U Eukaryota
ENOG41124VH LUCA
GeneTreeiENSGT00940000163089
HOGENOMiHOG000039249
InParanoidiP04038
KOiK02268
OMAiLYKFAVA
OrthoDBi1618740at2759
TreeFamiTF353619

Enzyme and pathway databases

BRENDAi1.9.3.1 908

Miscellaneous databases

EvolutionaryTraceiP04038

Gene expression databases

BgeeiENSBTAG00000014130 Expressed in 10 organ(s), highest expression level in brain

Family and domain databases

CDDicd00927 Cyt_c_Oxidase_VIc, 1 hit
Gene3Di4.10.93.10, 1 hit
InterProiView protein in InterPro
IPR004204 COX6C
IPR034884 Cytochrome_c_oxidase_VIc/VIIs
IPR037169 Cytochrome_c_oxidase_VIc_sf
PfamiView protein in Pfam
PF02937 COX6C, 1 hit
SUPFAMiSSF81415 SSF81415, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOX6C_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P04038
Secondary accession number(s): A0JNM4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: April 14, 2009
Last modified: September 18, 2019
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again