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Entry version 209 (18 Sep 2019)
Sequence version 1 (23 Oct 1986)
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Protein

Plasma kallikrein

Gene

KLKB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin. EC:3.4.21.34

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by SERPINA5.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei434Charge relay system1
Active sitei483Charge relay system1
Active sitei578Charge relay system1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processBlood coagulation, Fibrinolysis, Hemostasis, Inflammatory response

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.21.34 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation
R-HSA-1592389 Activation of Matrix Metalloproteinases

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P03952

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P03952

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S01.212

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plasma kallikrein (EC:3.4.21.34)
Alternative name(s):
Fletcher factor
Kininogenin
Plasma prekallikrein
Short name:
PKK
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KLKB1
Synonyms:KLK3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6371 KLKB1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
229000 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P03952

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Prekallikrein deficiency (PKK deficiency)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionThis disorder is a blood coagulation defect.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054907123G → R in PKK deficiency; reduces the binding activity of Apple domain 2 to HMW kininogen. 1 PublicationCorresponds to variant dbSNP:rs121964952EnsemblClinVar.1
Natural variantiVAR_013598143N → S in PKK deficiency; reduces the binding activity of Apple domain 2 to HMW kininogen. 3 PublicationsCorresponds to variant dbSNP:rs3733402Ensembl.1
Natural variantiVAR_054908548C → Y in PKK deficiency. 1 PublicationCorresponds to variant dbSNP:rs121964951EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
3818

MalaCards human disease database

More...
MalaCardsi
KLKB1
MIMi612423 phenotype

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
749 Congenital prekallikrein deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30160

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P03952

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2000

Drug and drug target database

More...
DrugBanki
DB09228 Conestat alfa
DB05311 Ecallantide
DB12831 Gabexate
DB06404 Human C1-esterase inhibitor
DB14597 Lanadelumab
DB01593 Zinc
DB14487 Zinc acetate
DB14533 Zinc chloride

DrugCentral

More...
DrugCentrali
P03952

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2379

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KLKB1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
125184

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Add BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002802120 – 390Plasma kallikrein heavy chainAdd BLAST371
ChainiPRO_0000028022391 – 638Plasma kallikrein light chainAdd BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi21 ↔ 1041 Publication
Disulfide bondi47 ↔ 771 Publication
Disulfide bondi51 ↔ 571 Publication
Disulfide bondi111 ↔ 1941 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi127N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi137 ↔ 1661 Publication
Disulfide bondi141 ↔ 1471 Publication
Disulfide bondi201 ↔ 2841 Publication
Disulfide bondi227 ↔ 2561 Publication
Disulfide bondi231 ↔ 2371 Publication
Disulfide bondi292 ↔ 3751 Publication
Glycosylationi308N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi318 ↔ 3471 Publication
Disulfide bondi322 ↔ 3281 Publication
Disulfide bondi340 ↔ 3451 Publication
Disulfide bondi383 ↔ 5031 Publication
Glycosylationi396N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi419 ↔ 4351 Publication
Glycosylationi453N-linked (GlcNAc...) asparagine4 Publications1
Glycosylationi494N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi517 ↔ 5841 Publication
Disulfide bondi548 ↔ 5631 Publication
Disulfide bondi574 ↔ 6021 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-682
CPTAC-683

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P03952

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P03952

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P03952

PeptideAtlas

More...
PeptideAtlasi
P03952

PRoteomics IDEntifications database

More...
PRIDEi
P03952

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
51622

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
714

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P03952

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P03952

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164344 Expressed in 150 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P03952 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P03952 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterodimer with SERPINA5. The zymogen is activated by factor XIIa, which cleaves the molecule into a light chain, which contains the active site, and a heavy chain, which associates with HMW kininogen. These chains are linked by one or more disulfide bonds.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110018, 6 interactors

Protein interaction database and analysis system

More...
IntActi
P03952, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000264690

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P03952

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1638
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P03952

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P03952

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 104Apple 1PROSITE-ProRule annotationAdd BLAST84
Domaini111 – 194Apple 2PROSITE-ProRule annotationAdd BLAST84
Domaini201 – 284Apple 3PROSITE-ProRule annotationAdd BLAST84
Domaini292 – 375Apple 4PROSITE-ProRule annotationAdd BLAST84
Domaini391 – 626Peptidase S1PROSITE-ProRule annotationAdd BLAST236

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1 family. Plasma kallikrein subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3627 Eukaryota
COG5640 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112467

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P03952

KEGG Orthology (KO)

More...
KOi
K01324

Database of Orthologous Groups

More...
OrthoDBi
1258047at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P03952

TreeFam database of animal gene trees

More...
TreeFami
TF343687

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01100 APPLE_Factor_XI_like, 4 hits
cd00190 Tryp_SPc, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000177 Apple
IPR003609 Pan_app
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00024 PAN_1, 4 hits
PF00089 Trypsin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00005 APPLEDOMAIN
PR00722 CHYMOTRYPSIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00223 APPLE, 4 hits
SM00020 Tryp_SPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494 SSF50494, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00495 APPLE, 4 hits
PS50948 PAN, 4 hits
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P03952-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILFKQATYF ISLFATVSCG CLTQLYENAF FRGGDVASMY TPNAQYCQMR
60 70 80 90 100
CTFHPRCLLF SFLPASSIND MEKRFGCFLK DSVTGTLPKV HRTGAVSGHS
110 120 130 140 150
LKQCGHQISA CHRDIYKGVD MRGVNFNVSK VSSVEECQKR CTNNIRCQFF
160 170 180 190 200
SYATQTFHKA EYRNNCLLKY SPGGTPTAIK VLSNVESGFS LKPCALSEIG
210 220 230 240 250
CHMNIFQHLA FSDVDVARVL TPDAFVCRTI CTYHPNCLFF TFYTNVWKIE
260 270 280 290 300
SQRNVCLLKT SESGTPSSST PQENTISGYS LLTCKRTLPE PCHSKIYPGV
310 320 330 340 350
DFGGEELNVT FVKGVNVCQE TCTKMIRCQF FTYSLLPEDC KEEKCKCFLR
360 370 380 390 400
LSMDGSPTRI AYGTQGSSGY SLRLCNTGDN SVCTTKTSTR IVGGTNSSWG
410 420 430 440 450
EWPWQVSLQV KLTAQRHLCG GSLIGHQWVL TAAHCFDGLP LQDVWRIYSG
460 470 480 490 500
ILNLSDITKD TPFSQIKEII IHQNYKVSEG NHDIALIKLQ APLNYTEFQK
510 520 530 540 550
PICLPSKGDT STIYTNCWVT GWGFSKEKGE IQNILQKVNI PLVTNEECQK
560 570 580 590 600
RYQDYKITQR MVCAGYKEGG KDACKGDSGG PLVCKHNGMW RLVGITSWGE
610 620 630
GCARREQPGV YTKVAEYMDW ILEKTQSSDG KAQMQSPA
Length:638
Mass (Da):71,370
Last modified:October 23, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE62F9C1053838FB4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YAC1H0YAC1_HUMAN
Plasma kallikrein
KLKB1
686Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J075C9J075_HUMAN
Plasma kallikrein
KLKB1
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PBC5E9PBC5_HUMAN
Plasma kallikrein
KLKB1
514Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JCT1C9JCT1_HUMAN
Plasma kallikrein
KLKB1
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054907123G → R in PKK deficiency; reduces the binding activity of Apple domain 2 to HMW kininogen. 1 PublicationCorresponds to variant dbSNP:rs121964952EnsemblClinVar.1
Natural variantiVAR_013598143N → S in PKK deficiency; reduces the binding activity of Apple domain 2 to HMW kininogen. 3 PublicationsCorresponds to variant dbSNP:rs3733402Ensembl.1
Natural variantiVAR_016280178A → T1 PublicationCorresponds to variant dbSNP:rs4253257Ensembl.1
Natural variantiVAR_013599202H → Q2 PublicationsCorresponds to variant dbSNP:rs4253373EnsemblClinVar.1
Natural variantiVAR_013600208H → P1 PublicationCorresponds to variant dbSNP:rs145640112Ensembl.1
Natural variantiVAR_020180210A → E. Corresponds to variant dbSNP:rs2278542Ensembl.1
Natural variantiVAR_016281269S → C1 PublicationCorresponds to variant dbSNP:rs4253376EnsemblClinVar.1
Natural variantiVAR_016282311F → V1 PublicationCorresponds to variant dbSNP:rs4253377Ensembl.1
Natural variantiVAR_016283358T → A1 PublicationCorresponds to variant dbSNP:rs4253379Ensembl.1
Natural variantiVAR_016284381S → A1 PublicationCorresponds to variant dbSNP:rs4253301Ensembl.1
Natural variantiVAR_016285442Q → P1 PublicationCorresponds to variant dbSNP:rs4253316Ensembl.1
Natural variantiVAR_054908548C → Y in PKK deficiency. 1 PublicationCorresponds to variant dbSNP:rs121964951EnsemblClinVar.1
Natural variantiVAR_016286560R → Q2 PublicationsCorresponds to variant dbSNP:rs4253325Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M13143 mRNA Translation: AAA60153.1
AF232742
, AF232734, AF232735, AF232736, AF232737, AF232738, AF232739, AF232740, AF232741 Genomic DNA Translation: AAF79940.1
AK313378 mRNA Translation: BAG36176.1
AY190920 Genomic DNA Translation: AAN84794.1
AC110771 Genomic DNA Translation: AAY40900.1
CH471056 Genomic DNA Translation: EAX04623.1
BC117349 mRNA Translation: AAI17350.1
BC117351 mRNA Translation: AAI17352.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34120.1

Protein sequence database of the Protein Information Resource

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PIRi
A00921 KQHUP

NCBI Reference Sequences

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RefSeqi
NP_000883.2, NM_000892.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000264690; ENSP00000264690; ENSG00000164344

Database of genes from NCBI RefSeq genomes

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GeneIDi
3818

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3818

UCSC genome browser

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UCSCi
uc003iyy.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13143 mRNA Translation: AAA60153.1
AF232742
, AF232734, AF232735, AF232736, AF232737, AF232738, AF232739, AF232740, AF232741 Genomic DNA Translation: AAF79940.1
AK313378 mRNA Translation: BAG36176.1
AY190920 Genomic DNA Translation: AAN84794.1
AC110771 Genomic DNA Translation: AAY40900.1
CH471056 Genomic DNA Translation: EAX04623.1
BC117349 mRNA Translation: AAI17350.1
BC117351 mRNA Translation: AAI17352.1
CCDSiCCDS34120.1
PIRiA00921 KQHUP
RefSeqiNP_000883.2, NM_000892.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ANWX-ray1.85A391-631[»]
2ANYX-ray1.40A391-631[»]
4OGXX-ray2.40A391-631[»]
4OGYX-ray2.10A/B391-631[»]
5F8TX-ray1.75A391-629[»]
5F8XX-ray1.55A391-629[»]
5F8ZX-ray1.50A391-629[»]
5TJXX-ray1.41A376-638[»]
6I44X-ray1.36A20-638[»]
6O1GX-ray2.20A1-638[»]
6O1SX-ray1.70E376-638[»]
SMRiP03952
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi110018, 6 interactors
IntActiP03952, 6 interactors
STRINGi9606.ENSP00000264690

Chemistry databases

BindingDBiP03952
ChEMBLiCHEMBL2000
DrugBankiDB09228 Conestat alfa
DB05311 Ecallantide
DB12831 Gabexate
DB06404 Human C1-esterase inhibitor
DB14597 Lanadelumab
DB01593 Zinc
DB14487 Zinc acetate
DB14533 Zinc chloride
DrugCentraliP03952
GuidetoPHARMACOLOGYi2379

Protein family/group databases

MEROPSiS01.212

PTM databases

GlyConnecti714
iPTMnetiP03952
PhosphoSitePlusiP03952

Polymorphism and mutation databases

BioMutaiKLKB1
DMDMi125184

Proteomic databases

CPTACiCPTAC-682
CPTAC-683
jPOSTiP03952
MassIVEiP03952
PaxDbiP03952
PeptideAtlasiP03952
PRIDEiP03952
ProteomicsDBi51622

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
P03952

The DNASU plasmid repository

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DNASUi
3818

Genome annotation databases

EnsembliENST00000264690; ENSP00000264690; ENSG00000164344
GeneIDi3818
KEGGihsa:3818
UCSCiuc003iyy.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3818
DisGeNETi3818

GeneCards: human genes, protein and diseases

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GeneCardsi
KLKB1
HGNCiHGNC:6371 KLKB1
MalaCardsiKLKB1
MIMi229000 gene
612423 phenotype
neXtProtiNX_P03952
Orphaneti749 Congenital prekallikrein deficiency
PharmGKBiPA30160

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
HOGENOMiHOG000112467
InParanoidiP03952
KOiK01324
OrthoDBi1258047at2759
PhylomeDBiP03952
TreeFamiTF343687

Enzyme and pathway databases

BRENDAi3.4.21.34 2681
ReactomeiR-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation
R-HSA-1592389 Activation of Matrix Metalloproteinases
SABIO-RKiP03952
SIGNORiP03952

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
KLKB1 human
EvolutionaryTraceiP03952

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KLKB1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3818
PharosiP03952

Protein Ontology

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PROi
PR:P03952

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164344 Expressed in 150 organ(s), highest expression level in liver
ExpressionAtlasiP03952 baseline and differential
GenevisibleiP03952 HS

Family and domain databases

CDDicd01100 APPLE_Factor_XI_like, 4 hits
cd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR000177 Apple
IPR003609 Pan_app
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00024 PAN_1, 4 hits
PF00089 Trypsin, 1 hit
PRINTSiPR00005 APPLEDOMAIN
PR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00223 APPLE, 4 hits
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS00495 APPLE, 4 hits
PS50948 PAN, 4 hits
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKLKB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P03952
Secondary accession number(s): A6NH96
, B2R8H9, Q17RE8, Q17RE9, Q4W5C3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: October 23, 1986
Last modified: September 18, 2019
This is version 209 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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