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Protein

Fibroblast growth factor 1

Gene

FGF1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis (By similarity).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Heparin-binding, Mitogen
Biological processAngiogenesis, Differentiation

Enzyme and pathway databases

ReactomeiR-BTA-109704 PI3K Cascade
R-BTA-1257604 PIP3 activates AKT signaling
R-BTA-190322 FGFR4 ligand binding and activation
R-BTA-190370 FGFR1b ligand binding and activation
R-BTA-190371 FGFR3b ligand binding and activation
R-BTA-190372 FGFR3c ligand binding and activation
R-BTA-190373 FGFR1c ligand binding and activation
R-BTA-190375 FGFR2c ligand binding and activation
R-BTA-190377 FGFR2b ligand binding and activation
R-BTA-5654219 Phospholipase C-mediated cascade: FGFR1
R-BTA-5654221 Phospholipase C-mediated cascade, FGFR2
R-BTA-5654227 Phospholipase C-mediated cascade, FGFR3
R-BTA-5654228 Phospholipase C-mediated cascade, FGFR4
R-BTA-5654687 Downstream signaling of activated FGFR1
R-BTA-5654688 SHC-mediated cascade:FGFR1
R-BTA-5654689 PI-3K cascade:FGFR1
R-BTA-5654693 FRS-mediated FGFR1 signaling
R-BTA-5654695 PI-3K cascade:FGFR2
R-BTA-5654699 SHC-mediated cascade:FGFR2
R-BTA-5654700 FRS-mediated FGFR2 signaling
R-BTA-5654704 SHC-mediated cascade:FGFR3
R-BTA-5654706 FRS-mediated FGFR3 signaling
R-BTA-5654710 PI-3K cascade:FGFR3
R-BTA-5654712 FRS-mediated FGFR4 signaling
R-BTA-5654719 SHC-mediated cascade:FGFR4
R-BTA-5654720 PI-3K cascade:FGFR4
R-BTA-5654726 Negative regulation of FGFR1 signaling
R-BTA-5654727 Negative regulation of FGFR2 signaling
R-BTA-5654732 Negative regulation of FGFR3 signaling
R-BTA-5654733 Negative regulation of FGFR4 signaling
R-BTA-5673001 RAF/MAP kinase cascade
R-BTA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 1
Short name:
FGF-1
Alternative name(s):
Acidic eye-derived growth factor II
Short name:
EDGF II
Acidic fibroblast growth factor
Short name:
aFGF
Endothelial cell growth factor
Short name:
ECGF
Heparin-binding growth factor 1
Short name:
HBGF-1
Prostatropin
Cleaved into the following 2 chains:
Gene namesi
Name:FGF1
Synonyms:AFGF, FGFA, HBGF-1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:28970 FGF1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000089042 – 155Endothelial cell growth factor betaAdd BLAST154
ChainiPRO_000000890516 – 155Fibroblast growth factor 1Add BLAST140
ChainiPRO_000000890622 – 155Endothelial cell growth factor alphaAdd BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Post-translational modificationi

In the nucleus, phosphorylated by PKC/PRKCD.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP03968

PTM databases

iPTMnetiP03968

Expressioni

Gene expression databases

BgeeiENSBTAG00000005198

Interactioni

Subunit structurei

Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu2+-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with S100A13. Interacts with FGFBP1 (By similarity). Interacts with LRRC59 (By similarity). Interacts with CSNKA, CSNKB and FIBP (By similarity). While binding with LRRC59, CSNKA and FIBP seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1 (By similarity). Interacts with SYT1 (PubMed:9712834). Forms a ternary complex with FGFR1 and ITGAV:ITGB3 and induces the recruitment of PTPN11 to the complex (By similarity).By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi158520, 1 interactor
IntActiP03968, 3 interactors
STRINGi9913.ENSBTAP00000040651

Structurei

Secondary structure

1155
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 31Combined sources5
Turni32 – 34Combined sources3
Beta strandi37 – 40Combined sources4
Beta strandi46 – 50Combined sources5
Helixi55 – 57Combined sources3
Beta strandi59 – 61Combined sources3
Beta strandi65 – 67Combined sources3
Beta strandi71 – 76Combined sources6
Beta strandi79 – 82Combined sources4
Beta strandi86 – 93Combined sources8
Helixi96 – 98Combined sources3
Beta strandi99 – 104Combined sources6
Beta strandi106 – 108Combined sources3
Beta strandi113 – 115Combined sources3
Turni116 – 121Combined sources6
Beta strandi130 – 132Combined sources3
Helixi135 – 137Combined sources3
Helixi143 – 145Combined sources3
Beta strandi147 – 150Combined sources4

3D structure databases

ProteinModelPortaliP03968
SMRiP03968
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03968

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 28Heparin-bindingSequence analysis5
Regioni113 – 116Heparin-bindingSequence analysis4

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi24 – 27Nuclear localization signalBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00730000110923
HOGENOMiHOG000236341
HOVERGENiHBG007580
InParanoidiP03968
KOiK18496
OMAiLGPRTHY
OrthoDBiEOG091G0NAY
TreeFamiTF317805

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028210 FGF1
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF86 PTHR11486:SF86, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P03968-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGETTTFT ALTEKFNLPL GNYKKPKLLY CSNGGYFLRI LPDGTVDGTK
60 70 80 90 100
DRSDQHIQLQ LCAESIGEVY IKSTETGQFL AMDTDGLLYG SQTPNEECLF
110 120 130 140 150
LERLEENHYN TYISKKHAEK HWFVGLKKNG RSKLGPRTHF GQKAILFLPL

PVSSD
Length:155
Mass (Da):17,493
Last modified:July 1, 1989 - v2
Checksum:iF636641F189F9BFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13221 mRNA Translation: CAA31610.1
X14032 mRNA Translation: CAA32192.1
M35608 mRNA Translation: AAA30517.1
BC103225 mRNA Translation: AAI03226.1
M13439 Genomic DNA Translation: AAA30516.1
X66446 mRNA Translation: CAA47063.1
M97660 mRNA Translation: AAA30563.1
M97661 mRNA Translation: AAA30564.1
PIRiJH0613 GKBOA
RefSeqiNP_001300935.1, NM_001314006.1
NP_776480.1, NM_174055.3
XP_015327761.1, XM_015472275.1
XP_015327762.1, XM_015472276.1
XP_015327763.1, XM_015472277.1
UniGeneiBt.5038

Genome annotation databases

EnsembliENSBTAT00000043056; ENSBTAP00000040651; ENSBTAG00000005198
GeneIDi281160
KEGGibta:281160

Similar proteinsi

Entry informationi

Entry nameiFGF1_BOVIN
AccessioniPrimary (citable) accession number: P03968
Secondary accession number(s): Q3ZBL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: July 1, 1989
Last modified: July 18, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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