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Protein

Envelope protein F13

Gene

VACWR052

Organism
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Envelope protein associated with the inner side of the enveloped virion (EV) membrane.

GO - Molecular functioni

GO - Biological processi

  • viral budding from Golgi membrane Source: UniProtKB
  • viral budding via host ESCRT complex Source: UniProtKB

Keywordsi

Biological processHost-virus interaction, Viral budding, Viral budding via the host ESCRT complexes, Viral release from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope protein F13
Alternative name(s):
37 kDa protein
Palmitoylated EV membrane protein
p37K
Gene namesi
Ordered Locus Names:VACWR052
ORF Names:F13L
OrganismiVaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Taxonomic identifieri10254 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000000344 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  • host cell endoplasmic reticulum membrane Source: UniProtKB
  • viral envelope Source: UniProtKB-KW
  • viral membrane Source: UniProtKB
  • virion membrane Source: UniProtKB-SubCell

Keywords - Cellular componenti

Host endoplasmic reticulum, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000991981 – 372Envelope protein F13Add BLAST372

Post-translational modificationi

Palmitoylated.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PRIDEiP04021

PTM databases

SwissPalmiP04021

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
VACWR156P686172EBI-7736497,EBI-7133633

Protein-protein interaction databases

IntActiP04021, 2 interactors
MINTiP04021

Structurei

3D structure databases

ProteinModelPortaliP04021
SMRiP04021
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini307 – 334PLD phosphodiesterasePROSITE-ProRule annotationAdd BLAST28

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi153 – 156YPPL4

Domaini

Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. F13 contains one L domain: a YPPL motif, which might interact with PDCD6IP/AIP1.1 Publication

Phylogenomic databases

OrthoDBiVOG090000AW

Family and domain databases

InterProiView protein in InterPro
IPR032803 PLDc_3
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF00614 PLDc, 1 hit
PF13918 PLDc_3, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
PROSITEiView protein in PROSITE
PS50035 PLD, 1 hit

Sequencei

Sequence statusi: Complete.

P04021-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWPFASVPAG AKCRLVETLP ENMDFRSDHL TTFECFNEII TLAKKYIYIA
60 70 80 90 100
SFCCNPLSTT RGALIFDKLK EASEKGIKII VLLDERGKRN LGELQSHCPD
110 120 130 140 150
INFITVNIDK KNNVGLLLGC FWVSDDERCY VGNASFTGGS IHTIKTLGVY
160 170 180 190 200
SDYPPLATDL RRRFDTFKAF NSAKNSWLNL CSAACCLPVS TAYHIKNPIG
210 220 230 240 250
GVFFTDSPEH LLGYSRDLDT DVVIDKLKSA KTSIDIEHLA IVPTTRVDGN
260 270 280 290 300
SYYWPDIYNS IIEAAINRGV KIRLLVGNWD KNDVYSMATA RSLDALCVQN
310 320 330 340 350
DLSVKVFTIQ NNTKLLIVDD EYVHITSANF DGTHYQNHGF VSFNSIDKQL
360 370
VSEAKKIFER DWVSSHSKSL KI
Length:372
Mass (Da):41,796
Last modified:October 23, 1986 - v1
Checksum:i27AE138A382EE934
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12882 Genomic DNA Translation: AAA48235.1
AY243312 Genomic DNA Translation: AAO89331.1
PIRiA03869 WMVZ37
RefSeqiYP_232934.1, NC_006998.1

Genome annotation databases

GeneIDi3707509
KEGGivg:3707509

Similar proteinsi

Entry informationi

Entry nameiF13_VACCW
AccessioniPrimary (citable) accession number: P04021
Secondary accession number(s): Q76ZW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: October 23, 1986
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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