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Protein

NADH-ubiquinone oxidoreductase chain 4L

Gene

MT-ND4L

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Protein family/group databases

TCDBi3.D.1.6.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4L (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4L
Gene namesi
Name:MT-ND4L
Synonyms:MTND4L, NADH4L, ND4L
Encoded oniMitochondrion
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Mitochondrion

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001183961 – 98NADH-ubiquinone oxidoreductase chain 4LAdd BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-formylmethionine1 Publication1

Keywords - PTMi

Formylation

Proteomic databases

PaxDbiP03902

Expressioni

Gene expression databases

BgeeiENSBTAG00000043559
ExpressionAtlasiP03902 baseline and differential

Interactioni

Protein-protein interaction databases

CORUMiP03902
DIPiDIP-62099N
STRINGi9913.ENSBTAP00000053153

Structurei

3D structure databases

SMRiP03902
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4L family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4669 Eukaryota
COG0713 LUCA
GeneTreeiENSGT00390000004755
HOGENOMiHOG000113880
HOVERGENiHBG071122
InParanoidiP03902
KOiK03882
OMAiLCLEGMM
OrthoDBiEOG091G0ZRL
TreeFamiTF338190

Family and domain databases

InterProiView protein in InterPro
IPR001133 NADH_UbQ_OxRdtase_chain4L/K
PANTHERiPTHR11434 PTHR11434, 1 hit

Sequencei

Sequence statusi: Complete.

P03902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMVYMNIMM AFTVSLVGLL MYRSHLMSSL LCLEGMMLSL FVMAALTILN
60 70 80 90
SHFTLASMMP IILLVFAACE AALGLSLLVM VSNTYGTDYV QNLNLLQC
Length:98
Mass (Da):10,797
Last modified:July 21, 1986 - v1
Checksum:i4DB48B7DA59C1881
GO

Mass spectrometryi

Molecular mass is 10825.4 Da from positions 1 - 98. Determined by ESI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti65V → A in strain: 66. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00654 Genomic DNA Translation: CAA24004.1
AF490528 Genomic DNA Translation: AAM08325.1
AF490529 Genomic DNA Translation: AAM08338.1
AF493541 Genomic DNA Translation: AAM12797.1
AF493542 Genomic DNA Translation: AAM12810.1
PIRiA00429 QXBO4L
RefSeqiYP_209213.1, NC_006853.1

Genome annotation databases

EnsembliENSBTAT00000060543; ENSBTAP00000053153; ENSBTAG00000043559
GeneIDi3283885
KEGGibta:3283885

Similar proteinsi

Entry informationi

Entry nameiNU4LM_BOVIN
AccessioniPrimary (citable) accession number: P03902
Secondary accession number(s): Q8SFX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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