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Protein

NADH-ubiquinone oxidoreductase chain 4L

Gene

Mtnd4l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionTranslocase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4L (EC:7.1.1.2)
Alternative name(s):
NADH dehydrogenase subunit 4L
Gene namesi
Name:Mtnd4l
Synonyms:mt-Nd4l, Nd4l
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Mitochondrion

Organism-specific databases

MGIiMGI:102497 mt-Nd4l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Transmembranei58 – 79HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001184481 – 98NADH-ubiquinone oxidoreductase chain 4LAdd BLAST98

Proteomic databases

PaxDbiP03903
PRIDEiP03903

PTM databases

iPTMnetiP03903
SwissPalmiP03903

Expressioni

Gene expression databases

BgeeiENSMUSG00000065947 Expressed in 19 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiP03903 baseline and differential

Interactioni

Protein-protein interaction databases

ComplexPortaliCPX-266 Mitochondrial respiratory chain complex I
STRINGi10090.ENSMUSP00000081021

Structurei

Secondary structure

198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP03903
SMRiP03903
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4L family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4669 Eukaryota
COG0713 LUCA
GeneTreeiENSGT00390000004755
HOVERGENiHBG071122
InParanoidiP03903
KOiK03882
OMAiLCLEGMM
OrthoDBiEOG091G0ZRL
PhylomeDBiP03903

Family and domain databases

InterProiView protein in InterPro
IPR001133 NADH_UbQ_OxRdtase_chain4L/K
IPR039428 NUOK/Mnh_C1-like
PANTHERiPTHR11434 PTHR11434, 1 hit
PfamiView protein in Pfam
PF00420 Oxidored_q2, 1 hit

Sequencei

Sequence statusi: Complete.

P03903-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSTFFNLTM AFSLSLLGTL MFRSHLMSTL LCLEGMVLSL FIMTSVTSLN
60 70 80 90
SNSMSSMPIP ITILVFAACE AAVGLALLVK VSNTYGTDYV QNLNLLQC
Length:98
Mass (Da):10,607
Last modified:April 1, 2015 - v2
Checksum:i48CAF698FF5F4C29
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63Missing in AAB48652 (PubMed:7332926).Curated1
Sequence conflicti63Missing in CAA24087 (PubMed:7332926).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA Translation: AAB48652.1
V00711 Genomic DNA Translation: CAA24087.1
AY172335 Genomic DNA Translation: AAN85130.1
PIRiA00430 QXMS4L
RefSeqiNP_904336.1, NC_005089.1

Genome annotation databases

EnsembliENSMUST00000084013; ENSMUSP00000081021; ENSMUSG00000065947
GeneIDi17720
KEGGimmu:17720

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA Translation: AAB48652.1
V00711 Genomic DNA Translation: CAA24087.1
AY172335 Genomic DNA Translation: AAN85130.1
PIRiA00430 QXMS4L
RefSeqiNP_904336.1, NC_005089.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6G2Jelectron microscopy3.30K1-98[»]
6G72electron microscopy3.90K1-98[»]
ProteinModelPortaliP03903
SMRiP03903
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-266 Mitochondrial respiratory chain complex I
STRINGi10090.ENSMUSP00000081021

PTM databases

iPTMnetiP03903
SwissPalmiP03903

Proteomic databases

PaxDbiP03903
PRIDEiP03903

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084013; ENSMUSP00000081021; ENSMUSG00000065947
GeneIDi17720
KEGGimmu:17720

Organism-specific databases

CTDi4539
MGIiMGI:102497 mt-Nd4l

Phylogenomic databases

eggNOGiKOG4669 Eukaryota
COG0713 LUCA
GeneTreeiENSGT00390000004755
HOVERGENiHBG071122
InParanoidiP03903
KOiK03882
OMAiLCLEGMM
OrthoDBiEOG091G0ZRL
PhylomeDBiP03903

Miscellaneous databases

PROiPR:P03903
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000065947 Expressed in 19 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiP03903 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001133 NADH_UbQ_OxRdtase_chain4L/K
IPR039428 NUOK/Mnh_C1-like
PANTHERiPTHR11434 PTHR11434, 1 hit
PfamiView protein in Pfam
PF00420 Oxidored_q2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNU4LM_MOUSE
AccessioniPrimary (citable) accession number: P03903
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 2015
Last modified: November 7, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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