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Protein

NADH-ubiquinone oxidoreductase chain 5

Gene

Mtnd5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  • NADH dehydrogenase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionTranslocase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-MMU-611105 Respiratory electron transport
R-MMU-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 5 (EC:7.1.1.2)
Alternative name(s):
NADH dehydrogenase subunit 5
Gene namesi
Name:Mtnd5
Synonyms:mt-Nd5, Nd5
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Mitochondrion

Organism-specific databases

MGIiMGI:102496 mt-Nd5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21
Transmembranei301 – 320HelicalSequence analysisAdd BLAST20
Transmembranei324 – 344HelicalSequence analysisAdd BLAST21
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Transmembranei405 – 427HelicalSequence analysisAdd BLAST23
Transmembranei457 – 477HelicalSequence analysisAdd BLAST21
Transmembranei482 – 502HelicalSequence analysisAdd BLAST21
Transmembranei586 – 606HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001181141 – 607NADH-ubiquinone oxidoreductase chain 5Add BLAST607

Proteomic databases

PaxDbiP03921
PeptideAtlasiP03921
PRIDEiP03921
TopDownProteomicsiP03921

PTM databases

iPTMnetiP03921
PhosphoSitePlusiP03921

Expressioni

Gene expression databases

BgeeiENSMUSG00000064367 Expressed in 35 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiP03921 baseline and differential

Interactioni

Protein-protein interaction databases

ComplexPortaliCPX-266 Mitochondrial respiratory chain complex I
IntActiP03921, 2 interactors
STRINGi10090.ENSMUSP00000081001

Structurei

Secondary structure

1607
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP03921
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4668 Eukaryota
COG1009 LUCA
GeneTreeiENSGT00730000111303
HOGENOMiHOG000100570
HOVERGENiHBG108343
InParanoidiP03921
KOiK03883
OMAiGVGIMSF
OrthoDBiEOG091G0M2F

Family and domain databases

InterProiView protein in InterPro
IPR010934 NADH_DH_su5_C
IPR003945 NADHpl_OxRdtase_5
IPR001750 ND/Mrp_mem
IPR001516 Proton_antipo_N
PfamiView protein in Pfam
PF06455 NADH5_C, 1 hit
PF00361 Proton_antipo_M, 1 hit
PF00662 Proton_antipo_N, 1 hit
TIGRFAMsiTIGR01974 NDH_I_L, 1 hit

Sequencei

Sequence statusi: Complete.

P03921-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNIFTTSILL IFILLLSPIL ISMSNLIKHI NFPLYTTTSI KFSFIISLLP
60 70 80 90 100
LLMFFHNNME YMITTWHWVT MNSMELKMSF KTDFFSILFT SVALFVTWSI
110 120 130 140 150
MQFSSWYMHS DPNINRFIKY LTLFLITMLI LTSANNMFQL FIGWEGVGIM
160 170 180 190 200
SFLLIGWWYG RTDANTAALQ AILYNRIGDI GFILAMVWFS LNMNSWELQQ
210 220 230 240 250
IMFSNNNDNL IPLMGLLIAA TGKSAQFGLH PWLPSAMEGP TPVSALLHSS
260 270 280 290 300
TMVVAGIFLL VRFHPLTTNN NFILTTMLCL GALTTLFTAI CALTQNDIKK
310 320 330 340 350
IIAFSTSSQL GLMMVTLGMN QPHLAFLHIC THAFFKAMLF MCSGSIIHSL
360 370 380 390 400
ADEQDIRKMG NITKIMPFTS SCLVIGSLAL TGMPFLTGFY SKDLIIEAIN
410 420 430 440 450
TCNTNAWALL ITLIATSMTA MYSMRIIYFV TMTKPRFPPL ISINENDPDL
460 470 480 490 500
MNPIKRLAFG SIFAGFVISY NIPPTSIPVL TMPWFLKTTA LIISVLGFLI
510 520 530 540 550
ALELNNLTMK LSMNKANPYS SFSTLLGFFP SIIHRITPMK SLNLSLKTSL
560 570 580 590 600
TLLDLIWLEK TIPKSTSTLH TNMTTLTTNQ KGLIKLYFMS FLINIILIII

LYSINLE
Length:607
Mass (Da):68,475
Last modified:April 1, 2015 - v3
Checksum:i31C10862CDC78B10
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103F → L in AAB48654 (PubMed:7332926).Curated1
Sequence conflicti103F → L in CAA24088 (PubMed:7332926).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA Translation: AAB48654.1
V00711 Genomic DNA Translation: CAA24088.1
AY172335 Genomic DNA Translation: AAN85132.1
PIRiA00451 QXMS5M
RefSeqiNP_904338.1, NC_005089.1

Genome annotation databases

EnsembliENSMUST00000082418; ENSMUSP00000081001; ENSMUSG00000064367
GeneIDi17721
KEGGimmu:17721

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA Translation: AAB48654.1
V00711 Genomic DNA Translation: CAA24088.1
AY172335 Genomic DNA Translation: AAN85132.1
PIRiA00451 QXMS5M
RefSeqiNP_904338.1, NC_005089.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6G2Jelectron microscopy3.30L1-607[»]
6G72electron microscopy3.90L1-607[»]
ProteinModelPortaliP03921
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-266 Mitochondrial respiratory chain complex I
IntActiP03921, 2 interactors
STRINGi10090.ENSMUSP00000081001

PTM databases

iPTMnetiP03921
PhosphoSitePlusiP03921

Proteomic databases

PaxDbiP03921
PeptideAtlasiP03921
PRIDEiP03921
TopDownProteomicsiP03921

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082418; ENSMUSP00000081001; ENSMUSG00000064367
GeneIDi17721
KEGGimmu:17721

Organism-specific databases

CTDi4540
MGIiMGI:102496 mt-Nd5

Phylogenomic databases

eggNOGiKOG4668 Eukaryota
COG1009 LUCA
GeneTreeiENSGT00730000111303
HOGENOMiHOG000100570
HOVERGENiHBG108343
InParanoidiP03921
KOiK03883
OMAiGVGIMSF
OrthoDBiEOG091G0M2F

Enzyme and pathway databases

ReactomeiR-MMU-611105 Respiratory electron transport
R-MMU-6799198 Complex I biogenesis

Miscellaneous databases

PROiPR:P03921
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000064367 Expressed in 35 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiP03921 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR010934 NADH_DH_su5_C
IPR003945 NADHpl_OxRdtase_5
IPR001750 ND/Mrp_mem
IPR001516 Proton_antipo_N
PfamiView protein in Pfam
PF06455 NADH5_C, 1 hit
PF00361 Proton_antipo_M, 1 hit
PF00662 Proton_antipo_N, 1 hit
TIGRFAMsiTIGR01974 NDH_I_L, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNU5M_MOUSE
AccessioniPrimary (citable) accession number: P03921
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 2015
Last modified: November 7, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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