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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

MT-ND4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-BTA-611105 Respiratory electron transport
R-BTA-6799198 Complex I biogenesis

Protein family/group databases

TCDBi3.D.1.6.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4
Gene namesi
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded oniMitochondrion
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Mitochondrion

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei94 – 112HelicalSequence analysisAdd BLAST19
Transmembranei116 – 138HelicalSequence analysisAdd BLAST23
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Transmembranei284 – 303HelicalSequence analysisAdd BLAST20
Transmembranei308 – 330HelicalSequence analysisAdd BLAST23
Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
Transmembranei393 – 413HelicalSequence analysisAdd BLAST21
Transmembranei435 – 455HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001179061 – 459NADH-ubiquinone oxidoreductase chain 4Add BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-formylmethionine1 Publication1

Keywords - PTMi

Formylation

Proteomic databases

PaxDbiP03910
PRIDEiP03910

Expressioni

Gene expression databases

BgeeiENSBTAG00000043577
ExpressionAtlasiP03910 baseline

Interactioni

Protein-protein interaction databases

CORUMiP03910
DIPiDIP-38798N
IntActiP03910, 1 interactor
STRINGi9913.ENSBTAP00000053150

Structurei

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4845 Eukaryota
COG1008 LUCA
GeneTreeiENSGT00730000111316
HOVERGENiHBG093667
InParanoidiP03910
KOiK03881
OMAiTAPVHML
OrthoDBiEOG091G0T7G
TreeFamiTF343520

Family and domain databases

InterProiView protein in InterPro
IPR000260 NADH4_N
IPR010227 NADH_Q_OxRdtase_chainM/4
IPR003918 NADH_UbQ_OxRdtase
IPR001750 ND/Mrp_mem
PANTHERiPTHR43507 PTHR43507, 1 hit
PfamiView protein in Pfam
PF01059 Oxidored_q5_N, 1 hit
PF00361 Proton_antipo_M, 1 hit
PRINTSiPR01437 NUOXDRDTASE4
TIGRFAMsiTIGR01972 NDH_I_M, 1 hit

Sequencei

Sequence statusi: Complete.

P03910-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKYIIPTIM LMPLTWLSKN NMIWVNSTAH SLLISFTSLL LMNQFGDNSL
60 70 80 90 100
NFSLLFFSDS LSTPLLILTM WLLPLMLMAS QHHLSKENLT RKKLFITMLI
110 120 130 140 150
SLQLFLIMTF TAMELILFYI LFEATLVPTL IIITRWGNQT ERLNAGLYFL
160 170 180 190 200
FYTLAGSLPL LVALIYIQNT VGSLNFLMLQ YWVQPVHNSW SNVFMWLACM
210 220 230 240 250
MAFMVKMPLY GLHLWLPKAH VEAPIAGSMV LAAVLLKLGG YGMLRITLIL
260 270 280 290 300
NPMTDFMAYP FIMLSLWGMI MTSSICLRQT DLKSLIAYSS VSHMALVIVA
310 320 330 340 350
ILIQTPWSYM GATALMIAHG LTSSMLFCLA NSNYERIHSR TMILARGLQT
360 370 380 390 400
LLPLMATWWL LASLTNLALP PTINLIGELF VVMSTFSWSN ITIILMGVNM
410 420 430 440 450
VITALYSLYM LIMTQRGKYT YHINNISPSF TRENALMSLH ILPLLLLTLN

PKIILGPLY
Length:459
Mass (Da):52,099
Last modified:July 21, 1986 - v1
Checksum:iEE7061AA41977CB4
GO

Mass spectrometryi

Molecular mass is 52130.0 Da from positions 1 - 459. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00654 Genomic DNA Translation: CAA24009.1 Sequence problems.
AF490528 Genomic DNA Translation: AAM08326.1 Sequence problems.
AF490529 Genomic DNA Translation: AAM08339.1 Sequence problems.
AF493541 Genomic DNA Translation: AAM12798.1 Sequence problems.
AF493542 Genomic DNA Translation: AAM12811.1 Sequence problems.
PIRiA00439 QXBO4M
RefSeqiYP_209214.1, NC_006853.1

Genome annotation databases

EnsembliENSBTAT00000060552; ENSBTAP00000053150; ENSBTAG00000043577
GeneIDi3283886
KEGGibta:3283886

Similar proteinsi

Entry informationi

Entry nameiNU4M_BOVIN
AccessioniPrimary (citable) accession number: P03910
Secondary accession number(s): Q8SE30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: February 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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