Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Gene

HMGCR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

Catalytic activityi

(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.PROSITE-ProRule annotation

Activity regulationi

Regulated by a negative feedback mechanism through sterols and non-sterol metabolites derived from mevalonate. Inhibited by statins, a class of hypolipidemic agents used as pharmaceuticals to lower cholesterol levels in individuals at risk from cardiovascular disease due to hypercholesterolemia. Inhibition of HMGCR in the liver stimulates the LDL-receptors, which results in an increased clearance of LDL from the bloodstream and a decrease in blood cholesterol levels. The first results can be seen after one week of statin use and the effect is maximal after four to six weeks.1 Publication

Pathwayi: (R)-mevalonate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes (R)-mevalonate from acetyl-CoA.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1), Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMGCS2), 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthase (HMGCS1), 3-hydroxy-3-methylglutaryl coenzyme A synthase
  3. 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), 3-hydroxy-3-methylglutaryl coenzyme A reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR)
This subpathway is part of the pathway (R)-mevalonate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-mevalonate from acetyl-CoA, the pathway (R)-mevalonate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei559Charge relay system1
Active sitei691Charge relay system1
Active sitei767Charge relay system1
Active sitei866Proton donor1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism
LigandNADP

Enzyme and pathway databases

BioCyciMetaCyc:HS03652-MONOMER
BRENDAi1.1.1.34 2681
ReactomeiR-HSA-191273 Cholesterol biosynthesis
R-HSA-1989781 PPARA activates gene expression
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
SABIO-RKiP04035
SIGNORiP04035
UniPathwayi
UPA00058;UER00103

Protein family/group databases

TCDBi2.A.6.6.5 the resistance-nodulation-cell division (rnd) superfamily

Chemistry databases

SwissLipidsiSLP:000001246

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC:1.1.1.34)
Short name:
HMG-CoA reductase
Gene namesi
Name:HMGCRImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113161.15
HGNCiHGNC:5006 HMGCR
MIMi142910 gene+phenotype
neXtProtiNX_P04035

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 39HelicalSequence analysisAdd BLAST30
Transmembranei57 – 78HelicalSequence analysisAdd BLAST22
Transmembranei90 – 114HelicalSequence analysisAdd BLAST25
Transmembranei124 – 149HelicalSequence analysisAdd BLAST26
Transmembranei160 – 187HelicalSequence analysisAdd BLAST28
Transmembranei192 – 220HelicalSequence analysisAdd BLAST29
Transmembranei315 – 339HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi75 – 77YIY → AIA: Reduced sterol-mediated release from the ER. Not deglycosylated in response to sterols. 1 Publication3
Mutagenesisi89K → R: Abolishes sterol-mediated ubiquitination and degradation; when associated with R-248. 1 Publication1
Mutagenesisi248K → R: Abolishes sterol-mediated ubiquitination and degradation; when associated with R-89. 1 Publication1

Organism-specific databases

DisGeNETi3156
MIMi142910 gene+phenotype
OpenTargetsiENSG00000113161
PharmGKBiPA189

Chemistry databases

ChEMBLiCHEMBL402
DrugBankiDB03169 (S)-Hmg-Coa
DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB04377 3-Hydroxy-3-Methyl-Glutaric Acid
DB01076 Atorvastatin
DB00439 Cerivastatin
DB01992 Coenzyme A
DB01095 Fluvastatin
DB00227 Lovastatin
DB06693 Mevastatin
DB00157 NADH
DB08860 Pitavastatin
DB00175 Pravastatin
DB01098 Rosuvastatin
DB00641 Simvastatin
DB05342 SP-01A
DB05317 TAK-475
GuidetoPHARMACOLOGYi639

Polymorphism and mutation databases

BioMutaiHMGCR
DMDMi123343

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001144191 – 8883-hydroxy-3-methylglutaryl-coenzyme A reductaseAdd BLAST888

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki89Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki248Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Glycosylationi281N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi419N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei504PhosphoserineCombined sources1
Glycosylationi518N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi870N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei872PhosphoserineCombined sources1

Post-translational modificationi

N-glycosylated. Deglycosylated by NGLY1 on release from the endoplasmic reticulum (ER) in a sterol-mediated manner.1 Publication
Undergoes sterol-mediated ubiquitination and ER-associated degradation (ERAD). Accumulation of sterols in the endoplasmic reticulum (ER) membrane, triggers binding of the reductase to the ER membrane protein INSIG1. This INSIG1 binding leads to the recruitment of the ubiquitin ligase, AMFR/gp78 or RNF145, initiating ubiquitination of the reductase. The ubiquitinated reductase is then extracted from the ER membrane and delivered to cytosolic 26S proteosomes by a mechanism probably mediated by the ATPase Valosin-containing protein VCP/p97. Lys-248 is the main site of ubiquitination. Ubiquitination is enhanced by the presence of a geranylgeranylated protein.By similarity3 Publications

Keywords - PTMi

Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP04035
MaxQBiP04035
PaxDbiP04035
PeptideAtlasiP04035
PRIDEiP04035
ProteomicsDBi51634
51635 [P04035-2]

PTM databases

GlyConnecti983
iPTMnetiP04035
PhosphoSitePlusiP04035

Expressioni

Gene expression databases

BgeeiENSG00000113161 Expressed in 227 organ(s), highest expression level in adrenal tissue
CleanExiHS_HMGCR
ExpressionAtlasiP04035 baseline and differential
GenevisibleiP04035 HS

Organism-specific databases

HPAiCAB016797
HPA008338

Interactioni

Subunit structurei

Homodimer. Interacts (via its SSD) with INSIG1; the interaction, accelerated by sterols, leads to the recruitment of HMGCR to AMFR/gp78 for its ubiquitination by the sterol-mediated ERAD pathway. Interacts with UBIAD1.5 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109399, 40 interactors
ELMiP04035
IntActiP04035, 7 interactors
STRINGi9606.ENSP00000287936

Chemistry databases

BindingDBiP04035

Structurei

Secondary structure

1888
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP04035
SMRiP04035
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04035

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 218SSDPROSITE-ProRule annotationAdd BLAST158

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni340 – 449LinkerAdd BLAST110
Regioni450 – 888CatalyticAdd BLAST439

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi75 – 78INSIG-binding motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi243 – 246Poly-Glu4

Sequence similaritiesi

Belongs to the HMG-CoA reductase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2480 Eukaryota
COG1257 LUCA
GeneTreeiENSGT00910000144151
HOGENOMiHOG000183489
HOVERGENiHBG000453
InParanoidiP04035
KOiK00021
OMAiCASHPWE
OrthoDBiEOG091G0I1B
PhylomeDBiP04035
TreeFamiTF105362

Family and domain databases

CDDicd00643 HMG-CoA_reductase_classI, 1 hit
Gene3Di1.10.3270.10, 1 hit
3.30.70.420, 1 hit
3.90.770.10, 1 hit
InterProiView protein in InterPro
IPR002202 HMG_CoA_Rdtase
IPR023074 HMG_CoA_Rdtase_cat_sf
IPR023076 HMG_CoA_Rdtase_CS
IPR004554 HMG_CoA_Rdtase_eu_arc
IPR004816 HMG_CoA_Rdtase_metazoan
IPR023282 HMG_CoA_Rdtase_N
IPR009023 HMG_CoA_Rdtase_NAD(P)-bd_sf
IPR009029 HMG_CoA_Rdtase_sub-bd_dom_sf
IPR000731 SSD
PANTHERiPTHR10572 PTHR10572, 1 hit
PfamiView protein in Pfam
PF00368 HMG-CoA_red, 1 hit
PF12349 Sterol-sensing, 1 hit
PRINTSiPR00071 HMGCOARDTASE
SUPFAMiSSF55035 SSF55035, 1 hit
SSF56542 SSF56542, 1 hit
TIGRFAMsiTIGR00920 2A060605, 1 hit
TIGR00533 HMG_CoA_R_NADP, 1 hit
PROSITEiView protein in PROSITE
PS00066 HMG_COA_REDUCTASE_1, 1 hit
PS00318 HMG_COA_REDUCTASE_2, 1 hit
PS01192 HMG_COA_REDUCTASE_3, 1 hit
PS50065 HMG_COA_REDUCTASE_4, 1 hit
PS50156 SSD, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P04035-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSRLFRMHG LFVASHPWEV IVGTVTLTIC MMSMNMFTGN NKICGWNYEC
60 70 80 90 100
PKFEEDVLSS DIIILTITRC IAILYIYFQF QNLRQLGSKY ILGIAGLFTI
110 120 130 140 150
FSSFVFSTVV IHFLDKELTG LNEALPFFLL LIDLSRASTL AKFALSSNSQ
160 170 180 190 200
DEVRENIARG MAILGPTFTL DALVECLVIG VGTMSGVRQL EIMCCFGCMS
210 220 230 240 250
VLANYFVFMT FFPACVSLVL ELSRESREGR PIWQLSHFAR VLEEEENKPN
260 270 280 290 300
PVTQRVKMIM SLGLVLVHAH SRWIADPSPQ NSTADTSKVS LGLDENVSKR
310 320 330 340 350
IEPSVSLWQF YLSKMISMDI EQVITLSLAL LLAVKYIFFE QTETESTLSL
360 370 380 390 400
KNPITSPVVT QKKVPDNCCR REPMLVRNNQ KCDSVEEETG INRERKVEVI
410 420 430 440 450
KPLVAETDTP NRATFVVGNS SLLDTSSVLV TQEPEIELPR EPRPNEECLQ
460 470 480 490 500
ILGNAEKGAK FLSDAEIIQL VNAKHIPAYK LETLMETHER GVSIRRQLLS
510 520 530 540 550
KKLSEPSSLQ YLPYRDYNYS LVMGACCENV IGYMPIPVGV AGPLCLDEKE
560 570 580 590 600
FQVPMATTEG CLVASTNRGC RAIGLGGGAS SRVLADGMTR GPVVRLPRAC
610 620 630 640 650
DSAEVKAWLE TSEGFAVIKE AFDSTSRFAR LQKLHTSIAG RNLYIRFQSR
660 670 680 690 700
SGDAMGMNMI SKGTEKALSK LHEYFPEMQI LAVSGNYCTD KKPAAINWIE
710 720 730 740 750
GRGKSVVCEA VIPAKVVREV LKTTTEAMIE VNINKNLVGS AMAGSIGGYN
760 770 780 790 800
AHAANIVTAI YIACGQDAAQ NVGSSNCITL MEASGPTNED LYISCTMPSI
810 820 830 840 850
EIGTVGGGTN LLPQQACLQM LGVQGACKDN PGENARQLAR IVCGTVMAGE
860 870 880
LSLMAALAAG HLVKSHMIHN RSKINLQDLQ GACTKKTA
Length:888
Mass (Da):97,476
Last modified:November 1, 1986 - v1
Checksum:i49B610DCCCFA26B6
GO
Isoform 2 (identifier: P04035-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     522-574: Missing.

Note: No experimental confirmation available.
Show »
Length:835
Mass (Da):92,021
Checksum:i20BBFC6C1FB46ADA
GO
Isoform 3 (identifier: P04035-3) [UniParc]FASTAAdd to basket
Also known as: HMGCR-1b

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQWMSHTRERDAGSKDSVATM

Note: Most highly expressed transcript in skin, esophagus, and uterine cervix.
Show »
Length:908
Mass (Da):99,752
Checksum:iA5CAD1217E9C40B9
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RIW0D6RIW0_HUMAN
3-hydroxy-3-methylglutaryl-coenzyme...
HMGCR
111Annotation score:
H0Y8F6H0Y8F6_HUMAN
3-hydroxy-3-methylglutaryl-coenzyme...
HMGCR
115Annotation score:
H0Y8K6H0Y8K6_HUMAN
3-hydroxy-3-methylglutaryl-coenzyme...
HMGCR
165Annotation score:
C9JKX7C9JKX7_HUMAN
3-hydroxy-3-methylglutaryl-coenzyme...
HMGCR
18Annotation score:

Sequence cautioni

The sequence BAH12375 differs from that shown. Reason: Frameshift at position 122.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011954638I → V1 PublicationCorresponds to variant dbSNP:rs5908Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0464921M → MQWMSHTRERDAGSKDSVAT M in isoform 3. 1 Publication1
Alternative sequenceiVSP_002207522 – 574Missing in isoform 2. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11058 mRNA Translation: AAA52679.1
AF273765
, AF273754, AF273755, AF273756, AF273757, AF273758, AF273759, AF273760, AF273761, AF273762, AF273763, AF273764 Genomic DNA Translation: AAG21343.1
AY321356 Genomic DNA Translation: AAP72015.1
AK296499 mRNA Translation: BAH12375.1 Frameshift.
AC008897 Genomic DNA No translation available.
BC033692 mRNA Translation: AAH33692.1
CCDSiCCDS4027.1 [P04035-1]
CCDS47234.1 [P04035-2]
PIRiA00356 RDHUE
RefSeqiNP_000850.1, NM_000859.2 [P04035-1]
NP_001124468.1, NM_001130996.1 [P04035-2]
XP_011541659.1, XM_011543357.1 [P04035-3]
XP_011541660.1, XM_011543358.1 [P04035-1]
UniGeneiHs.628096
Hs.643495

Genome annotation databases

EnsembliENST00000287936; ENSP00000287936; ENSG00000113161 [P04035-1]
ENST00000343975; ENSP00000340816; ENSG00000113161 [P04035-2]
ENST00000511206; ENSP00000426745; ENSG00000113161 [P04035-1]
GeneIDi3156
KEGGihsa:3156
UCSCiuc003kdp.4 human [P04035-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11058 mRNA Translation: AAA52679.1
AF273765
, AF273754, AF273755, AF273756, AF273757, AF273758, AF273759, AF273760, AF273761, AF273762, AF273763, AF273764 Genomic DNA Translation: AAG21343.1
AY321356 Genomic DNA Translation: AAP72015.1
AK296499 mRNA Translation: BAH12375.1 Frameshift.
AC008897 Genomic DNA No translation available.
BC033692 mRNA Translation: AAH33692.1
CCDSiCCDS4027.1 [P04035-1]
CCDS47234.1 [P04035-2]
PIRiA00356 RDHUE
RefSeqiNP_000850.1, NM_000859.2 [P04035-1]
NP_001124468.1, NM_001130996.1 [P04035-2]
XP_011541659.1, XM_011543357.1 [P04035-3]
XP_011541660.1, XM_011543358.1 [P04035-1]
UniGeneiHs.628096
Hs.643495

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DQ8X-ray2.10A/B/C/D426-888[»]
1DQ9X-ray2.80A/B/C/D426-888[»]
1DQAX-ray2.00A/B/C/D426-888[»]
1HW8X-ray2.10A/B/C/D426-888[»]
1HW9X-ray2.33A/B/C/D426-888[»]
1HWIX-ray2.30A/B/C/D426-888[»]
1HWJX-ray2.26A/B/C/D426-888[»]
1HWKX-ray2.22A/B/C/D426-888[»]
1HWLX-ray2.10A/B/C/D426-888[»]
2Q1LX-ray2.05A/B/C/D441-875[»]
2Q6BX-ray2.00A/B/C/D441-875[»]
2Q6CX-ray2.00A/B/C/D441-875[»]
2R4FX-ray1.70A/B/C/D441-875[»]
3BGLX-ray2.23A/B/C/D441-875[»]
3CCTX-ray2.12A/B/C/D441-875[»]
3CCWX-ray2.10A/B/C/D441-875[»]
3CCZX-ray1.70A/B/C/D441-875[»]
3CD0X-ray2.40A/B/C/D441-875[»]
3CD5X-ray2.39A/B/C/D441-875[»]
3CD7X-ray2.05A/B/C/D441-875[»]
3CDAX-ray2.07A/B/C/D441-875[»]
3CDBX-ray2.30A/B/C/D441-875[»]
ProteinModelPortaliP04035
SMRiP04035
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109399, 40 interactors
ELMiP04035
IntActiP04035, 7 interactors
STRINGi9606.ENSP00000287936

Chemistry databases

BindingDBiP04035
ChEMBLiCHEMBL402
DrugBankiDB03169 (S)-Hmg-Coa
DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB04377 3-Hydroxy-3-Methyl-Glutaric Acid
DB01076 Atorvastatin
DB00439 Cerivastatin
DB01992 Coenzyme A
DB01095 Fluvastatin
DB00227 Lovastatin
DB06693 Mevastatin
DB00157 NADH
DB08860 Pitavastatin
DB00175 Pravastatin
DB01098 Rosuvastatin
DB00641 Simvastatin
DB05342 SP-01A
DB05317 TAK-475
GuidetoPHARMACOLOGYi639
SwissLipidsiSLP:000001246

Protein family/group databases

TCDBi2.A.6.6.5 the resistance-nodulation-cell division (rnd) superfamily

PTM databases

GlyConnecti983
iPTMnetiP04035
PhosphoSitePlusiP04035

Polymorphism and mutation databases

BioMutaiHMGCR
DMDMi123343

Proteomic databases

EPDiP04035
MaxQBiP04035
PaxDbiP04035
PeptideAtlasiP04035
PRIDEiP04035
ProteomicsDBi51634
51635 [P04035-2]

Protocols and materials databases

DNASUi3156
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287936; ENSP00000287936; ENSG00000113161 [P04035-1]
ENST00000343975; ENSP00000340816; ENSG00000113161 [P04035-2]
ENST00000511206; ENSP00000426745; ENSG00000113161 [P04035-1]
GeneIDi3156
KEGGihsa:3156
UCSCiuc003kdp.4 human [P04035-1]

Organism-specific databases

CTDi3156
DisGeNETi3156
EuPathDBiHostDB:ENSG00000113161.15
GeneCardsiHMGCR
HGNCiHGNC:5006 HMGCR
HPAiCAB016797
HPA008338
MIMi142910 gene+phenotype
neXtProtiNX_P04035
OpenTargetsiENSG00000113161
PharmGKBiPA189
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2480 Eukaryota
COG1257 LUCA
GeneTreeiENSGT00910000144151
HOGENOMiHOG000183489
HOVERGENiHBG000453
InParanoidiP04035
KOiK00021
OMAiCASHPWE
OrthoDBiEOG091G0I1B
PhylomeDBiP04035
TreeFamiTF105362

Enzyme and pathway databases

UniPathwayi
UPA00058;UER00103

BioCyciMetaCyc:HS03652-MONOMER
BRENDAi1.1.1.34 2681
ReactomeiR-HSA-191273 Cholesterol biosynthesis
R-HSA-1989781 PPARA activates gene expression
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
SABIO-RKiP04035
SIGNORiP04035

Miscellaneous databases

ChiTaRSiHMGCR human
EvolutionaryTraceiP04035
GeneWikiiHMG-CoA_reductase
GenomeRNAii3156
PROiPR:P04035
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113161 Expressed in 227 organ(s), highest expression level in adrenal tissue
CleanExiHS_HMGCR
ExpressionAtlasiP04035 baseline and differential
GenevisibleiP04035 HS

Family and domain databases

CDDicd00643 HMG-CoA_reductase_classI, 1 hit
Gene3Di1.10.3270.10, 1 hit
3.30.70.420, 1 hit
3.90.770.10, 1 hit
InterProiView protein in InterPro
IPR002202 HMG_CoA_Rdtase
IPR023074 HMG_CoA_Rdtase_cat_sf
IPR023076 HMG_CoA_Rdtase_CS
IPR004554 HMG_CoA_Rdtase_eu_arc
IPR004816 HMG_CoA_Rdtase_metazoan
IPR023282 HMG_CoA_Rdtase_N
IPR009023 HMG_CoA_Rdtase_NAD(P)-bd_sf
IPR009029 HMG_CoA_Rdtase_sub-bd_dom_sf
IPR000731 SSD
PANTHERiPTHR10572 PTHR10572, 1 hit
PfamiView protein in Pfam
PF00368 HMG-CoA_red, 1 hit
PF12349 Sterol-sensing, 1 hit
PRINTSiPR00071 HMGCOARDTASE
SUPFAMiSSF55035 SSF55035, 1 hit
SSF56542 SSF56542, 1 hit
TIGRFAMsiTIGR00920 2A060605, 1 hit
TIGR00533 HMG_CoA_R_NADP, 1 hit
PROSITEiView protein in PROSITE
PS00066 HMG_COA_REDUCTASE_1, 1 hit
PS00318 HMG_COA_REDUCTASE_2, 1 hit
PS01192 HMG_COA_REDUCTASE_3, 1 hit
PS50065 HMG_COA_REDUCTASE_4, 1 hit
PS50156 SSD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHMDH_HUMAN
AccessioniPrimary (citable) accession number: P04035
Secondary accession number(s): B7Z3Y9, Q8N190
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: November 1, 1986
Last modified: November 7, 2018
This is version 216 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again