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Protein

Glial fibrillary acidic protein

Gene

Gfap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: MGI
  • integrin binding Source: MGI
  • kinase binding Source: MGI
  • structural constituent of cytoskeleton Source: MGI
  • structural molecule activity Source: MGI

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glial fibrillary acidic protein
Short name:
GFAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gfap
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:95697 Gfap

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Intermediate filament

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000638061 – 430Glial fibrillary acidic proteinAdd BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei7Phosphothreonine; by AURKB and ROCK1By similarity1
Modified residuei11Omega-N-methylarginineCombined sources1
Modified residuei12Phosphoserine; by AURKB and ROCK1By similarity1
Modified residuei20Omega-N-methylarginineCombined sources1
Modified residuei33CitrullineBy similarity1
Modified residuei35Phosphoserine; by AURKB and ROCK1By similarity1
Modified residuei40PhosphothreonineCombined sources1
Modified residuei79PhosphoserineBy similarity1
Modified residuei107PhosphothreonineBy similarity1
Modified residuei147PhosphothreonineBy similarity1
Modified residuei266PhosphoserineBy similarity1
Modified residuei267CitrullineBy similarity1
Modified residuei320PhosphoserineBy similarity1
Modified residuei380PhosphothreonineBy similarity1
Modified residuei382PhosphoserineBy similarity1
Modified residuei403CitrullineBy similarity1
Modified residuei413CitrullineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by PKN1.By similarity

Keywords - PTMi

Citrullination, Methylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P03995

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P03995

PeptideAtlas

More...
PeptideAtlasi
P03995

PRoteomics IDEntifications database

More...
PRIDEi
P03995

2D gel databases

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P03995

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P03995

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P03995

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain; isoform 2 expressed at 20-fold lower level than isoform 1.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000020932 Expressed in 136 organ(s), highest expression level in cranial nerve II

CleanEx database of gene expression profiles

More...
CleanExi
MM_GFAP

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P03995 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SYNM.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
199899, 6 interactors

Database of interacting proteins

More...
DIPi
DIP-1084N

Protein interaction database and analysis system

More...
IntActi
P03995, 6 interactors

Molecular INTeraction database

More...
MINTi
P03995

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000064691

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P03995

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P03995

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini66 – 374IF rodPROSITE-ProRule annotationAdd BLAST309

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 69HeadAdd BLAST69
Regioni70 – 101Coil 1AAdd BLAST32
Regioni102 – 112Linker 1Add BLAST11
Regioni113 – 211Coil 1BAdd BLAST99
Regioni212 – 227Linker 12Add BLAST16
Regioni228 – 249Coil 2AAdd BLAST22
Regioni250 – 253Linker 24
Regioni254 – 374Coil 2BAdd BLAST121
Regioni375 – 430TailAdd BLAST56

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJXF Eukaryota
ENOG410Y9QE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159539

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG013015

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P03995

KEGG Orthology (KO)

More...
KOi
K05640

Identification of Orthologs from Complete Genome Data

More...
OMAi
AQQVHVD

Database of Orthologous Groups

More...
OrthoDBi
EOG091G12MK

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P03995

TreeFam database of animal gene trees

More...
TreeFami
TF330122

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027701 GFAP
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR006821 Intermed_filament_DNA-bd

The PANTHER Classification System

More...
PANTHERi
PTHR23239 PTHR23239, 1 hit
PTHR23239:SF41 PTHR23239:SF41, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00038 Filament, 1 hit
PF04732 Filament_head, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01391 Filament, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P03995-1) [UniParc]FASTAAdd to basket
Also known as: GFAP alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERRRITSAR RSYASETVVR GLGPSRQLGT MPRFSLSRMT PPLPARVDFS
60 70 80 90 100
LAGALNAGFK ETRASERAEM MELNDRFASY IEKVRFLEQQ NKALAAELNQ
110 120 130 140 150
LRAKEPTKLA DVYQAELREL RLRLDQLTAN SARLEVERDN FAQDLGTLRQ
160 170 180 190 200
KLQDETNLRL EAENNLAAYR QEADEATLAR VDLERKVESL EEEIQFLRKI
210 220 230 240 250
YEEEVRELRE QLAQQQVHVE MDVAKPDLTA ALREIRTQYE AVATSNMQET
260 270 280 290 300
EEWYRSKFAD LTDAASRNAE LLRQAKHEAN DYRRQLQALT CDLESLRGTN
310 320 330 340 350
ESLERQMREQ EERHARESAS YQEALARLEE EGQSLKEEMA RHLQEYQDLL
360 370 380 390 400
NVKLALDIEI ATYRKLLEGE ENRITIPVQT FSNLQIRETS LDTKSVSEGH
410 420 430
LKRNIVVKTV EMRDGEVIKD SKQEHKDVVM
Length:430
Mass (Da):49,900
Last modified:May 1, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC0FB500AE1588377
GO
Isoform 2 (identifier: P03995-2) [UniParc]FASTAAdd to basket
Also known as: GFAP epsilon

The sequence of this isoform differs from the canonical sequence as follows:
     388-430: ETSLDTKSVS...SKQEHKDVVM → GGKSTKEGEG...IENGALPALP

Show »
Length:428
Mass (Da):49,365
Checksum:i778B9A6A8FDBA6D3
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA26571 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti141F → L in AAP33501 (Ref. 5) Curated1
Sequence conflicti141F → L in AAK56091 (PubMed:11471062).Curated1
Sequence conflicti174D → H in CAA26571 (PubMed:2994002).Curated1
Sequence conflicti174D → H in AAA37678 (PubMed:6585825).Curated1
Sequence conflicti174D → H in AAA37679 (PubMed:3866511).Curated1
Sequence conflicti174D → H in ABI54133 (Ref. 13) Curated1
Sequence conflicti180R → S in BAE24257 (PubMed:16141072).Curated1
Sequence conflicti207E → D in CAA26571 (PubMed:2994002).Curated1
Sequence conflicti207E → D in AAA37678 (PubMed:6585825).Curated1
Sequence conflicti207E → D in AAA37679 (PubMed:3866511).Curated1
Sequence conflicti347Q → H in CAA26571 (PubMed:2994002).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017053388 – 430ETSLD…KDVVM → GGKSTKEGEGQKVTRPLKRL TIQVVPIQAHQIENGALPAL P in isoform 2. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X02801 Genomic DNA Translation: CAA26571.1 Different initiation.
AK140151 mRNA Translation: BAE24257.1
AL731670 Genomic DNA Translation: CAM25115.1
AY279974 Genomic DNA Translation: AAP33501.1
X78141 Genomic DNA Translation: CAA55020.1
BC100728 mRNA Translation: AAI00729.1
BC100737 mRNA Translation: AAI00738.1
BC101968 mRNA Translation: AAI01969.1
BC103571 mRNA Translation: AAI03572.1
BC139357 mRNA Translation: AAI39358.1
BC139358 mRNA Translation: AAI39359.1
K01347 mRNA Translation: AAA37678.1
M25937 mRNA Translation: AAA37679.1
AF332061 mRNA Translation: AAK56090.1
AF332062 mRNA Translation: AAK56091.1
EF101554 mRNA Translation: ABK96803.1
DQ887822 mRNA Translation: ABI54133.1
AY142200 Genomic DNA Translation: AAN87913.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS25507.1 [P03995-1]
CCDS48950.1 [P03995-2]

Protein sequence database of the Protein Information Resource

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PIRi
B60052 VEMSGF

NCBI Reference Sequences

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RefSeqi
NP_001124492.1, NM_001131020.1 [P03995-2]
NP_034407.2, NM_010277.3 [P03995-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.1239

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000067444; ENSMUSP00000064691; ENSMUSG00000020932 [P03995-1]
ENSMUST00000077902; ENSMUSP00000077061; ENSMUSG00000020932 [P03995-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
14580

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:14580

UCSC genome browser

More...
UCSCi
uc007lsw.2 mouse [P03995-1]
uc007lsx.2 mouse [P03995-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02801 Genomic DNA Translation: CAA26571.1 Different initiation.
AK140151 mRNA Translation: BAE24257.1
AL731670 Genomic DNA Translation: CAM25115.1
AY279974 Genomic DNA Translation: AAP33501.1
X78141 Genomic DNA Translation: CAA55020.1
BC100728 mRNA Translation: AAI00729.1
BC100737 mRNA Translation: AAI00738.1
BC101968 mRNA Translation: AAI01969.1
BC103571 mRNA Translation: AAI03572.1
BC139357 mRNA Translation: AAI39358.1
BC139358 mRNA Translation: AAI39359.1
K01347 mRNA Translation: AAA37678.1
M25937 mRNA Translation: AAA37679.1
AF332061 mRNA Translation: AAK56090.1
AF332062 mRNA Translation: AAK56091.1
EF101554 mRNA Translation: ABK96803.1
DQ887822 mRNA Translation: ABI54133.1
AY142200 Genomic DNA Translation: AAN87913.1
CCDSiCCDS25507.1 [P03995-1]
CCDS48950.1 [P03995-2]
PIRiB60052 VEMSGF
RefSeqiNP_001124492.1, NM_001131020.1 [P03995-2]
NP_034407.2, NM_010277.3 [P03995-1]
UniGeneiMm.1239

3D structure databases

ProteinModelPortaliP03995
SMRiP03995
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199899, 6 interactors
DIPiDIP-1084N
IntActiP03995, 6 interactors
MINTiP03995
STRINGi10090.ENSMUSP00000064691

PTM databases

iPTMnetiP03995
PhosphoSitePlusiP03995

2D gel databases

UCD-2DPAGEiP03995

Proteomic databases

MaxQBiP03995
PaxDbiP03995
PeptideAtlasiP03995
PRIDEiP03995

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067444; ENSMUSP00000064691; ENSMUSG00000020932 [P03995-1]
ENSMUST00000077902; ENSMUSP00000077061; ENSMUSG00000020932 [P03995-2]
GeneIDi14580
KEGGimmu:14580
UCSCiuc007lsw.2 mouse [P03995-1]
uc007lsx.2 mouse [P03995-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2670
MGIiMGI:95697 Gfap

Phylogenomic databases

eggNOGiENOG410IJXF Eukaryota
ENOG410Y9QE LUCA
GeneTreeiENSGT00940000159539
HOVERGENiHBG013015
InParanoidiP03995
KOiK05640
OMAiAQQVHVD
OrthoDBiEOG091G12MK
PhylomeDBiP03995
TreeFamiTF330122

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P03995

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000020932 Expressed in 136 organ(s), highest expression level in cranial nerve II
CleanExiMM_GFAP
GenevisibleiP03995 MM

Family and domain databases

InterProiView protein in InterPro
IPR027701 GFAP
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR006821 Intermed_filament_DNA-bd
PANTHERiPTHR23239 PTHR23239, 1 hit
PTHR23239:SF41 PTHR23239:SF41, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF04732 Filament_head, 1 hit
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGFAP_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P03995
Secondary accession number(s): A1E2H7
, A2AH87, B2RTI7, Q09J71, Q3USS4, Q496R4, Q496S3, Q7TQ30, Q80VX6, Q925K2, Q925K3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: May 1, 2007
Last modified: December 5, 2018
This is version 166 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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