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Protein

Cytochrome c oxidase subunit 4, mitochondrial

Gene

COX4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.

Miscellaneous

Present with 9410 molecules/cell in log phase SD medium.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi111ZincPROSITE-ProRule annotation1
Metal bindingi134ZincPROSITE-ProRule annotation1
Metal bindingi137ZincPROSITE-ProRule annotation1

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: UniProtKB-EC
  • zinc ion binding Source: SGD

GO - Biological processi

  • aerobic respiration Source: SGD
  • mitochondrial ATP synthesis coupled proton transport Source: GO_Central
  • mitochondrial electron transport, cytochrome c to oxygen Source: SGD
  • mitochondrial respiratory chain complex IV assembly Source: CACAO

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:YGL187C-MONOMER
YEAST:YGL187C-MONOMER
UniPathwayiUPA00705

Protein family/group databases

TCDBi3.D.4.8.1 the proton-translocating cytochrome oxidase (cox) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 4, mitochondrial (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide IV
Gene namesi
Name:COX4
Ordered Locus Names:YGL187C
ORF Names:G1362
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL187C
SGDiS000003155 COX4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25Mitochondrion1 PublicationAdd BLAST25
ChainiPRO_000000611426 – 155Cytochrome c oxidase subunit 4, mitochondrialAdd BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei55PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP04037
PaxDbiP04037
PRIDEiP04037

PTM databases

iPTMnetiP04037

Interactioni

Subunit structurei

Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.1 Publication

Protein-protein interaction databases

BioGridi33068, 236 interactors
ComplexPortaliCPX-1721 Mitochondrial respiratory chain complex IV variant 1
CPX-1722 Mitochondrial electron transport complex IV variant 2
DIPiDIP-2763N
IntActiP04037, 13 interactors
MINTiP04037
STRINGi4932.YGL187C

Structurei

Secondary structure

1155
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi15 – 17Combined sources3
Beta strandi98 – 100Combined sources3
Beta strandi103 – 106Combined sources4
Beta strandi109 – 114Combined sources6
Beta strandi122 – 124Combined sources3
Beta strandi131 – 133Combined sources3
Beta strandi135 – 137Combined sources3
Beta strandi140 – 143Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HR8X-ray2.70O/P/Q/R2-25[»]
2ODXNMR-A79-155[»]
ProteinModelPortaliP04037
SMRiP04037
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04037

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000184129
InParanoidiP04037
KOiK02265
OMAiCGSVYKM
OrthoDBiEOG092C5SFW

Family and domain databases

CDDicd00924 Cyt_c_Oxidase_Vb, 1 hit
Gene3Di2.60.11.10, 1 hit
InterProiView protein in InterPro
IPR002124 Cyt_c_oxidase_su5b
IPR036972 Cyt_c_oxidase_su5b_sf
IPR020893 Cyt_c_oxidase_su5b_Zn_BS
PANTHERiPTHR10122 PTHR10122, 1 hit
PfamiView protein in Pfam
PF01215 COX5B, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007270 Cyt_c_oxidase_su5b, 1 hit
PROSITEiView protein in PROSITE
PS00848 COX5B_1, 1 hit
PS51359 COX5B_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04037-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLRQSIRF FKPATRTLCS SRYLLQQKPV VKTAQNLAEV NGPETLIGPG
60 70 80 90 100
AKEGTVPTDL DQETGLARLE LLGKLEGIDV FDTKPLDSSR KGTMKDPIII
110 120 130 140 150
ESYDDYRYVG CTGSPAGSHT IMWLKPTVNE VARCWECGSV YKLNPVGVPN

DDHHH
Length:155
Mass (Da):17,143
Last modified:November 1, 1986 - v1
Checksum:iAB2EE69878819E0F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26Q → E AA sequence (PubMed:6327686).Curated1
Sequence conflicti73G → C AA sequence (PubMed:6327686).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01418 Genomic DNA Translation: CAA25665.1
X91489 Genomic DNA Translation: CAA62787.1
Z72709 Genomic DNA Translation: CAA96899.1
EF123139 mRNA Translation: ABM97483.1
Y00152 Genomic DNA Translation: CAA68347.1
BK006941 Genomic DNA Translation: DAA07928.1
PIRiA22786 OLBY4
RefSeqiNP_011328.1, NM_001181052.1

Genome annotation databases

EnsemblFungiiYGL187C; YGL187C; YGL187C
GeneIDi852688
KEGGisce:YGL187C

Similar proteinsi

Entry informationi

Entry nameiCOX4_YEAST
AccessioniPrimary (citable) accession number: P04037
Secondary accession number(s): A2TBN6, D6VTW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: November 1, 1986
Last modified: June 20, 2018
This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

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