Mycn

Functionⁱ

Positively regulates the transcription of MYCNOS in neuroblastoma cells.By similarity

GO - Molecular functionⁱ

kinase binding Source: MGI
protein dimerization activity Source: InterPro
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

branching morphogenesis of an epithelial tube
Source: MGI
Inferred from mutant phenotypeⁱ
- 15716345
cartilage condensation
Source: MGI
Inferred from mutant phenotypeⁱ
- 17360777
embryonic digit morphogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 17360777
embryonic skeletal system morphogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 17360777
lung development
Source: MGI
Inferred from mutant phenotypeⁱ
- 15716345
negative regulation of astrocyte differentiation
Source: MGI
Inferred from direct assayⁱ
- 18640244
negative regulation of gene expression Source: MGI
negative regulation of reactive oxygen species metabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 17357786
positive regulation of cell death
Source: MGI
Inferred from mutant phenotypeⁱ
- 17360777
positive regulation of cell proliferation
Source: MGI
Inferred from mutant phenotypeⁱ
- 15716345
positive regulation of gene expression Source: MGI
positive regulation of mesenchymal cell proliferation
Source: MGI
Inferred from mutant phenotypeⁱ
- 17360777
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 17357786
positive regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21047779
regulation of inner ear auditory receptor cell differentiation
Source: MGI
Inferred from genetic interactionⁱ
- 23022312

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding

Molecular function

DNA-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: N-myc proto-oncogene protein
Gene namesⁱ	Name:Mycn Synonyms:Nmyc, Nmyc1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 12

Organism-specific databases

MGIⁱ	MGI:97357 Mycn

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Proto-oncogene

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127325	1 – 462	N-myc proto-oncogene proteinAdd BLAST		462

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	259	Phosphoserine; by CK2By similarity		1
Modified residueⁱ	261	Phosphoserine; by CK2By similarity		1

Post-translational modificationⁱ

Phosphorylated by GSK3-beta which may promote its degradation. Phosphorylated by AURKA.By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	P03966
PRIDEⁱ	P03966

PTM databases

iPTMnetⁱ	P03966
PhosphoSitePlusⁱ	P03966

Expressionⁱ

Developmental stageⁱ

Expressed in the proliferating cells of the developing CNS and the epidermis. In the spinal cord at embryonic days 10.5, 11.5 and 12.5 dpc, expressed in the proliferating cells of the ventricular zone of the neural tube and is expressed at reduced levels in the intermediate zone. At 14.5 dpc, found in regions containing differentiating post-mitotic neurons. In the developing epidermis at 17 dpc, expression is restricted to primary hair germ cells only.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000037169 Expressed in 302 organ(s), highest expression level in telencephalon
ExpressionAtlasⁱ	P03966 baseline and differential
Genevisibleⁱ	P03966 MM

Interactionⁱ

Subunit structureⁱ

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with KDM5A, KDM5B and HUWE1. Interacts with MYCNOS. Interacts with AURKA; interaction is phospho-independent and triggers AURKA activation; AURKA competes with FBXW7 for binding to unphosphorylated MYCN but not for binding to unphosphorylated MYCN. Interacts with FBXW7; FBXW7 competes with AURKA for binding to unphosphorylated MYCN but not for binding to phosphorylated MYCN.By similarity

GO - Molecular functionⁱ

kinase binding Source: MGI
protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	201795, 4 interactors
Database of interacting proteins More...DIPⁱ	DIP-49592N
IntActⁱ	P03966, 4 interactors
STRINGⁱ	10090.ENSMUSP00000045993

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P03966
SMRⁱ	P03966
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	379 – 431	bHLHPROSITE-ProRule annotationAdd BLAST		53

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	19 – 47	Interaction with AURKABy similarityAdd BLAST	29
Regionⁱ	61 – 90	Interaction with AURKA and FBXW7By similarityAdd BLAST	30
Regionⁱ	431 – 452	Leucine-zipperAdd BLAST	22

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	260 – 276	Asp/Glu-rich (acidic)Add BLAST		17

Phylogenomic databases

eggNOGⁱ	ENOG410IJ8V Eukaryota ENOG41105VW LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046414
HOGENOMⁱ	HOG000043075
HOVERGENⁱ	HBG000472
InParanoidⁱ	P03966
KEGG Orthology (KO) More...KOⁱ	K09109
OMAⁱ	FAEHSSE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ZJQ
PhylomeDBⁱ	P03966
TreeFamⁱ	TF106001

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR002418 Tscrpt_reg_Myc IPR012682 Tscrpt_reg_Myc_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit PF01056 Myc_N, 1 hit
PIRSFⁱ	PIRSF001705 Myc_protein, 1 hit
PRINTSⁱ	PR00044 LEUZIPPRMYC
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P03966-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPSCTASTMP GMICKNPDLE FDSLQPCFYP DEDDFYFGGP DSTPPGEDIW 
        60         70         80         90        100
KKFELLPTPP LSPSRAFPEH SPEPSNWATE MLLPEADLWG NPAEEDAFGL 
       110        120        130        140        150
GGLGGLTPNP VILQDCMWSG FSAREKLERA VNEKLQHGHG PPGVSSACSA 
       160        170        180        190        200
PGVGASSPGG RALGGSSSAS HTGATLPTDL SHPAAECVDP AVVFPFPVNK 
       210        220        230        240        250
RESASVPAAP TSAPATSAAV TSVSVPATAP VAAPARAGGR PASSGEAKAL 
       260        270        280        290        300
STSGEDTLSD SDDEDDEEED EEEEIDVVTV EKRRSSSNNK AVTTFTITVR 
       310        320        330        340        350
PKTSALGLGR AQPGELILKR CVPIHQQHNY AAPSPYVESE DAPPQKKIKS 
       360        370        380        390        400
EASPRPLKSV VPAKAKSLSP RNSDSEDSER RRNHNILERQ RRNDLRSSFL 
       410        420        430        440        450
TLRDHVPELV KNEKAAKVVI LKKATEYVHA LQANEHQLLL EKEKLQARQQ 
       460 
QLLKKIEHAR TC

Length:462

Mass (Da):49,572

Last modified:December 15, 1998 - v2

Checksum:ⁱE7AFD3DCBCABF290

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	28 – 29	FY → LH in AAA39788 (PubMed:3513190).Curated	2
Sequence conflictⁱ	36	Y → H in AAA39788 (PubMed:3513190).Curated	1
Sequence conflictⁱ	246 – 247	EA → GT in AAA39788 (PubMed:3513190).Curated	2
Sequence conflictⁱ	313	P → L in AAA39788 (PubMed:3513190).Curated	1
Sequence conflictⁱ	390	Q → E in CAA27557 (PubMed:3015591).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M12731 Genomic DNA Translation: AAA39788.1 X03919 Genomic DNA Translation: CAA27557.1 M36277 mRNA Translation: AAA39833.1 M29208 Genomic DNA Translation: AAA39830.1 X06993 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25818.1
PIRⁱ	A01356 TVMSMC A01357 TVMSM2
NCBI Reference Sequences More...RefSeqⁱ	NP_032735.3, NM_008709.3
UniGeneⁱ	Mm.16469

Genome annotation databases

Ensemblⁱ	ENSMUST00000043396; ENSMUSP00000045993; ENSMUSG00000037169 ENSMUST00000130990; ENSMUSP00000114225; ENSMUSG00000037169
GeneIDⁱ	18109
KEGGⁱ	mmu:18109
UCSC genome browser More...UCSCⁱ	uc007nbf.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P03966	V-myc myelocytomatosis viral related oncogene, neuroblastoma derived (Avian), isoform CRA_b		MOUSE		462	UniRef100_P03966
Mycn protein		MOUSE		454

Protein	Similar proteins		Species	Score	Length	Source
P03966	N-myc proto-oncogene protein		RAT		462	UniRef90_P03966
V-myc myelocytomatosis viral related oncogene, neuroblastoma derived (Avian), isoform CRA_b		MOUSE		462
LOW QUALITY PROTEIN: N-myc proto-oncogene protein		MESAU		553
UPI000A30ED85		MUSPA		465
UPI00038C0FE2		MICOH		462
+7

Protein	Similar proteins		Species	Score	Length	Source
P03966	N-myc proto-oncogene protein	)	HUMAN		464	UniRef50_P04198
N-myc proto-oncogene protein		MARMO		460
N-myc proto-oncogene protein		RAT		462
V-myc myelocytomatosis viral oncogene-like protein		MOUSE		464
Uncharacterized protein		FELCA		467
+84

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M12731 Genomic DNA Translation: AAA39788.1 X03919 Genomic DNA Translation: CAA27557.1 M36277 mRNA Translation: AAA39833.1 M29208 Genomic DNA Translation: AAA39830.1 X06993 Genomic DNA No translation available.
CCDSⁱ	CCDS25818.1
PIRⁱ	A01356 TVMSMC A01357 TVMSM2
RefSeqⁱ	NP_032735.3, NM_008709.3
UniGeneⁱ	Mm.16469

3D structure databases

ProteinModelPortalⁱ	P03966
SMRⁱ	P03966
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	201795, 4 interactors
DIPⁱ	DIP-49592N
IntActⁱ	P03966, 4 interactors
STRINGⁱ	10090.ENSMUSP00000045993

PTM databases

iPTMnetⁱ	P03966
PhosphoSitePlusⁱ	P03966

Proteomic databases

PaxDbⁱ	P03966
PRIDEⁱ	P03966

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000043396; ENSMUSP00000045993; ENSMUSG00000037169 ENSMUST00000130990; ENSMUSP00000114225; ENSMUSG00000037169
GeneIDⁱ	18109
KEGGⁱ	mmu:18109
UCSCⁱ	uc007nbf.2 mouse

Organism-specific databases

CTDⁱ	4613
MGIⁱ	MGI:97357 Mycn

Phylogenomic databases

eggNOGⁱ	ENOG410IJ8V Eukaryota ENOG41105VW LUCA
GeneTreeⁱ	ENSGT00510000046414
HOGENOMⁱ	HOG000043075
HOVERGENⁱ	HBG000472
InParanoidⁱ	P03966
KOⁱ	K09109
OMAⁱ	FAEHSSE
OrthoDBⁱ	EOG091G0ZJQ
PhylomeDBⁱ	P03966
TreeFamⁱ	TF106001

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P03966
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000037169 Expressed in 302 organ(s), highest expression level in telencephalon
ExpressionAtlasⁱ	P03966 baseline and differential
Genevisibleⁱ	P03966 MM

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR002418 Tscrpt_reg_Myc IPR012682 Tscrpt_reg_Myc_N
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit PF01056 Myc_N, 1 hit
PIRSFⁱ	PIRSF001705 Myc_protein, 1 hit
PRINTSⁱ	PR00044 LEUZIPPRMYC
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MYCN_MOUSE
Accessionⁱ	P03966Primary (citable) accession number: P03966 Secondary accession number(s): Q61978
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 23, 1986
	Last sequence update:	December 15, 1998
	Last modified:	November 7, 2018
	This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P03966 (MYCN_MOUSE)

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N-myc proto-oncogene protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ