UniProtKB - P03961 (KDPC_ECOLI)
Protein
Potassium-transporting ATPase KdpC subunit
Gene
kdpC
Organism
Escherichia coli (strain K12)
Status
Functioni
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm (PubMed:2849541, PubMed:8499455, PubMed:23930894). This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex (PubMed:21711450).4 Publications
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- potassium transmembrane transporter activity, phosphorylative mechanism Source: EcoCyc
GO - Biological processi
- cation transmembrane transport Source: EcoCyc
- potassium ion transmembrane transport Source: EcoCyc
Keywordsi
Biological process | Ion transport, Potassium transport, Transport |
Ligand | ATP-binding, Nucleotide-binding, Potassium |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10515-MONOMER MetaCyc:EG10515-MONOMER |
Protein family/group databases
TCDBi | 3.A.3.7.1, the p-type atpase (p-atpase) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium-transporting ATPase KdpC subunitUniRule annotationAlternative name(s): ATP phosphohydrolase [potassium-transporting] C chainUniRule annotation Potassium-binding and translocating subunit CUniRule annotation Potassium-translocating ATPase C chainUniRule annotation |
Gene namesi | Name:kdpCUniRule annotation Ordered Locus Names:b0696, JW0684 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane UniRule annotation1 Publication; Single-pass membrane protein UniRule annotation
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 9 | Periplasmic1 Publication | 9 | |
Transmembranei | 10 – 30 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 31 – 190 | Cytoplasmic1 PublicationAdd BLAST | 160 |
GO - Cellular componenti
- integral component of plasma membrane Source: UniProtKB-UniRule
- plasma membrane Source: EcoCyc
- potassium ion-transporting ATPase complex Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 140 – 150 | QIPRVAKARNL → AIPAASKSANA: Cell does not grow at low potassium concentrations. 1 PublicationAdd BLAST | 11 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000196990 | 1 – 190 | Potassium-transporting ATPase KdpC subunitAdd BLAST | 190 |
Proteomic databases
PaxDbi | P03961 |
Expressioni
Inductioni
Transcriptionally regulated by the KdpD/KdpE two-component regulatory system.1 Publication
Interactioni
Subunit structurei
The system is composed of three essential subunits: KdpA, KdpB and KdpC (PubMed:2849541, PubMed:9858692). The complex also contains KdpF, a small non-essential subunit (PubMed:10608856). The KdpFABC complex exists as a dimer above concentrations of 30-50 nM, whereas the complex exists as a functional monomer at lower concentrations (PubMed:18298081).
4 PublicationsBinary interactionsi
P03961
With | #Exp. | IntAct |
---|---|---|
kdpB [P03960] | 2 | EBI-6997216,EBI-1116956 |
Protein-protein interaction databases
BioGRIDi | 4259349, 20 interactors |
ComplexPortali | CPX-3564, KdpFABC potassium import complex |
IntActi | P03961, 2 interactors |
MINTi | P03961 |
STRINGi | 511145.b0696 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P03961 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the KdpC family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2156, Bacteria |
HOGENOMi | CLU_077094_2_0_6 |
InParanoidi | P03961 |
PhylomeDBi | P03961 |
Family and domain databases
HAMAPi | MF_00276, KdpC, 1 hit |
InterProi | View protein in InterPro IPR003820, KdpC |
PANTHERi | PTHR30042, PTHR30042, 1 hit |
Pfami | View protein in Pfam PF02669, KdpC, 1 hit |
PIRSFi | PIRSF001296, K_ATPase_KdpC, 1 hit |
TIGRFAMsi | TIGR00681, kdpC, 1 hit |
i Sequence
Sequence statusi: Complete.
P03961-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGLRPALST FIFLLLITGG VYPLLTTVLG QWWFPWQANG SLIREGDTVR
60 70 80 90 100
GSALIGQNFT GNGYFHGRPS ATAEMPYNPQ ASGGSNLAVS NPELDKLIAA
110 120 130 140 150
RVAALRAANP DASASVPVEL VTASASGLDN NITPQAAAWQ IPRVAKARNL
160 170 180 190
SVEQLTQLIA KYSQQPLVKY IGQPVVNIVE LNLALDKLDE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K02670 Genomic DNA Translation: AAB96337.1 U00096 Genomic DNA Translation: AAC73790.1 AP009048 Genomic DNA Translation: BAA35353.1 |
PIRi | A01073, PWECCK |
RefSeqi | NP_415224.1, NC_000913.3 WP_001300431.1, NZ_SSZK01000045.1 |
Genome annotation databases
EnsemblBacteriai | AAC73790; AAC73790; b0696 BAA35353; BAA35353; BAA35353 |
GeneIDi | 947508 |
KEGGi | ecj:JW0684 eco:b0696 |
PATRICi | fig|1411691.4.peg.1579 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K02670 Genomic DNA Translation: AAB96337.1 U00096 Genomic DNA Translation: AAC73790.1 AP009048 Genomic DNA Translation: BAA35353.1 |
PIRi | A01073, PWECCK |
RefSeqi | NP_415224.1, NC_000913.3 WP_001300431.1, NZ_SSZK01000045.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5MRW | X-ray | 2.90 | C/G/K | 4-190 | [»] | |
6HRA | electron microscopy | 3.70 | C | 1-190 | [»] | |
6HRB | electron microscopy | 4.00 | C | 1-190 | [»] | |
SMRi | P03961 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4259349, 20 interactors |
ComplexPortali | CPX-3564, KdpFABC potassium import complex |
IntActi | P03961, 2 interactors |
MINTi | P03961 |
STRINGi | 511145.b0696 |
Protein family/group databases
TCDBi | 3.A.3.7.1, the p-type atpase (p-atpase) superfamily |
Proteomic databases
PaxDbi | P03961 |
Genome annotation databases
EnsemblBacteriai | AAC73790; AAC73790; b0696 BAA35353; BAA35353; BAA35353 |
GeneIDi | 947508 |
KEGGi | ecj:JW0684 eco:b0696 |
PATRICi | fig|1411691.4.peg.1579 |
Organism-specific databases
EchoBASEi | EB0510 |
Phylogenomic databases
eggNOGi | COG2156, Bacteria |
HOGENOMi | CLU_077094_2_0_6 |
InParanoidi | P03961 |
PhylomeDBi | P03961 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10515-MONOMER MetaCyc:EG10515-MONOMER |
Miscellaneous databases
PROi | PR:P03961 |
Family and domain databases
HAMAPi | MF_00276, KdpC, 1 hit |
InterProi | View protein in InterPro IPR003820, KdpC |
PANTHERi | PTHR30042, PTHR30042, 1 hit |
Pfami | View protein in Pfam PF02669, KdpC, 1 hit |
PIRSFi | PIRSF001296, K_ATPase_KdpC, 1 hit |
TIGRFAMsi | TIGR00681, kdpC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KDPC_ECOLI | |
Accessioni | P03961Primary (citable) accession number: P03961 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 1986 |
Last sequence update: | October 23, 1986 | |
Last modified: | December 2, 2020 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families