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Protein

NADH-ubiquinone oxidoreductase chain 3

Gene

Mtnd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionTranslocase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-MMU-611105 Respiratory electron transport
R-MMU-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 3 (EC:7.1.1.2)
Alternative name(s):
NADH dehydrogenase subunit 3
Gene namesi
Name:Mtnd3
Synonyms:mt-Nd3, Nd3
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Mitochondrion

Organism-specific databases

MGIiMGI:102499 mt-Nd3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001177651 – 115NADH-ubiquinone oxidoreductase chain 3Add BLAST115

Proteomic databases

EPDiP03899
PaxDbiP03899
PeptideAtlasiP03899
PRIDEiP03899

PTM databases

iPTMnetiP03899
PhosphoSitePlusiP03899
SwissPalmiP03899

Expressioni

Gene expression databases

BgeeiENSMUSG00000064360 Expressed in 20 organ(s), highest expression level in thymus
ExpressionAtlasiP03899 baseline and differential

Interactioni

Protein-protein interaction databases

ComplexPortaliCPX-266 Mitochondrial respiratory chain complex I
CORUMiP03899
STRINGi10090.ENSMUSP00000080998

Structurei

Secondary structure

1115
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP03899
SMRiP03899
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4662 Eukaryota
COG0838 LUCA
GeneTreeiENSGT00390000011605
HOGENOMiHOG000100119
HOVERGENiHBG017392
InParanoidiP03899
KOiK03880
OMAiDAYECGI
OrthoDBiEOG091G14Y7
PhylomeDBiP03899

Family and domain databases

Gene3Di1.20.58.1610, 1 hit
InterProiView protein in InterPro
IPR000440 NADH_UbQ/plastoQ_OxRdtase_su3
IPR038430 NDAH_ubi_oxred_su3_sf
PANTHERiPTHR11058 PTHR11058, 1 hit
PfamiView protein in Pfam
PF00507 Oxidored_q4, 1 hit

Sequencei

Sequence statusi: Complete.

P03899-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLYTVIFIN ILLSLTLILV AFWLPQMNLY SEKANPYECG FDPTSSARLP
60 70 80 90 100
FSMKFFLVAI TFLLFDLEIA LLLPLPWAIQ TIKTSTMMIM AFILVTILSL
110
GLAYEWTQKG LEWTE
Length:115
Mass (Da):13,219
Last modified:November 16, 2001 - v3
Checksum:i6925F293601CB391
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16T → A in AAA19255 (PubMed:8022788).Curated1
Sequence conflicti33Missing in AAB48651 (PubMed:7332926).Curated1
Sequence conflicti33Missing in CAA24086 (PubMed:7332926).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA Translation: AAB48651.1
V00711 Genomic DNA Translation: CAA24086.1
U09637 Genomic DNA Translation: AAA19254.2
U09638 Genomic DNA Translation: AAA19255.2
AB042432 Genomic DNA Translation: BAA95623.1
AB042523 Genomic DNA Translation: BAA95660.1
AB042524 Genomic DNA Translation: BAA95647.1
AB042809 Genomic DNA Translation: BAA95802.1
AB049357 Genomic DNA Translation: BAB13808.1
AY172335 Genomic DNA Translation: AAN85129.1
PIRiA55746
B55746 QXMS3M
RefSeqiNP_904335.1, NC_005089.1
YP_220557.1, NC_006914.1

Genome annotation databases

EnsembliENSMUST00000082411; ENSMUSP00000080998; ENSMUSG00000064360
GeneIDi17718
3338896
KEGGimmu:17718

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA Translation: AAB48651.1
V00711 Genomic DNA Translation: CAA24086.1
U09637 Genomic DNA Translation: AAA19254.2
U09638 Genomic DNA Translation: AAA19255.2
AB042432 Genomic DNA Translation: BAA95623.1
AB042523 Genomic DNA Translation: BAA95660.1
AB042524 Genomic DNA Translation: BAA95647.1
AB042809 Genomic DNA Translation: BAA95802.1
AB049357 Genomic DNA Translation: BAB13808.1
AY172335 Genomic DNA Translation: AAN85129.1
PIRiA55746
B55746 QXMS3M
RefSeqiNP_904335.1, NC_005089.1
YP_220557.1, NC_006914.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6G2Jelectron microscopy3.30A1-115[»]
6G72electron microscopy3.90A1-115[»]
ProteinModelPortaliP03899
SMRiP03899
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-266 Mitochondrial respiratory chain complex I
CORUMiP03899
STRINGi10090.ENSMUSP00000080998

PTM databases

iPTMnetiP03899
PhosphoSitePlusiP03899
SwissPalmiP03899

Proteomic databases

EPDiP03899
PaxDbiP03899
PeptideAtlasiP03899
PRIDEiP03899

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082411; ENSMUSP00000080998; ENSMUSG00000064360
GeneIDi17718
3338896
KEGGimmu:17718

Organism-specific databases

CTDi4537
MGIiMGI:102499 mt-Nd3

Phylogenomic databases

eggNOGiKOG4662 Eukaryota
COG0838 LUCA
GeneTreeiENSGT00390000011605
HOGENOMiHOG000100119
HOVERGENiHBG017392
InParanoidiP03899
KOiK03880
OMAiDAYECGI
OrthoDBiEOG091G14Y7
PhylomeDBiP03899

Enzyme and pathway databases

ReactomeiR-MMU-611105 Respiratory electron transport
R-MMU-6799198 Complex I biogenesis

Miscellaneous databases

PROiPR:P03899
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000064360 Expressed in 20 organ(s), highest expression level in thymus
ExpressionAtlasiP03899 baseline and differential

Family and domain databases

Gene3Di1.20.58.1610, 1 hit
InterProiView protein in InterPro
IPR000440 NADH_UbQ/plastoQ_OxRdtase_su3
IPR038430 NDAH_ubi_oxred_su3_sf
PANTHERiPTHR11058 PTHR11058, 1 hit
PfamiView protein in Pfam
PF00507 Oxidored_q4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNU3M_MOUSE
AccessioniPrimary (citable) accession number: P03899
Secondary accession number(s): Q35039, Q35040, Q9MD73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 16, 2001
Last modified: November 7, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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