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UniProtKB - P03959 (KDPA_ECOLI)

Entry version 163 (07 Apr 2021)
Sequence version 1 (13 Aug 1987)
Previous versions | rss
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Protein

Potassium-transporting ATPase potassium-binding subunit

Gene

kdpA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm (PubMed:2849541, PubMed:8499455, PubMed:23930894). This subunit binds and transports the potassium across the cytoplasmic membrane (PubMed:7896809).4 Publications

Miscellaneous

Has two separate and distinct potassium-binding sites. One site is formed by three periplasmic loops and is inferred to be the site of initial binding. The other site is cytoplasmic.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:EG10513-MONOMER
MetaCyc:EG10513-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.6.3.12, 2026

Protein family/group databases

Transport Classification Database

More...TCDBi		3.A.3.7.1, the p-type atpase (p-atpase) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Potassium-transporting ATPase potassium-binding subunitUniRule annotation
Alternative name(s):
ATP phosphohydrolase [potassium-transporting] A chainUniRule annotation
Potassium-binding and translocating subunit AUniRule annotation
Potassium-translocating ATPase A chainUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:kdpAUniRule annotation
Ordered Locus Names:b0698, JW0686
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 4Periplasmic1 Publication4
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei5 – 25HelicalUniRule annotationAdd BLAST21
Topological domaini26 – 62Cytoplasmic1 PublicationAdd BLAST37
Transmembranei63 – 83HelicalUniRule annotationAdd BLAST21
Topological domaini84 – 131Periplasmic1 PublicationAdd BLAST48
Transmembranei132 – 152HelicalUniRule annotationAdd BLAST21
Topological domaini153 – 169Cytoplasmic1 PublicationAdd BLAST17
Transmembranei170 – 190HelicalUniRule annotationAdd BLAST21
Topological domaini191 – 252Periplasmic1 PublicationAdd BLAST62
Transmembranei253 – 273HelicalUniRule annotationAdd BLAST21
Topological domaini274 – 282Cytoplasmic1 Publication9
Transmembranei283 – 303HelicalUniRule annotationAdd BLAST21
Topological domaini304 – 328Periplasmic1 PublicationAdd BLAST25
Transmembranei329 – 349HelicalUniRule annotationAdd BLAST21
Topological domaini350 – 415Cytoplasmic1 PublicationAdd BLAST66
Transmembranei416 – 436HelicalUniRule annotationAdd BLAST21
Topological domaini437 – 483Periplasmic1 PublicationAdd BLAST47
Transmembranei484 – 504HelicalUniRule annotationAdd BLAST21
Topological domaini505 – 525Cytoplasmic1 PublicationAdd BLAST21
Transmembranei526 – 546HelicalUniRule annotationAdd BLAST21
Topological domaini547 – 557Periplasmic1 PublicationAdd BLAST11

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi232G → A or S: Decrease in K(+) affinity and loss of cation selectivity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001664941 – 557Potassium-transporting ATPase potassium-binding subunitAdd BLAST557

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P03959

PRoteomics IDEntifications database

More...PRIDEi		P03959

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Transcriptionally regulated by the KdpD/KdpE two-component regulatory system.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The system is composed of three essential subunits: KdpA, KdpB and KdpC (PubMed:2849541, PubMed:9858692). The complex also contains KdpF, a small non-essential subunit (PubMed:10608856). The KdpFABC complex exists as a dimer above concentrations of 30-50 nM, whereas the complex exists as a functional monomer at lower concentrations (PubMed:18298081).

4 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4259932, 35 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-3564, KdpFABC potassium import complex

Protein interaction database and analysis system

More...IntActi		P03959, 3 interactors

STRING: functional protein association networks

More...STRINGi		511145.b0698

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1557
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P03959

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KdpA family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG2060, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_018614_3_0_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P03959

Database for complete collections of gene phylogenies

More...PhylomeDBi		P03959

Family and domain databases

HAMAP database of protein families

More...HAMAPi		MF_00275, KdpA, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004623, KdpA

The PANTHER Classification System

More...PANTHERi		PTHR30607, PTHR30607, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03814, KdpA, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF001294, K_ATPaseA, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00680, kdpA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P03959-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAQGFLLIA TFLLVLMVLA RPLGSGLARL INDIPLPGTT GVERVLFRAL 
        60         70         80         90        100
GVSDREMNWK QYLCAILGLN MLGLAVLFFM LLGQHYLPLN PQQLPGLSWD 
       110        120        130        140        150
LALNTAVSFV TNTNWQSYSG ETTLSYFSQM AGLTVQNFLS AASGIAVIFA 
       160        170        180        190        200
LIRAFTRQSM STLGNAWVDL LRITLWVLVP VALLIALFFI QQGALQNFLP 
       210        220        230        240        250
YQAVNTVEGA QQLLPMGPVA SQEAIKMLGT NGGGFFNANS SHPFENPTAL 
       260        270        280        290        300
TNFVQMLAIF LIPTALCFAF GEVMGDRRQG RMLLWAMSVI FVICVGVVMW 
       310        320        330        340        350
AEVQGNPHLL ALGTDSSINM EGKESRFGVL VSSLFAVVTT AASCGAVIAM 
       360        370        380        390        400
HDSFTALGGM VPMWLMQIGE VVFGGVGSGL YGMMLFVLLA VFIAGLMIGR 
       410        420        430        440        450
TPEYLGKKID VREMKLTALA ILVTPTLVLM GAALAMMTDA GRSAMLNPGP 
       460        470        480        490        500
HGFSEVLYAV SSAANNNGSA FAGLSANSPF WNCLLAFCMF VGRFGVIIPV 
       510        520        530        540        550
MAIAGSLVSK KSQAASSGTL PTHGPLFVGL LIGTVLLVGA LTFIPALALG 

PVAEYLS
Length:557
Mass (Da):59,189
Last modified:August 13, 1987 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i88C397FC3D3DC17E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
K02670 Genomic DNA Translation: AAB96335.1
U00096 Genomic DNA Translation: AAC73792.1
AP009048 Genomic DNA Translation: BAA35356.1

Protein sequence database of the Protein Information Resource

More...PIRi		A01071, PWECAK

NCBI Reference Sequences

More...RefSeqi		NP_415226.1, NC_000913.3
WP_000741129.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC73792; AAC73792; b0698
BAA35356; BAA35356; BAA35356

Database of genes from NCBI RefSeq genomes

More...GeneIDi		946045

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW0686
eco:b0698

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.1577

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02670 Genomic DNA Translation: AAB96335.1
U00096 Genomic DNA Translation: AAC73792.1
AP009048 Genomic DNA Translation: BAA35356.1
PIRiA01071, PWECAK
RefSeqiNP_415226.1, NC_000913.3
WP_000741129.1, NZ_LN832404.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MRWX-ray2.90A/E/I1-557[»]
6HRAelectron microscopy3.70A1-557[»]
6HRBelectron microscopy4.00A1-557[»]
SMRiP03959
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi4259932, 35 interactors
ComplexPortaliCPX-3564, KdpFABC potassium import complex
IntActiP03959, 3 interactors
STRINGi511145.b0698

Protein family/group databases

TCDBi3.A.3.7.1, the p-type atpase (p-atpase) superfamily

Proteomic databases

PaxDbiP03959
PRIDEiP03959

Genome annotation databases

EnsemblBacteriaiAAC73792; AAC73792; b0698
BAA35356; BAA35356; BAA35356
GeneIDi946045
KEGGiecj:JW0686
eco:b0698
PATRICifig|1411691.4.peg.1577

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB0508

Phylogenomic databases

eggNOGiCOG2060, Bacteria
HOGENOMiCLU_018614_3_0_6
InParanoidiP03959
PhylomeDBiP03959

Enzyme and pathway databases

BioCyciEcoCyc:EG10513-MONOMER
MetaCyc:EG10513-MONOMER
BRENDAi3.6.3.12, 2026

Miscellaneous databases

Protein Ontology

More...PROi		PR:P03959

Family and domain databases

HAMAPiMF_00275, KdpA, 1 hit
InterProiView protein in InterPro
IPR004623, KdpA
PANTHERiPTHR30607, PTHR30607, 1 hit
PfamiView protein in Pfam
PF03814, KdpA, 1 hit
PIRSFiPIRSF001294, K_ATPaseA, 1 hit
TIGRFAMsiTIGR00680, kdpA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKDPA_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P03959
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: August 13, 1987
Last modified: April 7, 2021
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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