UniProtKB - P03972 (MIS_BOVIN)
Protein
Muellerian-inhibiting factor
Gene
AMH
Organism
Bos taurus (Bovine)
Status
Functioni
This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.
Miscellaneous
Although it does not compete with EGF for receptor binding sites, MIS can inhibit the autophosphorylation of the EGF receptor in vitro.
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- gonadal mesoderm development Source: UniProtKB-KW
- Mullerian duct regression Source: GO_Central
- urogenital system development Source: GO_Central
Keywordsi
Molecular function | Growth factor |
Biological process | Differentiation, Gonadal differentiation |
Names & Taxonomyi
Protein namesi | Recommended name: Muellerian-inhibiting factorAlternative name(s): Anti-Muellerian hormone Short name: AMH Muellerian-inhibiting substance Short name: MIS |
Gene namesi | Name:AMH |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
PropeptideiPRO_0000033744 | 18 – 24 | Sequence analysis | 7 | |
ChainiPRO_0000033745 | 25 – 575 | Muellerian-inhibiting factorAdd BLAST | 551 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 78 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 344 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 477 ↔ 541 | By similarity | ||
Disulfide bondi | 503 ↔ 572 | By similarity | ||
Disulfide bondi | 507 ↔ 574 | By similarity | ||
Disulfide bondi | 540 | InterchainBy similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P03972 |
PRIDEi | P03972 |
Interactioni
Subunit structurei
Homodimer; disulfide-linked.
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000019912 |
Family & Domainsi
Sequence similaritiesi
Belongs to the TGF-beta family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3900, Eukaryota |
InParanoidi | P03972 |
OrthoDBi | 516965at2759 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR006799, AMH_N IPR029034, Cystine-knot_cytokine IPR021203, Muellerian-inhibiting_factor IPR001839, TGF-b_C IPR017948, TGFb_CS |
PANTHERi | PTHR15009, PTHR15009, 1 hit |
Pfami | View protein in Pfam PF04709, AMH_N, 1 hit PF00019, TGF_beta, 1 hit |
PIRSFi | PIRSF037270, Muellerian-inhibiting_factor, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P03972-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPGPSLSLAL VLSAMGALLR PGTPREEVFS TSALPREQAT GSGALIFQQA
60 70 80 90 100
WDWPLSSLWL PGSPLDPLCL VTLHGSGNGS RAPLRVVGVL SSYEQAFLEA
110 120 130 140 150
VRRTHWGLSD LTTFAVCPAG NGQPVLPHLQ RLQAWLGEPG GRWLVVLHLE
160 170 180 190 200
EVTWEPTPLL RFQEPPPGGA SPPELALLVV YPGPGLEVTV TGAGLPGTQS
210 220 230 240 250
LCLTADSDFL ALVVDHPEGA WRRPGLALTL RRRGNGALLS TAQLQALLFG
260 270 280 290 300
ADSRCFTRKT PALLLLLPAR SSAPMPAHGR LDLVPFPQPR ASPEPEEAPP
310 320 330 340 350
SADPFLETLT RLVRALAGPP ARASPPRLAL DPGALAGFPQ GQVNLSDPAA
360 370 380 390 400
LERLLDGEEP LLLLLPPTAA TTGVPATPQG PKSPLWAAGL ARRVAAELQA
410 420 430 440 450
VAAELRALPG LPPAAPPLLA RLLALCPGNP DSPGGPLRAL LLLKALQGLR
460 470 480 490 500
AEWRGRERSG SARAQRSAGA AAADGPCALR ELSVDLRAER SVLIPETYQA
510 520 530 540 550
NNCQGACGWP QSDRNPRYGN HVVLLLKMQA RGATLARPPC CVPTAYTGKL
560 570
LISLSEERIS AHHVPNMVAT ECGCR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M13151 Genomic DNA Translation: AAA98765.1 |
PIRi | A01398, WFBOM |
RefSeqi | NP_776315.1, NM_173890.1 |
Genome annotation databases
GeneIDi | 280718 |
KEGGi | bta:280718 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M13151 Genomic DNA Translation: AAA98765.1 |
PIRi | A01398, WFBOM |
RefSeqi | NP_776315.1, NM_173890.1 |
3D structure databases
SMRi | P03972 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000019912 |
Proteomic databases
PaxDbi | P03972 |
PRIDEi | P03972 |
Genome annotation databases
GeneIDi | 280718 |
KEGGi | bta:280718 |
Organism-specific databases
CTDi | 268 |
Phylogenomic databases
eggNOGi | KOG3900, Eukaryota |
InParanoidi | P03972 |
OrthoDBi | 516965at2759 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR006799, AMH_N IPR029034, Cystine-knot_cytokine IPR021203, Muellerian-inhibiting_factor IPR001839, TGF-b_C IPR017948, TGFb_CS |
PANTHERi | PTHR15009, PTHR15009, 1 hit |
Pfami | View protein in Pfam PF04709, AMH_N, 1 hit PF00019, TGF_beta, 1 hit |
PIRSFi | PIRSF037270, Muellerian-inhibiting_factor, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MIS_BOVIN | |
Accessioni | P03972Primary (citable) accession number: P03972 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 1986 |
Last sequence update: | October 23, 1986 | |
Last modified: | December 2, 2020 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families