Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NADH-ubiquinone oxidoreductase chain 5

Gene

MT-ND5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 5 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 5
Gene namesi
Name:MT-ND5
Synonyms:MTND5, NADH5, ND5
Encoded oniMitochondrion
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Mitochondrion

Organism-specific databases

EuPathDBiHostDB:ENSG00000198786.2
HGNCiHGNC:7461 MT-ND5
MIMi516005 gene
neXtProtiNX_P03915

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Transmembranei144 – 160HelicalSequence analysisAdd BLAST17
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Transmembranei211 – 233HelicalSequence analysisAdd BLAST23
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21
Transmembranei301 – 320HelicalSequence analysisAdd BLAST20
Transmembranei325 – 347HelicalSequence analysisAdd BLAST23
Transmembranei370 – 390HelicalSequence analysisAdd BLAST21
Transmembranei407 – 429HelicalSequence analysisAdd BLAST23
Transmembranei458 – 478HelicalSequence analysisAdd BLAST21
Transmembranei482 – 502HelicalSequence analysisAdd BLAST21
Transmembranei582 – 602HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Involvement in diseasei

Leber hereditary optic neuropathy (LHON)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes.
See also OMIM:535000
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035426171A → V in LHON. 1 PublicationCorresponds to variant dbSNP:rs267606899Ensembl.1
Natural variantiVAR_004761458A → T in LHON; secondary mutation; does not seem to directly cause the disease. 2 PublicationsCorresponds to variant dbSNP:rs28359178Ensembl.1
Natural variantiVAR_004762465G → E in LHON; primary rare mutation. 1 PublicationCorresponds to variant dbSNP:rs387906425Ensembl.1
Leigh syndrome (LS)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn early-onset progressive neurodegenerative disorder characterized by the presence of focal, bilateral lesions in one or more areas of the central nervous system including the brainstem, thalamus, basal ganglia, cerebellum and spinal cord. Clinical features depend on which areas of the central nervous system are involved and include subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, and dysphagia.
See also OMIM:256000
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035429250S → C in LS. 1 PublicationCorresponds to variant dbSNP:rs267606896Ensembl.1
Mitochondrial complex I deficiency (MT-C1D)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder of the mitochondrial respiratory chain that causes a wide range of clinical manifestations from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease.
See also OMIM:252010
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035427236A → T in MT-C1D. 2 PublicationsCorresponds to variant dbSNP:rs267606898Ensembl.1
Natural variantiVAR_035428237M → L in MT-C1D. 1 PublicationCorresponds to variant dbSNP:rs267606895Ensembl.1
Natural variantiVAR_064566253V → A in MT-C1D. 1 Publication1
Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome (MELAS)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionGenetically heterogeneous disorder, characterized by episodic vomiting, seizures, and recurrent cerebral insults resembling strokes and causing hemiparesis, hemianopsia, or cortical blindness.
See also OMIM:540000
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035425145E → G in MELAS. 1 PublicationCorresponds to variant dbSNP:rs267606894Ensembl.1

Keywords - Diseasei

Disease mutation, Leber hereditary optic neuropathy, Leigh syndrome, MELAS syndrome, Primary mitochondrial disease

Organism-specific databases

DisGeNETi4540
GeneReviewsiMT-ND5
MalaCardsiMT-ND5
MIMi252010 phenotype
256000 phenotype
535000 phenotype
540000 phenotype
OpenTargetsiENSG00000198786
Orphaneti104 Leber hereditary optic neuropathy
255210 Maternally-inherited Leigh syndrome
550 MELAS
551 MERRF

Chemistry databases

ChEMBLiCHEMBL2363065
DrugBankiDB05382 molecular iodine
DB00157 NADH

Polymorphism and mutation databases

DMDMi6648059

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001181011 – 603NADH-ubiquinone oxidoreductase chain 5Add BLAST603

Proteomic databases

EPDiP03915
PaxDbiP03915
PeptideAtlasiP03915
PRIDEiP03915
ProteomicsDBi51616

PTM databases

iPTMnetiP03915
PhosphoSitePlusiP03915
SwissPalmiP03915

Expressioni

Gene expression databases

BgeeiENSG00000198786
ExpressionAtlasiP03915 baseline and differential
GenevisibleiP03915 HS

Interactioni

Protein-protein interaction databases

BioGridi110636, 32 interactors
ComplexPortaliCPX-577 Mitochondrial respiratory chain complex I
CORUMiP03915
IntActiP03915, 12 interactors
MINTiP03915
STRINGi9606.ENSP00000354813

Structurei

3D structure databases

ProteinModelPortaliP03915
SMRiP03915
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4668 Eukaryota
COG1009 LUCA
GeneTreeiENSGT00730000111303
HOGENOMiHOG000100570
HOVERGENiHBG108343
InParanoidiP03915
KOiK03883
OMAiFWYAQPL
OrthoDBiEOG091G0M2F
PhylomeDBiP03915
TreeFamiTF342974

Family and domain databases

InterProiView protein in InterPro
IPR010934 NADH_DH_su5_C
IPR003945 NADHpl_OxRdtase_5
IPR001750 ND/Mrp_mem
IPR001516 Proton_antipo_N
PfamiView protein in Pfam
PF06455 NADH5_C, 1 hit
PF00361 Proton_antipo_M, 1 hit
PF00662 Proton_antipo_N, 1 hit
TIGRFAMsiTIGR01974 NDH_I_L, 1 hit

Sequencei

Sequence statusi: Complete.

P03915-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMHTTMTTL TLTSLIPPIL TTLVNPNKKN SYPHYVKSIV ASTFIISLFP
60 70 80 90 100
TTMFMCLDQE VIISNWHWAT TQTTQLSLSF KLDYFSMMFI PVALFVTWSI
110 120 130 140 150
MEFSLWYMNS DPNINQFFKY LLIFLITMLI LVTANNLFQL FIGWEGVGIM
160 170 180 190 200
SFLLISWWYA RADANTAAIQ AILYNRIGDI GFILALAWFI LHSNSWDPQQ
210 220 230 240 250
MALLNANPSL TPLLGLLLAA AGKSAQLGLH PWLPSAMEGP TPVSALLHSS
260 270 280 290 300
TMVVAGIFLL IRFHPLAENS PLIQTLTLCL GAITTLFAAV CALTQNDIKK
310 320 330 340 350
IVAFSTSSQL GLMMVTIGIN QPHLAFLHIC THAFFKAMLF MCSGSIIHNL
360 370 380 390 400
NNEQDIRKMG GLLKTMPLTS TSLTIGSLAL AGMPFLTGFY SKDHIIETAN
410 420 430 440 450
MSYTNAWALS ITLIATSLTS AYSTRMILLT LTGQPRFPTL TNINENNPTL
460 470 480 490 500
LNPIKRLAAG SLFAGFLITN NISPASPFQT TIPLYLKLTA LAVTFLGLLT
510 520 530 540 550
ALDLNYLTNK LKMKSPLCTF YFSNMLGFYP SITHRTIPYL GLLTSQNLPL
560 570 580 590 600
LLLDLTWLEK LLPKTISQHQ ISTSIITSTQ KGMIKLYFLS FFFPLILTLL

LIT
Length:603
Mass (Da):67,027
Last modified:May 30, 2000 - v2
Checksum:i18A06227ABC9162A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti456R → G in CAA24036 (PubMed:7219534).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00886417P → S1 Publication1
Natural variantiVAR_00886595F → S1 Publication1
Natural variantiVAR_00886699S → P1 Publication1
Natural variantiVAR_035424124F → L in LS and MT-C1D. 2 PublicationsCorresponds to variant dbSNP:rs267606893Ensembl.1
Natural variantiVAR_035425145E → G in MELAS. 1 PublicationCorresponds to variant dbSNP:rs267606894Ensembl.1
Natural variantiVAR_008867146G → D1 Publication1
Natural variantiVAR_008868160A → V1 Publication1
Natural variantiVAR_008869165N → S1 Publication1
Natural variantiVAR_035426171A → V in LHON. 1 PublicationCorresponds to variant dbSNP:rs267606899Ensembl.1
Natural variantiVAR_011357211T → P1 Publication1
Natural variantiVAR_035427236A → T in MT-C1D. 2 PublicationsCorresponds to variant dbSNP:rs267606898Ensembl.1
Natural variantiVAR_035428237M → L in MT-C1D. 1 PublicationCorresponds to variant dbSNP:rs267606895Ensembl.1
Natural variantiVAR_035429250S → C in LS. 1 PublicationCorresponds to variant dbSNP:rs267606896Ensembl.1
Natural variantiVAR_064566253V → A in MT-C1D. 1 Publication1
Natural variantiVAR_011358257I → V2 PublicationsCorresponds to variant dbSNP:rs2853501Ensembl.1
Natural variantiVAR_008870304F → S1 Publication1
Natural variantiVAR_011359314M → V1 PublicationCorresponds to variant dbSNP:rs2853502Ensembl.1
Natural variantiVAR_008871331T → A1 Publication1
Natural variantiVAR_035430393D → N in MELAS and MT-C1D. 3 PublicationsCorresponds to variant dbSNP:rs267606897Ensembl.1
Natural variantiVAR_064567447N → S Detected in a patient with mitochondrial complex I deficiency; uncertain pathological significance. 1 Publication1
Natural variantiVAR_004761458A → T in LHON; secondary mutation; does not seem to directly cause the disease. 2 PublicationsCorresponds to variant dbSNP:rs28359178Ensembl.1
Natural variantiVAR_004762465G → E in LHON; primary rare mutation. 1 PublicationCorresponds to variant dbSNP:rs387906425Ensembl.1
Natural variantiVAR_008603475A → T1 PublicationCorresponds to variant dbSNP:rs386420024Ensembl.1
Natural variantiVAR_008872503D → G1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01415 Genomic DNA Translation: AAB58953.1
V00662 Genomic DNA Translation: CAA24036.1
D38112 Genomic DNA Translation: BAA07297.1
AF465942 Genomic DNA Translation: AAN14557.1
AY339402 Genomic DNA Translation: AAP89046.1
AY339403 Genomic DNA Translation: AAP89059.1
AY339404 Genomic DNA Translation: AAP89072.1
AY339405 Genomic DNA Translation: AAP89085.1
AY339406 Genomic DNA Translation: AAP89098.1
AY339407 Genomic DNA Translation: AAP89111.1
AY339408 Genomic DNA Translation: AAP89124.1
AY339409 Genomic DNA Translation: AAP89137.1
AY339410 Genomic DNA Translation: AAP89150.1
AY339411 Genomic DNA Translation: AAP89163.1
AY339412 Genomic DNA Translation: AAP89176.1
AY339413 Genomic DNA Translation: AAP89189.1
AY339414 Genomic DNA Translation: AAP89202.1
AY339415 Genomic DNA Translation: AAP89215.1
AY339416 Genomic DNA Translation: AAP89228.1
AY339417 Genomic DNA Translation: AAP89241.1
AY339418 Genomic DNA Translation: AAP89254.1
AY339419 Genomic DNA Translation: AAP89267.1
AY339420 Genomic DNA Translation: AAP89280.1
AY339421 Genomic DNA Translation: AAP89293.1
AY339422 Genomic DNA Translation: AAP89306.1
AY339423 Genomic DNA Translation: AAP89319.1
AY339424 Genomic DNA Translation: AAP89332.1
AY339425 Genomic DNA Translation: AAP89345.1
AY339426 Genomic DNA Translation: AAP89358.1
AY339427 Genomic DNA Translation: AAP89371.1
AY339428 Genomic DNA Translation: AAP89384.1
AY339429 Genomic DNA Translation: AAP89397.1
AY339430 Genomic DNA Translation: AAP89410.1
AY339431 Genomic DNA Translation: AAP89423.1
AY339432 Genomic DNA Translation: AAP89436.1
AY339433 Genomic DNA Translation: AAP89449.1
AY339434 Genomic DNA Translation: AAP89462.1
AY339435 Genomic DNA Translation: AAP89475.1
AY339436 Genomic DNA Translation: AAP89488.1
AY339437 Genomic DNA Translation: AAP89501.1
AY339438 Genomic DNA Translation: AAP89514.1
AY339439 Genomic DNA Translation: AAP89527.1
AY339440 Genomic DNA Translation: AAP89540.1
AY339441 Genomic DNA Translation: AAP89553.1
AY339442 Genomic DNA Translation: AAP89566.1
AY339443 Genomic DNA Translation: AAP89579.1
AY339444 Genomic DNA Translation: AAP89592.1
AY339445 Genomic DNA Translation: AAP89605.1
AY339446 Genomic DNA Translation: AAP89618.1
AY339447 Genomic DNA Translation: AAP89631.1
AY339448 Genomic DNA Translation: AAP89644.1
AY339449 Genomic DNA Translation: AAP89657.1
AY339451 Genomic DNA Translation: AAP89683.1
AY339452 Genomic DNA Translation: AAP89696.1
AY339453 Genomic DNA Translation: AAP89709.1
AY339454 Genomic DNA Translation: AAP89722.1
AY339455 Genomic DNA Translation: AAP89735.1
AY339456 Genomic DNA Translation: AAP89748.1
AY339457 Genomic DNA Translation: AAP89761.1
AY339458 Genomic DNA Translation: AAP89774.1
AY339459 Genomic DNA Translation: AAP89787.1
AY339460 Genomic DNA Translation: AAP89800.1
AY339461 Genomic DNA Translation: AAP89813.1
AY339462 Genomic DNA Translation: AAP89826.1
AY339463 Genomic DNA Translation: AAP89839.1
AY339464 Genomic DNA Translation: AAP89852.1
AY339465 Genomic DNA Translation: AAP89865.1
AY339466 Genomic DNA Translation: AAP89878.1
AY339467 Genomic DNA Translation: AAP89891.1
AY339468 Genomic DNA Translation: AAP89904.1
AY339469 Genomic DNA Translation: AAP89917.1
AY339470 Genomic DNA Translation: AAP89930.1
AY339471 Genomic DNA Translation: AAP89943.1
AY339472 Genomic DNA Translation: AAP89956.1
AY339473 Genomic DNA Translation: AAP89969.1
AY339474 Genomic DNA Translation: AAP89982.1
AY339475 Genomic DNA Translation: AAP89995.1
AY339476 Genomic DNA Translation: AAP90008.1
AY339477 Genomic DNA Translation: AAP90021.1
AY339478 Genomic DNA Translation: AAP90034.1
AY339479 Genomic DNA Translation: AAP90047.1
AY339480 Genomic DNA Translation: AAP90060.1
AY339481 Genomic DNA Translation: AAP90073.1
AY339482 Genomic DNA Translation: AAP90086.1
AY339483 Genomic DNA Translation: AAP90099.1
AY339484 Genomic DNA Translation: AAP90112.1
AY339485 Genomic DNA Translation: AAP90125.1
AY339486 Genomic DNA Translation: AAP90138.1
AY339487 Genomic DNA Translation: AAP90151.1
AY339488 Genomic DNA Translation: AAP90164.1
AY339489 Genomic DNA Translation: AAP90177.1
AY339490 Genomic DNA Translation: AAP90190.1
AY339491 Genomic DNA Translation: AAP90203.1
AY339492 Genomic DNA Translation: AAP90216.1
AY339493 Genomic DNA Translation: AAP90229.1
AY339494 Genomic DNA Translation: AAP90242.1
AY339495 Genomic DNA Translation: AAP90255.1
AY339496 Genomic DNA Translation: AAP90268.1
AY339514 Genomic DNA Translation: AAP90502.1
AY339515 Genomic DNA Translation: AAP90515.1
AY339516 Genomic DNA Translation: AAP90528.1
AY339517 Genomic DNA Translation: AAP90541.1
AY339518 Genomic DNA Translation: AAP90554.1
AY339519 Genomic DNA Translation: AAP90567.1
AY339520 Genomic DNA Translation: AAP90580.1
AY339521 Genomic DNA Translation: AAP90593.1
AY339522 Genomic DNA Translation: AAP90606.1
AY339523 Genomic DNA Translation: AAP90619.1
AY339528 Genomic DNA Translation: AAP90684.1
AY339529 Genomic DNA Translation: AAP90697.1
AY339530 Genomic DNA Translation: AAP90710.1
AY339531 Genomic DNA Translation: AAP90723.1
AY339532 Genomic DNA Translation: AAP90736.1
AY339533 Genomic DNA Translation: AAP90749.1
AY339534 Genomic DNA Translation: AAP90762.1
AY339535 Genomic DNA Translation: AAP90775.1
AY339536 Genomic DNA Translation: AAP90788.1
AY339537 Genomic DNA Translation: AAP90801.1
AY339538 Genomic DNA Translation: AAP90814.1
AY339539 Genomic DNA Translation: AAP90827.1
AY339540 Genomic DNA Translation: AAP90840.1
AY339541 Genomic DNA Translation: AAP90853.1
AY339542 Genomic DNA Translation: AAP90866.1
AY339543 Genomic DNA Translation: AAP90879.1
AY339547 Genomic DNA Translation: AAP90931.1
AY339548 Genomic DNA Translation: AAP90944.1
AY339549 Genomic DNA Translation: AAP90957.1
AY339550 Genomic DNA Translation: AAP90970.1
AY339554 Genomic DNA Translation: AAP91022.1
AY339555 Genomic DNA Translation: AAP91035.1
AY339556 Genomic DNA Translation: AAP91048.1
AY339557 Genomic DNA Translation: AAP91061.1
AY339558 Genomic DNA Translation: AAP91074.1
AY339559 Genomic DNA Translation: AAP91087.1
AY339560 Genomic DNA Translation: AAP91100.1
AY339563 Genomic DNA Translation: AAP91139.1
AY339564 Genomic DNA Translation: AAP91152.1
AY339565 Genomic DNA Translation: AAP91165.1
AY339566 Genomic DNA Translation: AAP91178.1
AY339567 Genomic DNA Translation: AAP91191.1
AY339568 Genomic DNA Translation: AAP91204.1
AY339569 Genomic DNA Translation: AAP91217.1
AY339570 Genomic DNA Translation: AAP91230.1
AY339571 Genomic DNA Translation: AAP91243.1
AY339572 Genomic DNA Translation: AAP91256.1
AY339573 Genomic DNA Translation: AAP91269.1
AY339574 Genomic DNA Translation: AAP91282.1
AY339575 Genomic DNA Translation: AAP91295.1
AY339576 Genomic DNA Translation: AAP91308.1
AF346970 Genomic DNA Translation: AAK17308.1
AF346971 Genomic DNA Translation: AAK17321.1
AF346972 Genomic DNA Translation: AAK17334.1
AF346976 Genomic DNA Translation: AAK17386.1
AF346977 Genomic DNA Translation: AAK17399.1
AF346979 Genomic DNA Translation: AAK17425.1
AF346980 Genomic DNA Translation: AAK17438.1
AF346981 Genomic DNA Translation: AAK17451.1
AF346982 Genomic DNA Translation: AAK17464.1
AF346984 Genomic DNA Translation: AAK17490.1
AF346988 Genomic DNA Translation: AAK17542.1
AF346989 Genomic DNA Translation: AAK17555.1
AF346990 Genomic DNA Translation: AAK17568.1
AF346991 Genomic DNA Translation: AAK17581.1
AF346993 Genomic DNA Translation: AAK17607.1
AF346994 Genomic DNA Translation: AAK17620.1
AF347000 Genomic DNA Translation: AAK17698.1
AF347001 Genomic DNA Translation: AAK17711.1
AF347006 Genomic DNA Translation: AAK17776.1
AF347007 Genomic DNA Translation: AAK17789.1
AF347010 Genomic DNA Translation: AAK17828.1
AF347011 Genomic DNA Translation: AAK17841.1
AF347012 Genomic DNA Translation: AAK17854.1
AF347013 Genomic DNA Translation: AAK17867.1
AY289051 Genomic DNA Translation: AAP47890.1
AY289053 Genomic DNA Translation: AAP47916.1
AY289056 Genomic DNA Translation: AAP47955.1
AY289057 Genomic DNA Translation: AAP47968.1
AY289058 Genomic DNA Translation: AAP47981.1
AY289061 Genomic DNA Translation: AAP48020.1
AY289062 Genomic DNA Translation: AAP48033.1
AY289064 Genomic DNA Translation: AAP48059.1
AY289066 Genomic DNA Translation: AAP48085.1
AY289067 Genomic DNA Translation: AAP48098.1
AY289068 Genomic DNA Translation: AAP48111.1
AY289069 Genomic DNA Translation: AAP48124.1
AY289070 Genomic DNA Translation: AAP48137.1
AY289072 Genomic DNA Translation: AAP48163.1
AY289076 Genomic DNA Translation: AAP48215.1
AY289077 Genomic DNA Translation: AAP48228.1
AY289080 Genomic DNA Translation: AAP48267.1
AY289083 Genomic DNA Translation: AAP48306.1
AY289084 Genomic DNA Translation: AAP48319.1
AY289088 Genomic DNA Translation: AAP48371.1
AY289093 Genomic DNA Translation: AAP48435.1
AY289094 Genomic DNA Translation: AAP48448.1
AY289097 Genomic DNA Translation: AAP48487.1
AY289098 Genomic DNA Translation: AAP48500.1
AY289100 Genomic DNA Translation: AAP48526.1
AY289101 Genomic DNA Translation: AAP48539.1
AY289102 Genomic DNA Translation: AAP48552.1
AY495090 Genomic DNA Translation: AAR92506.1
AY495091 Genomic DNA Translation: AAR92519.1
AY495092 Genomic DNA Translation: AAR92532.1
AY495094 Genomic DNA Translation: AAR92558.1
AY495095 Genomic DNA Translation: AAR92571.1
AY495097 Genomic DNA Translation: AAR92597.1
AY495098 Genomic DNA Translation: AAR92610.1
AY495099 Genomic DNA Translation: AAR92623.1
AY495100 Genomic DNA Translation: AAR92636.1
AY495101 Genomic DNA Translation: AAR92649.1
AY495102 Genomic DNA Translation: AAR92662.1
AY495103 Genomic DNA Translation: AAR92675.1
AY495104 Genomic DNA Translation: AAR92688.1
AY495105 Genomic DNA Translation: AAR92701.1
AY495107 Genomic DNA Translation: AAR92727.1
AY495108 Genomic DNA Translation: AAR92740.1
AY495109 Genomic DNA Translation: AAR92753.1
AY495110 Genomic DNA Translation: AAR92766.1
AY495111 Genomic DNA Translation: AAR92779.1
AY495112 Genomic DNA Translation: AAR92792.1
AY495113 Genomic DNA Translation: AAR92805.1
AY495114 Genomic DNA Translation: AAR92818.1
AY495115 Genomic DNA Translation: AAR92831.1
AY495117 Genomic DNA Translation: AAR92857.1
AY495118 Genomic DNA Translation: AAR92870.1
AY495119 Genomic DNA Translation: AAR92883.1
AY495120 Genomic DNA Translation: AAR92896.1
AY495121 Genomic DNA Translation: AAR92909.1
AY495122 Genomic DNA Translation: AAR92922.1
AY495123 Genomic DNA Translation: AAR92935.1
AY495124 Genomic DNA Translation: AAR92948.1
AY495125 Genomic DNA Translation: AAR92961.1
AY495126 Genomic DNA Translation: AAR92974.1
AY495127 Genomic DNA Translation: AAR92987.1
AY495128 Genomic DNA Translation: AAR93000.1
AY495129 Genomic DNA Translation: AAR93013.1
AY495130 Genomic DNA Translation: AAR93026.1
AY495131 Genomic DNA Translation: AAR93039.1
AY495132 Genomic DNA Translation: AAR93052.1
AY495133 Genomic DNA Translation: AAR93065.1
AY495134 Genomic DNA Translation: AAR93078.1
AY495135 Genomic DNA Translation: AAR93091.1
AY495136 Genomic DNA Translation: AAR93104.1
AY495137 Genomic DNA Translation: AAR93117.1
AY495138 Genomic DNA Translation: AAR93130.1
AY495139 Genomic DNA Translation: AAR93143.1
AY495140 Genomic DNA Translation: AAR93156.1
AY495141 Genomic DNA Translation: AAR93169.1
AY495142 Genomic DNA Translation: AAR93182.1
AY495143 Genomic DNA Translation: AAR93195.1
AY495144 Genomic DNA Translation: AAR93208.1
AY495145 Genomic DNA Translation: AAR93221.1
AY495146 Genomic DNA Translation: AAR93234.1
AY495147 Genomic DNA Translation: AAR93247.1
AY495148 Genomic DNA Translation: AAR93260.1
AY495149 Genomic DNA Translation: AAR93273.1
AY495150 Genomic DNA Translation: AAR93286.1
AY495151 Genomic DNA Translation: AAR93299.1
AY495152 Genomic DNA Translation: AAR93312.1
AY495154 Genomic DNA Translation: AAR93338.1
AY495155 Genomic DNA Translation: AAR93351.1
AY495156 Genomic DNA Translation: AAR93364.1
AY495157 Genomic DNA Translation: AAR93377.1
AY495158 Genomic DNA Translation: AAR93390.1
AY495159 Genomic DNA Translation: AAR93403.1
AY495160 Genomic DNA Translation: AAR93416.1
AY495161 Genomic DNA Translation: AAR93429.1
AY495162 Genomic DNA Translation: AAR93442.1
AY495163 Genomic DNA Translation: AAR93455.1
AY495164 Genomic DNA Translation: AAR93468.1
AY495165 Genomic DNA Translation: AAR93481.1
AY495166 Genomic DNA Translation: AAR93494.1
AY495167 Genomic DNA Translation: AAR93507.1
AY495168 Genomic DNA Translation: AAR93520.1
AY495169 Genomic DNA Translation: AAR93533.1
AY495170 Genomic DNA Translation: AAR93546.1
AY495171 Genomic DNA Translation: AAR93559.1
AY495172 Genomic DNA Translation: AAR93572.1
AY495173 Genomic DNA Translation: AAR93585.1
AY495174 Genomic DNA Translation: AAR93598.1
AY495175 Genomic DNA Translation: AAR93611.1
AY495176 Genomic DNA Translation: AAR93624.1
AY495177 Genomic DNA Translation: AAR93637.1
AY495178 Genomic DNA Translation: AAR93650.1
AY495179 Genomic DNA Translation: AAR93663.1
AY495180 Genomic DNA Translation: AAR93676.1
AY495181 Genomic DNA Translation: AAR93689.1
AY495182 Genomic DNA Translation: AAR93702.1
AY495183 Genomic DNA Translation: AAR93715.1
AY495184 Genomic DNA Translation: AAR93728.1
AY495185 Genomic DNA Translation: AAR93741.1
AY495186 Genomic DNA Translation: AAR93754.1
AY495187 Genomic DNA Translation: AAR93767.1
AY495188 Genomic DNA Translation: AAR93780.1
AY495189 Genomic DNA Translation: AAR93793.1
AY495190 Genomic DNA Translation: AAR93806.1
AY495191 Genomic DNA Translation: AAR93819.1
AY495192 Genomic DNA Translation: AAR93832.1
AY495193 Genomic DNA Translation: AAR93845.1
AY495194 Genomic DNA Translation: AAR93858.1
AY495239 Genomic DNA Translation: AAR94443.1
AY495240 Genomic DNA Translation: AAR94456.1
AY495241 Genomic DNA Translation: AAR94469.1
AY495242 Genomic DNA Translation: AAR94482.1
AY495243 Genomic DNA Translation: AAR94495.1
AY495244 Genomic DNA Translation: AAR94508.1
AY495245 Genomic DNA Translation: AAR94521.1
AY495246 Genomic DNA Translation: AAR94534.1
AY495247 Genomic DNA Translation: AAR94547.1
AY495248 Genomic DNA Translation: AAR94560.1
AY495250 Genomic DNA Translation: AAR94586.1
AY495251 Genomic DNA Translation: AAR94599.1
AY495252 Genomic DNA Translation: AAR94612.1
AY495253 Genomic DNA Translation: AAR94625.1
AY495254 Genomic DNA Translation: AAR94638.1
AY495255 Genomic DNA Translation: AAR94651.1
AY495257 Genomic DNA Translation: AAR94677.1
AY495259 Genomic DNA Translation: AAR94703.1
AY495261 Genomic DNA Translation: AAR94729.1
AY495262 Genomic DNA Translation: AAR94742.1
AY495263 Genomic DNA Translation: AAR94755.1
AY495266 Genomic DNA Translation: AAR94794.1
AY495267 Genomic DNA Translation: AAR94807.1
AY495268 Genomic DNA Translation: AAR94820.1
AY495269 Genomic DNA Translation: AAR94833.1
AY495270 Genomic DNA Translation: AAR94846.1
AY495271 Genomic DNA Translation: AAR94859.1
AY495272 Genomic DNA Translation: AAR94872.1
AY495273 Genomic DNA Translation: AAR94885.1
AY495274 Genomic DNA Translation: AAR94898.1
AY495275 Genomic DNA Translation: AAR94911.1
AY495276 Genomic DNA Translation: AAR94924.1
AY495277 Genomic DNA Translation: AAR94937.1
AY495278 Genomic DNA Translation: AAR94950.1
AY495279 Genomic DNA Translation: AAR94963.1
AY495280 Genomic DNA Translation: AAR94976.1
AY495282 Genomic DNA Translation: AAR95002.1
AY495283 Genomic DNA Translation: AAR95015.1
AY495284 Genomic DNA Translation: AAR95028.1
AY495285 Genomic DNA Translation: AAR95041.1
AY495286 Genomic DNA Translation: AAR95054.1
AY495287 Genomic DNA Translation: AAR95067.1
AY495288 Genomic DNA Translation: AAR95080.1
AY495289 Genomic DNA Translation: AAR95093.1
AY495290 Genomic DNA Translation: AAR95106.1
AY495291 Genomic DNA Translation: AAR95119.1
AY495292 Genomic DNA Translation: AAR95132.1
AY495293 Genomic DNA Translation: AAR95145.1
AY495294 Genomic DNA Translation: AAR95158.1
AY495295 Genomic DNA Translation: AAR95171.1
AY495296 Genomic DNA Translation: AAR95184.1
AY495297 Genomic DNA Translation: AAR95197.1
AY495298 Genomic DNA Translation: AAR95210.1
AY495299 Genomic DNA Translation: AAR95223.1
AY495300 Genomic DNA Translation: AAR95236.1
AY495301 Genomic DNA Translation: AAR95249.1
AY495302 Genomic DNA Translation: AAR95262.1
AY495303 Genomic DNA Translation: AAR95275.1
AY495304 Genomic DNA Translation: AAR95288.1
AY495305 Genomic DNA Translation: AAR95301.1
AY495306 Genomic DNA Translation: AAR95314.1
AY495307 Genomic DNA Translation: AAR95327.1
AY495308 Genomic DNA Translation: AAR95340.1
AY495309 Genomic DNA Translation: AAR95353.1
AY495311 Genomic DNA Translation: AAR95379.1
AY495312 Genomic DNA Translation: AAR95392.1
AY495315 Genomic DNA Translation: AAR95431.1
AY495316 Genomic DNA Translation: AAR95444.1
AY495318 Genomic DNA Translation: AAR95470.1
AY495320 Genomic DNA Translation: AAR95496.1
AY495321 Genomic DNA Translation: AAR95509.1
AY495324 Genomic DNA Translation: AAR95548.1
AY495325 Genomic DNA Translation: AAR95561.1
AY495326 Genomic DNA Translation: AAR95574.1
AY495327 Genomic DNA Translation: AAR95587.1
AY495328 Genomic DNA Translation: AAR95600.1
AY495330 Genomic DNA Translation: AAR95626.1
PIRiA00446 DNHUN5
RefSeqiYP_003024036.1, NC_012920.1

Genome annotation databases

EnsembliENST00000361567; ENSP00000354813; ENSG00000198786
GeneIDi4540
KEGGihsa:4540

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNU5M_HUMAN
AccessioniPrimary (citable) accession number: P03915
Secondary accession number(s): Q34773, Q8WCY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: May 30, 2000
Last modified: June 20, 2018
This is version 183 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health