Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 186 (08 May 2019)
Sequence version 3 (30 Nov 2010)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Muellerian-inhibiting factor

Gene

AMH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.

Miscellaneous

Although it does not compete with EGF for receptor binding sites, MIS can inhibit the autophosphorylation of the EGF receptor in vitro.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor
Biological processDifferentiation, Gonadal differentiation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-201451 Signaling by BMP

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P03971

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P03971

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Muellerian-inhibiting factor
Alternative name(s):
Anti-Muellerian hormone
Short name:
AMH
Muellerian-inhibiting substance
Short name:
MIS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AMH
Synonyms:MIF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:464 AMH

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600957 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P03971

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Persistent Muellerian duct syndrome 1 (PMDS1)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00748312V → G in PMDS1. 1 PublicationCorresponds to variant dbSNP:rs149082963EnsemblClinVar.1
Natural variantiVAR_00748570L → P in PMDS1. 1 Publication1
Natural variantiVAR_007486101G → V in PMDS1. 1 Publication1
Natural variantiVAR_007487123R → W in PMDS1. 1 PublicationCorresponds to variant dbSNP:rs569914235Ensembl.1
Natural variantiVAR_007488167Y → C in PMDS1. 1 PublicationCorresponds to variant dbSNP:rs371874189Ensembl.1
Natural variantiVAR_007490194R → C in PMDS1. 1 PublicationCorresponds to variant dbSNP:rs777003373Ensembl.1
Natural variantiVAR_007492477V → A in PMDS1. 1 PublicationCorresponds to variant dbSNP:rs1358787117Ensembl.1
Natural variantiVAR_031027506H → Q in PMDS1. 1 PublicationCorresponds to variant dbSNP:rs138571039Ensembl.1
Natural variantiVAR_031028525C → Y in PMDS1. 1 Publication1

Keywords - Diseasei

Disease mutation, Pseudohermaphroditism

Organism-specific databases

DisGeNET

More...
DisGeNETi
268

MalaCards human disease database

More...
MalaCardsi
AMH
MIMi261550 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000104899

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2856 Persistent Muellerian duct syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24769

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AMH

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104218

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000003374619 – 25Sequence analysis7
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003374726 – 560Muellerian-inhibiting factorAdd BLAST535

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi329N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi462 ↔ 526By similarity
Disulfide bondi488 ↔ 557By similarity
Disulfide bondi492 ↔ 559By similarity
Disulfide bondi525InterchainBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P03971

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P03971

PeptideAtlas

More...
PeptideAtlasi
P03971

PRoteomics IDEntifications database

More...
PRIDEi
P03971

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51624

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P03971

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P03971

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000104899 Expressed in 89 organ(s), highest expression level in cerebellar hemisphere

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P03971 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA066973

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106765, 5 interactors

Protein interaction database and analysis system

More...
IntActi
P03971, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000221496

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P03971

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3900 Eukaryota
ENOG410XT8Z LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006337

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113593

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P03971

KEGG Orthology (KO)

More...
KOi
K04665

Identification of Orthologs from Complete Genome Data

More...
OMAi
DPAPLHD

Database of Orthologous Groups

More...
OrthoDBi
516965at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P03971

TreeFam database of animal gene trees

More...
TreeFami
TF335595

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006799 AMH_N
IPR029034 Cystine-knot_cytokine
IPR021203 Muellerian-inhibiting_factor
IPR001839 TGF-b_C
IPR017948 TGFb_CS

The PANTHER Classification System

More...
PANTHERi
PTHR15009 PTHR15009, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04709 AMH_N, 1 hit
PF00019 TGF_beta, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037270 Muellerian-inhibiting_factor, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00204 TGFB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57501 SSF57501, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P03971-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRDLPLTSLA LVLSALGALL GTEALRAEEP AVGTSGLIFR EDLDWPPGSP
60 70 80 90 100
QEPLCLVALG GDSNGSSSPL RVVGALSAYE QAFLGAVQRA RWGPRDLATF
110 120 130 140 150
GVCNTGDRQA ALPSLRRLGA WLRDPGGQRL VVLHLEEVTW EPTPSLRFQE
160 170 180 190 200
PPPGGAGPPE LALLVLYPGP GPEVTVTRAG LPGAQSLCPS RDTRYLVLAV
210 220 230 240 250
DRPAGAWRGS GLALTLQPRG EDSRLSTARL QALLFGDDHR CFTRMTPALL
260 270 280 290 300
LLPRSEPAPL PAHGQLDTVP FPPPRPSAEL EESPPSADPF LETLTRLVRA
310 320 330 340 350
LRVPPARASA PRLALDPDAL AGFPQGLVNL SDPAALERLL DGEEPLLLLL
360 370 380 390 400
RPTAATTGDP APLHDPTSAP WATALARRVA AELQAAAAEL RSLPGLPPAT
410 420 430 440 450
APLLARLLAL CPGGPGGLGD PLRALLLLKA LQGLRVEWRG RDPRGPGRAQ
460 470 480 490 500
RSAGATAADG PCALRELSVD LRAERSVLIP ETYQANNCQG VCGWPQSDRN
510 520 530 540 550
PRYGNHVVLL LKMQVRGAAL ARPPCCVPTA YAGKLLISLS EERISAHHVP
560
NMVATECGCR
Length:560
Mass (Da):59,195
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD05DCEE4FEDF94C2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00748312V → G in PMDS1. 1 PublicationCorresponds to variant dbSNP:rs149082963EnsemblClinVar.1
Natural variantiVAR_00748449S → I1 PublicationCorresponds to variant dbSNP:rs10407022EnsemblClinVar.1
Natural variantiVAR_00748570L → P in PMDS1. 1 Publication1
Natural variantiVAR_007486101G → V in PMDS1. 1 Publication1
Natural variantiVAR_007487123R → W in PMDS1. 1 PublicationCorresponds to variant dbSNP:rs569914235Ensembl.1
Natural variantiVAR_007488167Y → C in PMDS1. 1 PublicationCorresponds to variant dbSNP:rs371874189Ensembl.1
Natural variantiVAR_007489185Q → E. Corresponds to variant dbSNP:rs200523942Ensembl.1
Natural variantiVAR_007490194R → C in PMDS1. 1 PublicationCorresponds to variant dbSNP:rs777003373Ensembl.1
Natural variantiVAR_007491325Q → R1 PublicationCorresponds to variant dbSNP:rs140765565EnsemblClinVar.1
Natural variantiVAR_007492477V → A in PMDS1. 1 PublicationCorresponds to variant dbSNP:rs1358787117Ensembl.1
Natural variantiVAR_031027506H → Q in PMDS1. 1 PublicationCorresponds to variant dbSNP:rs138571039Ensembl.1
Natural variantiVAR_065100515V → A2 PublicationsCorresponds to variant dbSNP:rs10417628Ensembl.1
Natural variantiVAR_031028525C → Y in PMDS1. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
K03474 Genomic DNA Translation: AAA98805.1
AC005263 Genomic DNA Translation: AAC25614.1
BC049194 mRNA Translation: AAH49194.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12085.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A01397 WFHUM

NCBI Reference Sequences

More...
RefSeqi
NP_000470.2, NM_000479.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000221496; ENSP00000221496; ENSG00000104899

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
268

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:268

UCSC genome browser

More...
UCSCi
uc002lvh.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Anti-Mullerian hormone entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K03474 Genomic DNA Translation: AAA98805.1
AC005263 Genomic DNA Translation: AAC25614.1
BC049194 mRNA Translation: AAH49194.1
CCDSiCCDS12085.1
PIRiA01397 WFHUM
RefSeqiNP_000470.2, NM_000479.4

3D structure databases

SMRiP03971
ModBaseiSearch...

Protein-protein interaction databases

BioGridi106765, 5 interactors
IntActiP03971, 4 interactors
STRINGi9606.ENSP00000221496

PTM databases

iPTMnetiP03971
PhosphoSitePlusiP03971

Polymorphism and mutation databases

BioMutaiAMH
DMDMi313104218

Proteomic databases

MaxQBiP03971
PaxDbiP03971
PeptideAtlasiP03971
PRIDEiP03971
ProteomicsDBi51624

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
268
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221496; ENSP00000221496; ENSG00000104899
GeneIDi268
KEGGihsa:268
UCSCiuc002lvh.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
268
DisGeNETi268

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AMH
HGNCiHGNC:464 AMH
HPAiHPA066973
MalaCardsiAMH
MIMi261550 phenotype
600957 gene
neXtProtiNX_P03971
OpenTargetsiENSG00000104899
Orphaneti2856 Persistent Muellerian duct syndrome
PharmGKBiPA24769

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00390000006337
HOGENOMiHOG000113593
InParanoidiP03971
KOiK04665
OMAiDPAPLHD
OrthoDBi516965at2759
PhylomeDBiP03971
TreeFamiTF335595

Enzyme and pathway databases

ReactomeiR-HSA-201451 Signaling by BMP
SignaLinkiP03971
SIGNORiP03971

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
268

Protein Ontology

More...
PROi
PR:P03971

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000104899 Expressed in 89 organ(s), highest expression level in cerebellar hemisphere
GenevisibleiP03971 HS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR006799 AMH_N
IPR029034 Cystine-knot_cytokine
IPR021203 Muellerian-inhibiting_factor
IPR001839 TGF-b_C
IPR017948 TGFb_CS
PANTHERiPTHR15009 PTHR15009, 1 hit
PfamiView protein in Pfam
PF04709 AMH_N, 1 hit
PF00019 TGF_beta, 1 hit
PIRSFiPIRSF037270 Muellerian-inhibiting_factor, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMIS_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P03971
Secondary accession number(s): O75246, Q6GTN3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: November 30, 2010
Last modified: May 8, 2019
This is version 186 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again