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Protein

Potassium-transporting ATPase KdpC subunit

Gene

kdpC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm (PubMed:2849541, PubMed:8499455, PubMed:23930894). This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex (PubMed:21711450).4 Publications

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • potassium-transporting ATPase activity Source: EcoCyc

GO - Biological processi

  • potassium ion transport Source: EcoCyc

Keywordsi

Biological processIon transport, Potassium transport, Transport
LigandATP-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

BioCyciEcoCyc:EG10515-MONOMER
MetaCyc:EG10515-MONOMER

Protein family/group databases

TCDBi3.A.3.7.1 the p-type atpase (p-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-transporting ATPase KdpC subunitUniRule annotation
Alternative name(s):
ATP phosphohydrolase [potassium-transporting] C chainUniRule annotation
Potassium-binding and translocating subunit CUniRule annotation
Potassium-translocating ATPase C chainUniRule annotation
Gene namesi
Name:kdpCUniRule annotation
Ordered Locus Names:b0696, JW0684
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10515 kdpC

Subcellular locationi

  • Cell inner membrane UniRule annotation1 Publication; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9Periplasmic1 Publication9
Transmembranei10 – 30HelicalUniRule annotationAdd BLAST21
Topological domaini31 – 190Cytoplasmic1 PublicationAdd BLAST160

GO - Cellular componenti

  • integral component of membrane Source: EcoCyc
  • plasma membrane Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi140 – 150QIPRVAKARNL → AIPAASKSANA: Cell does not grow at low potassium concentrations. 1 PublicationAdd BLAST11

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001969901 – 190Potassium-transporting ATPase KdpC subunitAdd BLAST190

Proteomic databases

PaxDbiP03961
PRIDEiP03961

Expressioni

Inductioni

Transcriptionally regulated by the KdpD/KdpE two-component regulatory system.1 Publication

Interactioni

Subunit structurei

The system is composed of three essential subunits: KdpA, KdpB and KdpC (PubMed:2849541, PubMed:9858692). The complex also contains KdpF, a small non-essential subunit (PubMed:10608856). The KdpFABC complex exists as a dimer above concentrations of 30-50 nM, whereas the complex exists as a functional monomer at lower concentrations (PubMed:18298081).4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
kdpBP039602EBI-6997216,EBI-1116956

Protein-protein interaction databases

BioGridi4259349, 20 interactors
IntActiP03961, 1 interactor
MINTiP03961
STRINGi316385.ECDH10B_0762

Structurei

Secondary structure

1190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 19Combined sources15
Helixi21 – 33Combined sources13
Helixi35 – 38Combined sources4
Beta strandi42 – 45Combined sources4
Beta strandi48 – 52Combined sources5
Turni53 – 55Combined sources3
Beta strandi62 – 64Combined sources3
Beta strandi73 – 75Combined sources3
Turni79 – 81Combined sources3
Helixi92 – 108Combined sources17
Beta strandi114 – 116Combined sources3
Helixi118 – 121Combined sources4
Beta strandi125 – 127Combined sources3
Helixi134 – 139Combined sources6
Helixi141 – 148Combined sources8
Helixi152 – 161Combined sources10
Turni169 – 171Combined sources3
Beta strandi175 – 177Combined sources3
Helixi178 – 189Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MRWX-ray2.90C/G/K4-190[»]
ProteinModelPortaliP03961
SMRiP03961
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KdpC family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108R80 Bacteria
COG2156 LUCA
HOGENOMiHOG000244124
InParanoidiP03961
KOiK01548
OMAiFQVPRVA
PhylomeDBiP03961

Family and domain databases

HAMAPiMF_00276 KdpC, 1 hit
InterProiView protein in InterPro
IPR003820 KdpC
PANTHERiPTHR30042 PTHR30042, 1 hit
PfamiView protein in Pfam
PF02669 KdpC, 1 hit
PIRSFiPIRSF001296 K_ATPase_KdpC, 1 hit
TIGRFAMsiTIGR00681 kdpC, 1 hit

Sequencei

Sequence statusi: Complete.

P03961-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGLRPALST FIFLLLITGG VYPLLTTVLG QWWFPWQANG SLIREGDTVR
60 70 80 90 100
GSALIGQNFT GNGYFHGRPS ATAEMPYNPQ ASGGSNLAVS NPELDKLIAA
110 120 130 140 150
RVAALRAANP DASASVPVEL VTASASGLDN NITPQAAAWQ IPRVAKARNL
160 170 180 190
SVEQLTQLIA KYSQQPLVKY IGQPVVNIVE LNLALDKLDE
Length:190
Mass (Da):20,267
Last modified:October 23, 1986 - v1
Checksum:i17F58EC839B6B95A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02670 Genomic DNA Translation: AAB96337.1
U00096 Genomic DNA Translation: AAC73790.1
AP009048 Genomic DNA Translation: BAA35353.1
PIRiA01073 PWECCK
RefSeqiNP_415224.1, NC_000913.3
WP_001300431.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73790; AAC73790; b0696
BAA35353; BAA35353; BAA35353
GeneIDi947508
KEGGiecj:JW0684
eco:b0696
PATRICifig|1411691.4.peg.1579

Similar proteinsi

Entry informationi

Entry nameiKDPC_ECOLI
AccessioniPrimary (citable) accession number: P03961
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: October 23, 1986
Last modified: March 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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