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Protein

NADH-ubiquinone oxidoreductase chain 6

Gene

Mtnd6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTranslocase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-MMU-611105 Respiratory electron transport
R-MMU-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 6 (EC:7.1.1.2)
Alternative name(s):
NADH dehydrogenase subunit 6
Gene namesi
Name:Mtnd6
Synonyms:mt-Nd6, Nd6
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Mitochondrion

Organism-specific databases

MGIiMGI:102495 mt-Nd6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001183041 – 172NADH-ubiquinone oxidoreductase chain 6Add BLAST172

Proteomic databases

PaxDbiP03925
PRIDEiP03925

Expressioni

Gene expression databases

BgeeiENSMUSG00000064368 Expressed in 19 organ(s), highest expression level in female gonad
ExpressionAtlasiP03925 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi201553, 1 interactor
ComplexPortaliCPX-266 Mitochondrial respiratory chain complex I
STRINGi10090.ENSMUSP00000081002

Structurei

Secondary structure

1172
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 6 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYM9 Eukaryota
ENOG410YP23 LUCA
GeneTreeiENSGT00390000003988
HOGENOMiHOG000113881
HOVERGENiHBG007487
InParanoidiP03925
KOiK03884
OMAiMAIEEYP
OrthoDBiEOG091G111J
PhylomeDBiP03925
TreeFamiTF343324

Family and domain databases

InterProiView protein in InterPro
IPR001457 NADH_UbQ/plastoQ_OxRdtase_su6
PfamiView protein in Pfam
PF00499 Oxidored_q3, 1 hit

Sequencei

Sequence statusi: Complete.

P03925-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNNYIFVLSS LFLVGCLGLA LKPSPIYGGL GLIVSGFVGC LMVLGFGGSF
60 70 80 90 100
LGLMVFLIYL GGMLVVFGYT TAMATEEYPE TWGSNWLILG FLVLGVIMEV
110 120 130 140 150
FLICVLNYYD EVGVINLDGL GDWLMYEVDD VGVMLEGGIG VAAMYSCATW
160 170
MMVVAGWSLF AGIFIIIEIT RD
Length:172
Mass (Da):18,626
Last modified:July 21, 1986 - v1
Checksum:i55DE2331AB0A1115
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA Translation: AAB48655.1
V00711 Genomic DNA Translation: CAA24089.1
AY172335 Genomic DNA Translation: AAN85133.1
PIRiA00457 DEMSN6
RefSeqiNP_904339.1, NC_005089.1

Genome annotation databases

EnsembliENSMUST00000082419; ENSMUSP00000081002; ENSMUSG00000064368
GeneIDi17722
KEGGimmu:17722

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA Translation: AAB48655.1
V00711 Genomic DNA Translation: CAA24089.1
AY172335 Genomic DNA Translation: AAN85133.1
PIRiA00457 DEMSN6
RefSeqiNP_904339.1, NC_005089.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6G2Jelectron microscopy3.30J1-172[»]
6G72electron microscopy3.90J1-172[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201553, 1 interactor
ComplexPortaliCPX-266 Mitochondrial respiratory chain complex I
STRINGi10090.ENSMUSP00000081002

Proteomic databases

PaxDbiP03925
PRIDEiP03925

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082419; ENSMUSP00000081002; ENSMUSG00000064368
GeneIDi17722
KEGGimmu:17722

Organism-specific databases

CTDi4541
MGIiMGI:102495 mt-Nd6

Phylogenomic databases

eggNOGiENOG410IYM9 Eukaryota
ENOG410YP23 LUCA
GeneTreeiENSGT00390000003988
HOGENOMiHOG000113881
HOVERGENiHBG007487
InParanoidiP03925
KOiK03884
OMAiMAIEEYP
OrthoDBiEOG091G111J
PhylomeDBiP03925
TreeFamiTF343324

Enzyme and pathway databases

ReactomeiR-MMU-611105 Respiratory electron transport
R-MMU-6799198 Complex I biogenesis

Miscellaneous databases

PROiPR:P03925
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000064368 Expressed in 19 organ(s), highest expression level in female gonad
ExpressionAtlasiP03925 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001457 NADH_UbQ/plastoQ_OxRdtase_su6
PfamiView protein in Pfam
PF00499 Oxidored_q3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNU6M_MOUSE
AccessioniPrimary (citable) accession number: P03925
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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