Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

HLA class I histocompatibility antigen, B-27 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  • peptide antigen binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processImmunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-27 alpha chain
Alternative name(s):
MHC class I antigen B*27
Gene namesi
Name:HLA-B
Synonyms:HLAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4932 HLA-B
MIMi142830 gene
neXtProtiNX_P03989

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 308ExtracellularSequence analysisAdd BLAST284
Transmembranei309 – 332HelicalSequence analysisAdd BLAST24
Topological domaini333 – 362CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Involvement in diseasei

Spondyloarthropathy 1 (SPDA1)
Disease susceptibility is associated with variations affecting the gene represented in this entry. A restricted number of HLA-B27 subtypes can be associated with ankylosing spondylitis and other B27-related diseases, and an elevated frequency of the B*2702 allele in ankylosing spondylitis patients is identified. The allele B*2707 seems to have a protective role some populations because it was found only in the healthy controls.
Disease descriptionA chronic rheumatic disease with multifactorial inheritance. It includes a spectrum of related disorders comprising ankylosing spondylitis, a subset of psoriatic arthritis, reactive arthritis (e.g. Reiter syndrome), arthritis associated with inflammatory bowel disease and undifferentiated spondyloarthropathy. These disorders may occur simultaneously or sequentially in the same patient, probably representing various phenotypic expressions of the same disease. Ankylosing spondylitis is the form of rheumatoid arthritis affecting the spine and is considered the prototype of seronegative spondyloarthropathies. It produces pain and stiffness as a result of inflammation of the sacroiliac, intervertebral, and costovertebral joints.
See also OMIM:106300

Organism-specific databases

DisGeNETi3106
MalaCardsiHLA-B
MIMi106300 phenotype

Chemistry databases

DrugBankiDB04464 N-Formylmethionine

Polymorphism and mutation databases

DMDMi34305677

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000001883925 – 362HLA class I histocompatibility antigen, B-27 alpha chainAdd BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi125 ↔ 188
Disulfide bondi227 ↔ 283

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PeptideAtlasiP03989
PRIDEiP03989

PTM databases

iPTMnetiP03989
SwissPalmiP03989

Expressioni

Gene expression databases

CleanExiHS_HLA-B

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).By similarity

Binary interactionsi

Protein-protein interaction databases

DIPiDIP-6188N
IntActiP03989, 6 interactors
MINTiP03989

Structurei

Secondary structure

1362
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP03989
SMRiP03989
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03989

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-like C1-typeAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 308Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709
OrthoDBiEOG091G09OH
PhylomeDBiP03989

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 54 potential isoforms that are computationally mapped.Show allAlign All

P03989-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVTAPRTLL LLLWGAVALT ETWAGSHSMR YFHTSVSRPG RGEPRFITVG
60 70 80 90 100
YVDDTLFVRF DSDAASPREE PRAPWIEQEG PEYWDRETQI CKAKAQTDRE
110 120 130 140 150
DLRTLLRYYN QSEAGSHTLQ NMYGCDVGPD GRLLRGYHQD AYDGKDYIAL
160 170 180 190 200
NEDLSSWTAA DTAAQITQRK WEAARVAEQL RAYLEGECVE WLRRYLENGK
210 220 230 240 250
ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,428
Last modified:August 13, 1987 - v2
Checksum:iC8D2F154E3292031
GO

Computationally mapped potential isoform sequencesi

There are 54 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P018891B07_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
P304601B08_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
Q048261B40_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
P304751B39_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
Q953651B38_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
P304861B48_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
Q298361B67_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
P304641B15_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
Q316101B81_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
P304801B42_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti206A → V (PubMed:3485286).Curated1
Sequence conflicti266Q → E AA sequence (PubMed:2408663).Curated1

Polymorphismi

The following alleles of B-27 are known: B*27:01=B*27:05, B*27:02 (B27.2; B-27k; B27e), B*27:03 (B27d), B*27:04, B*27:06, B*27:07, B*27:08 (B7Qui) and B*27:09 (B27-ci). The sequence shown is that of B*27:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05634165A → TCombined sourcesCorresponds to variant dbSNP:rs1050529Ensembl.1
Natural variantiVAR_01637983Y → H in allele B*27:03. 1
Natural variantiVAR_016380101D → N in allele B*27:02. 1
Natural variantiVAR_016381101D → S in allele B*27:04, allele B*27:06 and allele B*27:08; requires 2 nucleotide substitutions. 1
Natural variantiVAR_016382104 – 105TL → IA in allele B*27:02. 2
Natural variantiVAR_016383104T → N in allele B*27:08. 1
Natural variantiVAR_016384106 – 107LR → RG in allele B*27:08. 2
Natural variantiVAR_016385121N → S in allele B*27:07. 1
Natural variantiVAR_016386137 – 138YH → HN in allele B*27:07. 2
Natural variantiVAR_016387138H → D in allele B*27:06. 1
Natural variantiVAR_016388140D → H in allele B*27:09. 1
Natural variantiVAR_016389140D → Y in allele B*27:06 and allele B*27:07. 1
Natural variantiVAR_016390155S → R in allele B*27:07. 1
Natural variantiVAR_016391176V → E in allele B*27:04 and allele B*27:06. 1
Natural variantiVAR_016392235A → G in allele B*27:04 and allele B*27:06. 1
Natural variantiVAR_056342306V → I. Corresponds to variant dbSNP:rs1131500Ensembl.1
Natural variantiVAR_056343329A → T. Corresponds to variant dbSNP:rs1051488Ensembl.1
Natural variantiVAR_061402349C → S. Corresponds to variant dbSNP:rs2308655Ensembl.1
Natural variantiVAR_061403349C → Y. Corresponds to variant dbSNP:rs2308655Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03945 Genomic DNA Translation: CAA27578.1 Sequence problems.
X03664, X03667 Genomic DNA Translation: CAA27301.1
L38504 mRNA Translation: AAA69724.1
M54883 Genomic DNA Translation: AAA59616.1
X03665, X03666 Genomic DNA Translation: CAA27302.1
M12967 Genomic DNA Translation: AAA36221.1
U27608 mRNA Translation: AAC50444.1
U35734 mRNA Translation: AAC50447.1
M14013 Genomic DNA Translation: AAA59643.1
X73578 mRNA Translation: CAA51980.1
M62852 mRNA Translation: AAA59647.1
L19923 mRNA Translation: AAA59658.1
Z33453 mRNA Translation: CAA83876.1
PIRiI37515
I56116
S07441 HLHUB2
UniGeneiHs.654404
Hs.726974
Hs.77961

Genome annotation databases

EnsembliENST00000435618; ENSP00000405178; ENSG00000224608

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03945 Genomic DNA Translation: CAA27578.1 Sequence problems.
X03664, X03667 Genomic DNA Translation: CAA27301.1
L38504 mRNA Translation: AAA69724.1
M54883 Genomic DNA Translation: AAA59616.1
X03665, X03666 Genomic DNA Translation: CAA27302.1
M12967 Genomic DNA Translation: AAA36221.1
U27608 mRNA Translation: AAC50444.1
U35734 mRNA Translation: AAC50447.1
M14013 Genomic DNA Translation: AAA59643.1
X73578 mRNA Translation: CAA51980.1
M62852 mRNA Translation: AAA59647.1
L19923 mRNA Translation: AAA59658.1
Z33453 mRNA Translation: CAA83876.1
PIRiI37515
I56116
S07441 HLHUB2
UniGeneiHs.654404
Hs.726974
Hs.77961

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HSAX-ray2.10A/D25-300[»]
1JGDX-ray1.90A25-300[»]
1JGEX-ray2.10A25-300[»]
1K5NX-ray1.09A25-300[»]
1OF2X-ray2.20A25-300[»]
1OGTX-ray1.47A25-300[»]
1ROGmodel-A25-206[»]
1ROHmodel-A25-206[»]
1ROImodel-A25-206[»]
1ROJmodel-A25-206[»]
1ROKmodel-A25-206[»]
1ROLmodel-A25-206[»]
1UXSX-ray1.55A25-300[»]
1UXWX-ray1.71A25-300[»]
1W0VX-ray2.27A25-300[»]
1W0WX-ray2.10A25-300[»]
2A83X-ray1.40A25-300[»]
2BSRX-ray2.30A25-300[»]
2BSSX-ray2.00A25-300[»]
2BSTX-ray2.10A25-300[»]
3B3IX-ray1.86A25-300[»]
3B6SX-ray1.80A25-300[»]
3BP4X-ray1.85A25-300[»]
3BP7X-ray1.80A25-300[»]
3CZFX-ray1.20A25-300[»]
3D18X-ray1.74A25-300[»]
3DTXX-ray2.10A25-300[»]
3HCVX-ray1.95A25-300[»]
3LV3X-ray1.94A25-300[»]
4G8GX-ray2.40A25-300[»]
4G8IX-ray1.60A25-300[»]
4G9DX-ray1.60A25-300[»]
4G9FX-ray1.90A25-300[»]
5DEFX-ray1.60A25-300[»]
5DEGX-ray1.83A25-300[»]
5IB1X-ray1.91A25-300[»]
5IB2X-ray1.44A25-300[»]
5IB3X-ray1.91A25-300[»]
5IB4X-ray1.95A25-300[»]
5IB5X-ray2.49A/D25-300[»]
ProteinModelPortaliP03989
SMRiP03989
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6188N
IntActiP03989, 6 interactors
MINTiP03989

Chemistry databases

DrugBankiDB04464 N-Formylmethionine

PTM databases

iPTMnetiP03989
SwissPalmiP03989

Polymorphism and mutation databases

DMDMi34305677

Proteomic databases

PeptideAtlasiP03989
PRIDEiP03989

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000435618; ENSP00000405178; ENSG00000224608

Organism-specific databases

DisGeNETi3106
GeneCardsiHLA-B
HGNCiHGNC:4932 HLA-B
MalaCardsiHLA-B
MIMi106300 phenotype
142830 gene
neXtProtiNX_P03989
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG016709
OrthoDBiEOG091G09OH
PhylomeDBiP03989

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Miscellaneous databases

ChiTaRSiHLA-B human
EvolutionaryTraceiP03989
SOURCEiSearch...

Gene expression databases

CleanExiHS_HLA-B

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei1B27_HUMAN
AccessioniPrimary (citable) accession number: P03989
Secondary accession number(s): O19692
, P10317, P10318, P19373, P30467, Q08136, Q29693, Q29846, Q29961
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: August 13, 1987
Last modified: September 12, 2018
This is version 186 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again