Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Inhibin beta A chain

Gene

INHBA

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor, Hormone

Enzyme and pathway databases

ReactomeiR-SSC-1502540 Signaling by Activin
R-SSC-209822 Glycoprotein hormones
R-SSC-2473224 Antagonism of Activin by Follistatin

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin beta A chain
Alternative name(s):
Activin beta-A chain
Gene namesi
Name:INHBA
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
PropeptideiPRO_000003371221 – 3081 PublicationAdd BLAST288
ChainiPRO_0000033713309 – 424Inhibin beta A chainAdd BLAST116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi312 ↔ 320By similarity
Disulfide bondi319 ↔ 389By similarity
Disulfide bondi348 ↔ 421By similarity
Disulfide bondi352 ↔ 423By similarity
Disulfide bondi388InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP03970
PRIDEiP03970

Interactioni

Subunit structurei

Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000024268

Structurei

3D structure databases

ProteinModelPortaliP03970
SMRiP03970
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00910000143982
HOGENOMiHOG000220890
HOVERGENiHBG105613
InParanoidiP03970
KOiK04667

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR000491 Inhibin_betaA
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
PRINTSiPR00670 INHIBINBA
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P03970-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLLWLRGFL LASCWIIVRS SPTPGSGGHS AAPDCPSCAL ATLPKDVPNS
60 70 80 90 100
QPEMVEAVKK HILNMLHLKK RPDVTQPVPK AALLNAIRKL HVGKVGENGY
110 120 130 140 150
VELEDDIGRR AEMNELMEQT SEIITFAEAG TARKTLRFEI SKEGSDLSVV
160 170 180 190 200
ERAEIWLFLK VPKANRTRTK VSIRLFQQQR RPQGSADAGE EAEDVGFPEE
210 220 230 240 250
KSEVLISEKV VDARKSTWHI FPVSSSIQRL LDQGKSALDI RTACEQCHET
260 270 280 290 300
GASLVLLGKK KKKEEEAEGR KRDGEGAGVD EEKEQSHRPF LMLQARQSEE
310 320 330 340 350
HPHRRRRRGL ECDGKVNICC KKQFFVSFKD IGWNDWIIAP SGYHANYCEG
360 370 380 390 400
ECPSHIAGTS GSSLSFHSTV INHYRMRGHS PFANLKSCCV PTKLRPMSML
410 420
YYDDGQNIIK KDIQNMIVEE CGCS
Length:424
Mass (Da):47,476
Last modified:October 23, 1986 - v1
Checksum:i436BC62226FDAF52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03266 mRNA Translation: CAA27020.1
PIRiA01393 WFPGBA
RefSeqiNP_999193.1, NM_214028.1
UniGeneiSsc.52080

Genome annotation databases

EnsembliENSSSCT00000061917; ENSSSCP00000051495; ENSSSCG00000035077
GeneIDi397093
KEGGissc:397093

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03266 mRNA Translation: CAA27020.1
PIRiA01393 WFPGBA
RefSeqiNP_999193.1, NM_214028.1
UniGeneiSsc.52080

3D structure databases

ProteinModelPortaliP03970
SMRiP03970
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000024268

Proteomic databases

PaxDbiP03970
PRIDEiP03970

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000061917; ENSSSCP00000051495; ENSSSCG00000035077
GeneIDi397093
KEGGissc:397093

Organism-specific databases

CTDi3624

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00910000143982
HOGENOMiHOG000220890
HOVERGENiHBG105613
InParanoidiP03970
KOiK04667

Enzyme and pathway databases

ReactomeiR-SSC-1502540 Signaling by Activin
R-SSC-209822 Glycoprotein hormones
R-SSC-2473224 Antagonism of Activin by Follistatin

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR000491 Inhibin_betaA
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
PRINTSiPR00670 INHIBINBA
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINHBA_PIG
AccessioniPrimary (citable) accession number: P03970
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: October 23, 1986
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again