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Entry version 223 (03 Jul 2019)
Sequence version 1 (23 Oct 1986)
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Protein

Coagulation factor XI

Gene

F11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa. EC:3.4.21.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by SERPINA5.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei431Charge relay system1
Active sitei480Charge relay system1
Active sitei575Charge relay system1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHeparin-binding, Hydrolase, Protease, Serine protease
Biological processBlood coagulation, Hemostasis

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.21.27 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P03951

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P03951

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S01.213

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coagulation factor XI (EC:3.4.21.27)
Short name:
FXI
Alternative name(s):
Plasma thromboplastin antecedent
Short name:
PTA
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:F11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3529 F11

Online Mendelian Inheritance in Man (OMIM)

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MIMi
264900 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P03951

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Factor XI deficiency (FA11D)21 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07651530F → S in FA11D. 1 Publication1
Natural variantiVAR_06792932G → R in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875259EnsemblClinVar.1
Natural variantiVAR_01208534D → H in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875267EnsemblClinVar.1
Natural variantiVAR_06793043A → T in FA11D; dominant-negative mutation that results in severely decreased protein secretion. 1 PublicationCorresponds to variant dbSNP:rs281875264EnsemblClinVar.1
Natural variantiVAR_05489446C → F in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875271EnsemblClinVar.1
Natural variantiVAR_06793151T → I in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875252EnsemblClinVar.1
Natural variantiVAR_06793251T → P in FA11D. 2 PublicationsCorresponds to variant dbSNP:rs281875243EnsemblClinVar.1
Natural variantiVAR_06793353H → Q in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875261EnsemblClinVar.1
Natural variantiVAR_05489556C → R in FA11D; secretion of the mutant protein is impaired. 2 PublicationsCorresponds to variant dbSNP:rs121965069EnsemblClinVar.1
Natural variantiVAR_06793463A → V in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875244EnsemblClinVar.1
Natural variantiVAR_054896101K → R in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875272EnsemblClinVar.1
Natural variantiVAR_076516109A → T in FA11D. 1 PublicationCorresponds to variant dbSNP:rs768474112EnsemblClinVar.1
Natural variantiVAR_067935140C → Y in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875256EnsemblClinVar.1
Natural variantiVAR_054897151Y → C in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875273EnsemblClinVar.1
Natural variantiVAR_076517216D → N in FA11D. 1 Publication1
Natural variantiVAR_067936222D → Y in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875245EnsemblClinVar.1
Natural variantiVAR_067937228R → Q in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875246EnsemblClinVar.1
Natural variantiVAR_067938241F → L in FA11D; dominant-negative mutation that results in severely decreased protein secretion. 1 PublicationCorresponds to variant dbSNP:rs281875265EnsemblClinVar.1
Natural variantiVAR_012086246W → C in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875279EnsemblClinVar.1
Natural variantiVAR_067939252R → T in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875260EnsemblClinVar.1
Natural variantiVAR_054898255C → Y in FA11D; secretion of the mutant protein is impaired. 1 PublicationCorresponds to variant dbSNP:rs281875277EnsemblClinVar.1
Natural variantiVAR_054899263G → E in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875274EnsemblClinVar.1
Natural variantiVAR_012087266S → N in FA11D. 1 PublicationCorresponds to variant dbSNP:rs145168351Ensembl.1
Natural variantiVAR_054900270K → I in FA11D; although the mutant protein is synthesized the secretion is reduced. 1 PublicationCorresponds to variant dbSNP:rs121965070EnsemblClinVar.1
Natural variantiVAR_067940276S → C in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875247EnsemblClinVar.1
Natural variantiVAR_067941277G → D in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875248EnsemblClinVar.1
Natural variantiVAR_006622301F → L in FA11D. 2 PublicationsCorresponds to variant dbSNP:rs121965064EnsemblClinVar.1
Natural variantiVAR_067942315E → K in FA11D. 2 PublicationsCorresponds to variant dbSNP:rs281875257EnsemblClinVar.1
Natural variantiVAR_012088320L → P in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875268EnsemblClinVar.1
Natural variantiVAR_012089322T → I in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875269EnsemblClinVar.1
Natural variantiVAR_012090326R → C in FA11D. 1 PublicationCorresponds to variant dbSNP:rs28934608EnsemblClinVar.1
Natural variantiVAR_067943331T → I in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875253EnsemblClinVar.1
Natural variantiVAR_012091341E → K in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875270EnsemblClinVar.1
Natural variantiVAR_067944360L → P in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875254EnsemblClinVar.1
Natural variantiVAR_067945401W → R in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875262EnsemblClinVar.1
Natural variantiVAR_067946403V → M in FA11D; dominant-negative mutation that results in severely decreased protein secretion. 1 PublicationCorresponds to variant dbSNP:rs281875266EnsemblClinVar.1
Natural variantiVAR_012092404T → N in FA11D. 1 PublicationCorresponds to variant dbSNP:rs121965067EnsemblClinVar.1
Natural variantiVAR_054901418G → V in FA11D; mutant is not secreted by transfected fibroblasts; dominant-negative effect. 1 PublicationCorresponds to variant dbSNP:rs121965071EnsemblClinVar.1
Natural variantiVAR_012093430A → V in FA11D. 1 PublicationCorresponds to variant dbSNP:rs121965068EnsemblClinVar.1
Natural variantiVAR_067947454I → K in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875241EnsemblClinVar.1
Natural variantiVAR_012094460F → V in FA11D. 1 PublicationCorresponds to variant dbSNP:rs121965065EnsemblClinVar.1
Natural variantiVAR_067948481I → S in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875242EnsemblClinVar.1
Natural variantiVAR_012095493T → I in FA11D. 1 Publication1
Natural variantiVAR_067949503S → P in FA11D. 1 PublicationCorresponds to variant dbSNP:rs140068026EnsemblClinVar.1
Natural variantiVAR_067950506D → G in FA11D; mild phenotype. 1 PublicationCorresponds to variant dbSNP:rs281875258EnsemblClinVar.1
Natural variantiVAR_054902511Y → H in FA11D; transfected cells contain reduced amount of mutant protein and display decreased secretion. 1 PublicationCorresponds to variant dbSNP:rs281875278EnsemblClinVar.1
Natural variantiVAR_067951514C → F in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875249EnsemblClinVar.1
Natural variantiVAR_067952526D → E in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875263EnsemblClinVar.1
Natural variantiVAR_054903538P → L in FA11D. 1 PublicationCorresponds to variant dbSNP:rs139695003EnsemblClinVar.1
Natural variantiVAR_076518543E → K in FA11D. 1 PublicationCorresponds to variant dbSNP:rs142952627EnsemblClinVar.1
Natural variantiVAR_076519552H → R in FA11D. 1 PublicationCorresponds to variant dbSNP:rs369935706Ensembl.1
Natural variantiVAR_054904565E → K in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875275EnsemblClinVar.1
Natural variantiVAR_067953575S → L in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875250EnsemblClinVar.1
Natural variantiVAR_054905587W → S in FA11D; mutant is not secreted by transfected fibroblasts; dominant-negative effect. 1 PublicationCorresponds to variant dbSNP:rs121965072EnsemblClinVar.1
Natural variantiVAR_012096594S → R in FA11D. 1 PublicationCorresponds to variant dbSNP:rs28934609EnsemblClinVar.1
Natural variantiVAR_067954597E → K in FA11D. 2 PublicationsCorresponds to variant dbSNP:rs281875251EnsemblClinVar.1
Natural variantiVAR_067955608Y → H in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875255EnsemblClinVar.1
Natural variantiVAR_054906618I → S in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875276EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
2160

MalaCards human disease database

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MalaCardsi
F11
MIMi612416 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000088926

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
329 Congenital factor XI deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27941

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2820

Drug and drug target database

More...
DrugBanki
DB07022 3-HYDROXYPROPYL 3-[({7-[AMINO(IMINO)METHYL]-1-NAPHTHYL}AMINO)CARBONYL]BENZENESULFONATE
DB07299 4-METHYL-PENTANOIC ACID {1-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYLCARBAMOYL]-2-METHYL-PROPYL}-AMIDE
DB07074 6-CARBAMIMIDOYL-4-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-NAPHTHALENE-2-CARBOXYLIC ACID METHYL ESTER
DB06404 C1 Esterase Inhibitor (Human)
DB09228 C1 Esterase Inhibitor (Recombinant)
DB00100 Coagulation Factor IX (Recombinant)
DB07212 N-(7-CARBAMIMIDOYL-NAPHTHALEN-1-YL)-3-HYDROXY-2-METHYL-BENZAMIDE

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2360

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
F11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
119762

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Add BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002782519 – 387Coagulation factor XIa heavy chainAdd BLAST369
ChainiPRO_0000027826388 – 625Coagulation factor XIa light chainAdd BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi20 ↔ 103Sequence analysis
Disulfide bondi29Interchain
Disulfide bondi46 ↔ 761 Publication
Disulfide bondi50 ↔ 561 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi90N-linked (GlcNAc...) (complex) asparagine1 Publication1
Disulfide bondi110 ↔ 1931 Publication
Glycosylationi126N-linked (GlcNAc...) (complex) asparagine2 Publications1
Disulfide bondi136 ↔ 1651 Publication
Disulfide bondi140 ↔ 1461 Publication
Glycosylationi163N-linked (GlcNAc...) (complex) asparagine; atypical1 Publication1
Disulfide bondi200 ↔ 283
Disulfide bondi226 ↔ 2551 Publication
Disulfide bondi230 ↔ 2361 Publication
Disulfide bondi291 ↔ 3741 Publication
Disulfide bondi317 ↔ 3461 Publication
Disulfide bondi321 ↔ 3271 Publication
Disulfide bondi339InterchainSequence analysis
Disulfide bondi380 ↔ 500Interchain (between heavy and light chains)
Disulfide bondi416 ↔ 4321 Publication
Glycosylationi450N-linked (GlcNAc...) (complex) asparagine3 Publications1
Glycosylationi491N-linked (GlcNAc...) (complex) asparagine4 Publications1
Disulfide bondi514 ↔ 581
Disulfide bondi545 ↔ 5601 Publication
Disulfide bondi571 ↔ 599

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated on both chains. N-glycosylated sites mainly consist of nonfucosylated sialylated biantennary (in high abundance) and/or triantennary (in low abundance) complex structures. Glycosylation at Asn-163 uses a rare non-canonical Asn-X-Cys glycosite.1 Publication
Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P03951

PeptideAtlas

More...
PeptideAtlasi
P03951

PRoteomics IDEntifications database

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PRIDEi
P03951

ProteomicsDB human proteome resource

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ProteomicsDBi
51620
51621 [P03951-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
818

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P03951

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P03951

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P03951

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000088926 Expressed in 97 organ(s), highest expression level in right lobe of liver

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P03951 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P03951 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039808

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked.

Forms a heterodimer with SERPINA5. After activation the heavy and light chains are also linked by a disulfide bond.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ecoP238273EBI-1041019,EBI-1029159From Escherichia coli (strain K12).

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108458, 6 interactors

Database of interacting proteins

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DIPi
DIP-29085N

Protein interaction database and analysis system

More...
IntActi
P03951, 3 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000384957

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P03951

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1625
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P03951

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P03951

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 103Apple 1PROSITE-ProRule annotationAdd BLAST84
Domaini110 – 193Apple 2PROSITE-ProRule annotationAdd BLAST84
Domaini200 – 283Apple 3PROSITE-ProRule annotationAdd BLAST84
Domaini291 – 374Apple 4PROSITE-ProRule annotationAdd BLAST84
Domaini388 – 623Peptidase S1PROSITE-ProRule annotationAdd BLAST236

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni547 – 550Heparin-binding4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1 family. Plasma kallikrein subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3627 Eukaryota
COG5640 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158569

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112467

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P03951

KEGG Orthology (KO)

More...
KOi
K01323

Identification of Orthologs from Complete Genome Data

More...
OMAi
TCILKDS

Database of Orthologous Groups

More...
OrthoDBi
1340284at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P03951

TreeFam database of animal gene trees

More...
TreeFami
TF343687

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01100 APPLE_Factor_XI_like, 4 hits
cd00190 Tryp_SPc, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000177 Apple
IPR003609 Pan_app
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00024 PAN_1, 4 hits
PF00089 Trypsin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00005 APPLEDOMAIN
PR00722 CHYMOTRYPSIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00223 APPLE, 4 hits
SM00020 Tryp_SPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494 SSF50494, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00495 APPLE, 4 hits
PS50948 PAN, 4 hits
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P03951-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIFLYQVVHF ILFTSVSGEC VTQLLKDTCF EGGDITTVFT PSAKYCQVVC
60 70 80 90 100
TYHPRCLLFT FTAESPSEDP TRWFTCVLKD SVTETLPRVN RTAAISGYSF
110 120 130 140 150
KQCSHQISAC NKDIYVDLDM KGINYNSSVA KSAQECQERC TDDVHCHFFT
160 170 180 190 200
YATRQFPSLE HRNICLLKHT QTGTPTRITK LDKVVSGFSL KSCALSNLAC
210 220 230 240 250
IRDIFPNTVF ADSNIDSVMA PDAFVCGRIC THHPGCLFFT FFSQEWPKES
260 270 280 290 300
QRNLCLLKTS ESGLPSTRIK KSKALSGFSL QSCRHSIPVF CHSSFYHDTD
310 320 330 340 350
FLGEELDIVA AKSHEACQKL CTNAVRCQFF TYTPAQASCN EGKGKCYLKL
360 370 380 390 400
SSNGSPTKIL HGRGGISGYT LRLCKMDNEC TTKIKPRIVG GTASVRGEWP
410 420 430 440 450
WQVTLHTTSP TQRHLCGGSI IGNQWILTAA HCFYGVESPK ILRVYSGILN
460 470 480 490 500
QSEIKEDTSF FGVQEIIIHD QYKMAESGYD IALLKLETTV NYTDSQRPIC
510 520 530 540 550
LPSKGDRNVI YTDCWVTGWG YRKLRDKIQN TLQKAKIPLV TNEECQKRYR
560 570 580 590 600
GHKITHKMIC AGYREGGKDA CKGDSGGPLS CKHNEVWHLV GITSWGEGCA
610 620
QRERPGVYTN VVEYVDWILE KTQAV
Length:625
Mass (Da):70,109
Last modified:October 23, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i147AFA94B7709E8F
GO
Isoform 2 (identifier: P03951-2) [UniParc]FASTAAdd to basket
Also known as: Platelet

The sequence of this isoform differs from the canonical sequence as follows:
     109-162: Missing.

Show »
Length:571
Mass (Da):63,840
Checksum:iFB9D65D72151755E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RB32D6RB32_HUMAN
Coagulation factor XI
F11
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y596H0Y596_HUMAN
Coagulation factor XI
F11
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6R3B1X6R3B1_HUMAN
Coagulation factor XI
F11
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti226C → S in AAA51985 (PubMed:2827746).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07651530F → S in FA11D. 1 Publication1
Natural variantiVAR_06792932G → R in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875259EnsemblClinVar.1
Natural variantiVAR_01208534D → H in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875267EnsemblClinVar.1
Natural variantiVAR_06793043A → T in FA11D; dominant-negative mutation that results in severely decreased protein secretion. 1 PublicationCorresponds to variant dbSNP:rs281875264EnsemblClinVar.1
Natural variantiVAR_05489446C → F in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875271EnsemblClinVar.1
Natural variantiVAR_06793151T → I in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875252EnsemblClinVar.1
Natural variantiVAR_06793251T → P in FA11D. 2 PublicationsCorresponds to variant dbSNP:rs281875243EnsemblClinVar.1
Natural variantiVAR_06793353H → Q in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875261EnsemblClinVar.1
Natural variantiVAR_05489556C → R in FA11D; secretion of the mutant protein is impaired. 2 PublicationsCorresponds to variant dbSNP:rs121965069EnsemblClinVar.1
Natural variantiVAR_06793463A → V in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875244EnsemblClinVar.1
Natural variantiVAR_01177466P → L1 PublicationCorresponds to variant dbSNP:rs5968Ensembl.1
Natural variantiVAR_054896101K → R in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875272EnsemblClinVar.1
Natural variantiVAR_076516109A → T in FA11D. 1 PublicationCorresponds to variant dbSNP:rs768474112EnsemblClinVar.1
Natural variantiVAR_067935140C → Y in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875256EnsemblClinVar.1
Natural variantiVAR_054897151Y → C in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875273EnsemblClinVar.1
Natural variantiVAR_076517216D → N in FA11D. 1 Publication1
Natural variantiVAR_067936222D → Y in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875245EnsemblClinVar.1
Natural variantiVAR_067937228R → Q in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875246EnsemblClinVar.1
Natural variantiVAR_067938241F → L in FA11D; dominant-negative mutation that results in severely decreased protein secretion. 1 PublicationCorresponds to variant dbSNP:rs281875265EnsemblClinVar.1
Natural variantiVAR_011775244Q → R Found in a patient with factor XI deficiency that also carries mutation N-266. 2 PublicationsCorresponds to variant dbSNP:rs5969Ensembl.1
Natural variantiVAR_012086246W → C in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875279EnsemblClinVar.1
Natural variantiVAR_067939252R → T in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875260EnsemblClinVar.1
Natural variantiVAR_054898255C → Y in FA11D; secretion of the mutant protein is impaired. 1 PublicationCorresponds to variant dbSNP:rs281875277EnsemblClinVar.1
Natural variantiVAR_054899263G → E in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875274EnsemblClinVar.1
Natural variantiVAR_012087266S → N in FA11D. 1 PublicationCorresponds to variant dbSNP:rs145168351Ensembl.1
Natural variantiVAR_054900270K → I in FA11D; although the mutant protein is synthesized the secretion is reduced. 1 PublicationCorresponds to variant dbSNP:rs121965070EnsemblClinVar.1
Natural variantiVAR_067940276S → C in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875247EnsemblClinVar.1
Natural variantiVAR_067941277G → D in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875248EnsemblClinVar.1
Natural variantiVAR_006622301F → L in FA11D. 2 PublicationsCorresponds to variant dbSNP:rs121965064EnsemblClinVar.1
Natural variantiVAR_011776308I → F1 PublicationCorresponds to variant dbSNP:rs5972Ensembl.1
Natural variantiVAR_067942315E → K in FA11D. 2 PublicationsCorresponds to variant dbSNP:rs281875257EnsemblClinVar.1
Natural variantiVAR_012088320L → P in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875268EnsemblClinVar.1
Natural variantiVAR_012089322T → I in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875269EnsemblClinVar.1
Natural variantiVAR_012090326R → C in FA11D. 1 PublicationCorresponds to variant dbSNP:rs28934608EnsemblClinVar.1
Natural variantiVAR_067943331T → I in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875253EnsemblClinVar.1
Natural variantiVAR_011777339C → F3 PublicationsCorresponds to variant dbSNP:rs5967EnsemblClinVar.1
Natural variantiVAR_012091341E → K in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875270EnsemblClinVar.1
Natural variantiVAR_067944360L → P in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875254EnsemblClinVar.1
Natural variantiVAR_011778399W → R. Corresponds to variant dbSNP:rs1800439Ensembl.1
Natural variantiVAR_067945401W → R in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875262EnsemblClinVar.1
Natural variantiVAR_067946403V → M in FA11D; dominant-negative mutation that results in severely decreased protein secretion. 1 PublicationCorresponds to variant dbSNP:rs281875266EnsemblClinVar.1
Natural variantiVAR_012092404T → N in FA11D. 1 PublicationCorresponds to variant dbSNP:rs121965067EnsemblClinVar.1
Natural variantiVAR_054901418G → V in FA11D; mutant is not secreted by transfected fibroblasts; dominant-negative effect. 1 PublicationCorresponds to variant dbSNP:rs121965071EnsemblClinVar.1
Natural variantiVAR_012093430A → V in FA11D. 1 PublicationCorresponds to variant dbSNP:rs121965068EnsemblClinVar.1
Natural variantiVAR_067947454I → K in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875241EnsemblClinVar.1
Natural variantiVAR_012094460F → V in FA11D. 1 PublicationCorresponds to variant dbSNP:rs121965065EnsemblClinVar.1
Natural variantiVAR_067948481I → S in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875242EnsemblClinVar.1
Natural variantiVAR_012095493T → I in FA11D. 1 Publication1
Natural variantiVAR_067949503S → P in FA11D. 1 PublicationCorresponds to variant dbSNP:rs140068026EnsemblClinVar.1
Natural variantiVAR_067950506D → G in FA11D; mild phenotype. 1 PublicationCorresponds to variant dbSNP:rs281875258EnsemblClinVar.1
Natural variantiVAR_054902511Y → H in FA11D; transfected cells contain reduced amount of mutant protein and display decreased secretion. 1 PublicationCorresponds to variant dbSNP:rs281875278EnsemblClinVar.1
Natural variantiVAR_067951514C → F in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875249EnsemblClinVar.1
Natural variantiVAR_067952526D → E in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875263EnsemblClinVar.1
Natural variantiVAR_054903538P → L in FA11D. 1 PublicationCorresponds to variant dbSNP:rs139695003EnsemblClinVar.1
Natural variantiVAR_076518543E → K in FA11D. 1 PublicationCorresponds to variant dbSNP:rs142952627EnsemblClinVar.1
Natural variantiVAR_076519552H → R in FA11D. 1 PublicationCorresponds to variant dbSNP:rs369935706Ensembl.1
Natural variantiVAR_054904565E → K in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875275EnsemblClinVar.1
Natural variantiVAR_067953575S → L in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875250EnsemblClinVar.1
Natural variantiVAR_054905587W → S in FA11D; mutant is not secreted by transfected fibroblasts; dominant-negative effect. 1 PublicationCorresponds to variant dbSNP:rs121965072EnsemblClinVar.1
Natural variantiVAR_012096594S → R in FA11D. 1 PublicationCorresponds to variant dbSNP:rs28934609EnsemblClinVar.1
Natural variantiVAR_067954597E → K in FA11D. 2 PublicationsCorresponds to variant dbSNP:rs281875251EnsemblClinVar.1
Natural variantiVAR_067955608Y → H in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875255EnsemblClinVar.1
Natural variantiVAR_054906618I → S in FA11D. 1 PublicationCorresponds to variant dbSNP:rs281875276EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_005388109 – 162Missing in isoform 2. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M13142 mRNA Translation: AAA52487.1
M20218
, M18296, M21184, M18298, M18299, M18300, M18301, M18302, M18303, M18304, M19417, M20217 Genomic DNA Translation: AAA51985.1
AF045649 mRNA Translation: AAC24506.1
AY191837 Genomic DNA Translation: AAN85554.1
AC110771 Genomic DNA Translation: AAY40901.1
CH471056 Genomic DNA Translation: EAX04621.1
BC119014 mRNA Translation: AAI19015.1
BC122863 mRNA Translation: AAI22864.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3847.1 [P03951-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A27431 KFHU1

NCBI Reference Sequences

More...
RefSeqi
NP_000119.1, NM_000128.3 [P03951-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264692; ENSP00000264692; ENSG00000088926 [P03951-2]
ENST00000403665; ENSP00000384957; ENSG00000088926 [P03951-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2160

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2160

UCSC genome browser

More...
UCSCi
uc003iza.2 human [P03951-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Factor XI entry

SeattleSNPs
Mendelian genes Coagulation factor XI (F11)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13142 mRNA Translation: AAA52487.1
M20218
, M18296, M21184, M18298, M18299, M18300, M18301, M18302, M18303, M18304, M19417, M20217 Genomic DNA Translation: AAA51985.1
AF045649 mRNA Translation: AAC24506.1
AY191837 Genomic DNA Translation: AAN85554.1
AC110771 Genomic DNA Translation: AAY40901.1
CH471056 Genomic DNA Translation: EAX04621.1
BC119014 mRNA Translation: AAI19015.1
BC122863 mRNA Translation: AAI22864.1
CCDSiCCDS3847.1 [P03951-1]
PIRiA27431 KFHU1
RefSeqiNP_000119.1, NM_000128.3 [P03951-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XX9X-ray2.20A/B388-625[»]
1XXDX-ray2.91A/B388-625[»]
1XXFX-ray2.60A/B388-625[»]
1ZHMX-ray1.96A388-624[»]
1ZHPX-ray2.70A388-625[»]
1ZHRX-ray1.73A388-625[»]
1ZJDX-ray2.60A388-624[»]
1ZLRX-ray2.50A388-624[»]
1ZMJX-ray2.00A388-624[»]
1ZMLX-ray2.25A388-625[»]
1ZMNX-ray2.05A388-625[»]
1ZOMX-ray2.25A388-624[»]
1ZPBX-ray2.10A388-624[»]
1ZPCX-ray2.60A388-624[»]
1ZPZX-ray2.50A388-625[»]
1ZRKX-ray2.30A388-625[»]
1ZSJX-ray1.90A388-625[»]
1ZSKX-ray1.90A388-625[»]
1ZSLX-ray2.05A388-625[»]
1ZTJX-ray2.05A388-624[»]
1ZTKX-ray2.50A388-624[»]
1ZTLX-ray2.60A388-624[»]
2F83X-ray2.87A1-625[»]
2FDAX-ray2.00A388-625[»]
2J8JNMR-A/B290-379[»]
2J8LNMR-A/B290-379[»]
3BG8X-ray1.60A388-625[»]
3SORX-ray1.80A388-625[»]
3SOSX-ray2.58A388-625[»]
4CR5X-ray2.00A388-625[»]
4CR9X-ray1.70A388-625[»]
4CRAX-ray1.80A388-625[»]
4CRBX-ray1.85A388-625[»]
4CRCX-ray1.60A388-625[»]
4CRDX-ray2.10A388-625[»]
4CREX-ray1.73A388-625[»]
4CRFX-ray2.30A388-625[»]
4CRGX-ray1.25A388-625[»]
4D76X-ray1.77A388-625[»]
4D7FX-ray1.62A388-625[»]
4D7GX-ray2.33A388-625[»]
4NA7X-ray2.80A388-625[»]
4NA8X-ray2.30A388-625[»]
4TY6X-ray1.85A388-625[»]
H375-387[»]
4TY7X-ray2.09A388-625[»]
4WXIX-ray2.60A388-625[»]
4X6MX-ray2.40A388-625[»]
4X6NX-ray2.10A388-625[»]
H375-387[»]
4X6OX-ray2.10A388-625[»]
4X6PX-ray1.93A/B388-625[»]
4Y8XX-ray1.90A388-625[»]
4Y8YX-ray2.60A388-625[»]
4Y8ZX-ray2.20A388-625[»]
5E2OX-ray2.08A388-625[»]
5E2PX-ray2.11A388-625[»]
5EODX-ray3.10A20-625[»]
5EOKX-ray2.80A20-625[»]
5EXLX-ray2.30A388-625[»]
5EXMX-ray2.09A388-625[»]
5EXNX-ray1.49A388-625[»]
5I25X-ray2.85A19-625[»]
5Q0DX-ray2.12A388-625[»]
5Q0EX-ray2.12A388-625[»]
5Q0FX-ray2.12A388-625[»]
5Q0GX-ray2.60A388-625[»]
5Q0HX-ray2.50A388-625[»]
5QCKX-ray2.64A388-625[»]
5QCLX-ray2.11A388-625[»]
5QCMX-ray2.20A388-625[»]
5QCNX-ray2.30A388-625[»]
5TKSX-ray1.55A388-625[»]
5TKTX-ray2.12A388-625[»]
5TKUX-ray2.12A388-625[»]
5WB6X-ray2.35A388-625[»]
6AODX-ray1.80C388-624[»]
6C0SX-ray2.35A388-625[»]
6I58X-ray2.60A19-625[»]
6R8XX-ray2.04A388-625[»]
SMRiP03951
ModBaseiSearch...

Protein-protein interaction databases

BioGridi108458, 6 interactors
DIPiDIP-29085N
IntActiP03951, 3 interactors
STRINGi9606.ENSP00000384957

Chemistry databases

BindingDBiP03951
ChEMBLiCHEMBL2820
DrugBankiDB07022 3-HYDROXYPROPYL 3-[({7-[AMINO(IMINO)METHYL]-1-NAPHTHYL}AMINO)CARBONYL]BENZENESULFONATE
DB07299 4-METHYL-PENTANOIC ACID {1-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYLCARBAMOYL]-2-METHYL-PROPYL}-AMIDE
DB07074 6-CARBAMIMIDOYL-4-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-NAPHTHALENE-2-CARBOXYLIC ACID METHYL ESTER
DB06404 C1 Esterase Inhibitor (Human)
DB09228 C1 Esterase Inhibitor (Recombinant)
DB00100 Coagulation Factor IX (Recombinant)
DB07212 N-(7-CARBAMIMIDOYL-NAPHTHALEN-1-YL)-3-HYDROXY-2-METHYL-BENZAMIDE
GuidetoPHARMACOLOGYi2360

Protein family/group databases

MEROPSiS01.213

PTM databases

GlyConnecti818
iPTMnetiP03951
PhosphoSitePlusiP03951

Polymorphism and mutation databases

BioMutaiF11
DMDMi119762

Proteomic databases

PaxDbiP03951
PeptideAtlasiP03951
PRIDEiP03951
ProteomicsDBi51620
51621 [P03951-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
P03951
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264692; ENSP00000264692; ENSG00000088926 [P03951-2]
ENST00000403665; ENSP00000384957; ENSG00000088926 [P03951-1]
GeneIDi2160
KEGGihsa:2160
UCSCiuc003iza.2 human [P03951-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2160
DisGeNETi2160

GeneCards: human genes, protein and diseases

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GeneCardsi
F11
HGNCiHGNC:3529 F11
HPAiHPA039808
MalaCardsiF11
MIMi264900 gene
612416 phenotype
neXtProtiNX_P03951
OpenTargetsiENSG00000088926
Orphaneti329 Congenital factor XI deficiency
PharmGKBiPA27941

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00940000158569
HOGENOMiHOG000112467
InParanoidiP03951
KOiK01323
OMAiTCILKDS
OrthoDBi1340284at2759
PhylomeDBiP03951
TreeFamiTF343687

Enzyme and pathway databases

BRENDAi3.4.21.27 2681
ReactomeiR-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation
SABIO-RKiP03951
SIGNORiP03951

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
F11 human
EvolutionaryTraceiP03951

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Factor_XI

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2160
PMAP-CutDBiP03951

Protein Ontology

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PROi
PR:P03951

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000088926 Expressed in 97 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiP03951 baseline and differential
GenevisibleiP03951 HS

Family and domain databases

CDDicd01100 APPLE_Factor_XI_like, 4 hits
cd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR000177 Apple
IPR003609 Pan_app
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00024 PAN_1, 4 hits
PF00089 Trypsin, 1 hit
PRINTSiPR00005 APPLEDOMAIN
PR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00223 APPLE, 4 hits
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS00495 APPLE, 4 hits
PS50948 PAN, 4 hits
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFA11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P03951
Secondary accession number(s): D3DP64, Q4W5C2, Q9Y495
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: October 23, 1986
Last modified: July 3, 2019
This is version 223 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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