N-myc proto-oncogene protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
• kinase binding Source: MGI
• protein dimerization activity Source: InterPro
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI

GO - Biological processⁱ

• branching morphogenesis of an epithelial tube Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation."
    Okubo T., Knoepfler P.S., Eisenman R.N., Hogan B.L.
    Development 132:1363-1374(2005) [PubMed] [Europe PMC] [Abstract]
• cartilage condensation Source: MGIInferred from mutant phenotypeⁱ
  • "Activities of N-Myc in the developing limb link control of skeletal size with digit separation."
    Ota S., Zhou Z.Q., Keene D.R., Knoepfler P., Hurlin P.J.
    Development 134:1583-1592(2007) [PubMed] [Europe PMC] [Abstract]
• embryonic digit morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Activities of N-Myc in the developing limb link control of skeletal size with digit separation."
    Ota S., Zhou Z.Q., Keene D.R., Knoepfler P., Hurlin P.J.
    Development 134:1583-1592(2007) [PubMed] [Europe PMC] [Abstract]
• embryonic skeletal system morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Activities of N-Myc in the developing limb link control of skeletal size with digit separation."
    Ota S., Zhou Z.Q., Keene D.R., Knoepfler P., Hurlin P.J.
    Development 134:1583-1592(2007) [PubMed] [Europe PMC] [Abstract]
• lung development Source: MGIInferred from mutant phenotypeⁱ
  • "Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation."
    Okubo T., Knoepfler P.S., Eisenman R.N., Hogan B.L.
    Development 132:1363-1374(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of astrocyte differentiation Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Identification of genes that restrict astrocyte differentiation of midgestational neural precursor cells."
    Sanosaka T., Namihira M., Asano H., Kohyama J., Aisaki K., Igarashi K., Kanno J., Nakashima K.
    Neuroscience 155:780-788(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: MGI
• negative regulation of reactive oxygen species metabolic process Source: UniProtKBInferred from direct assayⁱ
  • "Pax-2 and N-myc regulate epithelial cell proliferation and apoptosis in a positive autocrine feedback loop."
    Zhang S.L., Chen Y.W., Tran S., Liu F., Nestoridi E., Hebert M.J., Ingelfinger J.R.
    Pediatr. Nephrol. 22:813-824(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell death Source: MGIInferred from mutant phenotypeⁱ
  • "Activities of N-Myc in the developing limb link control of skeletal size with digit separation."
    Ota S., Zhou Z.Q., Keene D.R., Knoepfler P., Hurlin P.J.
    Development 134:1583-1592(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell population proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation."
    Okubo T., Knoepfler P.S., Eisenman R.N., Hogan B.L.
    Development 132:1363-1374(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: MGI
• positive regulation of mesenchymal cell proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "Activities of N-Myc in the developing limb link control of skeletal size with digit separation."
    Ota S., Zhou Z.Q., Keene D.R., Knoepfler P., Hurlin P.J.
    Development 134:1583-1592(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • "Pax-2 and N-myc regulate epithelial cell proliferation and apoptosis in a positive autocrine feedback loop."
    Zhang S.L., Chen Y.W., Tran S., Liu F., Nestoridi E., Hebert M.J., Ingelfinger J.R.
    Pediatr. Nephrol. 22:813-824(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci."
    Popkie A.P., Zeidner L.C., Albrecht A.M., D'Ippolito A., Eckardt S., Newsom D.E., Groden J., Doble B.W., Aronow B., McLaughlin K.J., White P., Phiel C.J.
    J. Biol. Chem. 285:41337-41347(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of inner ear auditory receptor cell differentiation Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "N-Myc and L-Myc are essential for hair cell formation but not maintenance."
    Kopecky B.J., Decook R., Fritzsch B.
    Brain Res. 1484:1-14(2012) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Keywords - Diseaseⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• kinase binding Source: MGI
• protein dimerization activity Source: InterPro

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MPSCTASTMP GMICKNPDLE FDSLQPCFYP DEDDFYFGGP DSTPPGEDIW 
        60         70         80         90        100
KKFELLPTPP LSPSRAFPEH SPEPSNWATE MLLPEADLWG NPAEEDAFGL 
       110        120        130        140        150
GGLGGLTPNP VILQDCMWSG FSAREKLERA VNEKLQHGHG PPGVSSACSA 
       160        170        180        190        200
PGVGASSPGG RALGGSSSAS HTGATLPTDL SHPAAECVDP AVVFPFPVNK 
       210        220        230        240        250
RESASVPAAP TSAPATSAAV TSVSVPATAP VAAPARAGGR PASSGEAKAL 
       260        270        280        290        300
STSGEDTLSD SDDEDDEEED EEEEIDVVTV EKRRSSSNNK AVTTFTITVR 
       310        320        330        340        350
PKTSALGLGR AQPGELILKR CVPIHQQHNY AAPSPYVESE DAPPQKKIKS 
       360        370        380        390        400
EASPRPLKSV VPAKAKSLSP RNSDSEDSER RRNHNILERQ RRNDLRSSFL 
       410        420        430        440        450
TLRDHVPELV KNEKAAKVVI LKKATEYVHA LQANEHQLLL EKEKLQARQQ 
       460 
QLLKKIEHAR TC                                          

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot